WO2002013907A1 - Radiotherapy simulation apparatus - Google Patents

Radiotherapy simulation apparatus Download PDF

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Publication number
WO2002013907A1
WO2002013907A1 PCT/GB2001/003452 GB0103452W WO0213907A1 WO 2002013907 A1 WO2002013907 A1 WO 2002013907A1 GB 0103452 W GB0103452 W GB 0103452W WO 0213907 A1 WO0213907 A1 WO 0213907A1
Authority
WO
WIPO (PCT)
Prior art keywords
imager
accelerator
patient
simulator
simulator according
Prior art date
Application number
PCT/GB2001/003452
Other languages
French (fr)
Inventor
Kevin John Brown
Original Assignee
Elekta Ab (Publ)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elekta Ab (Publ) filed Critical Elekta Ab (Publ)
Publication of WO2002013907A1 publication Critical patent/WO2002013907A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048Monitoring, verifying, controlling systems and methods
    • A61N5/1049Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/42Arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/4225Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector using image intensifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/44Constructional features of apparatus for radiation diagnosis
    • A61B6/4429Constructional features of apparatus for radiation diagnosis related to the mounting of source units and detector units
    • A61B6/4435Constructional features of apparatus for radiation diagnosis related to the mounting of source units and detector units the source unit and the detector unit being coupled by a rigid structure
    • A61B6/4441Constructional features of apparatus for radiation diagnosis related to the mounting of source units and detector units the source unit and the detector unit being coupled by a rigid structure the rigid structure being a C-arm or U-arm

Definitions

  • the present invention relates to a radiotherapy apparatus.
  • One such method is a simulator, a low energy source combined with a visible light source. An image can be prepared which corresponds to the therapeutic dose subsequently applied on the full scale accelerator. The visible light source allows the patient to be marked up for subsequent alignment. This form of simulation is suitable for simple treatment plans but is unable to simulate modern complex plans.
  • portal image This is an image produced by placing a photographic plate or electronic imaging plate beneath the patient during a brief period of irradiation. The beam is attenuated by the patient's internal organs and structures, leaving an image in the plate. This can then be checked either before complete treatment or after a dose, to ensure that the aim was correct.
  • Portal images are however extremely difficult to interpret as the energy of the beam which is necessary to have a useful therapeutic effect is very much greater than that used for medical imaging. At these higher energies there is smaller ratio in the relative attenuation between bony and tissue structure, which results in portal images with poor contrast. Structures within the patient are difficult to discern.
  • CT computerised tomography
  • a digitally reconstructed radiograph can be constructed that will be a prediction of the portal image that would be created.
  • the DRR can be set up to enhance the contrast obtained and accordingly avoids the difficulties inherent in the portal image.
  • dedicated CT scanners have an aperture limitation which means they cannot simulate the full range of the therapeutic accelerator.
  • Simpler CT scanners based around a simulator can in theory simulate the full therapeutic range, but require a full rotation of the gantry to acquire each CT slice.
  • the available speed of rotation of a simulator gantry means that it is only practical to obtain about 5 slices within a reasonable time. This is sufficient to cater for simple treatment plans but is inadequate for modern 3D treatment planning or Intensity Modulated Radiation Therapy (IMRT) treatment.
  • IMRT Intensity Modulated Radiation Therapy
  • CT scanners do not cast an image on the patient which can be used to mark up for later realignment.
  • the present invention therefore provides a radiotherapy simulator comprising a radiation source, a planar digital detector, a patient support table to lie between the accelerator and the imager, and a processing means adapted to interpret the output of the imager to produce a simulated treatment outcome.
  • the accelerator can include an aligned visible light course to assist in patient mark-up.
  • the imager is preferable of amorphous silicon. Such imagers are available as flat panel items.
  • the accelerator and the imager are mounted on opposing arms of a C-shaped support. This provides a simple form of alignment which can be rotated around the patient easily.
  • the imager arm is preferably retractable to allow easy access.
  • patient 1 0 is supported on patient table 1 2 .
  • a radiation source 14 capable of producing low energy radiation such as is normally used in simulation.
  • Beneath the patient table 12 lies a planar digital detector 1 6 on a suitable support arrangement 1 8.
  • the detector 1 6 is positioned so as to lie in the path of a beam of radiation 20 that has been omitted by the source 14 and has passed through the patient 10.
  • the output of the detector 1 6 is fed to a computing apparatus 22.
  • the radiation source 14 and detector 1 6 are mounted on the ends of a rotatable C-arm and can therefore be rotated in a corelated fashion around the patient, as shown in dotted lines.
  • the two dimensional nature of the planar detector 1 6 means that a single rotational scan of the detector and the source will enable multiple slices to be reconstructed via cone beam CT methods.
  • Cone beam reconstruction inherently has the same resolution in all directions and is therefore suited for generation of digitally reconstructed radiographs using the computing apparatus 22.
  • the need for a DRR will in many cases be eliminated as the required image will be available directly from the detector, either as a by-product of the rotational scan or as a deliberate imaging action.
  • the reconstruction process for generation of DRR is complex and therefore dedicated hardware within the computing apparatus is likely to be beneficial in order to reduce the reconstruction time into a period which is effectively on-line. However, it is also possible to generate the image off-line for subsequent use in planning.
  • a source of optical light can be incorporated within radiation source 14 in order to provide one or more (preferably two or more) reference points for marking up the patient.
  • the present invention provides a simulator which is able to produce a data set suitable for use in preparation of DRR's and treatment and planning which does not require extended CT scan times. Meanwhile, as opposed to existing scanners, the simulator is sufficiently similar to a treatment apparatus as to provide a reliable simulation process.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

A radiotherapy simulator comprises a radiation source, a planar digital detector, a patient support table to lie between the accelerator and the imager, and a processing means adapted to interpret the output of the imager to produce a simulated treatment outcome. The accelerator can include an aligned visible light course to assist in patient mark up. The imager is preferable of amorphous silicon. Such imagers are available as flat panel items. It is further preferred that the accelerator and the imager are mounted on opposing arms of a C-shaped support. This provides a simple form of alignment which can be rotated around the patient easily. The imager arm is preferably retractable to allow easy access.

Description

RADIOTHERAPY SIMULATION APPARATUS
The present invention relates to a radiotherapy apparatus.
In the use of radiotherapy to treat cancer and other ailments, a powerful beam of the appropriate radiation is directed at the area of the patient which is affected. This beam is apt to kill living cells in its path, hence its use against cancerous cells, and therefore it is highly desirable to ensure that the beam is correctly aimed. Failure to do so may result in the unnecessary destruction of healthy cells of the patient.
Several methods are used to check that the alignment of the beam is correct. One such method is a simulator, a low energy source combined with a visible light source. An image can be prepared which corresponds to the therapeutic dose subsequently applied on the full scale accelerator. The visible light source allows the patient to be marked up for subsequent alignment. This form of simulation is suitable for simple treatment plans but is unable to simulate modern complex plans.
Another method is the use of a so-called "portal image". This is an image produced by placing a photographic plate or electronic imaging plate beneath the patient during a brief period of irradiation. The beam is attenuated by the patient's internal organs and structures, leaving an image in the plate. This can then be checked either before complete treatment or after a dose, to ensure that the aim was correct. Portal images are however extremely difficult to interpret as the energy of the beam which is necessary to have a useful therapeutic effect is very much greater than that used for medical imaging. At these higher energies there is smaller ratio in the relative attenuation between bony and tissue structure, which results in portal images with poor contrast. Structures within the patient are difficult to discern.
Another more recent approach is the use of CT simulation. A CT (computerised tomography) scanner is used to scan the patient. From the CT dataset, a digitally reconstructed radiograph (DRR) can be constructed that will be a prediction of the portal image that would be created. The DRR can be set up to enhance the contrast obtained and accordingly avoids the difficulties inherent in the portal image. However, dedicated CT scanners have an aperture limitation which means they cannot simulate the full range of the therapeutic accelerator. Simpler CT scanners based around a simulator can in theory simulate the full therapeutic range, but require a full rotation of the gantry to acquire each CT slice. The available speed of rotation of a simulator gantry means that it is only practical to obtain about 5 slices within a reasonable time. This is sufficient to cater for simple treatment plans but is inadequate for modern 3D treatment planning or Intensity Modulated Radiation Therapy (IMRT) treatment. In addition, CT scanners do not cast an image on the patient which can be used to mark up for later realignment.
Accordingly, there remains a need to provide a practical simulator which can accurately simulate complex treatment plans.
The present invention therefore provides a radiotherapy simulator comprising a radiation source, a planar digital detector, a patient support table to lie between the accelerator and the imager, and a processing means adapted to interpret the output of the imager to produce a simulated treatment outcome. The accelerator can include an aligned visible light course to assist in patient mark-up.
The imager is preferable of amorphous silicon. Such imagers are available as flat panel items.
It is further preferred that the accelerator and the imager are mounted on opposing arms of a C-shaped support. This provides a simple form of alignment which can be rotated around the patient easily. The imager arm is preferably retractable to allow easy access.
An embodiment of the present invention will now be described by way of example, with reference to the accompanying figure, which shows a schematic view of the system.
As shown in Figure 1 , patient 1 0 is supported on patient table 1 2 . Above the patient is disposed a radiation source 14 capable of producing low energy radiation such as is normally used in simulation. Beneath the patient table 12 lies a planar digital detector 1 6 on a suitable support arrangement 1 8. The detector 1 6 is positioned so as to lie in the path of a beam of radiation 20 that has been omitted by the source 14 and has passed through the patient 10. The output of the detector 1 6 is fed to a computing apparatus 22.
The radiation source 14 and detector 1 6 are mounted on the ends of a rotatable C-arm and can therefore be rotated in a corelated fashion around the patient, as shown in dotted lines. The two dimensional nature of the planar detector 1 6 means that a single rotational scan of the detector and the source will enable multiple slices to be reconstructed via cone beam CT methods. Cone beam reconstruction inherently has the same resolution in all directions and is therefore suited for generation of digitally reconstructed radiographs using the computing apparatus 22. However, the need for a DRR will in many cases be eliminated as the required image will be available directly from the detector, either as a by-product of the rotational scan or as a deliberate imaging action.
The reconstruction process for generation of DRR is complex and therefore dedicated hardware within the computing apparatus is likely to be beneficial in order to reduce the reconstruction time into a period which is effectively on-line. However, it is also possible to generate the image off-line for subsequent use in planning.
A source of optical light can be incorporated within radiation source 14 in order to provide one or more (preferably two or more) reference points for marking up the patient.
Accordingly, the present invention provides a simulator which is able to produce a data set suitable for use in preparation of DRR's and treatment and planning which does not require extended CT scan times. Meanwhile, as opposed to existing scanners, the simulator is sufficiently similar to a treatment apparatus as to provide a reliable simulation process.
It will of course be appreciated that many variations can be made to the above described embodiment without departing from the scope of the present invention.

Claims

1 . A radiotherapy simulator comprising a radiation source and a planar digital detector together forming a cone beam CT arrangement, a patient support table lying between the accelerator and the imager, and a processing means adapted to interpret the output of the imager as a cone beam CT image to produce a simulated treatment outcome.
2. A simulator according to claim 1 including an aligned visible light source.
3. A simulator according to claim 1 or claim 2 in which the imager is of amorphous silicon.
4. A simulator according to any preceding claim in which the accelerator and the imager are mounted on opposing arms of a C-shaped support.
5. A simulator according to claim 4 in which the imager arm is retractable.
6. A simulator substantially as described herein with reference to and/or as illustrated in the accompanying figure.
PCT/GB2001/003452 2000-08-16 2001-07-31 Radiotherapy simulation apparatus WO2002013907A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0020030A GB2366501B (en) 2000-08-16 2000-08-16 Radiotherapy simulation apparatus
GB0020030.3 2000-08-16

Publications (1)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004004829A1 (en) * 2002-07-02 2004-01-15 Pencilbeam Technologies Ab Radiation system with inner and outer gantry, to enable precise positioning when rotating the inner gantry
EP1581804A2 (en) * 2002-12-18 2005-10-05 Varian Medical Systems Technologies, Inc. A multi-mode cone beam ct radiotherapy simulator and treatment machine with a flat panel imager
US9498167B2 (en) 2005-04-29 2016-11-22 Varian Medical Systems, Inc. System and methods for treating patients using radiation
US9630025B2 (en) 2005-07-25 2017-04-25 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US10004650B2 (en) 2005-04-29 2018-06-26 Varian Medical Systems, Inc. Dynamic patient positioning system
USRE46953E1 (en) 2007-04-20 2018-07-17 University Of Maryland, Baltimore Single-arc dose painting for precision radiation therapy
US10773101B2 (en) 2010-06-22 2020-09-15 Varian Medical Systems International Ag System and method for estimating and manipulating estimated radiation dose

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US5081661A (en) * 1989-09-27 1992-01-14 Siemens Aktiengesellschaft X-ray examination apparatus
US5247555A (en) * 1988-10-28 1993-09-21 Nucletron Manufacturing Corp. Radiation image generating system and method
US5335255A (en) * 1992-03-24 1994-08-02 Seppi Edward J X-ray scanner with a source emitting plurality of fan beams
US5825842A (en) * 1995-07-05 1998-10-20 Kabushiki Kaisha Toshiba X-ray computed tomographic imaging device and x-ray computed tomographic method
DE19941149A1 (en) * 1998-08-31 2000-03-02 Shimadzu Corp Radiotherapy mapping arrangement, e.g. for cancer; has computer tomographic simulator, X-ray simulator, determination arrangement, superposition and display device

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US5247555A (en) * 1988-10-28 1993-09-21 Nucletron Manufacturing Corp. Radiation image generating system and method
US5079426A (en) * 1989-09-06 1992-01-07 The Regents Of The University Of Michigan Multi-element-amorphous-silicon-detector-array for real-time imaging and dosimetry of megavoltage photons and diagnostic X rays
US5081661A (en) * 1989-09-27 1992-01-14 Siemens Aktiengesellschaft X-ray examination apparatus
US5335255A (en) * 1992-03-24 1994-08-02 Seppi Edward J X-ray scanner with a source emitting plurality of fan beams
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Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6865254B2 (en) 2002-07-02 2005-03-08 Pencilbeam Technologies Ab Radiation system with inner and outer gantry parts
WO2004004829A1 (en) * 2002-07-02 2004-01-15 Pencilbeam Technologies Ab Radiation system with inner and outer gantry, to enable precise positioning when rotating the inner gantry
US9901750B2 (en) 2002-12-18 2018-02-27 Varian Medical Systems, Inc. Multi-mode cone beam CT radiotherapy simulator and treatment machine with a flat panel imager
EP1581804A2 (en) * 2002-12-18 2005-10-05 Varian Medical Systems Technologies, Inc. A multi-mode cone beam ct radiotherapy simulator and treatment machine with a flat panel imager
EP1581804A4 (en) * 2002-12-18 2011-02-23 Varian Med Sys Inc A multi-mode cone beam ct radiotherapy simulator and treatment machine with a flat panel imager
US8116430B1 (en) 2002-12-18 2012-02-14 Varian Medical Systems, Inc. Multi-mode cone beam CT radiotherapy simulator and treatment machine with a flat panel imager
US8867703B2 (en) 2002-12-18 2014-10-21 Varian Medical Systems, Inc. Multi-mode cone beam CT radiotherapy simulator and treatment machine with a flat panel imager
US9421399B2 (en) 2002-12-18 2016-08-23 Varian Medical Systems, Inc. Multi-mode cone beam CT radiotherapy simulator and treatment machine with a flat panel imager
US11344748B2 (en) 2002-12-18 2022-05-31 Varian Medical Systems, Inc. Multi-mode cone beam CT radiotherapy simulator and treatment machine with a flat panel imager
US9974494B2 (en) 2005-04-29 2018-05-22 Varian Medical Systems, Inc. System and methods for treating patients using radiation
US10004650B2 (en) 2005-04-29 2018-06-26 Varian Medical Systems, Inc. Dynamic patient positioning system
US9498167B2 (en) 2005-04-29 2016-11-22 Varian Medical Systems, Inc. System and methods for treating patients using radiation
US10881878B2 (en) 2005-04-29 2021-01-05 Varian Medical Systems, Inc. Dynamic patient positioning system
US9630025B2 (en) 2005-07-25 2017-04-25 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US9687677B2 (en) 2005-07-25 2017-06-27 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US9764159B2 (en) 2005-07-25 2017-09-19 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US9788783B2 (en) 2005-07-25 2017-10-17 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US9687674B2 (en) 2005-07-25 2017-06-27 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US9687675B2 (en) 2005-07-25 2017-06-27 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US9687673B2 (en) 2005-07-25 2017-06-27 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US11642027B2 (en) 2005-07-25 2023-05-09 Siemens Healthineers International Ag Methods and apparatus for the planning and delivery of radiation treatments
US10595774B2 (en) 2005-07-25 2020-03-24 Varian Medical Systems International Methods and apparatus for the planning and delivery of radiation treatments
US9687678B2 (en) 2005-07-25 2017-06-27 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
US9687676B2 (en) 2005-07-25 2017-06-27 Varian Medical Systems International Ag Methods and apparatus for the planning and delivery of radiation treatments
USRE46953E1 (en) 2007-04-20 2018-07-17 University Of Maryland, Baltimore Single-arc dose painting for precision radiation therapy
US10773101B2 (en) 2010-06-22 2020-09-15 Varian Medical Systems International Ag System and method for estimating and manipulating estimated radiation dose
US11986671B2 (en) 2010-06-22 2024-05-21 Siemens Healthineers International Ag System and method for estimating and manipulating estimated radiation dose

Also Published As

Publication number Publication date
GB2366501B (en) 2002-07-17
GB2366501A (en) 2002-03-06
GB0020030D0 (en) 2000-10-04

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