WO2002011674A3 - Procede et reactif permettant d'inhiber le canal chlorure active par le calcium 1 (clca-1) - Google Patents

Procede et reactif permettant d'inhiber le canal chlorure active par le calcium 1 (clca-1) Download PDF

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Publication number
WO2002011674A3
WO2002011674A3 PCT/US2001/024970 US0124970W WO0211674A3 WO 2002011674 A3 WO2002011674 A3 WO 2002011674A3 US 0124970 W US0124970 W US 0124970W WO 0211674 A3 WO0211674 A3 WO 0211674A3
Authority
WO
WIPO (PCT)
Prior art keywords
chloride channel
clca
inhibition
reagent
calcium activated
Prior art date
Application number
PCT/US2001/024970
Other languages
English (en)
Other versions
WO2002011674A2 (fr
Inventor
James Mcswiggen
James Thompson
Timothy Mckenzie
David Ayers
David E Szymkowski
Andrew Grupe
Original Assignee
Ribozyme Pharm Inc
Syntex Llc
James Mcswiggen
James Thompson
Timothy Mckenzie
David Ayers
David E Szymkowski
Andrew Grupe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribozyme Pharm Inc, Syntex Llc, James Mcswiggen, James Thompson, Timothy Mckenzie, David Ayers, David E Szymkowski, Andrew Grupe filed Critical Ribozyme Pharm Inc
Priority to AU2001283222A priority Critical patent/AU2001283222A1/en
Publication of WO2002011674A2 publication Critical patent/WO2002011674A2/fr
Publication of WO2002011674A3 publication Critical patent/WO2002011674A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead

Abstract

L'invention concerne des molécules d'acide nucléique, notamment des molécules d'acide nucléique antisens et enzymatiques telles que les ribozymes en tête de marteau, les ADNzymes et les GeneBlocs, qui modulent l'expression des canaux chlorure activés par le calcium (CLCA1, CLCA2, CLCA3, et CLCA4).
PCT/US2001/024970 2000-08-09 2001-08-09 Procede et reactif permettant d'inhiber le canal chlorure active par le calcium 1 (clca-1) WO2002011674A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001283222A AU2001283222A1 (en) 2000-08-09 2001-08-09 Method and reagent for the inhibition of calcium activated chloride channel-1 (clca-1)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22438300P 2000-08-09 2000-08-09
US60/224,383 2000-08-09

Publications (2)

Publication Number Publication Date
WO2002011674A2 WO2002011674A2 (fr) 2002-02-14
WO2002011674A3 true WO2002011674A3 (fr) 2003-09-25

Family

ID=22840434

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024970 WO2002011674A2 (fr) 2000-08-09 2001-08-09 Procede et reactif permettant d'inhiber le canal chlorure active par le calcium 1 (clca-1)

Country Status (2)

Country Link
AU (1) AU2001283222A1 (fr)
WO (1) WO2002011674A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001038530A1 (fr) * 1999-11-24 2001-05-31 Takeda Chemical Industries, Ltd. Utilisation d'un gene associe a une maladie
MXPA05012728A (es) * 2003-05-28 2006-02-13 Wyeth Corp Clca-1 soluble y antagonistas para el clca-1.
EP3263115A1 (fr) * 2016-06-30 2018-01-03 Technische Hochschule Mittelhessen Invention concernant un agent actif contre le pseudomonas aeruginosa

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011304A1 (fr) * 1993-10-18 1995-04-27 Ribozyme Pharmaceuticals, Inc. Adn catalytique
WO1997026270A2 (fr) * 1996-01-16 1997-07-24 Ribozyme Pharmaceuticals, Inc. Synthese de methoxy nucleosides et de molecules d'acide nucleique enzymatique
WO1998032846A2 (fr) * 1997-01-23 1998-07-30 Ribozyme Pharmaceuticals, Inc. Traitement par acides nucleiques enzymatiques des maladies ou des etats lies aux niveaux de c-fos
WO1999055857A2 (fr) * 1998-04-29 1999-11-04 Ribozyme Pharmaceuticals, Inc. Nucleoside triphosphates et leur integration aux ribozymes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011304A1 (fr) * 1993-10-18 1995-04-27 Ribozyme Pharmaceuticals, Inc. Adn catalytique
WO1997026270A2 (fr) * 1996-01-16 1997-07-24 Ribozyme Pharmaceuticals, Inc. Synthese de methoxy nucleosides et de molecules d'acide nucleique enzymatique
WO1998032846A2 (fr) * 1997-01-23 1998-07-30 Ribozyme Pharmaceuticals, Inc. Traitement par acides nucleiques enzymatiques des maladies ou des etats lies aux niveaux de c-fos
WO1999055857A2 (fr) * 1998-04-29 1999-11-04 Ribozyme Pharmaceuticals, Inc. Nucleoside triphosphates et leur integration aux ribozymes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
COUTURE L A ET AL: "Anti-gene therapy: the use of ribozymes to inhibit gene function", TRENDS IN GENETICS, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 12, no. 12, 1 December 1996 (1996-12-01), pages 509, XP004071051, ISSN: 0168-9525 *
DATABASE GENBANK [online] 14 December 1998 (1998-12-14), "Homo sapiens calcium-dependent chloride channel-1 (hCLCA1) mRNA, complete cds", XP002219572, Database accession no. AF039400 *
GRUBER A D ET AL: "GENOMIC CLONING, MOLECULAR CHARACTERIZATION, AND FUNCTIONAL ANALYSIS OF HUMAN CLCA1, THE FIRST HUMAN MEMBER OF THE FAMILY OF CA2+-ACTIVATED CI CHANNEL PROTEINS", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 54, 1998, pages 200 - 214, XP002945247, ISSN: 0888-7543 *
LUDWIG J ET AL: "Extending the cleavage rules for the hammerhead ribozyme: mutating adenosine15.1 to inosine15.1 changes the cleavage site specificity from N16.2U16.1H17 to N16.2C16.1H17", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 26, no. 10, 15 May 1998 (1998-05-15), pages 2279 - 2285, XP002084035, ISSN: 0305-1048 *
VAISH ET AL: "In vitro selection of a purine nucleotide-specific hammerhead-like ribozyme", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, no. 5, 1 March 1998 (1998-03-01), pages 2158 - 2162, XP002097465, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
AU2001283222A1 (en) 2002-02-18
WO2002011674A2 (fr) 2002-02-14

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