WO2002010206A3 - Nucleotide sequences which code for the metf gene - Google Patents

Nucleotide sequences which code for the metf gene Download PDF

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Publication number
WO2002010206A3
WO2002010206A3 PCT/EP2001/008224 EP0108224W WO0210206A3 WO 2002010206 A3 WO2002010206 A3 WO 2002010206A3 EP 0108224 W EP0108224 W EP 0108224W WO 0210206 A3 WO0210206 A3 WO 0210206A3
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotide
amino acid
acid sequence
code
nucleotide sequences
Prior art date
Application number
PCT/EP2001/008224
Other languages
French (fr)
Other versions
WO2002010206A2 (en
Inventor
Brigitte Bathe
Bettina Moeckel
Walter Pfefferle
Klaus Huthmacher
Michael Binder
Dieter Greissinger
Georg Thierbach
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10109686A external-priority patent/DE10109686A1/en
Application filed by Degussa filed Critical Degussa
Priority to EP01967192A priority Critical patent/EP1307477A2/en
Priority to AU2001287631A priority patent/AU2001287631A1/en
Publication of WO2002010206A2 publication Critical patent/WO2002010206A2/en
Publication of WO2002010206A3 publication Critical patent/WO2002010206A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/12—Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine

Abstract

The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70 % to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metF gene is present in enhanced form, and the use of the polynucleotide sequences as hybridization probes.
PCT/EP2001/008224 2000-08-02 2001-07-17 Nucleotide sequences which code for the metf gene WO2002010206A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01967192A EP1307477A2 (en) 2000-08-02 2001-07-17 Nucleotide sequences which code for the metf gene
AU2001287631A AU2001287631A1 (en) 2000-08-02 2001-07-17 Nucleotide sequences which code for the metf gene

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10053942 2000-08-02
DE10053942.4 2000-08-02
DE10109686.0 2001-02-28
DE10109686A DE10109686A1 (en) 2000-08-02 2001-02-28 New nucleotide sequences coding for the metf gene

Publications (2)

Publication Number Publication Date
WO2002010206A2 WO2002010206A2 (en) 2002-02-07
WO2002010206A3 true WO2002010206A3 (en) 2002-05-02

Family

ID=26007537

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/008224 WO2002010206A2 (en) 2000-08-02 2001-07-17 Nucleotide sequences which code for the metf gene

Country Status (3)

Country Link
EP (1) EP1307477A2 (en)
AU (1) AU2001287631A1 (en)
WO (1) WO2002010206A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1247868A3 (en) * 2001-04-03 2002-10-30 Degussa AG Process for the production by fermentation of D-pantothenic acid and/or its salts
DE10239073A1 (en) * 2002-08-26 2004-03-11 Basf Ag Fermentative production of sulfur-containing fine chemicals, useful e.g. as feed additive, by culturing bacteria containing heterologous sequence for homoserine O-acetyltransferase
DE10239082A1 (en) * 2002-08-26 2004-03-04 Basf Ag Fermentative production of sulfur-containing fine chemicals, useful e.g. as feed additive, by culturing bacteria containing heterologous sequence for O-acetylhomoserine sulfhydrolase
DE10239308A1 (en) * 2002-08-27 2004-03-11 Basf Ag Fermentative production of sulfur-containing fine chemicals, useful e.g. as feed additive, by culturing bacteria containing heterologous sequence for methionine synthase
KR100651220B1 (en) * 2004-06-29 2006-11-29 씨제이 주식회사 - - L-methionine producing microorganism and method of producing L-methionine using the microorganism
AR083468A1 (en) 2010-10-25 2013-02-27 Metabolic Explorer Sa INCREASING NADPH'S AVAILABILITY FOR METIONIN PRODUCTION

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988009819A2 (en) * 1987-06-12 1988-12-15 Massachusetts Institute Of Technology C. glutamicum threonine biosynthetic pathway
EP0358940A1 (en) * 1988-09-12 1990-03-21 Degussa Aktiengesellschaft DNA fragment coding for phosphoenolpyruvat corboxylase, recombinant DNA carrying said fragment, strains carrying the recombinant DNA and method for producing L-aminino acids using said strains
EP0387527A1 (en) * 1989-03-14 1990-09-19 Degussa Aktiengesellschaft Process for the fermentative production of L-lysine
KR920008381B1 (en) * 1990-12-31 1992-09-26 제일제당 주식회사 Method for producins l-lysine
WO1993017112A1 (en) * 1992-02-20 1993-09-02 Genencor International, Inc. Biosynthesis of methionine using a reduced source of sulfur
WO2001000843A2 (en) * 1999-06-25 2001-01-04 Basf Aktiengesellschaft Corynebacterium glutamicum genes encoding metabolic pathway proteins

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988009819A2 (en) * 1987-06-12 1988-12-15 Massachusetts Institute Of Technology C. glutamicum threonine biosynthetic pathway
EP0358940A1 (en) * 1988-09-12 1990-03-21 Degussa Aktiengesellschaft DNA fragment coding for phosphoenolpyruvat corboxylase, recombinant DNA carrying said fragment, strains carrying the recombinant DNA and method for producing L-aminino acids using said strains
EP0387527A1 (en) * 1989-03-14 1990-09-19 Degussa Aktiengesellschaft Process for the fermentative production of L-lysine
KR920008381B1 (en) * 1990-12-31 1992-09-26 제일제당 주식회사 Method for producins l-lysine
WO1993017112A1 (en) * 1992-02-20 1993-09-02 Genencor International, Inc. Biosynthesis of methionine using a reduced source of sulfur
WO2001000843A2 (en) * 1999-06-25 2001-01-04 Basf Aktiengesellschaft Corynebacterium glutamicum genes encoding metabolic pathway proteins

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BLANCO JORGE ET AL: "The folate branch of the methionine biosynthesis pathway in Streptomyces lividans: Disruption of the 5,10-methylenetetrahydrofol ate reductase gene leads to methionine auxotrophy.", JOURNAL OF BACTERIOLOGY, vol. 180, no. 6, March 1998 (1998-03-01), pages 1586 - 1591, XP002191540, ISSN: 0021-9193 *
DATABASE WPI Section Ch Week 199332, Derwent World Patents Index; Class B05, AN 1993-256072, XP002186165 *
DATABASE WPI Section Ch Week 200114, Derwent World Patents Index; Class B04, AN 2001-137957, XP002186601 *
KRAMER R: "Genetic and physiological approaches for the production of amino acids", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 45, no. 1, 12 February 1996 (1996-02-12), pages 1 - 21, XP004036833, ISSN: 0168-1656 *
OLD I G ET AL: "PHYSICAL MAPPING OF THE SCATTERED METHIONINE GENES ON THE ESCHERICHIA COLI CHROMOSOME", JOURNAL OF BACTERIOLOGY, WASHINGTON, DC, US, vol. 175, no. 11, June 1993 (1993-06-01), pages 3689 - 3691, XP001037964, ISSN: 0021-9193 *

Also Published As

Publication number Publication date
WO2002010206A2 (en) 2002-02-07
AU2001287631A1 (en) 2002-02-13
EP1307477A2 (en) 2003-05-07

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