WO2002008415A1 - Procede de criblage de l'activite de promoteurs ou d'inhibiteurs du ptp$g(j) - Google Patents

Procede de criblage de l'activite de promoteurs ou d'inhibiteurs du ptp$g(j) Download PDF

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Publication number
WO2002008415A1
WO2002008415A1 PCT/JP2001/006343 JP0106343W WO0208415A1 WO 2002008415 A1 WO2002008415 A1 WO 2002008415A1 JP 0106343 W JP0106343 W JP 0106343W WO 0208415 A1 WO0208415 A1 WO 0208415A1
Authority
WO
WIPO (PCT)
Prior art keywords
ptpz
inhibitor
pleiotrophin
activity promoter
extent
Prior art date
Application number
PCT/JP2001/006343
Other languages
English (en)
French (fr)
Inventor
Masaharu Noda
Akihiro Fujikawa
Original Assignee
Japan Science And Technology Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Science And Technology Corporation filed Critical Japan Science And Technology Corporation
Priority to DE60144563T priority Critical patent/DE60144563D1/de
Priority to JP2002513898A priority patent/JP3785460B2/ja
Priority to EP01950037A priority patent/EP1306429B1/en
Priority to US10/333,786 priority patent/US7166761B2/en
Priority to CA002418267A priority patent/CA2418267C/en
Publication of WO2002008415A1 publication Critical patent/WO2002008415A1/ja
Priority to US11/639,343 priority patent/US20070079389A1/en
Priority to US12/420,639 priority patent/US20100287626A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0368—Animal model for inflammation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/205—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Campylobacter (G)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Plant Pathology (AREA)
  • Animal Husbandry (AREA)
PCT/JP2001/006343 2000-07-24 2001-07-23 Procede de criblage de l'activite de promoteurs ou d'inhibiteurs du ptp$g(j) WO2002008415A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE60144563T DE60144563D1 (de) 2000-07-24 2001-07-23 Verfahren zum screening der promoteraktivität oder eines hemmstoffs von ptp zeta
JP2002513898A JP3785460B2 (ja) 2000-07-24 2001-07-23 ＰＴＰζ活性促進又は抑制物質のスクリーニング方法
EP01950037A EP1306429B1 (en) 2000-07-24 2001-07-23 Method of screening ptp zeta activity promoter or inhibitor
US10/333,786 US7166761B2 (en) 2000-07-24 2001-07-23 Method of screening PTPζ activity promoter or inhibitor
CA002418267A CA2418267C (en) 2000-07-24 2001-07-23 Method of screening ptp zeta activity promoter or inhibitor
US11/639,343 US20070079389A1 (en) 2000-07-24 2006-12-15 Method for screening PTPzeta activity promoter or inhibitor
US12/420,639 US20100287626A1 (en) 2000-07-24 2009-04-08 Method of screening ptp zeta activity promoter or inhibitor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000-223184 2000-07-24
JP2000223184 2000-07-24

Publications (1)

Publication Number Publication Date
WO2002008415A1 true WO2002008415A1 (fr) 2002-01-31

Family

ID=18717315

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/006343 WO2002008415A1 (fr) 2000-07-24 2001-07-23 Procede de criblage de l'activite de promoteurs ou d'inhibiteurs du ptp$g(j)

Country Status (6)

Country Link
US (3) US7166761B2 (ja)
EP (1) EP1306429B1 (ja)
JP (1) JP3785460B2 (ja)
CA (1) CA2418267C (ja)
DE (1) DE60144563D1 (ja)
WO (1) WO2002008415A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004092371A1 (ja) * 2003-04-18 2004-10-28 Japan Science And Technology Agency グルタミン酸トランスポーターｇｌａｓｔ機能欠損マウス

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9277737B2 (en) 2006-09-21 2016-03-08 Probiodrug Ag Mouse models carrying a knock-out mutation of the QPCTL-gene
EP2432314B1 (en) * 2009-05-19 2017-12-20 Probiodrug AG Mouse models carrying a knock-out mutation of the qpctl-gene
CN106957892A (zh) * 2016-01-08 2017-07-18 中国科学院生态环境研究中心 一种用于蛋白质酪氨酸磷酸酶活性的免标记电化学传感检测方法
KR102234449B1 (ko) * 2019-04-04 2021-03-30 재단법인대구경북과학기술원 불안 장애 예방 또는 치료를 위한 PTPσ　유전자 및 이를 이용한 스크리닝 방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030106083A1 (en) * 2000-12-06 2003-06-05 Allen Keith D. Transgenic mice containing RPTPB tyrosine phosphatase gene disruptions

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
KINNOSUKE YAHIRO ET AL.: "Activation of helicobacter pylori VacA toxin by alkaline or acid conditions increases its binding to a 250-kDa receptor protein-tyrosine phosphatase beta", J. BIOL. CHEM., vol. 274, no. 51, 1999, pages 36693 - 36699, XP002944884 *
NOBUAKI MAEDA ET AL.: "6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase zeta/RPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM)", J. BIOL. CHEM., vol. 271, no. 35, 1996, pages 21446 - 21452, XP002944885 *
NOBUAKI MAEDA ET AL.: "A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta", J. BIOL. CHEM., vol. 274, no. 18, 1999, pages 12474 - 12479, XP002944886 *
See also references of EP1306429A4 *
TAKAFUMI SHINTANI ET AL.: "Neurons as well as astrocytes express proteoglycan-type protein tyrosine phosphatase zeta/RPTPbeta: analysis of mice in which the PTPzeta/RPTPbeta gene was replaced with the LacZ gene", NEUROSCIENCE LETTERS, vol. 247, 1998, pages 135 - 138, XP002944863 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004092371A1 (ja) * 2003-04-18 2004-10-28 Japan Science And Technology Agency グルタミン酸トランスポーターｇｌａｓｔ機能欠損マウス
JPWO2004092371A1 (ja) * 2003-04-18 2006-07-06 独立行政法人科学技術振興機構 グルタミン酸トランスポーターｇｌａｓｔ機能欠損マウス
US7642399B2 (en) 2003-04-18 2010-01-05 Japan Science And Technology Agency Mouse with deficiency of glutamate transporter GLAST function
JP4494340B2 (ja) * 2003-04-18 2010-06-30 独立行政法人科学技術振興機構 グルタミン酸トランスポーターｇｌａｓｔ機能欠損マウス

Also Published As

Publication number Publication date
US7166761B2 (en) 2007-01-23
CA2418267C (en) 2007-09-18
US20030186284A1 (en) 2003-10-02
US20070079389A1 (en) 2007-04-05
DE60144563D1 (de) 2011-06-16
CA2418267A1 (en) 2003-01-23
EP1306429A1 (en) 2003-05-02
JP3785460B2 (ja) 2006-06-14
EP1306429B1 (en) 2011-05-04
EP1306429A4 (en) 2005-01-26
US20100287626A1 (en) 2010-11-11

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