WO2002004111A3 - Polymer-chip - Google Patents

Polymer-chip Download PDF

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Publication number
WO2002004111A3
WO2002004111A3 PCT/EP2001/007726 EP0107726W WO0204111A3 WO 2002004111 A3 WO2002004111 A3 WO 2002004111A3 EP 0107726 W EP0107726 W EP 0107726W WO 0204111 A3 WO0204111 A3 WO 0204111A3
Authority
WO
WIPO (PCT)
Prior art keywords
probe
sequence
sequences
site
polymer chip
Prior art date
Application number
PCT/EP2001/007726
Other languages
English (en)
French (fr)
Other versions
WO2002004111A2 (de
Inventor
Mark Achtmann
Roland Kirchner
Wolfgang Mann
Giovanna Morelli
Hans-Hilger Ropers
Original Assignee
Max Planck Gesellschaft
Mark Achtmann
Roland Kirchner
Wolfgang Mann
Giovanna Morelli
Hans-Hilger Ropers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft, Mark Achtmann, Roland Kirchner, Wolfgang Mann, Giovanna Morelli, Hans-Hilger Ropers filed Critical Max Planck Gesellschaft
Priority to AU2001283928A priority Critical patent/AU2001283928A1/en
Publication of WO2002004111A2 publication Critical patent/WO2002004111A2/de
Publication of WO2002004111A3 publication Critical patent/WO2002004111A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Abstract

Vorgeschlagen wird ein Polymer-Chip enthaltend eine Vielzahl von Sonden, wobei unterschiedliche Sonden jeweils an einem anderen Sondenpunkt auf einem Träger angeordnet sind und jede Sonde eine Oligomer-Sequenz aufweist und die Oligomer-Sequenz aus einer bekannten Anzahl Monomeren zusammengesetzt ist und an jedem Sondenpunkt mehrere Oligomer-Sequenzen angeordnet sind, die jeweils aus einer Sonden-Sequenz und einer Wobbel-Sequenz zusammengesetzt sind, wobei die Sonden-Sequenzen eines Sondenpunktes identisch zueinander sind und die Sonde darstellen und die Wobbel-Sequenzen eines Sondenpunktes jeweils Permutationen der Monomere aufweist.
PCT/EP2001/007726 2000-07-07 2001-07-05 Polymer-chip WO2002004111A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001283928A AU2001283928A1 (en) 2000-07-07 2001-07-05 Polymer chip

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10033091.6 2000-07-07
DE10033091A DE10033091A1 (de) 2000-07-07 2000-07-07 Polymer-Chip

Publications (2)

Publication Number Publication Date
WO2002004111A2 WO2002004111A2 (de) 2002-01-17
WO2002004111A3 true WO2002004111A3 (de) 2003-03-13

Family

ID=7648148

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/007726 WO2002004111A2 (de) 2000-07-07 2001-07-05 Polymer-chip

Country Status (3)

Country Link
AU (1) AU2001283928A1 (de)
DE (1) DE10033091A1 (de)
WO (1) WO2002004111A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004532034A (ja) * 2001-05-07 2004-10-21 アマシャム・バイオサイエンス・コーポレイション 遺伝子発現分析システムでコントロールとして使用するための人工遺伝子のデザイン
EP1593425B1 (de) * 2004-05-04 2006-08-09 Eppendorf Array Technologies SA Herstellungsverfahren und Verwendung von Mikro-Array-Trägern zur Detektion mehrfacher Polynukleotidsequenzen mit hoher Empfindlichkeit

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994011530A1 (en) * 1992-11-06 1994-05-26 Trustees Of Boston University Positional sequencing by hybridization
WO1998015651A1 (en) * 1996-10-04 1998-04-16 Brax Genomics Limited Identifying antisense oligonucleotide binding
WO1999032654A1 (en) * 1997-12-22 1999-07-01 Hitachi Chemical Co., Ltd. Direct rt-pcr on oligonucleotide-immobilized pcr microplates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US6027880A (en) * 1995-08-02 2000-02-22 Affymetrix, Inc. Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
US6060288A (en) * 1994-08-03 2000-05-09 Mosaic Technologies Method for performing amplification of nucleic acid on supports

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994011530A1 (en) * 1992-11-06 1994-05-26 Trustees Of Boston University Positional sequencing by hybridization
WO1998015651A1 (en) * 1996-10-04 1998-04-16 Brax Genomics Limited Identifying antisense oligonucleotide binding
WO1999032654A1 (en) * 1997-12-22 1999-07-01 Hitachi Chemical Co., Ltd. Direct rt-pcr on oligonucleotide-immobilized pcr microplates

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BEIER M ET AL: "Versatile derivatisation of solid support media for covalent bonding on DNA-microchips", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 27, no. 9, 1999, pages 1970 - 1977, XP002145887, ISSN: 0305-1048 *
GUNDERSON K.L. ET AL.: "Mutation detection by ligation to complete n-mer DNA arrays", GENOME RESEARCH, vol. 8, 1998, pages 1142 - 1153, XP002225305 *

Also Published As

Publication number Publication date
DE10033091A1 (de) 2002-01-31
AU2001283928A1 (en) 2002-01-21
WO2002004111A2 (de) 2002-01-17

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