WO2002003957A2 - Compositions for sustained release of antineoplastic taxanes, and methods of making and using the same - Google Patents

Compositions for sustained release of antineoplastic taxanes, and methods of making and using the same Download PDF

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Publication number
WO2002003957A2
WO2002003957A2 PCT/US2001/021594 US0121594W WO0203957A2 WO 2002003957 A2 WO2002003957 A2 WO 2002003957A2 US 0121594 W US0121594 W US 0121594W WO 0203957 A2 WO0203957 A2 WO 0203957A2
Authority
WO
WIPO (PCT)
Prior art keywords
composition
polymer
taxane
alkyl
percent
Prior art date
Application number
PCT/US2001/021594
Other languages
English (en)
French (fr)
Other versions
WO2002003957A3 (en
Inventor
Wenbin Dang
Original Assignee
Guilford Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharmaceuticals, Inc. filed Critical Guilford Pharmaceuticals, Inc.
Priority to AU2001270310A priority Critical patent/AU2001270310A1/en
Publication of WO2002003957A2 publication Critical patent/WO2002003957A2/en
Publication of WO2002003957A3 publication Critical patent/WO2002003957A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
PCT/US2001/021594 2000-07-07 2001-07-09 Compositions for sustained release of antineoplastic taxanes, and methods of making and using the same WO2002003957A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001270310A AU2001270310A1 (en) 2000-07-07 2001-07-09 Compositions for sustained release of antineoplastic taxanes, and methods of making and using the same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21687400P 2000-07-07 2000-07-07
US60/216,874 2000-07-07
US23979800P 2000-10-12 2000-10-12
US60/239,798 2000-10-12

Publications (2)

Publication Number Publication Date
WO2002003957A2 true WO2002003957A2 (en) 2002-01-17
WO2002003957A3 WO2002003957A3 (en) 2003-03-13

Family

ID=26911410

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021594 WO2002003957A2 (en) 2000-07-07 2001-07-09 Compositions for sustained release of antineoplastic taxanes, and methods of making and using the same

Country Status (3)

Country Link
US (1) US20020041897A1 (US20020041897A1-20020411-C00022.png)
AU (1) AU2001270310A1 (US20020041897A1-20020411-C00022.png)
WO (1) WO2002003957A2 (US20020041897A1-20020411-C00022.png)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002040001A2 (en) * 2000-11-16 2002-05-23 Guilford Pharmaceuticals Inc. Compositions for treatment of malignant effusions comprising a biocompatible polymer and antineoplastic taxane
US6537585B1 (en) 1999-03-26 2003-03-25 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors
WO2003060799A2 (en) * 2002-01-09 2003-07-24 Guilford Pharmaceuticals, Inc. Compositions for treatment of central nervous system neoplasms, and methods of making and using the same
EP1569620A1 (en) * 2002-10-30 2005-09-07 Spherics, Inc. Nanoparticulate bioactive agents

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007060649A2 (en) * 2005-11-22 2007-05-31 Common Sense Ltd. Diagnostic composition and article for monitoring intravaginal infections
US7811602B2 (en) * 2004-05-17 2010-10-12 Tekmira Pharmaceuticals Corporation Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof
CN101291659A (zh) 2005-08-31 2008-10-22 阿布拉科斯生物科学有限公司 包含水难溶性药剂和抗微生物剂的组合物
NZ592132A (en) * 2005-08-31 2012-12-21 Abraxis Bioscience Llc Composition comprising nanoparticles of docitaxel and a citrate
CN109613177B (zh) 2014-07-01 2021-08-20 科蒙森斯公司 用于鉴定羊水的诊断组合物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998044020A1 (en) * 1997-04-03 1998-10-08 Guilford Pharmaceuticals Inc. Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same
WO1998048859A1 (en) * 1997-04-30 1998-11-05 Guilford Pharmaceuticals Inc. Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same
WO2000041678A1 (en) * 1999-01-11 2000-07-20 Guilford Pharmaceuticals Inc. Methods for treating ovarian cancer, poly(phosphoester) compositions, and biodegradable articles for same
WO2000057852A2 (en) * 1999-03-26 2000-10-05 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998044020A1 (en) * 1997-04-03 1998-10-08 Guilford Pharmaceuticals Inc. Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same
WO1998048859A1 (en) * 1997-04-30 1998-11-05 Guilford Pharmaceuticals Inc. Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same
WO2000041678A1 (en) * 1999-01-11 2000-07-20 Guilford Pharmaceuticals Inc. Methods for treating ovarian cancer, poly(phosphoester) compositions, and biodegradable articles for same
WO2000057852A2 (en) * 1999-03-26 2000-10-05 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537585B1 (en) 1999-03-26 2003-03-25 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors
US7101568B2 (en) 1999-03-26 2006-09-05 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors
WO2002040001A2 (en) * 2000-11-16 2002-05-23 Guilford Pharmaceuticals Inc. Compositions for treatment of malignant effusions comprising a biocompatible polymer and antineoplastic taxane
WO2002040001A3 (en) * 2000-11-16 2002-11-07 Guilford Pharm Inc Compositions for treatment of malignant effusions comprising a biocompatible polymer and antineoplastic taxane
WO2003060799A2 (en) * 2002-01-09 2003-07-24 Guilford Pharmaceuticals, Inc. Compositions for treatment of central nervous system neoplasms, and methods of making and using the same
WO2003060799A3 (en) * 2002-01-09 2003-11-06 Guilford Pharm Inc Compositions for treatment of central nervous system neoplasms, and methods of making and using the same
EP1569620A1 (en) * 2002-10-30 2005-09-07 Spherics, Inc. Nanoparticulate bioactive agents
EP1569620A4 (en) * 2002-10-30 2006-03-22 Spherics Inc NANOPARTICULAR BIOACTIVE AGENTS
JP2006514698A (ja) * 2002-10-30 2006-05-11 スフェリックス， インコーポレイテッド ナノ粒子生物活性物質

Also Published As

Publication number Publication date
WO2002003957A3 (en) 2003-03-13
AU2001270310A1 (en) 2002-01-21
US20020041897A1 (en) 2002-04-11

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