WO2002003793A3 - Transgenic mice containing targeted gene disruptions - Google Patents

Transgenic mice containing targeted gene disruptions Download PDF

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Publication number
WO2002003793A3
WO2002003793A3 PCT/US2001/021923 US0121923W WO0203793A3 WO 2002003793 A3 WO2002003793 A3 WO 2002003793A3 US 0121923 W US0121923 W US 0121923W WO 0203793 A3 WO0203793 A3 WO 0203793A3
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WO
WIPO (PCT)
Prior art keywords
transgenic mice
targeted gene
mice containing
gene disruptions
containing targeted
Prior art date
Application number
PCT/US2001/021923
Other languages
French (fr)
Other versions
WO2002003793A2 (en
Inventor
Keith D Allen
Thomas J Brennan
Original Assignee
Deltagen Inc
Keith D Allen
Thomas J Brennan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deltagen Inc, Keith D Allen, Thomas J Brennan filed Critical Deltagen Inc
Priority to AU2001273383A priority Critical patent/AU2001273383A1/en
Publication of WO2002003793A2 publication Critical patent/WO2002003793A2/en
Publication of WO2002003793A3 publication Critical patent/WO2002003793A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Neurology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Husbandry (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a GPCR gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.
PCT/US2001/021923 2000-07-10 2001-07-10 Transgenic mice containing targeted gene disruptions WO2002003793A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001273383A AU2001273383A1 (en) 2000-07-10 2001-07-10 Transgenic mice containing targeted gene disruptions

Applications Claiming Priority (42)

Application Number Priority Date Filing Date Title
US21725300P 2000-07-10 2000-07-10
US21722300P 2000-07-10 2000-07-10
US21725600P 2000-07-10 2000-07-10
US21725500P 2000-07-10 2000-07-10
US21725700P 2000-07-10 2000-07-10
US21717900P 2000-07-10 2000-07-10
US21705800P 2000-07-10 2000-07-10
US60/217,257 2000-07-10
US60/217,223 2000-07-10
US60/217,256 2000-07-10
US60/217,058 2000-07-10
US60/217,255 2000-07-10
US60/217,253 2000-07-10
US60/217,179 2000-07-10
US21734700P 2000-07-11 2000-07-11
US21762900P 2000-07-11 2000-07-11
US60/217,629 2000-07-11
US60/217,347 2000-07-11
US21807400P 2000-07-12 2000-07-12
US21806900P 2000-07-12 2000-07-12
US21835800P 2000-07-12 2000-07-12
US21753700P 2000-07-12 2000-07-12
US60/217,537 2000-07-12
US60/218,074 2000-07-12
US60/218,358 2000-07-12
US60/218,069 2000-07-12
US22148300P 2000-07-27 2000-07-27
US60/221,483 2000-07-27
US22312200P 2000-08-07 2000-08-07
US22312000P 2000-08-07 2000-08-07
US60/223,120 2000-08-07
US60/223,122 2000-08-07
US24395800P 2000-10-26 2000-10-26
US60/243,958 2000-10-26
US24940800P 2000-11-15 2000-11-15
US60/249,408 2000-11-15
US25229900P 2000-11-20 2000-11-20
US60/252,299 2000-11-20
US26220501P 2001-01-16 2001-01-16
US26211301P 2001-01-16 2001-01-16
US60/262,113 2001-01-16
US60/262,205 2001-01-16

Publications (2)

Publication Number Publication Date
WO2002003793A2 WO2002003793A2 (en) 2002-01-17
WO2002003793A3 true WO2002003793A3 (en) 2003-02-13

Family

ID=27586535

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021923 WO2002003793A2 (en) 2000-07-10 2001-07-10 Transgenic mice containing targeted gene disruptions

Country Status (2)

Country Link
AU (1) AU2001273383A1 (en)
WO (1) WO2002003793A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003513645A (en) * 1999-11-12 2003-04-15 メルク エンド カムパニー インコーポレーテッド Melanocortin-3 receptor deficient cells, non-human transgenic animals and methods for selecting compounds that regulate body weight
US7321074B1 (en) 1999-11-12 2008-01-22 Merck & Co., Inc. Melanocortin-3 receptor deficient cells, non-human transgenic animals and methods of selecting compounds which regulate body weight
WO2003008445A1 (en) * 2001-07-19 2003-01-30 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor protein and dna thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997047316A1 (en) * 1996-06-10 1997-12-18 Millennium Pharmaceuticals, Inc. Screening methods for compounds useful in the regulation of body weight
WO1998010068A2 (en) * 1996-09-04 1998-03-12 Oregon Health Sciences University Methods and reagents for discovering and using mammalian melanocortin receptor agonists and antagonists to modulate feeding behavior in animals
WO1998056914A1 (en) * 1997-06-13 1998-12-17 Oregon Health Sciences University Mammalian melanocortin receptors and uses
WO2000027862A1 (en) * 1998-11-09 2000-05-18 Merck & Co., Inc. Dna molecules encoding the melanocortin 3 receptor protein from rhesus monkey
WO2001033954A1 (en) * 1999-11-12 2001-05-17 Merck & Co., Inc. Melanocortin-3 receptor deficient cells, non-human transgenic animals and methods of selecting compounds which regulate body weight

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997047316A1 (en) * 1996-06-10 1997-12-18 Millennium Pharmaceuticals, Inc. Screening methods for compounds useful in the regulation of body weight
WO1998010068A2 (en) * 1996-09-04 1998-03-12 Oregon Health Sciences University Methods and reagents for discovering and using mammalian melanocortin receptor agonists and antagonists to modulate feeding behavior in animals
WO1998056914A1 (en) * 1997-06-13 1998-12-17 Oregon Health Sciences University Mammalian melanocortin receptors and uses
WO2000027862A1 (en) * 1998-11-09 2000-05-18 Merck & Co., Inc. Dna molecules encoding the melanocortin 3 receptor protein from rhesus monkey
WO2001033954A1 (en) * 1999-11-12 2001-05-17 Merck & Co., Inc. Melanocortin-3 receptor deficient cells, non-human transgenic animals and methods of selecting compounds which regulate body weight

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BUTLER A A ET AL: "A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse.", ENDOCRINOLOGY. UNITED STATES SEP 2000, vol. 141, no. 9, September 2000 (2000-09-01), pages 3518 - 3521, XP002205109, ISSN: 0013-7227 *

Also Published As

Publication number Publication date
AU2001273383A1 (en) 2002-01-21
WO2002003793A2 (en) 2002-01-17

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