WO2001098508A3 - Transgenic mice containing targeted gene disruptions - Google Patents
Transgenic mice containing targeted gene disruptions Download PDFInfo
- Publication number
- WO2001098508A3 WO2001098508A3 PCT/US2001/020015 US0120015W WO0198508A3 WO 2001098508 A3 WO2001098508 A3 WO 2001098508A3 US 0120015 W US0120015 W US 0120015W WO 0198508 A3 WO0198508 A3 WO 0198508A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gene
- transgenic mice
- targeted gene
- mice containing
- gene disruptions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knockout animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002504656A JP2004517605A (en) | 2000-06-21 | 2001-06-21 | Transgenic mice containing targeted gene disruptions |
EP01967934A EP1365645A2 (en) | 2000-06-21 | 2001-06-21 | Transgenic mice containing targeted gene disruptions |
AU2001288214A AU2001288214A1 (en) | 2000-06-21 | 2001-06-21 | Transgenic mice containing targeted gene disruptions |
CA002411978A CA2411978A1 (en) | 2000-06-21 | 2001-06-21 | Transgenic mice containing targeted gene disruptions |
Applications Claiming Priority (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21367100P | 2000-06-21 | 2000-06-21 | |
US21367000P | 2000-06-21 | 2000-06-21 | |
US21319000P | 2000-06-21 | 2000-06-21 | |
US21320100P | 2000-06-21 | 2000-06-21 | |
US21402800P | 2000-06-21 | 2000-06-21 | |
US60/213,671 | 2000-06-21 | ||
US60/213,670 | 2000-06-21 | ||
US60/213,190 | 2000-06-21 | ||
US60/213,201 | 2000-06-21 | ||
US60/214,028 | 2000-06-21 | ||
US22312300P | 2000-08-07 | 2000-08-07 | |
US60/223,123 | 2000-08-07 | ||
US26604601P | 2001-02-01 | 2001-02-01 | |
US60/266,046 | 2001-02-01 | ||
US28070501P | 2001-03-29 | 2001-03-29 | |
US60/280,705 | 2001-03-29 | ||
US28266801P | 2001-04-09 | 2001-04-09 | |
US28270101P | 2001-04-09 | 2001-04-09 | |
US60/282,701 | 2001-04-09 | ||
US60/282,668 | 2001-04-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001098508A2 WO2001098508A2 (en) | 2001-12-27 |
WO2001098508A3 true WO2001098508A3 (en) | 2003-10-02 |
Family
ID=27581158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/020015 WO2001098508A2 (en) | 2000-06-21 | 2001-06-21 | Transgenic mice containing targeted gene disruptions |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1365645A2 (en) |
JP (1) | JP2004517605A (en) |
AU (1) | AU2001288214A1 (en) |
CA (1) | CA2411978A1 (en) |
WO (1) | WO2001098508A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8958881B2 (en) | 2005-08-19 | 2015-02-17 | Brainsgate Ltd. | Neuroprotective electrical stimulation |
US9233245B2 (en) | 2004-02-20 | 2016-01-12 | Brainsgate Ltd. | SPG stimulation |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002002599A2 (en) * | 2000-06-30 | 2002-01-10 | Ingenium Pharmaceuticals Ag | HUMAN G PROTEIN-COUPLED RECEPTOR IGPcR17, AND USES THEROF |
US7514594B2 (en) | 2001-05-11 | 2009-04-07 | Wyeth | Transgenic animal model of bone mass modulation |
EP1483288A4 (en) * | 2001-05-11 | 2005-09-21 | Genome Therapeutics Corp | Hbm variants that modulate bone mass and lipid levels |
JPWO2004074483A1 (en) * | 2003-02-20 | 2006-06-01 | 哲哉 野阪 | TSG gene knockout animal |
US8010189B2 (en) | 2004-02-20 | 2011-08-30 | Brainsgate Ltd. | SPG stimulation for treating complications of subarachnoid hemorrhage |
US9675796B2 (en) | 2013-11-10 | 2017-06-13 | Brainsgate Ltd. | Implant and delivery system for neural stimulator |
US10271907B2 (en) | 2015-05-13 | 2019-04-30 | Brainsgate Ltd. | Implant and delivery system for neural stimulator |
-
2001
- 2001-06-21 CA CA002411978A patent/CA2411978A1/en not_active Abandoned
- 2001-06-21 AU AU2001288214A patent/AU2001288214A1/en not_active Abandoned
- 2001-06-21 EP EP01967934A patent/EP1365645A2/en not_active Withdrawn
- 2001-06-21 JP JP2002504656A patent/JP2004517605A/en not_active Withdrawn
- 2001-06-21 WO PCT/US2001/020015 patent/WO2001098508A2/en not_active Application Discontinuation
Non-Patent Citations (4)
Title |
---|
ALBERTS B ET AL.: "MOLECULAR BIOLOGY OF THE CELL, THIRD EDITION", 1994, MOLECULAR BIOLOGY OF THE CELL, NEW YORK, GARLAND PUBLISHING, US, PAGE(S) 329-330, ISBN: 0-8153-1620-8, XP002227010 * |
ISHII SATOSHI ET AL: "Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor.", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 187, no. 11, 1 June 1998 (1998-06-01), pages 1779 - 1788, XP002227009, ISSN: 0022-1007 * |
M BUY, TRANSGENIC ANIMALS, 1997, pages 1 - 4, XP002227011, Retrieved from the Internet <URL:www.ucalgary.ca/ browder/transgenic.html> [retrieved on 20030211] * |
MARCHESE ADRIANO ET AL: "Novel GPCRs and their endogenous ligands: Expanding the boundaries of physiology and pharmacology", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 20, no. 9, 1999, pages 370 - 375, XP002187420, ISSN: 0165-6147 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9233245B2 (en) | 2004-02-20 | 2016-01-12 | Brainsgate Ltd. | SPG stimulation |
US8958881B2 (en) | 2005-08-19 | 2015-02-17 | Brainsgate Ltd. | Neuroprotective electrical stimulation |
Also Published As
Publication number | Publication date |
---|---|
EP1365645A2 (en) | 2003-12-03 |
CA2411978A1 (en) | 2001-12-27 |
JP2004517605A (en) | 2004-06-17 |
WO2001098508A2 (en) | 2001-12-27 |
AU2001288214A1 (en) | 2002-01-02 |
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