WO2001092296A3 - Regulation of human isotocin-like g protein-coupled receptor - Google Patents

Regulation of human isotocin-like g protein-coupled receptor Download PDF

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Publication number
WO2001092296A3
WO2001092296A3 PCT/EP2001/005965 EP0105965W WO0192296A3 WO 2001092296 A3 WO2001092296 A3 WO 2001092296A3 EP 0105965 W EP0105965 W EP 0105965W WO 0192296 A3 WO0192296 A3 WO 0192296A3
Authority
WO
WIPO (PCT)
Prior art keywords
isotocin
human
protein
coupled receptor
regulation
Prior art date
Application number
PCT/EP2001/005965
Other languages
French (fr)
Other versions
WO2001092296A2 (en
Inventor
Shyam Ramakrishnan
Original Assignee
Bayer Ag
Shyam Ramakrishnan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Shyam Ramakrishnan filed Critical Bayer Ag
Priority to AU2001266020A priority Critical patent/AU2001266020A1/en
Priority to EP01943443A priority patent/EP1290172A2/en
Publication of WO2001092296A2 publication Critical patent/WO2001092296A2/en
Publication of WO2001092296A3 publication Critical patent/WO2001092296A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reagents which regulate human isotocin G protein-coupled receptor (isotocin-like GPCR) and reagents which bind to human isotocin-like GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, obesity and diseases related to obesity, cancer, diabetes, osteoporosis, anxiety, depression, hypertension, migraine, compulsive disorders, schizophrenia, autism, neurodegenerative disorders, such as Alzheimer's disease, Parkinsonism, and Huntington's chorea, and cancer chemotherapy-induced vomiting.
PCT/EP2001/005965 2000-05-26 2001-05-25 Regulation of human isotocin-like g protein-coupled receptor WO2001092296A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001266020A AU2001266020A1 (en) 2000-05-26 2001-05-25 Regulation of human isotocin-like g protein-coupled receptor
EP01943443A EP1290172A2 (en) 2000-05-26 2001-05-25 Regulation of human isotocin-like g protein-coupled receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20722400P 2000-05-26 2000-05-26
US60/207,224 2000-05-26

Publications (2)

Publication Number Publication Date
WO2001092296A2 WO2001092296A2 (en) 2001-12-06
WO2001092296A3 true WO2001092296A3 (en) 2002-05-30

Family

ID=22769681

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/005965 WO2001092296A2 (en) 2000-05-26 2001-05-25 Regulation of human isotocin-like g protein-coupled receptor

Country Status (3)

Country Link
EP (1) EP1290172A2 (en)
AU (1) AU2001266020A1 (en)
WO (1) WO2001092296A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0811684A2 (en) * 1991-10-09 1997-12-10 Rohto Pharmaceutical Co., Ltd. Oxytocin receptor portion or variant, and dna coding for the same
WO2001018206A1 (en) * 1999-09-08 2001-03-15 Lexicon Genetics Incorporated Human g-protein coupled 7 transmembrane receptor and polynucleotides encoding the same
WO2001048188A1 (en) * 1999-12-28 2001-07-05 Helix Research Institute Novel guanosine triphosphate-binding protein-coupled receptors, genes thereof and production and use of the same
WO2001048015A2 (en) * 1999-12-28 2001-07-05 Pharmacia & Upjohn Company G protein-coupled receptors
JP2001245666A (en) * 2000-03-06 2001-09-11 Kyowa Hakko Kogyo Co Ltd New polypeptide
WO2001096400A2 (en) * 2000-06-16 2001-12-20 Millennium Pharmaceuticals, Inc. 52871, a novel human g protein coupled receptor and uses thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0811684A2 (en) * 1991-10-09 1997-12-10 Rohto Pharmaceutical Co., Ltd. Oxytocin receptor portion or variant, and dna coding for the same
WO2001018206A1 (en) * 1999-09-08 2001-03-15 Lexicon Genetics Incorporated Human g-protein coupled 7 transmembrane receptor and polynucleotides encoding the same
WO2001048188A1 (en) * 1999-12-28 2001-07-05 Helix Research Institute Novel guanosine triphosphate-binding protein-coupled receptors, genes thereof and production and use of the same
WO2001048015A2 (en) * 1999-12-28 2001-07-05 Pharmacia & Upjohn Company G protein-coupled receptors
JP2001245666A (en) * 2000-03-06 2001-09-11 Kyowa Hakko Kogyo Co Ltd New polypeptide
WO2001096400A2 (en) * 2000-06-16 2001-12-20 Millennium Pharmaceuticals, Inc. 52871, a novel human g protein coupled receptor and uses thereof

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 13 June 1995 (1995-06-13) *
DATABASE EMBL 23 October 1998 (1998-10-23), IADONATO S.P.,: "Homo sapiens clone UWGC:g1564a307 from 7p14-15, complete sequence.", XP002190706 *
DATABASE EMBL 27 March 2000 (2000-03-27), ADAMS, M.D., ET AL.: "Drosophila melanogaster genomic scaffold 142000013386035 section 79 of 105, complete sequence.", XP002190707 *
DATABASE SWISSPROT 1 April 1993 (1993-04-01) *
DATABASE TREMBL 1 May 2000 (2000-05-01), "CG6111 PROTEIN", XP002190708 *
DATABASE WPI Section Ch Week 200170, Derwent World Patents Index; Class B04, AN 2001-610074, XP002190915 *
HAUSMANN HOLGER ET AL: "Teleost isotocin receptor: Structure, functional expression, mRNA distribution and phylogeny.", FEBS LETTERS, vol. 370, no. 3, 1995, pages 227 - 230, XP002190705, ISSN: 0014-5793 *
KIMURA T ET AL: "STRUCTURE AND EXPRESSION OF A HUMAN OXYTOCIN RECEPTOR", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 356, no. 6369, 9 April 1992 (1992-04-09), pages 526 - 529, XP002045710, ISSN: 0028-0836 *
KIMURA, T., ET AL.: "Structure and expression of a human oxytocin receptor", NATURE, vol. 357, 1992, pages 176, XP002190731 *
See also references of EP1290172A2 *

Also Published As

Publication number Publication date
AU2001266020A1 (en) 2001-12-11
WO2001092296A2 (en) 2001-12-06
EP1290172A2 (en) 2003-03-12

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