WO2002002797A3 - Regulation of human 11 beta-hydroxysteroid dehydrogenase 1-like enzyme - Google Patents
Regulation of human 11 beta-hydroxysteroid dehydrogenase 1-like enzyme Download PDFInfo
- Publication number
- WO2002002797A3 WO2002002797A3 PCT/EP2001/007632 EP0107632W WO0202797A3 WO 2002002797 A3 WO2002002797 A3 WO 2002002797A3 EP 0107632 W EP0107632 W EP 0107632W WO 0202797 A3 WO0202797 A3 WO 0202797A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- beta
- human
- enzyme
- hydroxysteroid dehydrogenase
- regulation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01146—11-Beta-hydroxysteroid dehydrogenase (1.1.1.146)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001276378A AU2001276378A1 (en) | 2000-07-05 | 2001-07-04 | Regulation of human 11 beta-hydroxysteroid dehydrogenase 1-like enzyme |
JP2002508037A JP2004502432A (en) | 2000-07-05 | 2001-07-04 | Regulation of human 11β-hydroxysteroid dehydrogenase 1-like enzyme |
EP01954005A EP1309697A2 (en) | 2000-07-05 | 2001-07-04 | Regulation of human 11 beta-hydroxysteroid dehydrogenase 1-like enzyme |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21635000P | 2000-07-05 | 2000-07-05 | |
US60/216,350 | 2000-07-05 | ||
US23129500P | 2000-09-08 | 2000-09-08 | |
US60/231,295 | 2000-09-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002002797A2 WO2002002797A2 (en) | 2002-01-10 |
WO2002002797A3 true WO2002002797A3 (en) | 2003-02-27 |
Family
ID=26910926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2001/007632 WO2002002797A2 (en) | 2000-07-05 | 2001-07-04 | Regulation of human 11 beta-hydroxysteroid dehydrogenase 1-like enzyme |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1309697A2 (en) |
JP (1) | JP2004502432A (en) |
AU (1) | AU2001276378A1 (en) |
WO (1) | WO2002002797A2 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002239398A1 (en) * | 2000-11-30 | 2002-06-11 | Millenium Pharmaceuticals, Inc. | 25206, a novel human short-chain dehydrogenase/reductase family member and uses thereof |
GB0107383D0 (en) * | 2001-03-23 | 2001-05-16 | Univ Edinburgh | Lipid profile modulation |
EP1597267A4 (en) * | 2003-02-21 | 2007-04-18 | Merck & Co Inc | Pharmacodynamic assay for inhibitors of 11-beta-hydroxysteroid dehydrogenase activity in animal tissues |
JP2006523311A (en) * | 2003-03-12 | 2006-10-12 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 9145, 1725, 311, 837, 58305, 156, 14175, 50352, 32678, 5560, 7240, 8865, 12396, 12397, 13644, 19938, 2077, 1735, 1786, 10220, 17822, 33945, 37748, 47161, 81982 or Methods and compositions for treating AIDS and HIV related disorders using 46777 |
US7501405B2 (en) | 2003-04-11 | 2009-03-10 | High Point Pharmaceuticals, Llc | Combination therapy using an 11β-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent for the treatment of metabolic syndrome and related diseases and disorders |
WO2004089416A2 (en) * | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Combination of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent |
EP1862181A3 (en) * | 2003-04-11 | 2010-09-15 | High Point Pharmaceuticals, LLC | New pyrazolo[1,5-a] pyrimidine derivatives and pharmaceutical use thereof |
WO2005119525A1 (en) * | 2004-06-04 | 2005-12-15 | Pfizer Products Inc. | 11βHSD1 CRYSTAL STRUCTURES FOR STRUCTURE BASED DRUG DESIGN |
WO2006059507A1 (en) * | 2004-11-30 | 2006-06-08 | Sankyo Company, Limited | 11β-HSD1 ANTISENSE COMPOUND |
CA2630665C (en) | 2005-11-21 | 2011-03-15 | Shionogi & Co., Ltd. | Heterocyclic compound having inhibitory activity on 11-.beta.-hydroxysteroid dehydrogenase type i |
JP4671369B2 (en) | 2007-05-18 | 2011-04-13 | 塩野義製薬株式会社 | Nitrogen-containing heterocyclic derivatives having type I 11β-hydroxysteroid dehydrogenase inhibitory activity |
MX2011005037A (en) | 2008-11-21 | 2011-06-16 | High Point Pharmaceuticals Llc | Adamantyl benzamide compounds. |
US8513430B2 (en) | 2010-07-27 | 2013-08-20 | High Point Pharmaceuticals, Llc | Substituted thiazol-2-ylamine derivatives, pharmaceutical compositions, and methods of use as 11-beta HSD1 modulators |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965372A (en) * | 1995-08-24 | 1999-10-12 | Baker Medical Research Institute | Genetic sequences encoding glucocorticoid dehydrogenases and uses thereof |
WO2001090090A1 (en) * | 2000-05-22 | 2001-11-29 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
-
2001
- 2001-07-04 JP JP2002508037A patent/JP2004502432A/en active Pending
- 2001-07-04 EP EP01954005A patent/EP1309697A2/en not_active Withdrawn
- 2001-07-04 AU AU2001276378A patent/AU2001276378A1/en not_active Abandoned
- 2001-07-04 WO PCT/EP2001/007632 patent/WO2002002797A2/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965372A (en) * | 1995-08-24 | 1999-10-12 | Baker Medical Research Institute | Genetic sequences encoding glucocorticoid dehydrogenases and uses thereof |
WO2001090090A1 (en) * | 2000-05-22 | 2001-11-29 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
Non-Patent Citations (4)
Title |
---|
DATABASE EMBL [online] 11 November 1999 (1999-11-11), XP002217921, Database accession no. AW163684 * |
HULT M ET AL: "Selective inhibition of human type 1 11beta-hydroxysteroid dehydrogenase by synthetic steroids and xenobiotics", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 441, no. 1, 11 December 1998 (1998-12-11), pages 25 - 28, XP004258864, ISSN: 0014-5793 * |
KROZOWSKI ZYGMUNT: "The 11beta-hydroxysteroid dehydrogenases: Functions and physiological effects.", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 151, no. 1-2, 25 May 1999 (1999-05-25), pages 121 - 127, XP002217920, ISSN: 0303-7207 * |
STEWART P M ET AL: "11BETA-HYDROXYSTEROID DEHYDROGENASE", VITAMINS AND HORMONES, ACADEMIC PRESS, NEW YORK, NY,, US, vol. 57, 1999, pages 249 - 324, XP001004592, ISSN: 0083-6729 * |
Also Published As
Publication number | Publication date |
---|---|
WO2002002797A2 (en) | 2002-01-10 |
JP2004502432A (en) | 2004-01-29 |
AU2001276378A1 (en) | 2002-01-14 |
EP1309697A2 (en) | 2003-05-14 |
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