WO2001090716A3 - Bras de liaison pour nanocristaux et composes de ces derniers - Google Patents

Bras de liaison pour nanocristaux et composes de ces derniers Download PDF

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Publication number
WO2001090716A3
WO2001090716A3 PCT/US2001/016739 US0116739W WO0190716A3 WO 2001090716 A3 WO2001090716 A3 WO 2001090716A3 US 0116739 W US0116739 W US 0116739W WO 0190716 A3 WO0190716 A3 WO 0190716A3
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WO
WIPO (PCT)
Prior art keywords
nanocrystal
compounds
linker arm
group
organic compound
Prior art date
Application number
PCT/US2001/016739
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English (en)
Other versions
WO2001090716A2 (fr
Inventor
Sandra J Rosenthall
Ian D Tomlinson
Tadd Kippeny
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Univ Vanderbilt
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Publication date
Application filed by Univ Vanderbilt filed Critical Univ Vanderbilt
Priority to AU2001264875A priority Critical patent/AU2001264875A1/en
Publication of WO2001090716A2 publication Critical patent/WO2001090716A2/fr
Publication of WO2001090716A3 publication Critical patent/WO2001090716A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/16—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Materials Engineering (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne des composés nanocristallins, et un bras de liaison pour ces derniers, qui fixe les nanocristaux aux composés organiques. Le composé nanocristallin comprend un nanocristal, un bras de liaison et un composé organique. Ce dernier est, de préférence, un composé biologiquement actif pouvant fournir un capteur fluorescent. Le bras de liaison est, de préférence, une chaîne polyéther dotée d'un point de fixation pour le nanocristal ou un point de fixation pour le composé organique. Plus spécialement, le nanocristal est fixé au bras de liaison par l'intermédiaire d'un groupe R et le composé organique est fixé au bras de liaison par l'intermédiaire d'un groupe R2. R est une liaison ou est sélectionné dans le groupe constitué par SH, O(CH2(n)O)nSH, NH(CH2(n)O)nSH, NH(CH2(n)NH)SH, S(CH2(n)O)nSH, et S(CH2(n)S)SH, n étant compris entre 1 et 10, et S étant fixé au nanocristal. R2 est une liaison ou est sélectionné dans le groupe constitué par carbonyle, NH, S, CONH, COO, alkyle C1-10, carbamate et thiocarbamate.
PCT/US2001/016739 2000-05-24 2001-05-24 Bras de liaison pour nanocristaux et composes de ces derniers WO2001090716A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001264875A AU2001264875A1 (en) 2000-05-24 2001-05-24 Linker arms for nanocrystals and compounds thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20677100P 2000-05-24 2000-05-24
US60/206,771 2000-05-24

Publications (2)

Publication Number Publication Date
WO2001090716A2 WO2001090716A2 (fr) 2001-11-29
WO2001090716A3 true WO2001090716A3 (fr) 2002-04-04

Family

ID=22767882

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2001/016947 WO2001090717A2 (fr) 2000-05-24 2001-05-24 Bras de liaison pour nanocristaux et composes correspondants
PCT/US2001/016739 WO2001090716A2 (fr) 2000-05-24 2001-05-24 Bras de liaison pour nanocristaux et composes de ces derniers

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2001/016947 WO2001090717A2 (fr) 2000-05-24 2001-05-24 Bras de liaison pour nanocristaux et composes correspondants

Country Status (2)

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AU (2) AU2001264875A1 (fr)
WO (2) WO2001090717A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090042032A1 (en) * 2005-05-04 2009-02-12 Agency For Science, Technology And Research Novel water-soluble nanocrystals comprising a low molecular weight coating reagent, and methods of preparing the same
CN110394167B (zh) * 2019-07-22 2021-10-08 中国科学院兰州化学物理研究所 四乙烯五胺碳量子点/单体共键合硅胶亲水色谱固定相的制备及应用
US11078144B2 (en) 2019-10-24 2021-08-03 Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C Process for synthesizing of hydroquinone derivatives with heptadecatrienyl side chain

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873680A (en) * 1972-08-30 1975-03-25 Minnesota Mining & Mfg Mercaptan and thioketal complexes of technetium 99M for diagnostic scanning
US3892878A (en) * 1973-04-25 1975-07-01 Int Flavors & Fragrances Inc Flavoring with sulfur containing compounds
US4188340A (en) * 1969-08-01 1980-02-12 The Dow Chemical Company Polyethers having aminothioether side chains
US4659370A (en) * 1982-04-20 1987-04-21 Nihon Tokushu Noyaku Seizo K.K. Substituted phenoxypropionates and herbicidal compositions containing same and their herbicidal use
US4720585A (en) * 1985-09-18 1988-01-19 E. R. Squibb & Sons, Inc. Aminopeptidase inhibitors
US5075511A (en) * 1986-10-30 1991-12-24 Shell Oil Company Process and alkylmercaptoamine catalyst for production of bisphenol-A
US5751018A (en) * 1991-11-22 1998-05-12 The Regents Of The University Of California Semiconductor nanocrystals covalently bound to solid inorganic surfaces using self-assembled monolayers
US5912319A (en) * 1997-02-19 1999-06-15 Courtaulds Aerospace, Inc. Compositions and method for producing fuel resistant liquid polythioether polymers with good low temperature flexibility
US6221602B1 (en) * 1998-11-10 2001-04-24 Bio-Pixels Ltd. Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6114038A (en) * 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems
WO2000027365A1 (fr) * 1998-11-10 2000-05-18 Biocrystal Limited Nanocristaux fonctionnalises et leur utilisation dans des systemes de detection

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188340A (en) * 1969-08-01 1980-02-12 The Dow Chemical Company Polyethers having aminothioether side chains
US3873680A (en) * 1972-08-30 1975-03-25 Minnesota Mining & Mfg Mercaptan and thioketal complexes of technetium 99M for diagnostic scanning
US3892878A (en) * 1973-04-25 1975-07-01 Int Flavors & Fragrances Inc Flavoring with sulfur containing compounds
US4659370A (en) * 1982-04-20 1987-04-21 Nihon Tokushu Noyaku Seizo K.K. Substituted phenoxypropionates and herbicidal compositions containing same and their herbicidal use
US4720585A (en) * 1985-09-18 1988-01-19 E. R. Squibb & Sons, Inc. Aminopeptidase inhibitors
US5075511A (en) * 1986-10-30 1991-12-24 Shell Oil Company Process and alkylmercaptoamine catalyst for production of bisphenol-A
US5751018A (en) * 1991-11-22 1998-05-12 The Regents Of The University Of California Semiconductor nanocrystals covalently bound to solid inorganic surfaces using self-assembled monolayers
US5912319A (en) * 1997-02-19 1999-06-15 Courtaulds Aerospace, Inc. Compositions and method for producing fuel resistant liquid polythioether polymers with good low temperature flexibility
US6221602B1 (en) * 1998-11-10 2001-04-24 Bio-Pixels Ltd. Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination

Also Published As

Publication number Publication date
WO2001090717A2 (fr) 2001-11-29
WO2001090716A2 (fr) 2001-11-29
AU2001266609A1 (en) 2001-12-03
WO2001090717A3 (fr) 2002-04-04
AU2001264875A1 (en) 2001-12-03

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