WO2001089617A1 - Appareil de dosage de gaz comportant un catheter - Google Patents

Appareil de dosage de gaz comportant un catheter Download PDF

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Publication number
WO2001089617A1
WO2001089617A1 PCT/EP2001/005684 EP0105684W WO0189617A1 WO 2001089617 A1 WO2001089617 A1 WO 2001089617A1 EP 0105684 W EP0105684 W EP 0105684W WO 0189617 A1 WO0189617 A1 WO 0189617A1
Authority
WO
WIPO (PCT)
Prior art keywords
gas
catheter
supply system
gas supply
breathing
Prior art date
Application number
PCT/EP2001/005684
Other languages
German (de)
English (en)
Inventor
Christian Krebs
Rainer Muellner
Stephan Haubenberger
Original Assignee
Ino Therapeutics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ino Therapeutics Gmbh filed Critical Ino Therapeutics Gmbh
Priority to EP01953149A priority Critical patent/EP1284774A1/fr
Publication of WO2001089617A1 publication Critical patent/WO2001089617A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/01—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes specially adapted for anaesthetising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/04—Tracheal tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/104—Preparation of respiratory gases or vapours specially adapted for anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
    • A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0266—Nitrogen (N)
    • A61M2202/0275—Nitric oxide [NO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/40—Respiratory characteristics
    • A61M2230/43—Composition of exhalation
    • A61M2230/437—Composition of exhalation the anaesthetic agent concentration

Definitions

  • the invention relates to a gas metering device with a catheter.
  • Ventilation devices are used for mechanical ventilation, for anesthesia and for respiratory therapy by treatment with gases, e.g. B. Oxygen donation or treatment with nitrogen monoxide (NO).
  • gases e.g. B. Oxygen donation or treatment with nitrogen monoxide (NO).
  • An inhalation anesthesia device is described for example in DE 37 12 598 A1. It is used to dose anesthetic gas into the breathing gas.
  • a device for supplying breathing gas or oxygen to a patient is described in DE 43 09 923 A1.
  • DE 43 25 319 C1 describes a device for the continuous dosing of NO to the breath of patients, containing a respirator, a NO dosing container, a dosing unit with control unit and an analyzer for determining the NO concentration in the breathing air.
  • the control unit takes over the dosing of the NO to be dosed by determining the volume flows of breathing gas and NO taking into account the NO analysis value.
  • the NO dosage is proportional to the volume or proportional to the volume flow, so that the NO concentration in the breathing gas is always kept constant.
  • the basic technical features of NO dosing in NO therapy are described in: "C. Krebs et al. ⁇ Technological basis for NO application and environmental security, Acta Anaesthesiologica Scandinavica Supplement 109, Vol. 40, 1996; Pp. 84-87 ".
  • WO 98/31282 (internal designation TG 2028/67) describes a gas supply system for ventilated or spontaneously breathing patients, in which one or more gases (for example NO, oxygen) are controlled by means of a controller (program control, sensor control or combined program) - / sensor control) be metered unevenly (continuously or discontinuously) into the breathing gas in a breathing tube.
  • gases for example NO, oxygen
  • controller program control, sensor control or combined program
  • the invention has for its object to provide a device for more effective care of patients with one or more gases.
  • Gas supply systems are arrangements or devices that deliver one or more gases to a patient or make them available for breathing.
  • the gases in particular medical gases, are preferably mixed with air, a breathing gas or oxygen, so that gas mixtures are obtained which maintain breathing.
  • a gas supply system is e.g. B. a ventilation system with respirator and Gasdo- sie ⁇ / orcardi for one or more gases.
  • a respiratory system consists, for example, of hose connections or gas lines, gas source, gas metering device
  • Ventilation systems with a ventilator are generally used for the inpatient treatment of patients.
  • Gas supply systems can be stationary or mobile, especially portable devices.
  • Gas supply systems according to the invention are preferably used for the treatment of humans or mammals with one or more gases, in particular for the inhalative treatment of the lungs.
  • the gas is generally not metered into the breathing gas, but is directed directly to the site of action, usually in the lungs, via a gas supply to which a catheter is connected.
  • the gas therefore does not have to keep breathing.
  • the gas supply system can therefore be used for administering both a breathable gas and a gas which does not maintain breathing. Clean gases, gas mixtures or aerosols are understood as gas.
  • a ventilation system that can be used with changes as a gas supply system is described, for example, in DE 43 25 319 C1, to which reference is made.
  • the gas metering ie gas or aerosol metering, takes place continuously or discontinuously, in particular sequentially (pulsed), via the catheter, during inspiration or expiration.
  • the gas supply system works advantageously controlled, according to the gas supply system for ventilated or spontaneously breathing patients described in WO 98/31282 (internal name TMG 2028/67), to which reference is made.
  • the gas supply systems are designed to direct the dosing gas directly into the catheter.
  • the time of dosing can be done by taking a negative pressure (spontaneous breathing) or taking a flow (artificial respiration).
  • the direct application of the gas in the lungs can lower the ventilation pressure, which relieves the patient.
  • the usual loss of gas when administering gases to the lungs is completely eliminated by using a catheter that is inserted into the trachea.
  • Medical gases or aerosols are supplied to the patient with one or more catheters.
  • the desired gas concentration can be applied directly to the catheter entrance, so that the gas reaches the desired lung areas with no loss.
  • several gases can be introduced into the body at the same time.
  • the gases can be directed through the catheter to any point in the airway, in particular from the tube to the alveolus area. This enables local and selective therapy.
  • NO administration a much smaller amount of NO can be directed directly into the lung areas without worsening the therapeutic effect.
  • the lower amount of NO increases the amount of 0 2 , which leads to an improvement in the amount of PaO 2 .
  • the risk of N ⁇ 2 formation is minimized, since NO and O 2 are only mixed in the lung areas.
  • the gas delivery catheter is used to advantage in both ventilated and spontaneously breathing patients.
  • the desired areas can be flowed to, so that possible side effects in healthy areas do not come into play.
  • the proportion of the metering gas increases, which in turn, depending on the gas, can lead to an undesirable reduction in Pa0. Therefore, the affected areas in the lungs should really only be subjected to selective flow in order to keep the proportion of dosing gas as low as possible.
  • the use of the gas supply system according to the invention is particularly advantageous.
  • gas supply system with catheter can be used for all types of lung diseases such as chronic bronchitis, asthma, fibrosis, emphysema and ARDS.
  • lung diseases such as chronic bronchitis, asthma, fibrosis, emphysema and ARDS.
  • gases containing NO, H 2 , He, 0, N 2 O, halothane, lloprost (llomedin), prostacyclin, H 2 O, saline solution, CO 2 or isoflurane are used as gases or aerosols. It is used both for breathers and for artificially ventilated patients.
  • the sensor is, for example, a gas sensor for determining the concentration of a metered gas or a metered gas component (eg NO, CO 2 or 0 2 ). This makes it possible to determine the local gas concentration at the site of action.
  • a pressure sensor is also advantageous.
  • Suitable microsensors are known, for example, from cardiac catheters (for example developed by the Fraunhofer Society for Microsystem Technology or US 4,815,472).
  • Fig. 1 shows schematically how a catheter for local gas metering is arranged in the lungs.
  • FIG. 2 shows the arrangement of two catheters for local gas metering (same or different gases) in different lung areas.
  • FIG. 3 shows a diagram of a system for local gas metering with a catheter in the case of a spontaneous breather (breathing donation).
  • FIG. 4 shows a schematic of a system for local gas metering with a catheter in a mechanically ventilated patient.
  • the gas or aerosol metering device 1 shown in FIG. 3 detects a breath via a negative pressure measurement 2, which is connected to the patient, and doses the preset amount of the gas or aerosol storage container 3 via the catheter 4 placed in the lungs respective gas or aerosol.
  • FIG. 4 shows schematically how a patient is connected to the respirator 6 via a ventilation hose 5.
  • the gas or aerosol metering device 1 recognizes the respective ventilation state via a flow measurement 7.
  • the gas or aerosol is dosed from the gas or aerosol storage container 3 via the catheter 4 placed in the lungs according to the setting on the dosing device 1.

Landscapes

  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un système d'alimentation de gaz comportant une unité de dosage de gaz (1) et au moins un cathéter (4). Ce système d'alimentation de gaz est mis en oeuvre dans une zone d'action, en particulier dans les poumons, pour l'administration locale d'un gaz ou d'un aérosol. Ledit système d'alimentation de gaz permet un dosage direct de gaz thérapeutique dans les voies respiratoires, ledit gaz thérapeutique n'entretenant pas la respiration.
PCT/EP2001/005684 2000-05-20 2001-05-18 Appareil de dosage de gaz comportant un catheter WO2001089617A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP01953149A EP1284774A1 (fr) 2000-05-20 2001-05-18 Appareil de dosage de gaz comportant un catheter

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10025202.8 2000-05-20
DE2000125202 DE10025202A1 (de) 2000-05-20 2000-05-20 Gasdosiergerät mit Katheter

Publications (1)

Publication Number Publication Date
WO2001089617A1 true WO2001089617A1 (fr) 2001-11-29

Family

ID=7643060

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/005684 WO2001089617A1 (fr) 2000-05-20 2001-05-18 Appareil de dosage de gaz comportant un catheter

Country Status (3)

Country Link
EP (1) EP1284774A1 (fr)
DE (1) DE10025202A1 (fr)
WO (1) WO2001089617A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8557300B2 (en) 2005-05-19 2013-10-15 University Of Cincinnati Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite
US8927030B2 (en) 2003-07-09 2015-01-06 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of nitrite salts for the treatment of cardiovascular conditions

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3712598A1 (de) 1987-04-14 1988-10-27 Siemens Ag Inhalations-anaesthesiegeraet
DE4325319C1 (de) 1993-07-29 1994-04-28 Messer Griesheim Gmbh Gerät zur kontrollierten Zudosierung von NO zur Atemluft von Patienten
DE4309923A1 (de) 1993-03-26 1994-09-29 Boesch Wilhelm Vorrichtungsanordnung zur Zufuhr von Atemgas zu einem Patienten
EP0768095A2 (fr) * 1995-10-13 1997-04-16 Siemens-Elema AB Tube trachéal et dispositif pour système de ventilation artificielle
WO1998031282A1 (fr) 1997-01-17 1998-07-23 Messer Griesheim Austria Ges.Mbh Systeme d'alimentation en gaz commande
WO1999045992A1 (fr) * 1998-03-10 1999-09-16 Instrumentarium Corporation Systeme d'apport de gaz tracheal insuffle destine a un equipement respiratoire
US5954050A (en) * 1997-10-20 1999-09-21 Christopher; Kent L. System for monitoring and treating sleep disorders using a transtracheal catheter
US5957134A (en) * 1997-11-18 1999-09-28 Lee; Han Shik Anesthesia delivery system
US6032667A (en) * 1997-10-30 2000-03-07 Instrumentarium Corporation Variable orifice pulse valve

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728499A (en) * 1986-08-13 1988-03-01 Fehder Carl G Carbon dioxide indicator device
AU3280289A (en) * 1988-02-26 1989-09-22 Brigham And Women's Hospital Co2 indicator for placement of tracheal tubes
WO1990001695A1 (fr) * 1988-07-29 1990-02-22 Mallinckrodt, Inc. Indicateur de gaz carbonique
GB8922049D0 (en) * 1989-09-29 1989-11-15 Medical Instrumentation Consul Carbon dioxide monitor
EP1208851A3 (fr) * 1991-11-14 2003-05-07 Alliance Pharmaceutical Corporation Médicament pour administration pulmonaire
GB9200431D0 (en) * 1992-01-09 1992-02-26 Abbey Biosystems Ltd Carbon dioxide detector
DE19528113C2 (de) * 1995-08-01 2002-09-12 Univ Ludwigs Albert Beatmungseinrichtung

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3712598A1 (de) 1987-04-14 1988-10-27 Siemens Ag Inhalations-anaesthesiegeraet
DE4309923A1 (de) 1993-03-26 1994-09-29 Boesch Wilhelm Vorrichtungsanordnung zur Zufuhr von Atemgas zu einem Patienten
DE4325319C1 (de) 1993-07-29 1994-04-28 Messer Griesheim Gmbh Gerät zur kontrollierten Zudosierung von NO zur Atemluft von Patienten
EP0768095A2 (fr) * 1995-10-13 1997-04-16 Siemens-Elema AB Tube trachéal et dispositif pour système de ventilation artificielle
WO1998031282A1 (fr) 1997-01-17 1998-07-23 Messer Griesheim Austria Ges.Mbh Systeme d'alimentation en gaz commande
US5954050A (en) * 1997-10-20 1999-09-21 Christopher; Kent L. System for monitoring and treating sleep disorders using a transtracheal catheter
US6032667A (en) * 1997-10-30 2000-03-07 Instrumentarium Corporation Variable orifice pulse valve
US5957134A (en) * 1997-11-18 1999-09-28 Lee; Han Shik Anesthesia delivery system
WO1999045992A1 (fr) * 1998-03-10 1999-09-16 Instrumentarium Corporation Systeme d'apport de gaz tracheal insuffle destine a un equipement respiratoire

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8927030B2 (en) 2003-07-09 2015-01-06 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of nitrite salts for the treatment of cardiovascular conditions
US9700578B2 (en) 2003-07-09 2017-07-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of nitrite salts for the treatment of cardiovascular conditions
US8557300B2 (en) 2005-05-19 2013-10-15 University Of Cincinnati Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite

Also Published As

Publication number Publication date
EP1284774A1 (fr) 2003-02-26
DE10025202A1 (de) 2001-11-29

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