WO2001086283A3 - Apparatus and method for multiple channel high throughput purification - Google Patents

Apparatus and method for multiple channel high throughput purification Download PDF

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Publication number
WO2001086283A3
WO2001086283A3 PCT/US2001/015469 US0115469W WO0186283A3 WO 2001086283 A3 WO2001086283 A3 WO 2001086283A3 US 0115469 W US0115469 W US 0115469W WO 0186283 A3 WO0186283 A3 WO 0186283A3
Authority
WO
WIPO (PCT)
Prior art keywords
high throughput
assembly
frame
multiple channel
purification system
Prior art date
Application number
PCT/US2001/015469
Other languages
French (fr)
Other versions
WO2001086283A2 (en
Inventor
Romaine Maiefski
Don Wendell
Jonathan D Krakover
Original Assignee
Ontogen Corp
Romaine Maiefski
Don Wendell
Jonathan D Krakover
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/569,377 external-priority patent/US6358414B1/en
Priority claimed from US09/569,378 external-priority patent/US6458273B1/en
Priority claimed from US09/569,382 external-priority patent/US6355164B1/en
Priority claimed from US09/569,374 external-priority patent/US6358413B1/en
Application filed by Ontogen Corp, Romaine Maiefski, Don Wendell, Jonathan D Krakover filed Critical Ontogen Corp
Priority to CA002408410A priority Critical patent/CA2408410A1/en
Priority to EP01935450A priority patent/EP1281075A2/en
Priority to JP2001583176A priority patent/JP2004510126A/en
Priority to AU2001261545A priority patent/AU2001261545A1/en
Publication of WO2001086283A2 publication Critical patent/WO2001086283A2/en
Publication of WO2001086283A3 publication Critical patent/WO2001086283A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D16/00—Control of fluid pressure
    • G05D16/20—Control of fluid pressure characterised by the use of electric means
    • G05D16/2006—Control of fluid pressure characterised by the use of electric means with direct action of electric energy on controlling means
    • G05D16/2013—Control of fluid pressure characterised by the use of electric means with direct action of electric energy on controlling means using throttling means as controlling means
    • G05D16/202—Control of fluid pressure characterised by the use of electric means with direct action of electric energy on controlling means using throttling means as controlling means actuated by an electric motor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1885—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in parallel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/40—Selective adsorption, e.g. chromatography characterised by the separation mechanism using supercritical fluid as mobile phase or eluent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B01J2219/00587—High throughput processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00759—Purification of compounds synthesised
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor

Abstract

This includes pressure regulator assembly usable in, as an example, a multiple channel high throughput purification system. The pressure regulator assembly is adjustable for pressure control of the fluid flow in the purification system. The apparatus includes a microsampling device useable in a multiple channel high throughput purification system for purifying a plurality of samples, preferably four or more samples from a chemical library. The apparatus also includes a high throughput liquid chromatography column assembly for separating a large sample with a selected mass weight and fluid volume. The apparatus also includes a fraction collection assembly having a frame and a dispensing head movably connected to the frame for movement about three axes. A rinse station is connected to the frame and positioned to removably receive the dispensing tube when the dispensing head is in the rinse position. A pickup station is provided adjacent to an expansion chamber distribution assembly to retain the expansion chambers in a selected position to be picked up by the dispensing head when in the pick up position prior to distribution of the sample into the receiving container.
PCT/US2001/015469 2000-05-11 2001-05-11 Apparatus and method for multiple channel high throughput purification WO2001086283A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002408410A CA2408410A1 (en) 2000-05-11 2001-05-11 Apparatus and method for multiple channel high throughput purification
EP01935450A EP1281075A2 (en) 2000-05-11 2001-05-11 Apparatus and method for multiple channel high throughput purification
JP2001583176A JP2004510126A (en) 2000-05-11 2001-05-11 Multi-channel high-throughput purification apparatus and method
AU2001261545A AU2001261545A1 (en) 2000-05-11 2001-05-11 Apparatus and method for multiple channel high throughput purification

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US09/569,374 2000-05-11
US09/569,377 US6358414B1 (en) 1999-10-29 2000-05-11 Pressure regulation apparatus and method for multiple channel high throughput purification
US09/569,378 US6458273B1 (en) 1999-10-29 2000-05-11 Sample separation apparatus and method for multiple channel high throughput purification
US09/569,377 2000-05-11
US09/569,382 2000-05-11
US09/569,378 2000-05-11
US09/569,382 US6355164B1 (en) 1999-10-29 2000-05-11 Sample collection apparatus and method for multiple channel high throughput purification
US09/569,374 US6358413B1 (en) 1999-10-29 2000-05-11 Microsampling apparatus and method for multiple channel high throughout purification

Publications (2)

Publication Number Publication Date
WO2001086283A2 WO2001086283A2 (en) 2001-11-15
WO2001086283A3 true WO2001086283A3 (en) 2002-05-16

Family

ID=27504881

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015469 WO2001086283A2 (en) 2000-05-11 2001-05-11 Apparatus and method for multiple channel high throughput purification

Country Status (5)

Country Link
EP (1) EP1281075A2 (en)
JP (1) JP2004510126A (en)
AU (1) AU2001261545A1 (en)
CA (1) CA2408410A1 (en)
WO (1) WO2001086283A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2517972C2 (en) * 2009-01-21 2014-06-10 Теском Корпорейшн Pressure temperature controller
RU2523334C2 (en) * 2009-01-21 2014-07-20 Теском Корпорейшн Pressure heat controller

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6880576B2 (en) 2001-06-07 2005-04-19 Nanostream, Inc. Microfluidic devices for methods development
CN100528363C (en) 2002-02-13 2009-08-19 安捷伦科技有限公司 Microfluidic separation column devices and preparation method thereof
US7261812B1 (en) 2002-02-13 2007-08-28 Nanostream, Inc. Multi-column separation devices and methods
US6936167B2 (en) 2002-10-31 2005-08-30 Nanostream, Inc. System and method for performing multiple parallel chromatographic separations
EP1775001A1 (en) * 2005-10-13 2007-04-18 Xendo Holding B.V. Device for chromatographic separations
JP5833925B2 (en) * 2008-09-29 2015-12-16 ウオーターズ・テクノロジーズ・コーポレイシヨン Supercritical fluid chromatography with parallel screening
EP2825878A4 (en) * 2012-03-08 2016-07-20 Waters Technologies Corp Back pressure regulation
CN110914684B (en) * 2017-09-15 2022-11-08 株式会社岛津制作所 Supercritical fluid device
CN212207226U (en) * 2020-06-10 2020-12-22 上海贝高医疗科技有限公司 Static sample introduction and flow fraction collection device matched with liquid chromatograph
CN113466105B (en) * 2021-07-01 2022-04-12 西南石油大学 Method for determining starting pressure gradient of compact gas reservoir

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0417882A2 (en) * 1989-09-14 1991-03-20 Intel Gasgards Private Limited Improvements in and relating to gas pressure regulators
US5522421A (en) * 1994-07-01 1996-06-04 Daniel A. Holt Fluid pressure regulator
US5810267A (en) * 1995-09-29 1998-09-22 Karasawa; Yukihiko Method and apparatus for pulverizing solid particles
WO2000026662A1 (en) * 1998-10-30 2000-05-11 Ontogen Corporation Apparatus and method for multiple channel high throughput purification

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0417882A2 (en) * 1989-09-14 1991-03-20 Intel Gasgards Private Limited Improvements in and relating to gas pressure regulators
US5522421A (en) * 1994-07-01 1996-06-04 Daniel A. Holt Fluid pressure regulator
US5810267A (en) * 1995-09-29 1998-09-22 Karasawa; Yukihiko Method and apparatus for pulverizing solid particles
WO2000026662A1 (en) * 1998-10-30 2000-05-11 Ontogen Corporation Apparatus and method for multiple channel high throughput purification

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2517972C2 (en) * 2009-01-21 2014-06-10 Теском Корпорейшн Pressure temperature controller
RU2523334C2 (en) * 2009-01-21 2014-07-20 Теском Корпорейшн Pressure heat controller

Also Published As

Publication number Publication date
AU2001261545A1 (en) 2001-11-20
JP2004510126A (en) 2004-04-02
EP1281075A2 (en) 2003-02-05
CA2408410A1 (en) 2001-11-15
WO2001086283A2 (en) 2001-11-15

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