CN212207226U - Static sample introduction and flow fraction collection device matched with liquid chromatograph - Google Patents
Static sample introduction and flow fraction collection device matched with liquid chromatograph Download PDFInfo
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- CN212207226U CN212207226U CN202021056964.5U CN202021056964U CN212207226U CN 212207226 U CN212207226 U CN 212207226U CN 202021056964 U CN202021056964 U CN 202021056964U CN 212207226 U CN212207226 U CN 212207226U
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/24—Automatic injection systems
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/80—Fraction collectors
- G01N30/82—Automatic means therefor
Abstract
The utility model relates to a with supporting static advance a kind of use of liquid chromatograph and flow fraction collection device, including programmable controller, autoinjector and flow fraction collector, the autoinjector includes syringe pump, first electronic multichannel diverter valve and electronic six-channel sampling valve, and the flow fraction collector includes programmable controller and the electronic multichannel diverter valve of second, and programmable controller advances a kind and sets for module and DA conversion module including advancing a kind, advances a kind and sets for the module and is connected with DA conversion module. The utility model discloses an automatic sample injector can be fixed arrange the sample container bottom in with the mouth of pipe of advancing the appearance, avoids the common sample of automatic sample injector sold in the market at present to remain, sample loss and mechanical failure scheduling problem, realizes the collection of flow fraction through combining to adopt electronic multichannel diverter valve, makes liquid chromatogram autoinjection and flow fraction collection function integrate into one, and the instrument simple structure, the operation of being convenient for, occupation space are little, can use with the liquid chromatograph of various models is supporting.
Description
Technical Field
The utility model relates to a separation and purification field of chemistry and biological sample, concretely relates to with supporting static advance appearance and the fraction collection device who uses of liquid chromatograph.
Background
Liquid chromatography is based on the difference in affinity of components in a mixture for two phases to effect separation of a sample. In recent years, high performance (also called high pressure) liquid chromatography with finer stationary phase support and higher mobile phase pressure is widely used by scientific research and production units, and becomes an effective means for separating and purifying chemical and biological samples.
A complete set of hplc apparatus generally consists of a high pressure infusion pump, a chromatographic column, a gradient mixer, a column oven, an on-line degasser, a detector (uv/differential/evaporative light scattering/fluorescence, etc.), an automatic or manual sample injector, a fraction collector and corresponding analysis control software. The automatic sample injector and the flow collector can reduce repeated operation and long-time watching of experiment and production personnel, improve working efficiency and reduce labor cost.
Currently, commercially available high performance liquid chromatographs have various brands and respectively have certain user groups. However, the prior technical scheme has the defects that:
the software is various and the operation is inconvenient, wherein the high-pressure infusion pump, the automatic sample injector, the detector and the flow collector are provided with own control/analysis software;
instruments of various brands are produced by different companies respectively, and the compatibility is poor;
the automatic sample injector sold in the market at present adopts a mechanical motion arm, and adopts X/Y/Z displacement to carry out sample injection, so that the position of a test tube/a sample bottle is strictly limited, and normal sample injection cannot be carried out if the position is deviated.
The auto-sampler on the market at present usually adopts a metal sampling needle, which can not be inserted into the bottom of the sample bottle to completely suck the sample, and the sample may be lost in the process of repeated movement.
Most of the flow collectors adopt a mechanical moving arm, and the flow collectors adopt X/Y displacement to collect flow, so that the positions of test tubes/sample bottles are strictly limited, and flow collection cannot be normally carried out if the positions of the test tubes/sample bottles are deviated.
The automatic sample injector and the flow collector are respectively and independently designed, so that a plurality of moving assemblies are adopted, the instrument occupies a large space, the power consumption of the instrument is high, and the reliability of long-time operation is poor.
SUMMERY OF THE UTILITY MODEL
Aiming at the defects of the prior art, the utility model aims at providing a static sample introduction and flow fraction collection device which is matched with a liquid chromatograph for use, wherein the automatic sample introduction and flow fraction collection function is realized by adopting an injection pump, an electric six-channel sample introduction valve, an electric multi-channel distribution valve and corresponding control software; the automatic sample introduction can be selectively carried out on the samples in different sample containers according to the requirements, and the separated flow fractions are selectively collected according to the requirements; because the instrument does not adopt a moving assembly in the traditional design, the reliability of long-time operation can be improved, the amount of samples to be separated is not limited, and the separation of a large number of samples which are long-time and unattended can be realized.
The above object of the present invention can be achieved by the following technical solutions:
a static sample introduction and fraction collection device matched with a liquid chromatograph comprises a programmable controller, an automatic sample injector and a fraction collector, wherein the automatic sample injector comprises an injection pump, a first electric multi-channel switching valve and an electric six-channel sample introduction valve; the outlet of the first electric multi-channel switching valve is connected with an electric six-channel sample injection valve through a main pipeline, and the other five interfaces of the electric six-channel sample injection valve are respectively connected with an injection pump, a quantitative ring occupying 2 interfaces, a mobile phase of a liquid chromatography pump and an inlet of a chromatographic column; the flow fraction collector comprises the programmable controller and a second electric multi-channel switching valve, a main pipeline of the second electric multi-channel switching valve is connected with a mobile phase of the detector, and branch pipelines of the second electric multi-channel switching valve are respectively connected with a flow fraction collecting container and a waste liquid collecting container; the programmable controller comprises a sample setting module and a D/A conversion module, the sample setting module is connected with the D/A conversion module, and the D/A conversion module is respectively connected with a first electric multi-channel switching valve, an electric six-channel sample injection valve and an injection pump in the automatic sample injector and a second electric multi-channel switching valve in the flow collector.
Through the technical scheme, the utility model discloses a with supporting static advance kind of use of liquid chromatograph and flow divide collection device to switch through the passageway of advancing kind settlement module, the first electronic multichannel diverter valve of DA conversion module control, and then can realize selective autoinjection as required to the sample in the different sample container under the condition that need not to remove the arm, this electronic multichannel diverter valve adopts one more way out mode, can reach 24 way at most and advance kind.
The present invention can be further configured in a preferred embodiment, further comprising a detector disposed outside for detecting the components of the flow, wherein the inlet of the detector is connected to the outlet of the chromatographic column through a pipeline, and the outlet of the detector is connected to the inlet of the second electric multi-channel switching valve through a pipeline.
By adopting the technical scheme, the components of the fraction separated by the chromatographic column can be detected.
The utility model discloses can further configure to in a preferred example, programmable controller still includes AD conversion module, information identification module and information storage module, and the information identification module is connected with AD conversion module, information storage module and DA conversion module respectively, the detector is connected with AD conversion module electricity in order to divide the flow that detects to transmit to programmable controller with analog signal.
Through adopting above-mentioned technical scheme, accessible detector, AD conversion module, information identification module, information storage module and DA conversion module, the switching of the passageway of the electronic multichannel diverter valve of control second, and then separate the collection to the different compositions that separate in the flow divides, can be accurate separate the collection to the different compositions in the flow divides, the separation effect to various compositions in the sample is better.
The utility model discloses can further configure to in a preferred example, still include the touch-control display screen, the touch-control display screen with programmable controller connects.
The present invention may be further configured in a preferred example, wherein the programmable controller further comprises a wireless transmitting module and a wireless receiving module.
By adopting the technical scheme, the remote control of the system and the automatic upgrade of software can be realized, and the control and analysis functions are integrated by adopting single control software, so that the control of each component is convenient.
The utility model discloses can further configure to in a preferred example, sampling system still includes kind pipeline arrangement seat, and kind pipeline arrangement seat sets up the top at first electronic multichannel diverter valve.
By adopting the technical scheme, the pipelines connected with the first electric multi-channel switching valve are arranged in order.
The utility model discloses can further configure to in a preferred example, fraction collecting system still includes flow distribution pipeline arrangement seat, and flow distribution pipeline arrangement seat sets up the top at the electronic multichannel diverter valve of second.
The present invention can be further configured in a preferred embodiment, and the programmable controller is further provided with a communication interface.
By adopting the technical scheme, the system can be connected with external PC equipment.
The present invention can be further configured in a preferred embodiment, wherein the touch display screen is integrated with the programmable controller.
By adopting the technical scheme, the size of the system is reduced, and the appearance effect is enhanced.
Drawings
Fig. 1 is a schematic diagram of a static sample introduction and fraction collection device used with a liquid chromatograph according to an embodiment of the present invention.
Fig. 2 is a schematic view of the integrated sample processor of fig. 1 from one perspective.
Fig. 3 is a schematic diagram of another perspective of the integrated sample processor of fig. 1.
Fig. 4 is a schematic diagram of the internal structure of the integrated sample processor of fig. 2.
Fig. 5 is an internal system diagram of a programmable controller of the integrated sample processor of fig. 1.
In the figure, 1, a display screen is touched; 2. a sample introduction pipeline arranging seat; 3. an electric six-way sample injection valve; 4. a first electrically powered multi-channel switching valve; 5. an electric three-way valve; 6. an injection pump; 7. a sample injection syringe; 8. a flow distribution pipeline arranging seat; 9. a second electrically operated multi-channel switching valve; 10. an electric signal input terminal; 11. a switch; 12. an RS232 communication interface; 13. cleaning a waste liquid collecting bottle; 14. a dosing ring; 15. a chromatographic column; 16. a sample container; 17. a detector; 18. a liquid chromatography pump; 19. an eluent bottle; 20. a fraction collection vessel; 21. a waste liquid collecting bottle; 22. a switching power supply; 23. a main control circuit board; 24. a stepper motor driver; 25. a screw rod; 26. a stepping motor; 27. a casing.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
Referring to fig. 1 to 4, the utility model discloses a static sampling and fraction collecting device used with a liquid chromatograph, which comprises an integrated sample processor, a chromatographic column 15, a liquid chromatographic pump 18, an eluent bottle 19 and a detector 17 for detecting the fraction component. The integrated sample processor includes a programmable controller, a sample introduction system, and a fraction collection system. The sample injection system comprises a sample container 16, an injection pump 6, an electric three-way valve 5, an electric six-way sample injection valve 3, a first electric multi-channel switching valve 4 and a sample injection needle 7 connected with the injection pump 6, and samples in the sample container 16 are absorbed through the sample injection system. The volume of the sample injection needle 7 can be selected by a user according to the requirement and is set in the software of the touch display screen 1, and the function of the volume is to suck a sample in the sample container 16. The electric three-way valve 5 is used for selectively injecting samples or discharging waste liquid in the sample injection needle 7 according to requirements. The electric six-way sample injection valve 3 is also provided with a quantitative ring 14 for absorbing and containing samples, and the electric six-way sample injection valve 3 can realize automatic cleaning of pipelines and sample injection needles. The injection pump 6 is arranged in a casing 27 and comprises a stepping motor 26, a screw rod 25, a switching power supply 22, a main control circuit board 23 and a stepping motor driver 24. The fraction collecting system includes a fraction collecting container 20 and a waste liquid container including a washing waste liquid collecting bottle 13 and a fraction waste liquid collecting bottle 21. The first electric multi-channel switching valve 4 includes 10 channels, 10 sample containers 16 are provided, and the sample containers 16 are labeled separately, and each sample container 16 is connected to each channel port of the first electric multi-channel switching valve 4 through each branch line. The outlet of the first electric multi-channel switching valve 4 is connected with the inlet of the external chromatographic column 15 through a main pipeline, and the injection pump 6 is arranged on the pipeline of the main pipeline. In other embodiments, when the apparatus is used for repeated sampling of only a single sample, as a simplified apparatus, the first electric multi-channel switching valve of the autosampler section may be eliminated and the sample solution to be separated may be directly aspirated by the sample sampling line connected to the electric six-channel switching valve.
Referring to fig. 1 to 4, the fraction collection system further comprises a second electrically operated multi-channel switching valve 9, the second electrically operated multi-channel switching valve 9 comprising 10 channels. 9 fraction collecting containers 20 are provided, and each fraction collecting container 20 is labeled, an inlet of the second electric multi-channel switching valve 9 is connected with an outlet of the chromatographic column 15 through a main pipeline, and each channel of the second electric multi-channel switching valve 9 is connected with the waste liquid container and each fraction collecting container 20 through branch pipelines. The sampling system further comprises a sampling pipeline arranging seat 2, the sampling pipeline arranging seat 2 is arranged above the first electric multi-channel switching valve 4, pipeline numbers are marked on the sampling pipeline arranging seat 2, and the sampling pipeline arranging seat 2 is used for arranging branch pipelines connected with the first electric multi-channel switching valve 4 to enable the branch pipelines to be orderly. The flow distribution collecting system further comprises a flow distribution pipeline arranging seat 8, the flow distribution pipeline arranging seat 8 is arranged above the second electric multi-channel switching valve 9, the flow distribution pipeline arranging seat 8 is marked with a pipeline number, and the flow distribution pipeline arranging seat 8 is used for arranging the branch pipelines connected with the second electric multi-channel switching valve 9 in order. In addition, a power socket and a switch are also arranged on the back plate of the integrated sample processor, and a power switch and a fuse are integrated on the power socket and the switch; the back plate is also provided with an electric signal input terminal 10 connected with the detector 17, an RS232 communication interface 12 connected with a PC, a power socket and a switch 11.
When the static sample introduction and flow fraction collection device matched with the liquid chromatograph is used, the inlet of the first electric multi-channel switching valve 4 is connected with each branch pipeline and is connected with the sample container 16 through the sample introduction pipeline arranging seat 2; connecting an outlet of the first electric multi-channel switching valve 4 with an inlet of the electric six-way sampling valve 3 by using a main pipeline; connecting a required quantitative ring 14 with a port 1 and a port 4 of an electric six-way sampling valve 3, and connecting a port 6 of the electric six-way sampling valve 3 with an inlet of an electric three-way valve 5 through a pipeline; the outlet of the electric three-way valve 5 is connected with a cleaning waste liquid collecting bottle 13 by a pipeline; installing a sample injection needle 7 on the injection pump 6, and connecting an inlet of the sample injection needle 7 with a bottom port of the electric three-way valve 5; 2 ports of the electric six-way sampling valve 3 are connected with an external liquid chromatography pump 18 by pipelines; connecting the 3 ports of the electric six-way sampling valve 3 with an external chromatographic column 15 by pipelines; the outlet below the outer column 15 is connected by a line to the inlet of an outer detector 17; an outlet of the external detector 17 is connected to an inlet of the second electric multi-channel switching valve 9 through a line; connecting a cable for signal output of the external detector 17 to the electric signal input terminal 10; the outlet of the second electric multi-channel switching valve 9 is connected to a fraction collection container 20 via a branch line arranging base 8, and the last outlet of the second electric multi-channel switching valve 9 is connected to a large fraction waste liquid collection bottle 21. When the device is used, the sample is injected through the sample injection needle 7 on the injection pump 6, the eluent in the eluent bottle 19 is injected into the chromatographic column through the electric six-way sample injection valve 3 through the liquid chromatographic pump 18 after the sample injection is finished, the sample component separation is carried out by utilizing the principle that the chromatographic column has different adsorption force for different sample components, then the fraction enters the detector 17 for component detection, and the detection information is fed back to the controller.
Referring to fig. 5, the utility model discloses a static advance kind and flow collection device with supporting use of liquid chromatograph still includes touch-control display screen 1, and touch-control display screen 1 embeds tall and erect system of ann or windows operating system to system control software has been installed on this touch-control display screen 1. The control software can control the sample injection system, the first electric multi-channel switching valve 4, the electric six-way sample injection valve 3 and the second electric multi-channel switching valve 9, and can draw an absorbance curve of a level signal from the external detector 17 through the electric signal input terminal 10. The sampling volume, the sampling speed, the sampling times, the sampling intervals and the like of the sampling system can be controlled, and the sampling time intervals are matched with the separation time of the chromatographic column 15, so that uninterrupted and repeated automatic sampling is realized, and unattended and long-time sample separation can be realized. The touch display screen 1 is connected with the programmable controller, and the touch display screen 1 and the programmable controller are integrated together. The programmable controller also comprises an A/D conversion module, an information identification module and an information storage module. The a/D conversion module is used for receiving the analog signal fed back by the detector 17 and converting the analog signal into a digital signal. The information identification module is respectively connected with the A/D conversion module, the information storage module and the D/A conversion module. The D/A conversion module is respectively and electrically connected with the first electric multi-channel switching valve 4, the second electric multi-channel switching valve 9 and the injection pump 6 to realize control. The detector 17 is electrically connected to the a/D conversion module to transmit the detected stream as analog signals to the programmable controller. The information identification module is connected with the A/D conversion module and used for receiving the converted digital signals and identifying whether the same signals are stored in the information storage module or not. If the current flow rate is higher than the preset value, the information storage module inquires the storage information of the stored signal, for example, the stored information is stored in which flow rate collection container 20, and sends a digital signal to the D/A conversion module, the D/A conversion module converts the digital signal into an analog signal and transmits the analog signal to the second electric multi-channel switching valve 9, and the second electric multi-channel switching valve 9 is controlled to collect the flow rate into the flow rate collection container 20 of the same flow rate which is collected before; if not, the flow component signal is transmitted to the information storage module for storage and recording, and meanwhile, a digital signal is sent to the D/A conversion module, and the second electric multi-channel switching valve 9 is controlled to collect the flow component into a new flow component collecting container 20. The programmable controller also comprises a sample introduction setting module which is used for setting single or a plurality of sample introduction types, sample introduction sequence, repeated sample introduction times, sample introduction time intervals and sample introduction quantity according to requirements and can assign a fraction collection container 20 for each sample. The separation capacity of the chromatographic column 15 can be fully and effectively utilized by reasonably setting the sample introduction time interval, the separation efficiency is improved, and the effective separation of samples is realized. The sample introduction setting module is connected with the D/A conversion module so as to control the on-off of each channel of the first electric multi-channel switching valve 4 and the second electric multi-channel switching valve 9 and further realize the set content. The programmable controller also comprises a wireless transmitting module and a wireless receiving module, so that the remote control and software upgrading of the system can be realized, and the running condition of the equipment can be monitored in real time.
The A/D conversion circuit can acquire data of signals of the detector 17, display separation curves of flow components on a display screen, and control the flow components into the sub-acquisition sets through a threshold method, a timing method and a peak shape method. The threshold method is that a threshold value is set on system software of the touch screen, peaks higher than the threshold value belong to samples to be collected, and the samples can be collected in sequence by controlling the second electric multi-channel switching valve 9. The principle of the timing method is that the same sample is separated according to the chromatographic column 15 with high repeatability, after the peak emergence time of each peak shape is determined, the sample collection can be carried out in a specific time period after each sample introduction set on software, and a collected fraction collection container 20 can be designated. The peak shape method is determined according to the peak-out characteristics, the peak shape method is collected according to the inflection point of the judged peak shape, compared with the threshold value method, the sample collection is more efficient, and two adjacent peaks can be separately collected, which cannot be achieved by the threshold value method.
The utility model discloses a static sampling and flow fraction collection device used with liquid chromatograph, set up the parameter in the system software procedure of touch-control display screen 1 first when using, including sample kind, advance appearance order, advance appearance speed and the volume of advancing of setting for advancing kind, set for advance appearance interval time, set for data acquisition time, set for advance appearance repetition number; and setting a sample collection mode, a timing method, a threshold value method or a peak shape and peak division method. After the setting is finished, clicking to start to carry out sample introduction and separation of the sample and fraction collection of the sample.
The implementation principle of the embodiment is as follows: the static sample introduction and flow fraction collection device used in cooperation with the liquid chromatograph controls the channel switching of the first electric multi-channel switching valve 4 through the sample introduction setting module and the D/A conversion module, and further can selectively and automatically introduce samples in different sample containers 16 according to the requirements; moreover, the switching of the channels of the second electric multi-channel switching valve 9 is controlled by the detector 17, the a/D conversion module, the information identification module, the information storage module and the D/a conversion module, so that different components separated from the flow are automatically separately collected, and the different components in the flow can be accurately separately collected. Additionally, the utility model discloses a static sampling and flow fraction collection device with supporting use of liquid chromatograph can realize the automatic repeat sampling of many samples, can realize full automatization sample separation operation, greatly reduce the human cost, improve production efficiency to the uniformity of sample separation effect has been guaranteed. In addition, the instrument can realize remote equipment monitoring, remote data collection and online upgrading of the system. Moreover, the sampling system, the flow collecting system, the detector 17, the touch display screen 1 and the wireless transceiver module are integrated into a whole, the adaptability of each part is better, and one set of control system, one set of power supply, one set of control software and one case can be shared, so that the overall cost can be greatly reduced, the after-sales and equipment maintenance are greatly simplified, the operation and the use of a user are more convenient, and the cost performance is higher.
The embodiment of this specific implementation mode is the preferred embodiment of the present invention, not limit according to this the utility model discloses a protection scope, so: all equivalent changes made according to the structure, shape and principle of the utility model are covered within the protection scope of the utility model.
Claims (9)
1. The utility model provides a with supporting static advance a kind of use of liquid chromatograph and flow fraction collection device which characterized in that: the automatic sampler comprises a programmable controller, an automatic sampler and a flow collector, wherein the automatic sampler comprises an injection pump (6), a first electric multi-channel switching valve (4) and an electric six-channel sampling valve (3); an outlet of the first electric multi-channel switching valve (4) is connected with an electric six-channel sample injection valve (3) through a main pipeline, and the other five interfaces of the electric six-channel sample injection valve (3) are respectively connected with an injection pump (6), a quantitative ring (14) occupying 2 interfaces, a mobile phase of a liquid chromatographic pump and an inlet of a chromatographic column (15); the flow fraction collector comprises the programmable controller and a second electric multi-channel switching valve (9), a main pipeline of the second electric multi-channel switching valve (9) is connected with a mobile phase of the detector (17), and branch pipelines of the second electric multi-channel switching valve (9) are respectively connected with a flow fraction collecting container (20) and a waste liquid collecting container; the programmable controller comprises a sample setting module and a D/A conversion module, the sample setting module is connected with the D/A conversion module, and the D/A conversion module is respectively connected with a first electric multi-channel switching valve (4), an electric six-channel sample valve (3) and an injection pump (6) in the automatic sample injector and a second electric multi-channel switching valve (9) in the flow collector.
2. The static sample introduction and fraction collection device of claim 1 for use with a liquid chromatograph, wherein: the device also comprises a detector (17) which is arranged outside and used for detecting the components of the flow, wherein the inlet of the detector (17) is connected with the outlet of the chromatographic column (15) through a pipeline, and the outlet of the detector (17) is connected with the inlet of the second electric multi-channel switching valve (9) through a pipeline.
3. The static sample introduction and fraction collection device for use with a liquid chromatograph of claim 1 or 2, wherein: the programmable controller also comprises an A/D conversion module, an information identification module and an information storage module, wherein the information identification module is respectively connected with the A/D conversion module, the information storage module and the D/A conversion module, and the detector (17) is electrically connected with the A/D conversion module so as to transmit the detected stream components to the programmable controller as analog signals.
4. The static sample introduction and fraction collection device for use with a liquid chromatograph of claim 1 or 2, wherein: the touch control display screen (1) is further included, and the touch control display screen (1) is connected with the programmable controller.
5. The static sample introduction and fraction collection device for use with a liquid chromatograph of claim 1 or 2, wherein: the programmable controller also comprises a wireless transmitting module and a wireless receiving module.
6. The static sample introduction and fraction collection device for use with a liquid chromatograph of claim 1 or 2, wherein: the automatic sample injector further comprises a sample injection pipeline arranging seat (2), and the sample injection pipeline arranging seat (2) is arranged above the first electric multi-channel switching valve (4).
7. The static sample introduction and fraction collection apparatus of claim 6 for use with a liquid chromatograph, wherein: the flow collector further comprises a flow distribution pipeline arranging seat (8), and the flow distribution pipeline arranging seat (8) is arranged above the second electric multi-channel switching valve (9).
8. The static sample introduction and fraction collection device for use with a liquid chromatograph of claim 1 or 2, wherein: and the programmable controller is also provided with a communication interface.
9. The static sample introduction and fraction collection apparatus of claim 4 for use with a liquid chromatograph, wherein: the touch display screen (1) and the programmable controller are integrated together.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021056964.5U CN212207226U (en) | 2020-06-10 | 2020-06-10 | Static sample introduction and flow fraction collection device matched with liquid chromatograph |
| PCT/CN2021/098644 WO2021249347A1 (en) | 2020-06-10 | 2021-06-07 | Static sample injection and fraction collection apparatus for use with liquid chromatograph |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021056964.5U CN212207226U (en) | 2020-06-10 | 2020-06-10 | Static sample introduction and flow fraction collection device matched with liquid chromatograph |
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| CN212207226U true CN212207226U (en) | 2020-12-22 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2021249347A1 (en) * | 2020-06-10 | 2021-12-16 | 上海贝高医疗科技有限公司 | Static sample injection and fraction collection apparatus for use with liquid chromatograph |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114994223A (en) * | 2022-04-29 | 2022-09-02 | 天津博纳艾杰尔科技有限公司 | Automatic sample injection liquid path system and automatic sample injection method |
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| CN109900840A (en) * | 2019-04-16 | 2019-06-18 | 李宜珊 | Multidimensional liquid chromatographic separation system based on double two position four-way valves |
| CN109944762A (en) * | 2019-04-16 | 2019-06-28 | 无锡赛那尔仪器设备制造有限公司 | The four-way binary high pressure pump system of high performance liquid chromatograph |
| CN110455970B (en) * | 2019-08-20 | 2021-07-23 | 大连依利特分析仪器有限公司 | Sampling fraction collecting device and system |
| CN110988228A (en) * | 2019-11-25 | 2020-04-10 | 清华大学 | Automatic sample introduction and analysis device for multiple samples |
| CN111060609A (en) * | 2019-12-06 | 2020-04-24 | 厦门大学 | Full-automatic analysis device and analysis method for solid-phase extraction and enrichment |
| CN212207226U (en) * | 2020-06-10 | 2020-12-22 | 上海贝高医疗科技有限公司 | Static sample introduction and flow fraction collection device matched with liquid chromatograph |
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2020
- 2020-06-10 CN CN202021056964.5U patent/CN212207226U/en active Active
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2021
- 2021-06-07 WO PCT/CN2021/098644 patent/WO2021249347A1/en active Application Filing
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021249347A1 (en) * | 2020-06-10 | 2021-12-16 | 上海贝高医疗科技有限公司 | Static sample injection and fraction collection apparatus for use with liquid chromatograph |
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