CN104330509A - Intelligent automatic switching multi-channel liquid chromatography column connection device - Google Patents
Intelligent automatic switching multi-channel liquid chromatography column connection device Download PDFInfo
- Publication number
- CN104330509A CN104330509A CN201410608204.3A CN201410608204A CN104330509A CN 104330509 A CN104330509 A CN 104330509A CN 201410608204 A CN201410608204 A CN 201410608204A CN 104330509 A CN104330509 A CN 104330509A
- Authority
- CN
- China
- Prior art keywords
- chromatographic column
- liquid
- hyperchannel
- coupling arrangement
- column connection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The invention provides an intelligent automatic switching multi-channel liquid chromatography column connection device, comprising a fixed base, a plurality of liquid chromatography columns, a control panel and two multi-channel chromatography column connection device bodies, wherein the control panel is provided with a display screen; each multi-channel chromatography column connection device body comprises a plurality of fluid channels; fluid flows through the different liquid chromatography columns by rotary switching fluid channels; the multi-channel chromatography column connection device bodies are respectively arranged at the top and the bottom of the fixed base; the control panel is respectively connected with two multi-channel chromatography column connection device circuits and is used for controlling and switching the multi-channel chromatography column connection device bodies to switch fluid channels; the liquid chromatography columns are connected between corresponding fluid channels of the two multi-channel chromatography column connection device bodies through a chromatography column connection pipe in parallel. The liquid chromatography columns do not need to be dismantled and installed again when being replaced by using the intelligent automatic switching multi-channel liquid chromatography column connection device; samples can be automatically switched and controlled to enter the different chromatography columns by one key; scheduled flushing maintenance on the plurality of chromatography columns is facilitated; and the intelligent automatic switching multi-channel liquid chromatography column connection device is simple in operation, low in construction cost and easy to popularize.
Description
Technical field
The invention belongs to laboratory analytical instrument field, particularly relate to a kind of intelligent automatic switchover hyperchannel liquid-phase chromatographic column coupling arrangement.
Background technology
Liquid chromatograph (Lquid Chromatography) is a kind of difference utilizing potpourri distribution ratio between liquid-solid or immiscible two kinds of liquid, is first separated, then the instrument of Analysis and Identification to potpourri.Liquid chromatograph is liquid or solid according to Stationary liquid, is divided into again liquid-liquid chromatograph (LLC) and liquid-solid chromatography (LSC).Modern liquid chromatography instrument is made up of parts such as high pressure pump, sampling system, temperature control system, chromatographic column, detecting device, signal recording systems.Mobile phase in reservoir is squeezed into system by high-pressure pump, sample solution enters mobile phase through injector, be loaded in chromatographic column (Stationary liquid) by mobile phase, because each component in sample solution has different partition factors in two-phase, when doing relative motion in two-phase, through the assigning process of repeated multiple times absorption-desorption, each component produces larger difference in translational speed, be separated into single component to flow out in post successively, during by detecting device, sample concentration is converted into electric signal and is sent to registering instrument, and data print with collection of illustrative plates form.
Current liquid chromatograph is all only equipped with the connector of single chromatographic column, and the frequent analysis in laboratory often needs the chromatographic column often using different model in testing, all need manual teardown to reinstall during replacing at every turn, both be unfavorable for the use of chromatographic column, also inconvenience carries out flushing maintenance to chromatographic column.
Summary of the invention
For above-mentioned technical matters, the present invention is intended to solve the problems of the technologies described above at least to a certain extent, there is provided a kind of when often using the chromatographic column of different model, without the need to all needing manual teardown to reinstall the intelligence automatic switchover hyperchannel liquid-phase chromatographic column coupling arrangement of chromatographic column at every turn.
The present invention is achieved by the following technical solution:
Intelligence automatic switchover hyperchannel liquid-phase chromatographic column coupling arrangement, comprise fixed pedestal, multiple liquid-phase chromatographic column, also comprise the control panel with display screen and two there are many fluid passages and make fluid flow through the hyperchannel chromatographic column coupling arrangement of different liquid-phase chromatographic columns by rotating switch fluids passage, described hyperchannel chromatographic column coupling arrangement is arranged at fixed pedestal top and bottom respectively, described control panel is connected with two hyperchannel chromatographic column coupling arrangement circuit respectively and switches hyperchannel chromatographic column coupling arrangement switch fluids passage for controlling, described liquid-phase chromatographic column is connected between the corresponding fluid passage of two hyperchannel chromatographic column coupling arrangements in parallel by chromatographic column connecting pipe.
Further, described hyperchannel chromatographic column coupling arrangement comprises the outer stator of the tubular be fixedly installed, be arranged at the column internal layer rotor of the endoporus of outer stator and the inner hole wall rotary seal with outer stator rotationally, top joint, follower gear, the drive motor be connected with control panel circuit, the fixing fluid passage that many connect liquid-phase chromatographic column is disposed radially in described outer stator, a L shape actuation fluid passage is provided with in described internal layer rotor, described actuation fluid passage upper end is connected with top joint, lower end is docked with corresponding fixing fluid channel seal after internal layer rotor turns predetermined angular, form complete fluid passage, described follower gear is fixedly installed on internal layer rotor upper end coaxially, described drive motor to be driven with follower gear by driving gear and is connected.
Further, described internal layer rotor is provided with on outer stator the graticule that aligns, and apparatus surface has graticule for characterizing handoff procedure actuation fluid passage and fixing fluid passage whether complete matching.
Further, described fixed pedestal is provided with chromatographic column geometrical clamp.
Further, described drive motor is stepper motor or servomotor, possesses function electric impulse signal being converted to angular displacement, applies a pulse signal by control panel to it, and drive motor just rotates a fixing angle according to the direction set.Pilot angle displacement can be carried out by gating pulse number, thus reach the object of accurately location.
Control panel is mainly used in drive motor input electric impulse signal, the corresponding each passage of display screen of control panel shows Digital ID, double mouse click tracking cross is only needed in correspondence numerically during use, now will send fixed number electric impulse signal to drive motor and control drive motor rotation, switch fluids passage makes fluid flow through the chromatographic column of corresponding digital number.
Hyperchannel chromatographic column coupling arrangement is mainly used in switching flow passage and makes sample introduction end be connected to different chromatographic columns, internal layer rotor can rotate, only has one with the actuation fluid passage of its synchronous axial system, actuation fluid passage top is interface, for connecting chromatographic apparatus port input, actuation fluid channel end is connected to the fixing fluid passage of outer stator.Internal layer rotor top is provided with follower gear, is meshed with the driving gear of drive motor, controls drive motor drive internal layer rotor rotation fixed angle to reach the object of switch fluids passage by control panel.Top joint and internal layer rotor are connected to each other, but top joint non rotating in internal layer rotor turns process, and ensure internal layer rotor, that outer stator frequently rotates channel seal in handoff procedure is good.Outer stator interior is provided with multiple fixing fluid passage and is composed of digital number, and the inner, fixing fluid passage can be connected with the actuation fluid passage of internal layer rotor, fixes outer end, fluid passage as interface for connecting liquid-phase chromatographic column.This device is formed by Precision Machining, thus it is good to ensure that internal layer rotor frequently rotates channel seal in handoff procedure.
Fixed pedestal is mainly used in the fixed installation of drive motor and conductive track thereof, hyperchannel chromatographic column coupling arrangement, liquid-phase chromatographic column.
Compared with prior art, present invention achieves a kind of separate unit liquid chromatograph and connect multiple liquid-phase chromatographic column, manual teardown is not needed to reinstall when changing liquid-phase chromatographic column, auto-changeover control sample introduction flows into the intelligence automatic switchover hyperchannel liquid-phase chromatographic column coupling arrangement of different liquid-phase chromatographic column, changing when using chromatographic column only needs a key to switch, without manual teardown, new chromatographic column is installed, multiple liquid-phase chromatographic column is daily is simultaneously fixed on pedestal, conveniently periodic flushing maintenance is carried out to liquid-phase chromatographic column, frequently liquid-phase chromatographic column is removed and installed when greatly reducing laboratory testing analysis, this device is simple to operate, cheap, be easy to promote, the analysis meeting laboratory chromatographic instrument uses.
Accompanying drawing explanation
Fig. 1 is the system architecture schematic diagram of the embodiment of the present invention.
Fig. 2 is hyperchannel chromatographic column coupling arrangement structural representation in the embodiment of the present invention.
Shown in figure be: 1-hyperchannel chromatographic column coupling arrangement; 2-fixed pedestal; 3-liquid-phase chromatographic column; 4-chromatographic column connecting pipe; 5-conductive track; 6-chromatographic column geometrical clamp; 7-control panel; 8-drive motor; 9-internal layer rotor; 10-top joint; 11-aligns graticule; The outer stator of 12-; 13-actuation fluid passage; 14-fixes fluid passage; 15-follower gear.
Embodiment
Be described in further detail goal of the invention of the present invention below in conjunction with the drawings and specific embodiments, embodiment can not repeat one by one at this, but therefore embodiments of the present invention are not defined in following examples.
As shown in Figures 1 and 2, a kind of intelligent automatic switchover hyperchannel liquid-phase chromatographic column coupling arrangement, comprise fixed pedestal 2, multiple liquid-phase chromatographic column 3, also comprise the control panel 7 with display screen and two there are many fluid passages and make fluid flow through the hyperchannel chromatographic column coupling arrangement 1 of different liquid-phase chromatographic columns 3 by rotating switch fluids passage, described hyperchannel chromatographic column coupling arrangement 1 is arranged at fixed pedestal 2 top and bottom respectively, described control panel 7 is connected with two hyperchannel chromatographic column coupling arrangement 1 circuit respectively and switches hyperchannel chromatographic column coupling arrangement 1 switch fluids passage for controlling, described liquid-phase chromatographic column 3 is connected between the corresponding fluid passage of two hyperchannel chromatographic column coupling arrangements 1 in parallel by chromatographic column connecting pipe 4.
Described hyperchannel chromatographic column coupling arrangement 1 comprises the outer stator 12 of the tubular be fixedly installed, be arranged at the column internal layer rotor 9 of the endoporus of outer stator 12 and the inner hole wall rotary seal with outer stator 12 rotationally, top joint 10, follower gear 15, the drive motor 8 be connected with control panel 7 circuit, the fixing fluid passage 14 that six connect liquid-phase chromatographic column 3 is disposed radially in described outer stator 12, a L shape actuation fluid passage 13 is provided with in described internal layer rotor 9, described actuation fluid passage 13 upper end is connected with top joint 10, lower end seals with corresponding fixing fluid passage 14 and docks after internal layer rotor 9 rotates predetermined angular, form complete fluid passage, described follower gear 15 is fixedly installed on internal layer rotor 9 upper end coaxially, described drive motor 8 to be driven with follower gear 15 by driving gear and is connected.
Described internal layer rotor 9 is provided with on outer stator 12 graticule 11 that aligns.
Described fixed pedestal 2 is provided with chromatographic column geometrical clamp 6, for fixed liquid phase chromatographic column 3, improves its stability.
Described drive motor 8 is stepper motor or servomotor, and the present embodiment selects servomotor, and precision is high.
Transmission gear ratio between drive motor 8 and hyperchannel chromatographic column coupling arrangement and the kind of drive need the number according to fluid passage and design, and the Digital ID number on display screen is consistent with the number of fixing fluid passage 14.
Use front installation: six roots of sensation liquid-phase chromatographic column 3 is connected to fixed pedestal 2(Fig. 1 according to accompanying drawing 1) on, and corresponding for liquid-phase chromatographic column 3 model and the corresponding digital number that is installed on fixed pedestal 2 are registered.
Use procedure: determine to test liquid-phase chromatographic column 3 model used, mouse moves tracking cross in required liquid-phase chromatographic column 3 correspondence numerically, double left button mouse click sends the pulse signal of predetermined quantity to drive motor 8, and after drive motor 8 drives internal layer rotor 9 to rotate to an angle, switch fluids passage makes fluid circulate in this liquid-phase chromatographic column 3.
Whole process greatly reduces the process frequently removing and installing liquid-phase chromatographic column 3 in analytical test process above; Pillar can be maintained by periodic flushing standby time at liquid-phase chromatographic column 3 simultaneously, substantially prolongs the serviceable life of liquid-phase chromatographic column 3.
The above embodiment of the present invention is only for example of the present invention is clearly described, and is not the restriction to embodiments of the present invention.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.All any amendments done within the spirit and principles in the present invention, equivalent to replace and improvement etc., within the protection domain that all should be included in the claims in the present invention.
Claims (4)
1. an intelligent automatic switchover hyperchannel liquid-phase chromatographic column coupling arrangement, comprise fixed pedestal (2), multiple liquid-phase chromatographic column (3), it is characterized in that: also comprise the control panel (7) with display screen and two there are many fluid passages and make fluid flow through the hyperchannel chromatographic column coupling arrangement (1) of different liquid-phase chromatographic columns (3) by rotating switch fluids passage, described hyperchannel chromatographic column coupling arrangement (1) is arranged at fixed pedestal (2) top and bottom respectively, described control panel (7) is connected with two hyperchannel chromatographic column coupling arrangement (1) circuit respectively and switches hyperchannel chromatographic column coupling arrangement (1) switch fluids passage for controlling, described liquid-phase chromatographic column (3) is connected between the corresponding fluid passage of two hyperchannel chromatographic column coupling arrangements (1) in parallel by chromatographic column connecting pipe (4).
2. intelligent automatic switchover hyperchannel liquid-phase chromatographic column coupling arrangement according to claim 1, it is characterized in that: described hyperchannel chromatographic column coupling arrangement (1) comprises the outer stator (12) of the tubular be fixedly installed, be arranged at the column internal layer rotor (9) of the endoporus of outer stator (12) and the inner hole wall rotary seal with outer stator (12) rotationally, top joint (10), follower gear (15), the drive motor (8) be connected with control panel (7) circuit, the fixing fluid passage (14) that many connect liquid-phase chromatographic column (3) is disposed radially in described outer stator (12), L shape actuation fluid passage (13) is provided with in described internal layer rotor (9), described actuation fluid passage (13) upper end is connected with top joint (10), lower end seals with corresponding fixing fluid passage (14) and docks after internal layer rotor (9) rotates predetermined angular, form complete fluid passage, described follower gear (15) is fixedly installed on internal layer rotor (9) upper end coaxially, described drive motor (8) to be driven with follower gear (15) by driving gear and is connected.
3. intelligent automatic switchover hyperchannel liquid-phase chromatographic column coupling arrangement according to claim 2, is characterized in that: described internal layer rotor (9) is provided with the graticule that aligns (11) with on outer stator (12).
4. intelligent automatic switchover hyperchannel liquid-phase chromatographic column coupling arrangement according to claim 3, is characterized in that: described fixed pedestal (2) is provided with chromatographic column geometrical clamp (6).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410608204.3A CN104330509A (en) | 2014-10-31 | 2014-10-31 | Intelligent automatic switching multi-channel liquid chromatography column connection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410608204.3A CN104330509A (en) | 2014-10-31 | 2014-10-31 | Intelligent automatic switching multi-channel liquid chromatography column connection device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104330509A true CN104330509A (en) | 2015-02-04 |
Family
ID=52405277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410608204.3A Pending CN104330509A (en) | 2014-10-31 | 2014-10-31 | Intelligent automatic switching multi-channel liquid chromatography column connection device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104330509A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107132299A (en) * | 2017-06-20 | 2017-09-05 | 哈尔滨工业大学 | A kind of multichannel pack tomographic system |
| CN107179359A (en) * | 2017-05-02 | 2017-09-19 | 维科托（北京）科技有限公司 | Flow path system for liquid chromatogram atomic fluorescence combined instrument |
| CN110917658A (en) * | 2019-10-28 | 2020-03-27 | 清华大学 | Automatic strontium-90 discharging and separating device |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11153586A (en) * | 1997-11-20 | 1999-06-08 | Tosoh Corp | Flow passage switch valve for chromatograph |
| CN101617225A (en) * | 2007-02-22 | 2009-12-30 | 通用电气健康护理生物科学股份公司 | Selector valve |
| CN102918309A (en) * | 2010-05-20 | 2013-02-06 | 生物辐射实验室股份有限公司 | Rotary column selector valve |
| WO2014031069A1 (en) * | 2012-08-22 | 2014-02-27 | Ge Healthcare Bio-Sciences Ab | Versatile rotary valve |
-
2014
- 2014-10-31 CN CN201410608204.3A patent/CN104330509A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11153586A (en) * | 1997-11-20 | 1999-06-08 | Tosoh Corp | Flow passage switch valve for chromatograph |
| CN101617225A (en) * | 2007-02-22 | 2009-12-30 | 通用电气健康护理生物科学股份公司 | Selector valve |
| CN102918309A (en) * | 2010-05-20 | 2013-02-06 | 生物辐射实验室股份有限公司 | Rotary column selector valve |
| WO2014031069A1 (en) * | 2012-08-22 | 2014-02-27 | Ge Healthcare Bio-Sciences Ab | Versatile rotary valve |
Non-Patent Citations (2)
| Title |
|---|
| PROMOCHROM TECHNOLOGIES LTD.: "《LC-08 Column Selector User Manual》", 31 January 2011 * |
| PROMOCHROM TECHNOLOGIES LTD.: "《LC-08 Column Selector User Manual》", 31 January 2011, article "LC-08 Column Selector User Manual", pages: 1-14 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107179359A (en) * | 2017-05-02 | 2017-09-19 | 维科托（北京）科技有限公司 | Flow path system for liquid chromatogram atomic fluorescence combined instrument |
| CN107132299A (en) * | 2017-06-20 | 2017-09-05 | 哈尔滨工业大学 | A kind of multichannel pack tomographic system |
| CN110917658A (en) * | 2019-10-28 | 2020-03-27 | 清华大学 | Automatic strontium-90 discharging and separating device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103278590B (en) | Integrated automatic sampling fraction collector | |
| CN104330509A (en) | Intelligent automatic switching multi-channel liquid chromatography column connection device | |
| CN204116276U (en) | The liquid conveying system of full-automatic capillary electrophoresis apparatus | |
| CN107561198A (en) | A kind of liquid chromatograph automatic sampler | |
| CN103235074B (en) | High performance liquid chromatography online analysis method and application thereof | |
| CN203954732U (en) | A kind of Multi-channel solid phase extraction device | |
| CN104330508A (en) | Intelligent automatic switching multi-channel gas chromatography column connection device | |
| CN109342159A (en) | A kind of separation of close and distant water component and collection device and method based on on-line checking | |
| CN104111300A (en) | Liquid Chromatograph Apparatus And Liquid Chromatograph Analysis Method | |
| CN102967495B (en) | Sample pretreatment device and sample treatment method | |
| CN104330492B (en) | Intelligence automatic switchover multichannel ion chromatographic column attachment means | |
| WO2021249347A1 (en) | Static sample injection and fraction collection apparatus for use with liquid chromatograph | |
| CN204129019U (en) | Intelligence automatic switchover hyperchannel gas chromatographic column coupling arrangement | |
| CN104653426A (en) | High-precision plunger type trace sampling pump | |
| CN204989098U (en) | Capillary electrophoresis and electrochromatography plug -in components | |
| CN204203172U (en) | Intelligence automatic switchover hyperchannel ion chromatographic column coupling arrangement | |
| CN204422491U (en) | Fluid on Full-automatic solid phase extraction instrument distributes retaining valve | |
| CN201223741Y (en) | Small-sized simulated moving bed chromatography device | |
| CN106321896B (en) | A kind of multi-functional chromatography switching valve and its application | |
| CN101620041B (en) | Automatic flow-path separation device | |
| CN101329310A (en) | Full-automatic pressurization capillary electric chromatogram system | |
| CN203870114U (en) | Active type micro-fluidic chip sampling device | |
| CN104707359A (en) | Automatic solid phase extraction apparatus | |
| CN204735190U (en) | Continuous quantitative injection device of reagent | |
| CN211043264U (en) | Multidimensional liquid chromatography separation system based on two-position multi-way valve |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150204 |