WO2001085768A3 - G-protein coupled receptors and uses therefor - Google Patents

G-protein coupled receptors and uses therefor Download PDF

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Publication number
WO2001085768A3
WO2001085768A3 PCT/US2001/015002 US0115002W WO0185768A3 WO 2001085768 A3 WO2001085768 A3 WO 2001085768A3 US 0115002 W US0115002 W US 0115002W WO 0185768 A3 WO0185768 A3 WO 0185768A3
Authority
WO
WIPO (PCT)
Prior art keywords
lgr6
nucleic acid
proteins
protein coupled
expression vectors
Prior art date
Application number
PCT/US2001/015002
Other languages
French (fr)
Other versions
WO2001085768A2 (en
WO2001085768A9 (en
Inventor
Wei Gu
Original Assignee
Millennium Pharm Inc
Wei Gu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc, Wei Gu filed Critical Millennium Pharm Inc
Priority to EP01937268A priority Critical patent/EP1285064A2/en
Priority to AU2001263020A priority patent/AU2001263020A1/en
Publication of WO2001085768A2 publication Critical patent/WO2001085768A2/en
Publication of WO2001085768A3 publication Critical patent/WO2001085768A3/en
Publication of WO2001085768A9 publication Critical patent/WO2001085768A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Novel G-protein coupled receptor molecules, designated LGR6 polypeptides, proteins, and nucleic acid molecules, are disclosed. In addition to isolated, LGR6 proteins, the invention further provides isolated LGR6 fusion proteins, antigenic peptides and anti-LGR6 antibodies. The invention also provides LGR6 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an LGR6 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
PCT/US2001/015002 2000-05-08 2001-05-08 G-protein coupled receptors and uses therefor WO2001085768A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01937268A EP1285064A2 (en) 2000-05-08 2001-05-08 G-protein coupled receptors and uses therefor
AU2001263020A AU2001263020A1 (en) 2000-05-08 2001-05-08 G-protein coupled receptors and uses therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56658800A 2000-05-08 2000-05-08
US09/566,588 2000-05-08

Publications (3)

Publication Number Publication Date
WO2001085768A2 WO2001085768A2 (en) 2001-11-15
WO2001085768A3 true WO2001085768A3 (en) 2002-05-23
WO2001085768A9 WO2001085768A9 (en) 2002-11-07

Family

ID=24263514

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015002 WO2001085768A2 (en) 2000-05-08 2001-05-08 G-protein coupled receptors and uses therefor

Country Status (3)

Country Link
EP (1) EP1285064A2 (en)
AU (1) AU2001263020A1 (en)
WO (1) WO2001085768A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1290030A2 (en) * 2000-05-30 2003-03-12 Bayer Aktiengesellschaft Regulation of human lgr4-like g protein-coupled receptor
EP1370658A2 (en) * 2001-02-26 2003-12-17 PE Corporation (NY) Isolated human g-protein coupled receptors, nucleic acid molecules encoding human gpcr proteins, and uses thereof
WO2003040371A1 (en) * 2001-11-06 2003-05-15 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor protein and dna thereof
US20050069549A1 (en) 2002-01-14 2005-03-31 William Herman Targeted ligands
AU2003303459A1 (en) * 2002-12-26 2004-07-22 Applied Research Systems Ars Holding N.V. Spliced variants of lgr6

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0950711A2 (en) * 1998-02-06 1999-10-20 Akzo Nobel N.V. Gonadotropin receptor
WO2001036473A2 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Human g protein-coupled receptors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0950711A2 (en) * 1998-02-06 1999-10-20 Akzo Nobel N.V. Gonadotropin receptor
WO2001036473A2 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Human g protein-coupled receptors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL EBI; 13 July 1999 (1999-07-13), NATIONAL CANCER INSTITUTE, CANCER GENOME ANATOMY PROJECT (CGAP): "Homo sapiens cDNA clone similar to orphan G protein-coupled receptor HG38", XP002187010 *
DATABASE EMBL EBI; 6 November 1994 (1994-11-06), GENEEXPRESS: "H. sapiens partial cDNA sequence", XP002187011 *
See also references of EP1285064A2 *
SHEAU YU HSU ET AL: "The three subfamilies of leucine-rich repeat -containing G protein-coupled receptors (LGR): Identification of LGR6 and LGR7 and the signaling mechanism for LGR7", MOLECULAR ENDOCRINOLOGY, vol. 14, no. 8, August 2000 (2000-08-01), usa, pages 1257 - 1271, XP002187009 *

Also Published As

Publication number Publication date
AU2001263020A1 (en) 2001-11-20
WO2001085768A2 (en) 2001-11-15
EP1285064A2 (en) 2003-02-26
WO2001085768A9 (en) 2002-11-07

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