WO2001078756A3 - Agens für den postoperativen einsatz nach entfernung von knochentumoren - Google Patents

Agens für den postoperativen einsatz nach entfernung von knochentumoren Download PDF

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Publication number
WO2001078756A3
WO2001078756A3 PCT/DE2001/001510 DE0101510W WO0178756A3 WO 2001078756 A3 WO2001078756 A3 WO 2001078756A3 DE 0101510 W DE0101510 W DE 0101510W WO 0178756 A3 WO0178756 A3 WO 0178756A3
Authority
WO
WIPO (PCT)
Prior art keywords
agent
removal
known per
bone tumours
postoperative use
Prior art date
Application number
PCT/DE2001/001510
Other languages
English (en)
French (fr)
Other versions
WO2001078756A2 (de
Inventor
Bernd Wiederanders
Gunter Maubach
Original Assignee
Depuy Biotech Jena Gmbh
Bernd Wiederanders
Gunter Maubach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Depuy Biotech Jena Gmbh, Bernd Wiederanders, Gunter Maubach filed Critical Depuy Biotech Jena Gmbh
Priority to EP01940177A priority Critical patent/EP1276877A2/de
Priority to AU2001273848A priority patent/AU2001273848B2/en
Priority to JP2001576056A priority patent/JP2004500124A/ja
Priority to CA002406590A priority patent/CA2406590A1/en
Priority to NZ522038A priority patent/NZ522038A/en
Priority to AU7384801A priority patent/AU7384801A/xx
Priority to US10/257,384 priority patent/US7179795B2/en
Publication of WO2001078756A2 publication Critical patent/WO2001078756A2/de
Publication of WO2001078756A3 publication Critical patent/WO2001078756A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Die Erfindung betrifft ein Agens zur Herstellung eines Arzneimittels für den postoperativen Einsatz nach Entfernung von Knochentumoren, das aus einer Nukleinsäure hergestellt wird, indem eine an sich bekannte Sequenz zur Knochenwachstumsförderung und ein an sich bekannter Proteinaseinhibitor durch ein variables Spacermolekül verknüpft werden. Durch diese Verknüpfung kommt es zu einem neuartigen bifunktionellen Wirkstoff, der beide Eigenschaften in einem biologischen Molekül vereinigt. Die Erfindung findet Anwendung im medizinischen Bereich, insbesondere im Fachgebiet der Orthopädie.
PCT/DE2001/001510 2000-04-18 2001-04-18 Agens für den postoperativen einsatz nach entfernung von knochentumoren WO2001078756A2 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP01940177A EP1276877A2 (de) 2000-04-18 2001-04-18 Agent für den postoperativen einsatz nach entfernung von knochentumoren
AU2001273848A AU2001273848B2 (en) 2000-04-18 2001-04-18 Agent for postoperative use after the removal of bone tumours
JP2001576056A JP2004500124A (ja) 2000-04-18 2001-04-18 骨腫瘍の除去後の術後使用のための薬剤
CA002406590A CA2406590A1 (en) 2000-04-18 2001-04-18 Agent for postoperative use after the removal of bone tumours
NZ522038A NZ522038A (en) 2000-04-18 2001-04-18 Agent for postoperative use after the removal of bone tumours
AU7384801A AU7384801A (en) 2000-04-18 2001-04-18 Agent for postoperative use after the removal of bone tumours
US10/257,384 US7179795B2 (en) 2000-04-18 2001-04-18 Nucleic acids encoding chimeric proteins comprising BMP-2 and a proteinase inhibitor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10020125.3 2000-04-18
DE10020125A DE10020125A1 (de) 2000-04-18 2000-04-18 Agens für den postoperativen Einsatz nach Entfernung von Knochentumoren

Publications (2)

Publication Number Publication Date
WO2001078756A2 WO2001078756A2 (de) 2001-10-25
WO2001078756A3 true WO2001078756A3 (de) 2002-07-11

Family

ID=7639812

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2001/001510 WO2001078756A2 (de) 2000-04-18 2001-04-18 Agens für den postoperativen einsatz nach entfernung von knochentumoren

Country Status (8)

Country Link
US (1) US7179795B2 (de)
EP (1) EP1276877A2 (de)
JP (1) JP2004500124A (de)
AU (2) AU7384801A (de)
CA (1) CA2406590A1 (de)
DE (1) DE10020125A1 (de)
NZ (1) NZ522038A (de)
WO (1) WO2001078756A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10020125A1 (de) 2000-04-18 2001-10-25 Friedrich Schiller Uni Jena Bu Agens für den postoperativen Einsatz nach Entfernung von Knochentumoren
CN100360674C (zh) * 2005-03-30 2008-01-09 中国科学院沈阳应用生态研究所 一种原核表达载体pASK-75-EX
US8075562B2 (en) * 2007-06-25 2011-12-13 Wisconsin Alumni Research Foundation Controlled release of biopharmaceutical growth factors from hydroxyapatite coating on bioresorbable interference screws used in cruciate ligament reconstruction surgery
CN110382523B (zh) 2016-12-30 2024-04-16 博晟生医股份有限公司 重组多肽及其组合物及方法
EP4017468A4 (de) * 2019-08-20 2023-07-05 Theradaptive, Inc. Materialien zur abgabe von bindefähigen proteinen in knochenimplantaten

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019510A1 (en) * 1990-06-18 1991-12-26 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
EP0504938A2 (de) * 1991-03-22 1992-09-23 Suntory Limited Dipeptide und Tripeptide als prophylaktische und therapeutische Mittel gegen Knochenkrankheiten
EP0704532A2 (de) * 1994-06-10 1996-04-03 United States Surgical Corporation Rekombinante Chimäre Proteine und Verfahren zur deren Verwendung
WO1998051788A2 (en) * 1997-05-12 1998-11-19 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Method and construct for inhibition of cell migration
WO1998055137A1 (en) * 1997-06-03 1998-12-10 Nimni Marcel E Bone morphogenetic proteins and their use in bone growth
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US5962427A (en) * 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0710288B1 (de) * 1993-06-10 2006-04-05 Genetic Therapy, Inc. Adenovirale vektoren für die behandlung der hämophilie
EP1021558A1 (de) * 1997-10-10 2000-07-26 President And Fellows Of Harvard College Oberflächengebundene, doppelsträngige dna-protein-arrays
DE10020125A1 (de) 2000-04-18 2001-10-25 Friedrich Schiller Uni Jena Bu Agens für den postoperativen Einsatz nach Entfernung von Knochentumoren

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019510A1 (en) * 1990-06-18 1991-12-26 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
EP0504938A2 (de) * 1991-03-22 1992-09-23 Suntory Limited Dipeptide und Tripeptide als prophylaktische und therapeutische Mittel gegen Knochenkrankheiten
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US5962427A (en) * 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
EP0704532A2 (de) * 1994-06-10 1996-04-03 United States Surgical Corporation Rekombinante Chimäre Proteine und Verfahren zur deren Verwendung
WO1998051788A2 (en) * 1997-05-12 1998-11-19 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Method and construct for inhibition of cell migration
WO1998055137A1 (en) * 1997-06-03 1998-12-10 Nimni Marcel E Bone morphogenetic proteins and their use in bone growth

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KOLKHORST V ET AL: "Inhibition of tumour cell invasion by protease inhibitors: correlation with the protease profile", J CANCER RES CLIN ONCOL., vol. 124, no. 11, 1998, pages 598 - 606, XP002179730 *
TAGUCHI S ET AL: "Microbial secretion of biologically active human transforming growth factor alpha fused to the Streptomyces protease inhibitor", GENE, vol. 159, no. 2, 4 July 1995 (1995-07-04), pages 239 - 243, XP002179729 *

Also Published As

Publication number Publication date
EP1276877A2 (de) 2003-01-22
DE10020125A1 (de) 2001-10-25
US7179795B2 (en) 2007-02-20
WO2001078756A2 (de) 2001-10-25
AU7384801A (en) 2001-10-30
US20040087524A1 (en) 2004-05-06
AU2001273848B2 (en) 2005-09-15
JP2004500124A (ja) 2004-01-08
CA2406590A1 (en) 2001-10-25
NZ522038A (en) 2005-11-25

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