Classifications

• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
  • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
  • G01N33/483—Physical analysis of biological material
  • G01N33/487—Physical analysis of biological material of liquid biological material
  • G01N33/4875—Details of handling test elements, e.g. dispensing or storage, not specific to a particular test method
  • G01N33/48771—Coding of information, e.g. calibration data, lot number
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
  • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
  • G01N27/28—Electrolytic cell components
  • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
  • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
  • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
  • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels

Definitions

• the present invention relates to a biosensor measuring device, and more particularly to a biosensor measuring device that takes a liquid sample into a sensor chip, connects the sample to a measuring device, and electrochemically measures the concentration of a specific component.
• a very small amount of body fluid such as blood is collected from the human body into a disposable sensor chip, and the current value generated by the reaction with a specific reagent carried on the sensor chip is measured by the sensor.
• Such a disposable sensor chip is composed of a casing for collecting body fluid, an electrode, and a reagent, but portions other than the reagent carried on the sensor chip can be shared.
• the hardware part can be used in essence by changing the calculation formula for converting the detected current value to the value corresponding to each concentration.
• a sensor chip for measuring blood glucose is connected to a measuring device for measuring cholesterol, for example, there is a problem that a normal measuring operation cannot be performed.
• By changing the shape of the connection part of the measuring instrument incorrect connection between different types of sensor chips and the measuring instrument was prevented.
• the measuring instrument corrects this manufacturing variation for the actually detected current value. It is necessary to display blood sugar and cholesterol levels.
• a calibration curve correction formula for correcting the variation of the output value of the sensor chip is set in the measuring device, and the sensor chip is provided with a calibration curve correction formula.
• the calibration curve correction must be set by the user using the switching tip, which makes it difficult and troublesome for visually impaired people, the elderly, and children. There was a problem that the correct value was not displayed when the line switching setting was forgotten.
• the present invention has been made to solve such a problem, and the operation of the measuring instrument is automatically switched according to the difference between the reagent carried on the sensor chip and the calibration curve correction type, and the operation according to each measurement purpose is performed. It is an object of the present invention to provide a biosensor measurement device that can reduce the time and effort required for a setting operation and improve user operability. Disclosure of the invention
• a biosensor measuring device comprises: a sensor chip having a pair of electrode terminals for detecting an electric signal generated by a reaction between a liquid sample and a reagent; and a sensor chip attached to the sensor chip.
• a biosensor measuring device for electrochemically measuring a component in the liquid sample using a measuring instrument having a connection terminal electrically connected to an electrode terminal of the sensor chip.
• the pair of electrode terminals are formed at positions different from each other according to the type of the sensor chip, and the connection terminals of the measuring device are formed at positions corresponding to the respective electrode terminals of the plurality of types of sensor chips.
• the measuring device detects which connection terminal of the connection terminals is electrically connected to the electrode terminal of the sensor chip, and determines the type of the sensor chip. It is characterized by the following.
• the operation of the measuring device can be automatically switched according to the position of the electrode terminal of the sensor chip.
• the operability of the user can be improved by reducing the time and effort required for the setting operation according to the purpose.
• members such as sensor chip casing can be shared, and the external shape of the sensor chip Since they can be shared, production costs can be reduced.
• the biosensor measuring device according to the present invention is the biosensor measuring device according to Claim 1, wherein a switch is connected to each of the plurality of connection terminals, According to another aspect of the present invention, the switch is sequentially switched to detect which of the plurality of connection terminals is electrically connected to the electrode terminal of the sensor chip.
• the type of a plurality of sensor chips can be automatically determined by one measuring device by sequentially switching the switches.
• the biosensor measuring device according to the present invention (Claim 3) is the biosensor measuring device according to Claim 2, wherein the measuring device is N (N is an arbitrary integer of 2 or more). It has a pair of connection terminals and can distinguish up to 2 N types of sensor chips.
• the biosensor measuring device having such a configuration, it is possible to determine the types of the sensor chips of up to 2N types with one measuring device having N pairs of connection terminals.
• a biosensor measuring device comprises: a sensor chip having a pair of electrode terminals for detecting an electric signal generated by a reaction between a liquid sample and a reagent; and a sensor chip attached to the sensor chip.
• a biosensor measuring device for electrochemically measuring a component in the liquid sample using a measuring instrument having a connection terminal electrically connected to an electrode terminal of the sensor chip.
• the first electrode terminal is formed at the same position regardless of the type of the sensor chip, and the second electrode terminal is formed at a different position depending on the type of the sensor chip.
• the measuring device includes: a connection terminal corresponding to the first electrode terminal; and a plurality of connection terminals corresponding to the second electrode terminal according to a type of the sensor chip. Serial any connection terminals of the plurality of connecting terminals to detect whether conduction with the electrode terminal of the sensor chip, determines the type of the sensor chip, and wherein the Is what you do.
• the operation of the measuring device can be automatically switched in accordance with the position of the electrode terminal of the sensor chip, and as a result, the labor involved in the setting operation corresponding to each measurement purpose can be reduced. This reduces the operability of the user by reducing the size of the sensor chip.
• the sensor chip casing and other members can be used in common, and the external shape of the sensor chip can be shared, reducing production costs. Further, by fixing the position of one of the pair of electrode terminals of the sensor chip irrespective of the type of the sensor chip, a measuring device that can determine the type of the sensor chip with a simpler configuration can be realized.
• the biosensor measuring device (claim 5) is the biosensor measuring device according to claim 4, wherein a switch is provided at each of the plurality of connection terminals corresponding to the second electrode terminal. Wherein the measuring device detects which of the plurality of connection terminals is conductive with the electrode terminal of the sensor chip by sequentially switching the switches. is there.
• the type of a plurality of sensor chips can be automatically determined by one measuring device by sequentially switching the switches.
• the biosensor measuring device (claim 6) is the biosensor measuring device according to claim 5, wherein the measuring device is an M (M is an arbitrary integer) type of sensor chip.
• M is an arbitrary integer
• M connection terminals corresponding to the second electrode terminals of each of the sensor chips are provided.
• the number of sensor terminals is equal to the number of connection terminals corresponding to the electrode terminals formed at different positions according to the type of the sensor chip, out of the pair of electrode terminals of the sensor chip.
• the type of the chip can be determined.
• the biosensor measuring device according to the present invention (Claim 7) is the biosensor measuring device according to any one of Claims 1 to 6, wherein the sensor chip is provided in a liquid sample.
• the type of reagent to be supported and the position of the electrode terminal are changed according to the component to be measured.
• the biosensor measurement device having such a configuration, the biosensor measurement device Measurement according to the reagent becomes possible.
• the biosensor measuring device according to the present invention is the biosensor measuring device according to any one of Claims 1 to 6, wherein the electrode terminal of the sensor chip comprises: It is formed at a different position according to the output characteristics of the sensor chip.
• the measured value obtained from the measuring device can be corrected according to the output characteristics of the sensor chip.
• FIG. 1 is a schematic configuration diagram showing a biosensor measurement device according to Embodiment 1 of the present invention.
• FIG. 2 is a plan view of a sensor chip used for the biosensor measurement device according to Embodiment 1 of the present invention.
• FIG. 3 is a schematic configuration diagram showing a biosensor measurement device according to Embodiment 2 of the present invention.
• FIG. 4 is a plan view of a sensor chip used for a biosensor measurement device according to Embodiment 2 of the present invention.
• Embodiment 1 corresponds to Claims 1, 2, 3, 7, and 8.
• Claim 1 corresponds to Claim 1, Claim 2, Claim 3, Claim 7, and Claim 8.
• FIG. 1 is a schematic configuration diagram showing a biosensor measurement device according to the first embodiment.
• a biosensor measuring device has a sensor chip 1 having a pair of electrode terminals 5 and 6 for detecting an electric signal generated by a reaction between a liquid sample and a reagent, and is mounted on the sensor chip 1.
• a measuring instrument 2 provided with connection terminals 8, 9, 10 and 11 for making an electrical connection with the electrode terminals 5 and 6 of the sensor chip 1.
• connection terminals 8, 9, 10 and 11 for making an electrical connection with the electrode terminals 5 and 6 of the sensor chip 1.
• the configuration of the connection portion with the sensor chip 1 is schematically enlarged.
• the sensor chip 1 is made by pressing a sheet of polyethylene resin or the like by press punching, etc.On a substrate 3, an enzyme reagent 4 that reacts with a liquid sample added thereto, and a reaction obtained between the working electrode and the counter electrode by an enzyme reaction It has electrode terminals 5 and 6 for detecting the current with the measuring instrument 2.
• connection part of the measuring instrument 2 has four connection terminals 8, 9, 10, 11 formed on a connector 7 molded of resin so as to engage with the outer shape of the sensor chip 1.
• the pair of electrode terminals 5 and 6 of the sensor chip 1 are formed at different positions depending on the type of the sensor chip. That is, one of the connection terminals 8 and 9 is connected to the electrode terminal 5 of the sensor chip 1, and one of the connection terminals 10 and 11 is connected to the electrode terminal 6.
• Switches 12, 9, 13, 14, and 15 are connected to connection terminals 8, 9, 10, and 11, respectively, and connected to the electric circuit (not shown) inside measuring instrument 2.
• Signal lines 16 and 17 and connection terminals 8, 9, 10 and 11 can be selectively connected.
• the combinations that connect switches 12, 13, 14, and 15 are: switch 12 and switch 15, switch 12 and switch 14, switch 13 and switch 15, switch 13 and switch 14, and so on. The switching is performed sequentially so as to close the switch in any combination.
• the sensor chip 1 has exactly the same outer shape, but electrode terminals 5 and 6 are formed at different positions due to differences in reagents or manufacturing lots.
• Fig. 2 (a) is a sensor chip for blood glucose
• Fig. 2 (b) is a sensor chip for cholesterol
• Fig. 2 (c) is a sensor chip for lactic acid
• Fig. 2 (d) is urine. It shall be used as a sensor chip for acid.
• the calibration curve correction formulas for different production lots correspond to the electrode terminal positions and the calibration curve correction formula to be applied. You.
• the measuring device 2 When such a sensor chip 1 is attached to the measuring device 2, the measuring device 2 immediately switches the switches 12, 13, 14, and 15 as follows, and conducts with the electrode terminals 5 and 6. Detect the connection terminal.
• the sensor chip 1 is determined to be a blood glucose sensor chip. If no response is obtained, only switches 13 and 15 are closed, and if a response is obtained, it is determined that sensor chip 1 is a cholesterol sensor chip. If no response is obtained, only switches 12 and 14 are closed, and if a response is obtained, sensor chip 1 is determined to be a lactic acid sensor chip. If a response is not obtained, the switches 12 and 15 are closed and the conduction is detected to determine that the sensor chip 1 is a uric acid sensor chip.
• the pair of electrode terminals 5 and 6 are formed at different positions on the sensor chip 1 according to differences in reagents, calibration curve correction, and the like.
• the connection terminals 8, 9, 10 and 11 are formed in the sensor chip 1 corresponding to the positions of the electrode terminals 5 and 6 of the sensor chip 1, so that the sensor chip 1 can handle the reagents Measurement ⁇ Calibration curve correction can be automatically set for the measured values obtained.
• members such as the casing of the sensor chip 1 can be shared, The external shape of (1) can be shared, and as a result, costs can be reduced.
• FIG. . The second embodiment corresponds to claims 4, 5, 5, 6, 7, and 8.
• FIG. 3 is a schematic configuration diagram showing a biosensor measurement device according to the second embodiment.
• a biosensor measuring device includes a sensor chip 21 having a pair of electrode terminals 25 and 26 for detecting an electric signal generated by a reaction between a liquid sample and a reagent; 1 and a measuring device 22 provided with connection terminals 28, 29, 30 and 31 for making an electrical connection with the electrode terminals 25 and 26 of the sensor chip 21.
• a measuring device 22 only the connection portion with the sensor chip 21 is schematically enlarged.
• the sensor chip 21 is provided on a substrate 23 obtained by stamping a sheet of polyethylene resin or the like onto a substrate 23.
• the reagent 2.4 reacts with the added liquid sample and the reaction current obtained by the reaction with the reagent.
• the electrode terminals 25 and 26 for detection are formed respectively.
• the mounting portion of the measuring instrument 22 has four connection terminals 28, 29, 30, and 31 formed on a connector 27 molded with resin so as to engage with the outer shape of the sensor chip 21. .
• the electrode terminal 25 is formed at the same position regardless of the type of the sensor chip 21, and the electrode terminal 26 is formed of the sensor chip 21. It is formed at a different position according to the type. That is, the connection terminal 28 is connected to the electrode terminal 25 of the sensor chip 21, and any one of the connection terminals 29, 30, 31 is connected to the electrode terminal 26.
• Switches 32, 33, and 34 are connected to connection terminals 29, 30, and 31, respectively, and are connected to the electric circuit (not shown) inside measuring instrument 22.
• the signal line 37 and the connection terminals 29, 30 and 31 can be selectively connected.
• the difference from the first embodiment is that one electrode terminal 25 of the pair of electrode terminals of the sensor chip is formed at the same position, and the connection terminal of the measuring device 22 also corresponds to the electrode terminal 25.
• the connection terminal is a common connection terminal 28, and the other three connection terminals 29, 30 and 31 are sequentially switched.
• the sensor chip 21 has exactly the same outer shape as shown in FIG. 4, for example.
• Fig. 4 (a), Fig. 4 (b), and Fig. 4 (c) depending on the difference in the calibration curve correction formula due to the difference in reagents or production lots.
• FIG. 4 (a) is used as a sensor chip for blood glucose
• FIG. 4 (b) is used as a sensor chip for cholesterol
• FIG. 4 (c) is used as a sensor chip for lactic acid.
• the measuring device 22 sequentially switches the switches 32, 33, and 34 as follows. '
• the sensor chip 21 is a blood glucose sensor chip. If a response is obtained when the switch 33 is connected, it is determined that the sensor chip 21 is a cholesterol sensor chip. If a response is obtained when the switch 34 is connected, the sensor chip 21 is determined to be a lactic acid sensor chip.
• the switch switching operation can be completed when a connection terminal that is electrically connected to the electrode terminal of the sensor chip can be detected.
• the measuring device 22 has M (M is an arbitrary integer) connection terminals corresponding to the electrode terminals 26 of each sensor chip 21, the type of the M types of sensor chips 21 can be determined. It is.
• the electrode terminal 26 of the pair of electrode terminals of the sensor chip 21 is located at a different position according to a difference in a reagent, a calibration curve correction formula, or the like.
• the electrode terminals 25 are fixed at the same position regardless of the type of the sensor chip 21, and the connection corresponding to the positions of the electrode terminals 25, 26 of the sensor chip 21 in the measuring instrument 22 Since the terminals 28, 29, 30 and 31 are formed, the type of the sensor chip 21 is determined with a simpler configuration than the biosensor measurement device described in the first embodiment, and the sensor chip 2 is determined. It is possible to automatically set the calibration curve correction etc. for the measurement according to the reagent carried on 1 and the obtained measured value, and also to set the sensor chip 21 regardless of the type of sensor chip 21. Components, such as the sensor chip 21 and the external shape of the sensor chip 21 Rukoto can, as a result, it is possible to reduce the cost.
• the type of the sensor chip 21 corresponding to the number of connection terminals corresponding to the electrode terminals 26 of each sensor chip 21 provided in the measuring device 22 can be determined.
• the biosensor measuring device can be used as a biosensor measuring device capable of discriminating the type of a sensor chip and switching the operation of the measuring device according to the difference between the reagent and the calibration curve correction formula.

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Citations (1)

• 2000
  • 2000-03-30 JP JP2000093178A patent/JP2001281197A/ja active Pending
• 2001
  • 2001-03-30 WO PCT/JP2001/002733 patent/WO2001073420A1/ja not_active Ceased

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