WO2001072266A1 - Cosmetic compositions having retarding action on the regrowth of superfluous hair - Google Patents
Cosmetic compositions having retarding action on the regrowth of superfluous hair Download PDFInfo
- Publication number
- WO2001072266A1 WO2001072266A1 PCT/EP2001/001522 EP0101522W WO0172266A1 WO 2001072266 A1 WO2001072266 A1 WO 2001072266A1 EP 0101522 W EP0101522 W EP 0101522W WO 0172266 A1 WO0172266 A1 WO 0172266A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cosmetic compositions
- phospholipids
- cosmetic
- vasal
- compositions
- Prior art date
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- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
- A61Q7/02—Preparations for inhibiting or slowing hair growth
Definitions
- the present invention relates to the cosmetic field.
- the present invention relates to cosmetic compositions having retarding action on the regrowth of superfluous hair.
- TECHNOLOGICAL BACKGROUND In humans, the main characteristics concerning the development of hair
- the present invention relates to cosmetic compositions having retarding action on the regrowth of superfluous hair. More particularly, the present invention relates to cosmetic compositions containing fatty acids and antiandrogenic sterols from serenoa (Serenoa repens) and/or from Cucurbita seeds (Cucurbita pepo).
- compositions of the invention can contain either said components pure or extracts containing them, in amounts from 0.1 to 3.0%.
- the present invention relates to cosmetic compositions further containing anti-inflammatory and/or vasal protective agents.
- the present invention relates to cosmetic compositions containing anti-inflammatory and/or vasal protective agents selected from: anti-inflammatory triterpenes from liquorice (Glycyrrhiza glabra); anti-edematous and anti-inflammatory saponins from horse chestnut
- vasal protective polyphenols from grapes seeds (Vitis vinifera); - vasal protective anthocyanosides from bilberries (Vaccinium myrtillus); vasal protective saponins from butcher's broom (Ruscus aculeatus).
- compositions of the invention can contain either the above indicated components pure or extracts containing them, in amounts from 0.1 to 3.0%. All the derivatives listed above can optionally be complexed with carriers capable of improving their absorption and effectiveness, in particular with phospholipids.
- the cosmetic compositions can be presented in the form of either post-depilatory or post-epilatory compositions, i.e. to be used subsequently depilation or epilation, or they may be included in depilatory formulations.
- Depilatory formulations herein means formulations capable of removing hair also by the cleavage of keratin disulfide bonds, thereby destroying hair or weakening it to the extent that it can easily be mechanically removed (by means of a spatula, a sponge or simply by washing with water).
- Conventional depilatory formulations can contain as active ingredient thiol derivatives, such as thioglycolic and thiolactic acids and the alkali and alkaline- earth metal salts thereof; ethanolamine -thioglycate; aminoethanethiol; mercaptopropionic acid; thioglycic and thioacetic acids; barium sulfate.
- Post-depilatory compositions as used in the following will mean both post-depilatory and post-epilatory compositions, for the sake of simplicity.
- compositions of the invention will be suitably formulated in liquid form, such as lotion, milk, solution, emulsion, or in the solid or semi-solid form, for example cream, paste, gel, foam.
- the compositions of the invention will contain cosmetically acceptable carriers conventionally used for the preparation of formulations for the topical use, for example viscosity agents, such as tragacanth, xanthan gum, gypsum, clay, magnesium oxide, talc; chelating agents, such as ethylenediaminotetracetic acid and disodium edetate; emollients, such as cetyl and stearyl alcohols, liquid paraffin, glyceryl stearate, silicon oils, hydrocarbon oils and waxes; wetting agents, such as urea or 1,3- butylene glycol; emulsif ⁇ ers, such as medium chain triglycerids, acrylic acid polymers, ethoxylated stearyl or cetyl alcohols, polyoxyethylene alkyl
- the present invention further relates to a method of cosmetic treatment in order to retard the growth of superfluous hair, which method consists in applying a cosmetically effective amount of the compositions of the invention on the body area where unwanted hair grows.
- the amount of the composition to be applied and the frequency of application will vary depending on the area to treat and on the personal characteristics of the user, but it will generally range from 0.01 to 0.1 ml of composition per cm ⁇ of skin area, to be applied 1 to 3 times a day during the first times of treatment, subsequently reducing the frequency to one application on alternate days, depending on the results obtained.
- Tests were carried out on healthy female volunteers, of age ranging from 22 to 40 years, using: a) post-depilatory compositions according to the invention, for use after superfluous hair had been removed with conventional methods; b) conventional depilatory compositions, containing the compositions of the invention; c) conventional depilatory compositions, containing no compositions of the invention.
- hair regrowth was complete not before 3 weeks, progressively decreasing with the progress of treatment; furthermore, regrown hair appeared weakened.
- hair regrowth was complete within 2 - 3 weeks.
- Zinc ricinoleate (Tegodor HY77 - Teco) 0.20 g
- Post-depilatory formulation as oil-in-water emulsion 1% GLYCYRRHETINIC ACID COMPLEX WITH PHOSPHOLIPIDS - 2% SERENOA REPENS - 1 % RUSCOGENINS 100 g contain:
- Polysorbate 60 (Tween 60 - ICI) 5.00 g
- Zinc ricinoleate (Tegodor CW90-Tego) 0.20 g
- Post-depilatory formulation as oil-in-water emulsion 1.5% SERICOSIDE COMPLEX WITH PHOSPHOLIPIDS - 2% CUCURBITA PEPO LIPOPHILIC EXTRACT - 0.5% RUSCOGENINS 100 g contain:
- Cetyl Palmitate (Emulgade SE- Henkel) 7.00 g
- Ceteareth-20 (Eumulgin B2 - Henkel) 2.00 g
- Zinc Ricinoleate (Tegodor CW90-Tego) 0.20 g
- Isostearyl isostearate (Gattefosse) 2.50 g
- Polysorbate 80 (Tween 80 - ICI) 1.00 g
- Zinc Ricinoleate (Tegodor CW90 - Tego) 0.20 g
- Glyceryl stearate (Cutina GMS - Henkel) 5.00 g
- Polysorbate 60 (Tween 60 - ICI) 3.00 g Hectorite (and) hydroxyethylcellulose
- Zinc Ricinoleate (Tegodor CW90 -Tego) 0.20 g
- Zinc Ricinoleate (Tegodor HY77- Tego) 0.20 g
- Dimethicone copolyol 2.50 g
- Triethanolamine 1.00 g Zinc ricinoleate (Tegodor HY77 - Teco) 0.20 g
- Antioxidants q.s. Purified water q.s. to 100.00 g
- Ceteareth-12 (and) Cetearyl Alcohol (and) Cetyl Palmitate (Emulgade SE- Henkel) 7.00 g
- Ceteareth-20 (Eumulgin B2 - Henkel) 2.00 g
- Zinc Ricinoleate (Tegodor CW90-Tego) 0.20 g Disodium edetate 0.10 g
Abstract
The present invention relates to cosmetic compositions having retarding action on the regrowth of superfluous hair, more particularly to cosmetic compositions containing fatty acids and antiandrogenic sterols from serenoa (Serenoa repens) and/or from Cucurbita seeds (Cucurbita pepo).
Description
COSMETIC COMPOSITIONS HAVING RETARDING ACTION ON THE REGROWTH OF SUPERFLUOUS HAIR
The present invention relates to the cosmetic field.
More precisely, the present invention relates to cosmetic compositions having retarding action on the regrowth of superfluous hair. TECHNOLOGICAL BACKGROUND In humans, the main characteristics concerning the development of hair
(number, color, thickness, length, and distribution) are the consequence of an action mediated by sexual hormones, which in their turn derive from a genetic expression.
In Western Countries, as well as in other socioeconomically advanced Countries, hair of limbs and armpits, pubic hair which can come out of bathing suits, as well as hair which can, although rarely, grow around the mammary areola, is considered unaesthetic in women. The term "superfluous hair" indicates indeed the growth of hair in these areas. As such superfluous hair is of course unwanted, it can be subjected to epilation (removal of the whole hair, roots included, by means of wax or electrolysis) or depilation (removal of the hair starting from the surface of the skin by chemical destruction of keratin, blade or electric shaving, or repeated traumatism of hair). :
All of these procedures are, however, at least partly traumatic to the skin, they may induce both inflammation in the tissues directly underlying the treated skin and lesions in capillaries and peripheral small vessels, there is therefore the need for such consequences to be reduced as well as for the regrowth of superfluous hair to be retarded as much as possible.
The present invention relates to cosmetic compositions having retarding action on the regrowth of superfluous hair. More particularly, the present invention relates to cosmetic compositions
containing fatty acids and antiandrogenic sterols from serenoa (Serenoa repens) and/or from Cucurbita seeds (Cucurbita pepo).
The compositions of the invention can contain either said components pure or extracts containing them, in amounts from 0.1 to 3.0%. According to a preferred aspect, the present invention relates to cosmetic compositions further containing anti-inflammatory and/or vasal protective agents.
According to a further preferred aspect, the present invention relates to cosmetic compositions containing anti-inflammatory and/or vasal protective agents selected from: anti-inflammatory triterpenes from liquorice (Glycyrrhiza glabra); anti-edematous and anti-inflammatory saponins from horse chestnut
(Aesculus hyppocastanum); triterpenes from Terminalia sericea; - analgesic and anti-inflammatory isobutylamides from Zanthoxylum bungeanum (sin Alatum); vasal protective gingkoflavoneglucosides and terpenes from ginkgo
(Ginkgo biloba); vasal protective polyphenols from grapes seeds (Vitis vinifera); - vasal protective anthocyanosides from bilberries (Vaccinium myrtillus); vasal protective saponins from butcher's broom (Ruscus aculeatus).
These preferred compositions of the invention can contain either the above indicated components pure or extracts containing them, in amounts from 0.1 to 3.0%. All the derivatives listed above can optionally be complexed with carriers capable of improving their absorption and effectiveness, in particular with phospholipids.
The vegetable derivatives indicated above, as well as the processes for the
preparation thereof, are known, inter alia, from US 5,547,673, WO 00/02570. EP 0.283,713, EP 0.250.953, EP 0.275,224.
It is known from the prior art that said derivatives have anti-inflammatory, analgesic, vasal tonifying, anti-edematous, tonifying activities, which make them useful in the treatment of inflammatory conditions and vasculopathies, also when in the presence of capillary fragility.
"Retarding action " on hair regrowth herein means an action which induces both a delay in hair growth rate and a decrease in the amount of growing hair. According to the present invention, the cosmetic compositions can be presented in the form of either post-depilatory or post-epilatory compositions, i.e. to be used subsequently depilation or epilation, or they may be included in depilatory formulations.
"Depilatory formulations" herein means formulations capable of removing hair also by the cleavage of keratin disulfide bonds, thereby destroying hair or weakening it to the extent that it can easily be mechanically removed (by means of a spatula, a sponge or simply by washing with water). Conventional depilatory formulations can contain as active ingredient thiol derivatives, such as thioglycolic and thiolactic acids and the alkali and alkaline- earth metal salts thereof; ethanolamine -thioglycate; aminoethanethiol; mercaptopropionic acid; thioglycic and thioacetic acids; barium sulfate.
"Post-depilatory compositions" as used in the following will mean both post-depilatory and post-epilatory compositions, for the sake of simplicity.
The compositions of the invention will be suitably formulated in liquid form, such as lotion, milk, solution, emulsion, or in the solid or semi-solid form, for example cream, paste, gel, foam. For this purpose, the compositions of the invention will contain cosmetically acceptable carriers conventionally used for the preparation of formulations for the topical use, for example viscosity agents,
such as tragacanth, xanthan gum, gypsum, clay, magnesium oxide, talc; chelating agents, such as ethylenediaminotetracetic acid and disodium edetate; emollients, such as cetyl and stearyl alcohols, liquid paraffin, glyceryl stearate, silicon oils, hydrocarbon oils and waxes; wetting agents, such as urea or 1,3- butylene glycol; emulsifϊers, such as medium chain triglycerids, acrylic acid polymers, ethoxylated stearyl or cetyl alcohols, polyoxyethylene alkyl ethers; absorption promoters, such as cyclodextrans and liposomes; antioxidants, such as ascorbyl palmitate, tocopherol; preservatives, such as glycerin, propylene glycol; stabilizing agents and fragrances. Depilatory compositions can further contain conventional depilation accelerators, such as those based on ureas, thioureas and biguanides.
The present invention further relates to a method of cosmetic treatment in order to retard the growth of superfluous hair, which method consists in applying a cosmetically effective amount of the compositions of the invention on the body area where unwanted hair grows. The amount of the composition to be applied and the frequency of application will vary depending on the area to treat and on the personal characteristics of the user, but it will generally range from 0.01 to 0.1 ml of composition per cm^ of skin area, to be applied 1 to 3 times a day during the first times of treatment, subsequently reducing the frequency to one application on alternate days, depending on the results obtained.
Tests were carried out on healthy female volunteers, of age ranging from 22 to 40 years, using: a) post-depilatory compositions according to the invention, for use after superfluous hair had been removed with conventional methods; b) conventional depilatory compositions, containing the compositions of the invention; c) conventional depilatory compositions, containing no compositions of the invention.
In the case of treatments with a) and b), hair regrowth was complete not before 3 weeks, progressively decreasing with the progress of treatment; furthermore, regrown hair appeared weakened. Conversely, in treatment with c), hair regrowth was complete within 2 - 3 weeks. Some examples of cosmetic compositions according to the invention are disclosed in the following. EXAMPLE 1
Post-depilatory formulation in gel 2% LIPOPHILIC EXTRACT OF SERENOA REPENS - 0.3% RUSCOGENINS - 0.5% ZANTHOXYLUM BUNGEANUM EXTRACT. 100 g contain:
SERENOA REPENS* LIPOPHILIC EXTRACT 2.00 g
RUSCOGENINS 0.30 g sol. 20% ZANTHOXYLUM BUNGEANUM** EXTRACT 0.50 g Ethanol 20.00 g
PEG-6-Caprylic /Capric Glycerides
(softigen 767-Huls) 15.00 g
Propylene glycol 10.00 g
Oleth 20 (Volpo 20 - Croda) 5.00 g Dimethicone copolyol 2.50 g
Carbomer 2.00 g
Triethanolamine 1.00 g
Zinc ricinoleate (Tegodor HY77 - Teco) 0.20 g
Menthol 0.50 g Preservatives q.s.
Antioxidants q.s.
Purified water q.s. to 100.00 g
* Prepared according to US 5,547,673.
** Prepared according to WO00/02570. EXAMPLE 2
Post-depilatory formulation as oil-in-water emulsion 1% GLYCYRRHETINIC ACID COMPLEX WITH PHOSPHOLIPIDS - 2% SERENOA REPENS - 1 % RUSCOGENINS 100 g contain:
GLYCYRRHETINIC ACID COMPLEX WITH PHOSPHOLIPIDS* 1.00 g
RUSCOGENINS** 1.00 g
SERENOA REPENS PURIFIED EXTRACT 2.00 g Glyceryl stearate (Cutina GMS-Henkel) 7.00 g
Polysorbate 60 (Tween 60 - ICI) 5.00 g
Propylene glycol 5.00 g
Octyldodecanol (Eutanol G - Henkel) 4.00 g
Wheat germ oil 3.00 g PEG-5 soy sterols 2.00 g (Generol 122 E5 - Henkel)
Dimethicone 1.00 g
Carbomer 0.60 g
Tocopherol 0.20 g Ascorbyl Palmitate 0.10 g
10% sol. NaOH 2.00 g
Disodium EDTA 0.10 g
Zinc ricinoleate (Tegodor CW90-Tego) 0.20 g
Preservatives q.s. Fragrance q.s.
Purified water q.s. to 100.00 g
* Prepared according to EP 0283713. ** Prepared according to EP 0250953.
EXAMPLE 3
Post-depilatory formulation as oil-in-water emulsion 1.5% SERICOSIDE COMPLEX WITH PHOSPHOLIPIDS - 2% CUCURBITA PEPO LIPOPHILIC EXTRACT - 0.5% RUSCOGENINS 100 g contain:
SERICOSIDE COMPLEX WITH PHOSPHOLIPIDS* 1.50 g
CUCURBITA PEPO LIPOPHILIC EXTRACT 2.00 g
RUSCOGENINS C 0.50 g
Glycerin 30.00 g Glyceryl Stearate (and) Ceteareth-20 (and) Ceteareth-12 (and) Cetearyl Alcohol (and)
Cetyl Palmitate (Emulgade SE- Henkel) 7.00 g
Ceteareth-20 (Eumulgin B2 - Henkel) 2.00 g
Dimethicone copolyol 2.00 g (SF 1188 - General Eletric)
Zinc Ricinoleate (Tegodor CW90-Tego) 0.20 g
Disodium edetate 0.10 g
Tocopherol 0.20 g
Ascorbyl Palmitate 0.10 g Preservatives q.s.
Fragrance q.s.
Purified water q.s. to 100.00 g
* Prepared according to EP 0283713. EXAMPLE 4 Post-depilatory formulation as oil-in-water lotion
1.5% ESCIN/β-Sitosterol COMPLEX WITH PHOSPHOLIPIDS - 2.0 % CUCURBITA PEPO LIPOPHILIC EXTRACT - 1.0% RUSCUS ACULEATUS EXTRACT
100 g contain:
ESCIN/β-sitosterol COMPLEX WITH PHOSPHOLIPIDS* 1.50 g
RUSCUS DRY EXTRACT 1.00 g
CUCURBITA PEPO LIPOPHILIC EXTRACT 2.00 g Glycerin 5.00 g
Polyisoprene (Syntesqual - Vevy) 2.50 g
Isostearyl isostearate (Gattefosse) 2.50 g
Cetyl Palmitate (Crodamol CP-Croda) 2.00 g
Decyl Oleate (Cetiol V - Henkel) 2.00 g Cetearyl Isononanoate (Cetiol SN - Henkel) 2.00 g
Polysorbate 80 (Tween 80 - ICI) 1.00 g
Zinc Ricinoleate (Tegodor CW90 - Tego) 0.20 g
Tocopherol 0.20 g
Ascorbyl palmitate 0.10 g Disodium edetate 0.10 g Polyacrylamide (and) C13-14 isoparaffϊn
(and) laureth-7 (Sepigel 305- Seppic) 2.00 g
Preservatives q.s.
Fragrance q.s. Purified water q.s. to 100.00 g * Prepared according to EP 0283713. EXAMPLE 5
Post-depilatory formulation as oil-in-water emulsion 1.5% GLYCYRRHETINIC ACID COMPLEX WITH PHOSPHOLIPIDS - 0.5% VITIS VINIFERA PROCYANIDOLIC OLIGOMERS COMPLEX WITH PHOSPHOLIPIDS - 2% SERENOA REPENS LIPOPHILIC EXTRACT 100 g contain: GLYCYRRHETINIC ACID COMPLEX WITH PHOSPHOLIPIDS * 1.50 g
VITIS VINIFERA PROCYANIDOLIC OLIGOMERS **
COMPLEX WITH PHOSPHOLIPIDS 0.50 g
SERENOA REPENS LIPOPHILIC EXTRACT 2.00 g
Propylene glycol 15.00 g Modified jojoba oil 5.00 g
(Cetiol J600 - Henkel)
Cetyl Alcohol 5.00 g
Glyceryl stearate (Cutina GMS - Henkel) 5.00 g
Polysorbate 60 (Tween 60 - ICI) 3.00 g Hectorite (and) hydroxyethylcellulose
(Betone LT - Rheox) 0.50 g
Dimethicone 350 0.50 g
Zinc Ricinoleate (Tegodor CW90 -Tego) 0.20 g
Disodium edetate 0.10 g Tocopherol 0.20 g
Ascorbyl palmitate 0.10 g
Sodium Metabisulfite 0.10 g
Citric acid 0.10 g
Preservatives q.s. Fragrance q.s.
Purified water q.s. to 100.00 g
* Prepared according to EP0283713.
** Prepared according to EP0275224.
EXAMPLE 6 Post-depilatory formulation as alcoholic lotion
0.1% 18/β-GLYCYRRHETINIC ACID - 1% GINGKO BILOBA - 0.5%
SERENOA R.
18/β-GLYCYRRHETINIC ACID 0.10 g
GINGKO BILOBA DRY EXTRACT 1.00 g
(cont. 20% saponins)
SERENOA REPENS PURIFIED EXTRACT 0.50 g
Ciclomethicone 10.00 g PEG-40 Hydrogenated castor oil
(Cremophor RH40-BASF) 1.00 g
Zinc Ricinoleate (Tegodor HY77- Tego) 0.20 g
Butylated Hydroxytoluene
0.05 g Fragrance q.s.
Alcohol q.s. to 100.00 ml
EXAMPLE 7
Post-depilatory formulation in gel
2% SERENOA REPENS LIPOPHILIC EXTRACT 100 g contain:
SERENOA REPENS LIPOPHILIC EXTRACT 2.00 g
Ethanol 20.00 g
PEG-6-Caprylic/Caρric Glycerides
(softigen 767-Huls) 15.00 g Propylene glycol 10.00 g
Oleth 20 (Volpo 20 - Croda) 5.00 g
Dimethicone copolyol 2.50 g
Carbomer 2.00 g
Triethanolamine 1.00 g Zinc ricinoleate (Tegodor HY77 - Teco) 0.20 g
Menthol . L 0.50 g
Preservatives q.s.
Antioxidants q.s.
Purified water q.s. to 100.00 g
EXAMPLE 8
Post-depilatory formulation as oil-in-water emulsion
2% CUCURBITA PEPO LIPOPHILIC EXTRACT 100 g contain:
CUCURBITA PEPO LIPOPHILIC EXTRACT 2.00 g
Glycerin 30.00 g
Glyceryl Stearate (and) Ceteareth-20 (and)
Ceteareth-12 (and) Cetearyl Alcohol (and) Cetyl Palmitate (Emulgade SE- Henkel) 7.00 g
Ceteareth-20 (Eumulgin B2 - Henkel) 2.00 g
Dimethicone copolyol 2.00 g
(SF 1188 - General Eletric)
Zinc Ricinoleate (Tegodor CW90-Tego) 0.20 g Disodium edetate 0.10 g
Tocopherol 0.20 g
Ascorbyl Palmitate 0.10 g
Preservatives q.s.
Fragrance q.s. Purified water q.s. to 100.00 g
Claims
1. Cosmetic compositions having retarding action on the growth of superfluous hair, which contain fatty acids and antiandrogenic sterols from serenoa (Serenoa repens) and/or from Cucurbita seeds (Cucurbita pepo).
2. Cosmetic compositions as claimed in claim 1, further containing anti- inflammatory and/or vasal protective agents.
3. Cosmetic compositions as claimed in claim 2, wherein the anti- inflammatory and/or vasal protective agents are selected from: - anti-inflammatory triterpenes from liquorice (Glycyrrhiza glabra); anti-edematous and anti-inflammatory saponins from horse chestnut
(Aesculus hyppocastanum); triterpenes from Terminalia sericea; analgesic and anti-inflammatory isobutylamides from Zanthoxylum bungeanum (sin Alatum); vasal protective gingkofiavoneglucosides and terpenes from ginkgo
(Ginkgo biloba); vasal protective polyphenols from grapes seeds (Vitis vinifera); vasal protective anthocyanosides from bilberries (Vaccinium myrtillus); - vasal protective saponins from butcher's broom (Ruscus aculeatus).
4. Cosmetic compositions as claimed in any one of the above claims, wherein the active ingredients are complexed with carriers improving absorption and effectiveness.
5. Cosmetic compositions as claimed in claim 4, wherein the complexing agents are phospholipids.
6. Cosmetic compositions as claimed in the above claims, wherein the active ingredients are present in amounts from 0.1 to 3.0%.
7. Cosmetic composition as claimed in the above claims, containing 2%
Serenoa repens lipophilic extract - 0.3% ruscogenins - 0.5% Xanthoxylum bungeanum lipophilic extract.
8. Cosmetic composition according to claims 1 - 6, containing 1% glycyrrhetinic acid complex with phospholipids - 2% Serenoa repens - 1% ruscogenins.
9. Cosmetic composition according to claims 1 - 6, containing 1.5% sericoside complex with phospholipids - 2% Cucurbita pepo lipophilic extract - 0.5%) ruscogenins.
10. Cosmetic composition according to claims 1 - 6, containing 1.5% escin/β- sitosterol complex with phospholipids - 2.% Cucurbita pepo lipophilic extract -
1.0% Ruscus extract.
11. Cosmetic composition according to claims 1 - 6, containing 1.5% glycyrrhetinic acid complex with phospholipids - 0.5% Vitis vinifera procyanidole oligomers complex with phospholipids - 2% Serenoa repens lipophilic extract.
12. Cosmetic composition according to claims 1 - 6, containing 0.1% 18/β- glycyrrhetinic acid - 1% Gingko biloba - 0.5% Serenoa repens.
13. Cosmetic compositions as claimed in the above claims, in the liquid, solid or semisolid form.
14. Cosmetic compositions as claimed in claim 13, in the form of lotion, milk, solution, emulsion, cream, paste, gel, foam.
15. Cosmetic compositions as claimed in the above claims, for the post- epilatory and post-depilatory applications.
16. Cosmetic compositions as claimed in the above claims, further containing one or more conventional depilatory agents selected from thiol derivatives, thioglycolic and thiolactic acids and the alkali and alkaline-earth metal salts thereof; ethanolamine thioglycate; aminoethanethiol; mercaptopropionic acid; thioglycic and thioacetic acids; barium sulfate.
17. Cosmetic compositions as claimed in claim 16, further containing a conventional depilation accelerator selected from the group consisting of ureas, thioureas and biguanides.
18. A method of cosmetic treatment for retarding the growth of superfluous hair, which consists in applying a cosmetically effective amount of the compositions of claims 1 - 17 on the body area where hair to be removed grow.
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020027012153A KR20020081583A (en) | 2000-03-24 | 2001-02-12 | Cosmetic compositions having retarding action on the regrowth of superfluous hair |
| SK1364-2002A SK13642002A3 (en) | 2000-03-24 | 2001-02-12 | Cosmetic compositions having retarding action on the regrowth of superfluous hair |
| CA002403744A CA2403744A1 (en) | 2000-03-24 | 2001-02-12 | Cosmetic compositions having retarding action on the regrowth of superfluous hair |
| EP01909738A EP1265586A1 (en) | 2000-03-24 | 2001-02-12 | Cosmetic compositions having retarding action on the regrowth of superfluous hair |
| HU0300328A HUP0300328A2 (en) | 2000-03-24 | 2001-02-12 | Cosmetic compositions having retarding action on the regrowth of superfluous hair |
| PL01357024A PL357024A1 (en) | 2000-03-24 | 2001-02-12 | Cosmetic compositions having retarding action on the regrowth of superfluous hair |
| JP2001570228A JP2003528123A (en) | 2000-03-24 | 2001-02-12 | Cosmetic composition having a delay effect on the regeneration of unwanted hair |
| IL15184601A IL151846A0 (en) | 2000-03-24 | 2001-02-12 | Cosmetic compositions having retarding action on the regrowth of superfluous hair |
| AU2001237375A AU2001237375A1 (en) | 2000-03-24 | 2001-02-12 | Cosmetic compositions having retarding action on the regrowth of superfluous hair |
| NO20024519A NO20024519L (en) | 2000-03-24 | 2002-09-20 | Cosmetic compositions with retarding effect on the afterglow of pubic hair |
| HK03104529.9A HK1052296A1 (en) | 2000-03-24 | 2003-06-24 | Cosmetic compositions having retarding action on the regrowth of superfluous hair |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000MI000628A ITMI20000628A1 (en) | 2000-03-24 | 2000-03-24 | COSMETIC COMPOSITIONS DELAYING THE GROWTH OF THE HAIR |
| ITMI2000A000628 | 2000-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2001072266A1 true WO2001072266A1 (en) | 2001-10-04 |
Family
ID=11444627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2001/001522 WO2001072266A1 (en) | 2000-03-24 | 2001-02-12 | Cosmetic compositions having retarding action on the regrowth of superfluous hair |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20010033849A1 (en) |
| EP (1) | EP1265586A1 (en) |
| JP (1) | JP2003528123A (en) |
| KR (1) | KR20020081583A (en) |
| CN (1) | CN1419436A (en) |
| AU (1) | AU2001237375A1 (en) |
| CA (1) | CA2403744A1 (en) |
| CZ (1) | CZ20023161A3 (en) |
| HK (1) | HK1052296A1 (en) |
| HU (1) | HUP0300328A2 (en) |
| IL (1) | IL151846A0 (en) |
| IT (1) | ITMI20000628A1 (en) |
| NO (1) | NO20024519L (en) |
| PL (1) | PL357024A1 (en) |
| RU (1) | RU2002125449A (en) |
| SK (1) | SK13642002A3 (en) |
| WO (1) | WO2001072266A1 (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2832418A1 (en) * | 2001-11-16 | 2003-05-23 | Fabre Pierre Dermo Cosmetique | New hydrolyzed marrow seed oil, useful e.g. for treating prostatic hypertrophy or acne, also as cosmetic and food, inhibits activity of 5alpha-reductase |
| EP1338283A1 (en) * | 2002-02-26 | 2003-08-27 | Pierre Fabre Dermo-Cosmetique | Use of neoruscine to treat alopecia |
| WO2007099503A2 (en) * | 2006-02-28 | 2007-09-07 | The Gillette Company | Reduction of hair growth |
| WO2007115840A1 (en) * | 2006-04-07 | 2007-10-18 | Delgado Acarreta Raul | Cosmetic composition for an autonomus shave |
| US7722901B2 (en) | 2004-01-16 | 2010-05-25 | Cognis Ip Management Gmbh | Uses for the extract of a plant of the family Asclepiadaceae |
| ES2412506A1 (en) * | 2011-12-23 | 2013-07-11 | Laboratorios Viñas S.A. | Dermatological composition for the topical treatment of rosacea and corresponding procedure and use (Machine-translation by Google Translate, not legally binding) |
| WO2012172358A3 (en) * | 2011-06-16 | 2013-07-18 | Reckitt & Colman (Overseas) Limited | Compositions for reducing human hair growth |
| ES2610208A1 (en) * | 2015-10-22 | 2017-04-26 | Innovativehealth Group, S.L. | Cosmetic formulation of topical use for the care of the atopic skin (Machine-translation by Google Translate, not legally binding) |
| US11052059B2 (en) | 2008-03-07 | 2021-07-06 | Lucolas - M.D. Ltd | Composition and uses for influencing hair growth |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7875650B2 (en) * | 2004-02-03 | 2011-01-25 | Yale University | Compounds and methods to increase anti-P-glycoprotein activity of baicalein by alkylation on the A ring |
| US20050260152A1 (en) * | 2004-05-03 | 2005-11-24 | Jaghab Khalil C | Hair growth composition |
| DE102004024463A1 (en) * | 2004-05-14 | 2005-12-08 | Phenion Gmbh & Co. Kg | Use of ammonium salts of glycyrrhizic acid and glycyrrhetinic acid for epilation |
| JP4630102B2 (en) * | 2005-03-30 | 2011-02-09 | 株式会社ナリス化粧品 | Hyaluronic acid production promoter and cosmetics containing the same |
| US20090068530A1 (en) * | 2005-05-18 | 2009-03-12 | Hideki Hiraoka | Membrane electrode assembly and direct liquid fuel cell |
| ES2350583T3 (en) * | 2005-05-23 | 2011-01-25 | Reckitt Benckiser (Uk) Limited | COMPOSITION THAT WORTMANINA INCLUDES AND TOPICAL USE OF THE SAME TO REDUCE THE GROWTH OF THE HUMAN VELLO. |
| JP2009508836A (en) * | 2005-09-16 | 2009-03-05 | レキット ベンキサー （ユーケイ） リミテッド | Improvements in or relating to cosmetic compositions |
| EP1882473A1 (en) * | 2006-07-28 | 2008-01-30 | Indena S.P.A. | Use of anthocyanosides to prepare formulations for the treatment of mucositis induced by antitumoral drugs |
| JP5654214B2 (en) * | 2008-06-04 | 2015-01-14 | 丸善製薬株式会社 | Hair suppressant and skin cosmetic for hair suppression |
| CN102772338B (en) * | 2012-08-17 | 2013-06-26 | 珀莱雅化妆品股份有限公司 | Anti-black eye lipid nanoparticle emulsion and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998033472A1 (en) * | 1997-02-03 | 1998-08-06 | Ehud Barr | A composition for the treatment of androgenetic alopecia and hirsutism |
| FR2791255A1 (en) * | 1999-03-26 | 2000-09-29 | Greentech Sa | Anti-androgenic compositions contain a vegetable-based complex derived from sabal, marrow and epilobium, for prevention of hair regrowth, loss of hair, and seborrhea |
-
2000
- 2000-03-24 IT IT2000MI000628A patent/ITMI20000628A1/en unknown
-
2001
- 2001-02-12 CZ CZ20023161A patent/CZ20023161A3/en unknown
- 2001-02-12 HU HU0300328A patent/HUP0300328A2/en unknown
- 2001-02-12 WO PCT/EP2001/001522 patent/WO2001072266A1/en not_active Application Discontinuation
- 2001-02-12 RU RU2002125449/15A patent/RU2002125449A/en not_active Application Discontinuation
- 2001-02-12 PL PL01357024A patent/PL357024A1/en unknown
- 2001-02-12 KR KR1020027012153A patent/KR20020081583A/en not_active Application Discontinuation
- 2001-02-12 IL IL15184601A patent/IL151846A0/en unknown
- 2001-02-12 AU AU2001237375A patent/AU2001237375A1/en not_active Abandoned
- 2001-02-12 CN CN01806953A patent/CN1419436A/en active Pending
- 2001-02-12 EP EP01909738A patent/EP1265586A1/en not_active Withdrawn
- 2001-02-12 SK SK1364-2002A patent/SK13642002A3/en unknown
- 2001-02-12 JP JP2001570228A patent/JP2003528123A/en active Pending
- 2001-02-12 CA CA002403744A patent/CA2403744A1/en not_active Abandoned
- 2001-02-13 US US09/781,301 patent/US20010033849A1/en not_active Abandoned
-
2002
- 2002-09-20 NO NO20024519A patent/NO20024519L/en not_active Application Discontinuation
-
2003
- 2003-06-24 HK HK03104529.9A patent/HK1052296A1/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998033472A1 (en) * | 1997-02-03 | 1998-08-06 | Ehud Barr | A composition for the treatment of androgenetic alopecia and hirsutism |
| FR2791255A1 (en) * | 1999-03-26 | 2000-09-29 | Greentech Sa | Anti-androgenic compositions contain a vegetable-based complex derived from sabal, marrow and epilobium, for prevention of hair regrowth, loss of hair, and seborrhea |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2832418A1 (en) * | 2001-11-16 | 2003-05-23 | Fabre Pierre Dermo Cosmetique | New hydrolyzed marrow seed oil, useful e.g. for treating prostatic hypertrophy or acne, also as cosmetic and food, inhibits activity of 5alpha-reductase |
| EP1338283A1 (en) * | 2002-02-26 | 2003-08-27 | Pierre Fabre Dermo-Cosmetique | Use of neoruscine to treat alopecia |
| FR2836383A1 (en) * | 2002-02-26 | 2003-08-29 | Fabre Pierre Dermo Cosmetique | USE OF NEORUSCIN FOR THE PREPARATION OF A HAIR COMPOSITION FOR THE TREATMENT OF ALOPECIA |
| US7722901B2 (en) | 2004-01-16 | 2010-05-25 | Cognis Ip Management Gmbh | Uses for the extract of a plant of the family Asclepiadaceae |
| WO2007099503A3 (en) * | 2006-02-28 | 2010-08-05 | The Gillette Company | Reduction of hair growth |
| WO2007099503A2 (en) * | 2006-02-28 | 2007-09-07 | The Gillette Company | Reduction of hair growth |
| WO2007115840A1 (en) * | 2006-04-07 | 2007-10-18 | Delgado Acarreta Raul | Cosmetic composition for an autonomus shave |
| US11052059B2 (en) | 2008-03-07 | 2021-07-06 | Lucolas - M.D. Ltd | Composition and uses for influencing hair growth |
| US11324711B2 (en) | 2008-03-07 | 2022-05-10 | S.W. Patentverwertungs Limited | Composition and uses for influencing hair growth |
| US11974977B2 (en) | 2008-03-07 | 2024-05-07 | Lucolas—M.D. Ltd | Composition and uses for influencing hair growth |
| WO2012172358A3 (en) * | 2011-06-16 | 2013-07-18 | Reckitt & Colman (Overseas) Limited | Compositions for reducing human hair growth |
| ES2412506A1 (en) * | 2011-12-23 | 2013-07-11 | Laboratorios Viñas S.A. | Dermatological composition for the topical treatment of rosacea and corresponding procedure and use (Machine-translation by Google Translate, not legally binding) |
| ES2610208A1 (en) * | 2015-10-22 | 2017-04-26 | Innovativehealth Group, S.L. | Cosmetic formulation of topical use for the care of the atopic skin (Machine-translation by Google Translate, not legally binding) |
Also Published As
| Publication number | Publication date |
|---|---|
| SK13642002A3 (en) | 2003-02-04 |
| HUP0300328A2 (en) | 2003-08-28 |
| US20010033849A1 (en) | 2001-10-25 |
| PL357024A1 (en) | 2004-07-12 |
| KR20020081583A (en) | 2002-10-28 |
| HK1052296A1 (en) | 2003-09-11 |
| ITMI20000628A0 (en) | 2000-03-24 |
| CZ20023161A3 (en) | 2003-02-12 |
| NO20024519L (en) | 2002-11-25 |
| RU2002125449A (en) | 2004-03-20 |
| ITMI20000628A1 (en) | 2001-09-24 |
| JP2003528123A (en) | 2003-09-24 |
| EP1265586A1 (en) | 2002-12-18 |
| CA2403744A1 (en) | 2001-10-04 |
| IL151846A0 (en) | 2003-04-10 |
| AU2001237375A1 (en) | 2001-10-08 |
| NO20024519D0 (en) | 2002-09-20 |
| CN1419436A (en) | 2003-05-21 |
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