WO2001071359A3 - Techniques d'identification et d'isolation de molecules specifiques de tissu placees cote lumiere - Google Patents

Techniques d'identification et d'isolation de molecules specifiques de tissu placees cote lumiere Download PDF

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Publication number
WO2001071359A3
WO2001071359A3 PCT/US2001/008705 US0108705W WO0171359A3 WO 2001071359 A3 WO2001071359 A3 WO 2001071359A3 US 0108705 W US0108705 W US 0108705W WO 0171359 A3 WO0171359 A3 WO 0171359A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
identifying
exposed
molecules
tissue
Prior art date
Application number
PCT/US2001/008705
Other languages
English (en)
Other versions
WO2001071359A2 (fr
Inventor
Paul Roben
Anthony C Stevens
Original Assignee
Target Protein Technologies In
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/528,742 external-priority patent/US6903196B1/en
Application filed by Target Protein Technologies In filed Critical Target Protein Technologies In
Priority to EP01922462A priority Critical patent/EP1269195A2/fr
Priority to CA002409333A priority patent/CA2409333A1/fr
Priority to JP2001569495A priority patent/JP2003528115A/ja
Priority to MXPA02009156A priority patent/MXPA02009156A/es
Priority to AU2001249260A priority patent/AU2001249260A1/en
Publication of WO2001071359A2 publication Critical patent/WO2001071359A2/fr
Publication of WO2001071359A3 publication Critical patent/WO2001071359A3/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6897—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
    • A61K47/6898—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies using avidin- or biotin-conjugated antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G01N33/567—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds utilising isolate of tissue or organ as binding agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Nanotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Cette invention a trait à de nouvelles méthodes de marquage et d'isolation, ainsi qu'aux matériels correspondants, de molécules placées côté lumière, notamment des polypeptides exprimés avec spécificité pour un tissu ou un organe. Il est possible d'utiliser ces techniques et les matériels correspondants pour isoler des molécules exposées sur le côté lumière d'espaces du revêtement cellulaire vasculaire, intracanalaire, sinusien, respiratoire, ou des fascias et d'autres espaces tissulaires pouvant être perfusés.
PCT/US2001/008705 2000-03-20 2001-03-19 Techniques d'identification et d'isolation de molecules specifiques de tissu placees cote lumiere WO2001071359A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01922462A EP1269195A2 (fr) 2000-03-20 2001-03-19 Techniques d'identification et d'isolation de molecules specifiques de tissu placees cote lumiere
CA002409333A CA2409333A1 (fr) 2000-03-20 2001-03-19 Techniques d'identification et d'isolation de molecules specifiques de tissu placees cote lumiere
JP2001569495A JP2003528115A (ja) 2000-03-20 2001-03-19 組織特異的管腔曝露分子の同定および単離方法
MXPA02009156A MXPA02009156A (es) 2000-03-20 2001-03-19 Metodos para identificar y aislar moleculas especificas de tejido expuestas en el lumen.
AU2001249260A AU2001249260A1 (en) 2000-03-20 2001-03-19 Methods for identifying and isolating tissue-specific lumen-exposed molecules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/528,742 2000-03-20
US09/528,742 US6903196B1 (en) 1999-06-17 2000-03-20 Methods for identifying and isolating tissue-specific lumen-exposed molecules

Publications (2)

Publication Number Publication Date
WO2001071359A2 WO2001071359A2 (fr) 2001-09-27
WO2001071359A3 true WO2001071359A3 (fr) 2002-07-18

Family

ID=24106972

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/008705 WO2001071359A2 (fr) 2000-03-20 2001-03-19 Techniques d'identification et d'isolation de molecules specifiques de tissu placees cote lumiere

Country Status (6)

Country Link
EP (1) EP1269195A2 (fr)
JP (1) JP2003528115A (fr)
AU (1) AU2001249260A1 (fr)
CA (1) CA2409333A1 (fr)
MX (1) MXPA02009156A (fr)
WO (1) WO2001071359A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6903196B1 (en) 1999-06-17 2005-06-07 Utah Ventures Ii, L.P. Methods for identifying and isolating tissue-specific lumen-exposed molecules
JP2005501011A (ja) * 2001-06-08 2005-01-13 ユタ ベンチャー ザ セカンド リミテッド パートナーシップ 組織特異的内皮膜タンパク質
EP1806587A1 (fr) 2006-01-07 2007-07-11 Université de Liège Procédé in vitro de criblage de marqueurs biologiques accessibles dans des tissus pathologiques

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BUSCH G ET AL: "SELECTIVE ISOLATION OF INDIVIDUAL CELL SURFACE PROTEINS FROM TISSUE CULTURE CELLS BY A CLEAVABLE BIOTIN LABEL", EUROPEAN JOURNAL OF CELL BIOLOGY, vol. 50, no. 2, 1989, pages 257 - 262, XP001064403, ISSN: 0171-9335 *
CHEN JIE-GUANG ET AL: "Determination of external loop topology in the serotonin transporter by site-directed chemical labeling.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 20, 15 May 1998 (1998-05-15), pages 12675 - 12681, XP002193765, ISSN: 0021-9258 *
DE LA FUENTE ELSA KATHLEEN ET AL: "Biotinylation of membrane proteins accessible via the pulmonary circulation in normal and hyperoxic rats.", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 272, no. 3 PART 1, 1997, pages L461 - L470, XP001064381, ISSN: 0002-9513 *
KANDROR K V: "Insulin regulation of protein traffic in rat adipose cells.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 36, pages 25210 - 25217, XP002193764, ISSN: 0021-9258 *
MOUTON C A ET AL: "A REAGENT FOR COVALENTLY ATTACHING BIOTIN TO PROTEINS VIA A CLEAVABLE CONNECTOR ARM", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 218, no. 1, 1982, pages 101 - 108, XP001064453, ISSN: 0003-9861 *

Also Published As

Publication number Publication date
JP2003528115A (ja) 2003-09-24
AU2001249260A1 (en) 2001-10-03
MXPA02009156A (es) 2004-09-06
EP1269195A2 (fr) 2003-01-02
WO2001071359A2 (fr) 2001-09-27
CA2409333A1 (fr) 2001-09-27

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