WO2001066803A3 - Phytomics: a genomic-based approach to herbal compositions - Google Patents

Phytomics: a genomic-based approach to herbal compositions Download PDF

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Publication number
WO2001066803A3
WO2001066803A3 PCT/US2001/007608 US0107608W WO0166803A3 WO 2001066803 A3 WO2001066803 A3 WO 2001066803A3 US 0107608 W US0107608 W US 0107608W WO 0166803 A3 WO0166803 A3 WO 0166803A3
Authority
WO
WIPO (PCT)
Prior art keywords
herbal
compositions
arrays
composition
herbal compositions
Prior art date
Application number
PCT/US2001/007608
Other languages
French (fr)
Other versions
WO2001066803A2 (en
Inventor
Patrick C Kung
Konan Peck
Yun-Shien Lee
Yuh-Pyng Sher
Yung-Chi Cheng
Original Assignee
Univ Yale
Patrick C Kung
Konan Peck
Lee Yun Shien
Sher Yuh Pyng
Cheng Yung Chi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale, Patrick C Kung, Konan Peck, Lee Yun Shien, Sher Yuh Pyng, Cheng Yung Chi filed Critical Univ Yale
Priority to EP01918496A priority Critical patent/EP1263988A2/en
Priority to JP2001565406A priority patent/JP2003525622A/en
Priority to US10/030,453 priority patent/US20030207270A1/en
Priority to AU45565/01A priority patent/AU4556501A/en
Priority to CA002373708A priority patent/CA2373708A1/en
Publication of WO2001066803A2 publication Critical patent/WO2001066803A2/en
Publication of WO2001066803A3 publication Critical patent/WO2001066803A3/en
Priority to HK03104392.3A priority patent/HK1053334A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides the tools and methodologies necessary to guide the standardization of herbal compositions, to determine which specific components of an herbal composition are responsible for any particular biological activity, to predict the biological activities of a particular herbal composition, to determine the relatedness of herbal compositions, and for the development of improved herbal therapeutics. This invention provides the tools and methodologies for creating, maintaining, improving and utilizing Herbal BioResponse Arrays (HBR Arrays), wherein the HBR Arrays constitute data sets associated with particular herbal compositions. The HBR Arrays of the present invention contain gene expression profiles and may also include information on the plant-related parameters of the herbal constituents, marker information collected following the exposure of a biosystem to the herbal composition, and biological response information collected following the exposure of a biosystem to the herbal composition.
PCT/US2001/007608 2000-03-09 2001-03-09 Phytomics: a genomic-based approach to herbal compositions WO2001066803A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP01918496A EP1263988A2 (en) 2000-03-09 2001-03-09 Phytomics: a genomic-based approach to herbal compositions
JP2001565406A JP2003525622A (en) 2000-03-09 2001-03-09 Phytomics: A genome-based approach to herbal compositions
US10/030,453 US20030207270A1 (en) 2001-03-09 2001-03-09 Phytomics: a genomic-based approach to herbal compositions
AU45565/01A AU4556501A (en) 2000-03-09 2001-03-09 Phytomics: a genomic-based approach to herbal compositions
CA002373708A CA2373708A1 (en) 2000-03-09 2001-03-09 Phytomics: a genomic-based approach to herbal compositions
HK03104392.3A HK1053334A1 (en) 2000-03-09 2003-06-18 Phytomics: a genomic-based approach to herbal compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18802100P 2000-03-09 2000-03-09
US60/188,021 2000-03-09

Publications (2)

Publication Number Publication Date
WO2001066803A2 WO2001066803A2 (en) 2001-09-13
WO2001066803A3 true WO2001066803A3 (en) 2002-04-18

Family

ID=22691448

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/007608 WO2001066803A2 (en) 2000-03-09 2001-03-09 Phytomics: a genomic-based approach to herbal compositions

Country Status (8)

Country Link
EP (1) EP1263988A2 (en)
JP (1) JP2003525622A (en)
KR (1) KR20030017459A (en)
CN (1) CN1386135A (en)
AU (1) AU4556501A (en)
CA (1) CA2373708A1 (en)
HK (1) HK1053334A1 (en)
WO (1) WO2001066803A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2762986C2 (en) * 2016-06-22 2021-12-24 Йейл Юниверсити Quality control of drug of plant origin based on mechanism

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1512970A1 (en) * 2003-09-05 2005-03-09 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Method for determining the impact of a multicomponent mixture on the biological profile of a disease
JP2006000113A (en) * 2004-05-20 2006-01-05 Masatomo Sakurai Gene used for diagnosis of herbal treatment, and method for using the same
KR101459805B1 (en) 2007-03-30 2014-11-07 9898 리미티드 Pharmaceutical platform technology for the development of natural products
JP2011015670A (en) * 2009-07-08 2011-01-27 Ｉｃｈｉｂａｎ Ｌｉｆｅｔｅｃｈ Ｓｏｌｕｔｉｏｎｓ株式会社 Beverage preparation from traditional ayurveda product
TWI622012B (en) * 2016-11-18 2018-04-21 財團法人資訊工業策進會 Drug combination prediction system and drug combination prediction method
CN110274981B (en) * 2018-03-13 2023-05-12 天士力医药集团股份有限公司 Method for detecting alkaloid components of diabetes clearing medicine
CN110970115B (en) * 2019-10-28 2023-03-21 广西科技大学 Informatization representation method for nature, taste and meridian tropism of traditional Chinese medicine prescription
CN112697949B (en) * 2020-12-09 2022-05-27 浙江金城阜通制药有限公司 Thin-layer identification method for Baoyuan decoction, similar formula extract and preparation thereof
CN112575005A (en) * 2021-01-04 2021-03-30 昆明理工大学 Method for improving heavy metal cadmium stress resistance of tobacco and reducing cadmium enrichment

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997006277A1 (en) * 1995-08-09 1997-02-20 The Regents Of The University Of California Methods for drug screening
WO1997013877A1 (en) * 1995-10-12 1997-04-17 Lynx Therapeutics, Inc. Measurement of gene expression profiles in toxicity determination
WO1997022720A1 (en) * 1995-12-21 1997-06-26 Kenneth Loren Beattie Arbitrary sequence oligonucleotide fingerprinting
WO1997027317A1 (en) * 1996-01-23 1997-07-31 Affymetrix, Inc. Nucleic acid analysis techniques
WO1998006874A1 (en) * 1995-08-09 1998-02-19 The Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices
WO1999044062A1 (en) * 1998-02-25 1999-09-02 The United States Of America As Represented By The Secretary Department Of Health And Human Services Cellular arrays for rapid molecular profiling
WO1999058720A1 (en) * 1998-05-12 1999-11-18 Acacia Biosciences, Inc. Quantitative methods, systems and apparatuses for gene expression analysis
WO2000024934A1 (en) * 1998-10-23 2000-05-04 Yale University Phytomics: a genomic-based approach to herbal compositions

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997006277A1 (en) * 1995-08-09 1997-02-20 The Regents Of The University Of California Methods for drug screening
WO1998006874A1 (en) * 1995-08-09 1998-02-19 The Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices
WO1997013877A1 (en) * 1995-10-12 1997-04-17 Lynx Therapeutics, Inc. Measurement of gene expression profiles in toxicity determination
WO1997022720A1 (en) * 1995-12-21 1997-06-26 Kenneth Loren Beattie Arbitrary sequence oligonucleotide fingerprinting
WO1997027317A1 (en) * 1996-01-23 1997-07-31 Affymetrix, Inc. Nucleic acid analysis techniques
WO1999044062A1 (en) * 1998-02-25 1999-09-02 The United States Of America As Represented By The Secretary Department Of Health And Human Services Cellular arrays for rapid molecular profiling
WO1999058720A1 (en) * 1998-05-12 1999-11-18 Acacia Biosciences, Inc. Quantitative methods, systems and apparatuses for gene expression analysis
WO2000024934A1 (en) * 1998-10-23 2000-05-04 Yale University Phytomics: a genomic-based approach to herbal compositions

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE ONLINE "History of the plant cell culture collection", XP002185949 *
DATABASE ONLINE 20 October 2001 (2001-10-20), "http://biobenchelper.hypermart.net/cell/cell_line_database.htm", XP002185950 *
GRAY N S: "EXPLOITING CHEMICAL LIBRARIES, STRUCTURE, AND GENOMICS IN THE SEARCH FOR KINASE INHIBITORS", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 281, no. 281, 24 July 1998 (1998-07-24), pages 533 - 538-538, XP002101911, ISSN: 0036-8075 *
HAY R J: "Cell line banking and authentication.", DEVELOPMENTS IN BIOLOGICAL STANDARDIZATION, vol. 93, 1998, Conference Centre of the Marcel-Merieux Foundation;Annecy, France; September 29-October 1, 1996, products prepared from mammalian cell culture. 1998 S. Karger AG; S. Karger AG P.O. Box, Allschwilerstr, pages 15 - 19, XP001031093, ISBN: 3-8055-6732-4 *
KOJIMA KEISUKE ET AL: "Long-term administration of "Sho-Saiko-To" increases cytochrome P-450 mRNA level in mouse liver.", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 21, no. 4, April 1998 (1998-04-01), pages 426 - 428, XP002186043, ISSN: 0918-6158 *
SCHENA M ET AL: "PARALLEL HUMAN GENOME ANALYSIS: MICROARRAY-BASED EXPRESSION MONITORING OF 1000 GENES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 93, 1 October 1996 (1996-10-01), pages 10614 - 10619, XP002070911, ISSN: 0027-8424 *
ZENG YI ET AL: "Screening of Epstein-Barr virus early antigen expression inducers from Chinese medicinal herbs and plants.", BIOMEDICAL AND ENVIRONMENTAL SCIENCES, vol. 7, no. 1, 1994, pages 50 - 55, XP002186044, ISSN: 0895-3988 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2762986C2 (en) * 2016-06-22 2021-12-24 Йейл Юниверсити Quality control of drug of plant origin based on mechanism

Also Published As

Publication number Publication date
CA2373708A1 (en) 2001-09-13
JP2003525622A (en) 2003-09-02
KR20030017459A (en) 2003-03-03
WO2001066803A2 (en) 2001-09-13
HK1053334A1 (en) 2003-10-17
CN1386135A (en) 2002-12-18
EP1263988A2 (en) 2002-12-11
AU4556501A (en) 2001-09-17

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