WO2001066740A3 - Compositions et methodes de traitement de maladies d'origine immune - Google Patents

Compositions et methodes de traitement de maladies d'origine immune Download PDF

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Publication number
WO2001066740A3
WO2001066740A3 PCT/US2001/006666 US0106666W WO0166740A3 WO 2001066740 A3 WO2001066740 A3 WO 2001066740A3 US 0106666 W US0106666 W US 0106666W WO 0166740 A3 WO0166740 A3 WO 0166740A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
methods
compositions
related diseases
immune related
Prior art date
Application number
PCT/US2001/006666
Other languages
English (en)
Other versions
WO2001066740A2 (fr
Inventor
Dan L Eaton
Sherman Fong
Audrey Goddard
Paul J Godowski
Christopher J Grimaldi
Austin L Gurney
Daniel Tumas
Colin K Watanabe
William I Wood
Zemin Zhang
Original Assignee
Genentech Inc
Dan L Eaton
Sherman Fong
Audrey Goddard
Paul J Godowski
Christopher J Grimaldi
Austin L Gurney
Daniel Tumas
Colin K Watanabe
William I Wood
Zemin Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2000/014941 external-priority patent/WO2000073348A2/fr
Priority claimed from PCT/US2000/023328 external-priority patent/WO2001016318A2/fr
Priority claimed from PCT/US2000/032678 external-priority patent/WO2001040466A2/fr
Application filed by Genentech Inc, Dan L Eaton, Sherman Fong, Audrey Goddard, Paul J Godowski, Christopher J Grimaldi, Austin L Gurney, Daniel Tumas, Colin K Watanabe, William I Wood, Zemin Zhang filed Critical Genentech Inc
Priority to AU2001255168A priority Critical patent/AU2001255168A1/en
Priority to AU6531101A priority patent/AU6531101A/xx
Priority to AU2001265311A priority patent/AU2001265311A1/en
Priority to EP05024025A priority patent/EP1666597A3/fr
Priority to CA002410162A priority patent/CA2410162A1/fr
Priority to EP05024023A priority patent/EP1683864A3/fr
Priority to EP05024028A priority patent/EP1686174A1/fr
Priority to EP05024034A priority patent/EP1666497A3/fr
Priority to EP05024027A priority patent/EP1666596A1/fr
Priority to PCT/US2001/017800 priority patent/WO2001093983A1/fr
Priority to EP01939834A priority patent/EP1286749A1/fr
Priority to EP05024032A priority patent/EP1659177A3/fr
Priority to CA002591656A priority patent/CA2591656A1/fr
Priority to CA002591841A priority patent/CA2591841A1/fr
Priority to EP05024031A priority patent/EP1666492A1/fr
Priority to CA002591814A priority patent/CA2591814A1/fr
Priority to CA002591590A priority patent/CA2591590A1/fr
Priority to CA002591930A priority patent/CA2591930A1/fr
Priority to CA002585822A priority patent/CA2585822A1/fr
Priority to EP05024033A priority patent/EP1666493A1/fr
Priority to JP2002501551A priority patent/JP2004510409A/ja
Priority to EP05024035A priority patent/EP1666594A3/fr
Priority to CA002594659A priority patent/CA2594659A1/fr
Priority to EP04005726A priority patent/EP1489095A1/fr
Priority to CA002591583A priority patent/CA2591583A1/fr
Priority to EP05024037A priority patent/EP1700867A3/fr
Priority to EP05024038A priority patent/EP1702928A3/fr
Priority to EP05024030A priority patent/EP1666491A1/fr
Priority to CA002591630A priority patent/CA2591630A1/fr
Priority to PCT/US2001/019692 priority patent/WO2002000690A2/fr
Priority to EP10182597A priority patent/EP2275549A1/fr
Priority to CA002648046A priority patent/CA2648046A1/fr
Priority to EP09004415A priority patent/EP2168980A1/fr
Priority to EP01957073A priority patent/EP1309620A2/fr
Priority to EP14166919.2A priority patent/EP2792747A1/fr
Priority to EP08019420.2A priority patent/EP2042597B1/fr
Priority to CA002648051A priority patent/CA2648051A1/fr
Priority to CA2709771A priority patent/CA2709771A1/fr
Priority to EP09004418A priority patent/EP2075253A1/fr
Priority to DK08019420.2T priority patent/DK2042597T3/da
Priority to EP09004417A priority patent/EP2077276A1/fr
Priority to AU2001278852A priority patent/AU2001278852A1/en
Priority to CA002648048A priority patent/CA2648048A1/fr
Priority to CA002412211A priority patent/CA2412211A1/fr
Priority to JP2002505812A priority patent/JP2004506413A/ja
Priority to KR10-2003-7002685A priority patent/KR20030029847A/ko
Priority to JP2002521524A priority patent/JP2004520806A/ja
Priority to EP04011258A priority patent/EP1445318A2/fr
Priority to AU2001270118A priority patent/AU2001270118A1/en
Priority to MXPA03001645A priority patent/MXPA03001645A/es
Priority to EP01948667A priority patent/EP1311674A2/fr
Priority to CA002420140A priority patent/CA2420140A1/fr
Priority to EP04011151A priority patent/EP1445317A3/fr
Priority to US09/888,257 priority patent/US20030060612A1/en
Priority to PCT/US2001/020118 priority patent/WO2002016429A2/fr
Priority to JP2002514192A priority patent/JP2004514420A/ja
Priority to AU2001273150A priority patent/AU2001273150A1/en
Priority to CA002416456A priority patent/CA2416456A1/fr
Priority to PCT/US2001/021066 priority patent/WO2002008288A2/fr
Priority to AU7315001A priority patent/AU7315001A/xx
Priority to EP01951036A priority patent/EP1309685A2/fr
Priority to CA002416538A priority patent/CA2416538A1/fr
Priority to AU2001271973A priority patent/AU2001271973A1/en
Priority to PCT/US2001/021735 priority patent/WO2002008284A2/fr
Priority to JP2002514188A priority patent/JP2004516013A/ja
Priority to US09/946,374 priority patent/US20030073129A1/en
Publication of WO2001066740A2 publication Critical patent/WO2001066740A2/fr
Priority to US09/990,456 priority patent/US20020137890A1/en
Priority to US10/001,054 priority patent/US20020192209A1/en
Priority to US10/006,768 priority patent/US6936697B2/en
Priority to US10/006,063 priority patent/US20030114652A1/en
Priority to US10/006,485 priority patent/US7026448B2/en
Priority to US10/006,172 priority patent/US7081514B2/en
Priority to US10/006,116 priority patent/US20030082626A1/en
Priority to US10/006,130 priority patent/US7098312B2/en
Priority to US10/006,867 priority patent/US7160985B2/en
Priority to US10/006,041 priority patent/US6951921B2/en
Priority to US10/007,236 priority patent/US7034123B2/en
Priority to US10/006,818 priority patent/US20030054406A1/en
Priority to US10/006,746 priority patent/US7026449B2/en
Priority to US10/006,856 priority patent/US7538086B2/en
Priority to US10/007,194 priority patent/US7041805B2/en
Priority to US10/006,117 priority patent/US7071304B2/en
Priority to US10/012,754 priority patent/US7375184B2/en
Priority to US10/012,121 priority patent/US7022817B2/en
Priority to US10/012,137 priority patent/US20030187189A1/en
Priority to US10/012,754 priority patent/US20030187191A1/en
Priority to US10/011,833 priority patent/US6951920B2/en
Priority to US10/012,755 priority patent/US20030096955A1/en
Priority to US10/011,795 priority patent/US7012131B2/en
Priority to US10/012,752 priority patent/US7026455B2/en
Priority to US10/012,231 priority patent/US6924355B2/en
Priority to US10/012,149 priority patent/US7038019B2/en
Priority to US10/011,692 priority patent/US20030109672A1/en
Priority to US10/012,237 priority patent/US20030191281A1/en
Priority to US10/012,101 priority patent/US20030187239A1/en
Priority to US10/012,064 priority patent/US6953841B2/en
Priority to US10/012,753 priority patent/US7488796B2/en
Priority to US10/011,671 priority patent/US20030096954A1/en
Priority to US10/013,430 priority patent/US20030092883A1/en
Priority to US10/013,909 priority patent/US20030186318A1/en
Priority to US10/013,906 priority patent/US20030191282A1/en
Priority to US10/013,907 priority patent/US20030064925A1/en
Priority to US10/015,822 priority patent/US20030130491A1/en
Priority to US10/013,911 priority patent/US20030187193A1/en
Priority to US10/013,913 priority patent/US20030083462A1/en
Priority to US10/013,910 priority patent/US7057018B2/en
Priority to US10/013,915 priority patent/US20030204053A1/en
Priority to US10/015,499 priority patent/US20030065142A1/en
Priority to US10/015,869 priority patent/US7189530B2/en
Priority to US10/015,389 priority patent/US6936436B2/en
Priority to US10/015,671 priority patent/US6946263B2/en
Priority to US10/015,653 priority patent/US20030187195A1/en
Priority to US10/015,480 priority patent/US7074912B2/en
Priority to US10/015,869 priority patent/US20030073130A1/en
Priority to US10/015,519 priority patent/US7033785B2/en
Priority to US10/015,393 priority patent/US6951737B2/en
Priority to US10/015,386 priority patent/US7022498B2/en
Priority to US10/015,715 priority patent/US7033786B2/en
Priority to US10/015,385 priority patent/US20030195347A1/en
Priority to US10/015,388 priority patent/US20030191299A1/en
Priority to US10/015,391 priority patent/US20030120053A1/en
Priority to US10/015,390 priority patent/US20030216562A1/en
Priority to US10/015,387 priority patent/US20030135034A1/en
Priority to US10/017,867 priority patent/US20030180792A1/en
Priority to US10/017,527 priority patent/US20030082628A1/en
Priority to US10/017,306 priority patent/US20030170718A1/en
Priority to US10/017,610 priority patent/US20030113795A1/en
Priority to US10/020,063 priority patent/US20030119097A1/en
Priority to US10/017,407 priority patent/US20030125535A1/en
Priority to US10/081,056 priority patent/US20040043927A1/en
Priority to US10/119,480 priority patent/US20040087769A1/en
Priority to US10/121,041 priority patent/US20030077776A1/en
Priority to US10/121,042 priority patent/US20030096386A1/en
Priority to US10/121,051 priority patent/US20030092147A1/en
Priority to US10/121,046 priority patent/US20030194791A1/en
Priority to US10/121,044 priority patent/US20030190717A1/en
Priority to US10/121,059 priority patent/US20030190721A1/en
Priority to US10/121,047 priority patent/US20030077778A1/en
Priority to US10/121,045 priority patent/US20030073210A1/en
Priority to US10/121,040 priority patent/US20030082759A1/en
Priority to US10/121,052 priority patent/US20030199052A1/en
Priority to US10/121,056 priority patent/US20030082760A1/en
Priority to US10/121,063 priority patent/US20030199055A1/en
Priority to US10/121,061 priority patent/US20030082761A1/en
Priority to US10/121,054 priority patent/US20030199054A1/en
Priority to US10/121,049 priority patent/US20030022239A1/en
Priority to US10/121,053 priority patent/US20030199053A1/en
Priority to US10/121,048 priority patent/US20030199051A1/en
Priority to US10/121,050 priority patent/US20030054516A1/en
Priority to US10/121,043 priority patent/US7220831B2/en
Priority to US10/121,058 priority patent/US20030190720A1/en
Priority to US10/121,057 priority patent/US20030190719A1/en
Priority to US10/121,062 priority patent/US20030077779A1/en
Priority to US10/121,055 priority patent/US20030190718A1/en
Priority to US10/121,060 priority patent/US20030190722A1/en
Priority to US10/123,213 priority patent/US20030199057A1/en
Priority to US10/123,108 priority patent/US7635478B2/en
Priority to US10/123,156 priority patent/US20030194792A1/en
Priority to US10/123,262 priority patent/US20030049816A1/en
Priority to US10/123,109 priority patent/US20030190723A1/en
Priority to US10/123,155 priority patent/US20030068794A1/en
Priority to US10/123,213 priority patent/US7193048B2/en
Priority to US10/123,214 priority patent/US7343721B2/en
Priority to US10/123,261 priority patent/US20030068796A1/en
Priority to US10/123,154 priority patent/US20030190724A1/en
Priority to US10/123,212 priority patent/US7276577B2/en
Priority to US10/123,292 priority patent/US20030073211A1/en
Priority to US10/123,215 priority patent/US7291329B2/en
Priority to US10/123,322 priority patent/US20030199059A1/en
Priority to US10/123,235 priority patent/US20030082762A1/en
Priority to US10/123,291 priority patent/US20030199058A1/en
Priority to US10/123,157 priority patent/US20030190725A1/en
Priority to US10/123,771 priority patent/US20030199060A1/en
Priority to US10/123,236 priority patent/US20030068795A1/en
Priority to US10/123,908 priority patent/US7335728B2/en
Priority to US10/123,911 priority patent/US7408032B2/en
Priority to US10/123,905 priority patent/US7285625B2/en
Priority to US10/123,905 priority patent/US20030087344A1/en
Priority to US10/123,909 priority patent/US7193049B2/en
Priority to US10/123,912 priority patent/US20030100087A1/en
Priority to US10/123,907 priority patent/US7084258B2/en
Priority to US10/123,903 priority patent/US20030073212A1/en
Priority to US10/123,906 priority patent/US20030190726A1/en
Priority to US10/123,904 priority patent/US20030022328A1/en
Priority to US10/123,910 priority patent/US7329404B2/en
Priority to US10/123,913 priority patent/US20030203462A1/en
Priority to US10/123,902 priority patent/US20030077781A1/en
Priority to US10/124,820 priority patent/US20030190729A1/en
Priority to US10/124,823 priority patent/US20030199062A1/en
Priority to US10/124,821 priority patent/US20030199023A1/en
Priority to US10/124,813 priority patent/US7312307B2/en
Priority to US10/124,818 priority patent/US20030082763A1/en
Priority to US10/125,805 priority patent/US20030194794A1/en
Priority to US10/124,822 priority patent/US7109305B2/en
Priority to US10/124,814 priority patent/US7105335B2/en
Priority to US10/124,824 priority patent/US20030077659A1/en
Priority to US10/125,704 priority patent/US7357926B2/en
Priority to US10/124,817 priority patent/US20030077786A1/en
Priority to US10/124,816 priority patent/US20030190728A1/en
Priority to US10/124,819 priority patent/US7285626B2/en
Priority to US10/125,795 priority patent/US7304131B2/en
Priority to US10/125,922 priority patent/US7309762B2/en
Priority to US10/125,932 priority patent/US7317079B2/en
Priority to US10/125,931 priority patent/US20030199063A1/en
Priority to US10/125,924 priority patent/US7342097B2/en
Priority to US10/125,927 priority patent/US20030190731A1/en
Priority to US10/127,831 priority patent/US20030082689A1/en
Priority to US10/128,689 priority patent/US20030087365A1/en
Priority to US10/131,825 priority patent/US7282566B2/en
Priority to US10/131,817 priority patent/US7291701B2/en
Priority to US10/131,823 priority patent/US7304132B2/en
Priority to US10/137,865 priority patent/US20030032155A1/en
Priority to US10/137,868 priority patent/US20030082764A1/en
Priority to US10/137,867 priority patent/US20030207349A1/en
Priority to US10/139,963 priority patent/US7288625B2/en
Priority to US10/140,023 priority patent/US20030207416A1/en
Priority to US10/140,474 priority patent/US20030032156A1/en
Priority to US10/140,470 priority patent/US20030022331A1/en
Priority to US10/140,020 priority patent/US20030207415A1/en
Priority to US10/139,980 priority patent/US7247710B2/en
Priority to US10/140,024 priority patent/US20040058424A1/en
Priority to US10/140,925 priority patent/US20030073215A1/en
Priority to US10/063,651 priority patent/US7193057B2/en
Priority to US10/140,864 priority patent/US20030207419A1/en
Priority to US10/140,921 priority patent/US7317080B2/en
Priority to US10/140,808 priority patent/US7425621B2/en
Priority to US10/140,805 priority patent/US20030207417A1/en
Priority to US10/140,860 priority patent/US7307151B2/en
Priority to US10/140,865 priority patent/US20030207420A1/en
Priority to US10/140,809 priority patent/US20030207418A1/en
Priority to US10/140,928 priority patent/US20030068798A1/en
Priority to US10/141,701 priority patent/US20030207421A1/en
Priority to US10/141,754 priority patent/US7361732B2/en
Priority to US10/141,756 priority patent/US7488586B2/en
Priority to US10/141,755 priority patent/US7297764B2/en
Priority to US10/141,760 priority patent/US7342104B2/en
Priority to US10/143,113 priority patent/US7329730B2/en
Priority to US10/142,430 priority patent/US7309766B2/en
Priority to US10/142,425 priority patent/US20030207424A1/en
Priority to US10/143,114 priority patent/US20030036180A1/en
Priority to US10/142,417 priority patent/US7304133B2/en
Priority to US10/142,423 priority patent/US20030049817A1/en
Priority to US10/142,419 priority patent/US7153941B2/en
Priority to US10/142,431 priority patent/US7285629B2/en
Priority to US10/143,032 priority patent/US7408033B2/en
Priority to US10/146,792 priority patent/US20030207428A1/en
Priority to US10/146,730 priority patent/US20030207427A1/en
Priority to US10/147,528 priority patent/US20030219885A1/en
Priority to US10/147,536 priority patent/US20040077064A1/en
Priority to US10/147,519 priority patent/US20030077791A1/en
Priority to US10/147,492 priority patent/US20030082765A1/en
Priority to US10/152,395 priority patent/US7189534B2/en
Priority to US10/153,934 priority patent/US20030129695A1/en
Priority to US10/156,843 priority patent/US20030207805A1/en
Priority to US10/157,786 priority patent/US20030208055A1/en
Priority to US10/157,782 priority patent/US20030077792A1/en
Priority to US10/158,782 priority patent/US20030082766A1/en
Priority to US10/160,498 priority patent/US20030073216A1/en
Priority to US10/158,791 priority patent/US20030207429A1/en
Priority to US10/227,874 priority patent/US20030100724A1/en
Publication of WO2001066740A3 publication Critical patent/WO2001066740A3/fr
Priority to US10/758,377 priority patent/US20040126807A1/en
Priority to US10/972,317 priority patent/US7208321B2/en
Priority to US11/025,607 priority patent/US20050181478A1/en
Priority to US11/341,175 priority patent/US7468427B2/en
Priority to JP2006266069A priority patent/JP2007049999A/ja
Priority to US11/796,725 priority patent/US20090197301A1/en
Priority to JP2008194721A priority patent/JP2009039118A/ja
Priority to JP2008194764A priority patent/JP2009039119A/ja
Priority to JP2008194678A priority patent/JP2009039117A/ja
Priority to JP2011173336A priority patent/JP6033531B2/ja
Priority to JP2014187275A priority patent/JP2015037408A/ja

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne des compositions contenant des protéines et des procédés d'utilisation de ces compositions pour le diagnostic et le traitement de maladies d'origine immune.
PCT/US2001/006666 1997-03-31 2001-03-01 Compositions et methodes de traitement de maladies d'origine immune WO2001066740A2 (fr)

Priority Applications (271)

Application Number Priority Date Filing Date Title
AU2001255168A AU2001255168A1 (en) 2000-03-03 2001-03-01 Compositions and methods for the treatment of immune related diseases
AU6531101A AU6531101A (en) 2000-06-02 2001-05-31 Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU2001265311A AU2001265311A1 (en) 2000-06-02 2001-06-01 Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP05024025A EP1666597A3 (fr) 2000-06-02 2001-06-01 Polypeptides sécrétés et transmembranaires ainsi que les acides nucléiques codant pour ceux-ci
CA002410162A CA2410162A1 (fr) 2000-06-02 2001-06-01 Polypeptide pro 4332 marqueur de tumeurs du poumon, du colon, du rectum et du sein et acide nucleique codant pour ce polypeptide
EP05024023A EP1683864A3 (fr) 2000-06-02 2001-06-01 Polypeptides sécrétés et transmembranaires ainsi que les acides nucléiques codant pour ceux-ci
EP05024028A EP1686174A1 (fr) 2000-06-02 2001-06-01 Polypeptides sécrétés et transmembranaires, ainsi que les acides nucléiques codant pour ceux-ci
EP05024034A EP1666497A3 (fr) 2000-06-02 2001-06-01 Polypeptide, acides nucléiques le codant, et leur utilisation pour le diagnostic du cancer
EP05024027A EP1666596A1 (fr) 2000-06-02 2001-06-01 Polypeptides sécrétés et transmembranaires ainsi que les acides nucléiques codant pour ceux-ci
PCT/US2001/017800 WO2001093983A1 (fr) 2000-06-02 2001-06-01 Polypeptides secretes et transmembranaires et acides nucleiques codant lesdits polypeptides
EP01939834A EP1286749A1 (fr) 2000-06-02 2001-06-01 Polypeptides secretes et transmembranaires et acides nucleiques codant lesdits polypeptides
EP05024032A EP1659177A3 (fr) 2000-06-02 2001-06-01 Polypeptides sécrétés et transmembranaires ainsi que les acides nucléiques codant pour ceux-ci
CA002591656A CA2591656A1 (fr) 2000-06-02 2001-06-01 Polypeptides secretes et transmembranaires et acides nucleiques codant lesdits polypeptides
CA002591841A CA2591841A1 (fr) 2000-06-02 2001-06-01 Polypeptides secretes et transmembranaires et acides nucleiques codant lesdits polypeptides
EP05024031A EP1666492A1 (fr) 2000-06-02 2001-06-01 Polypeptides sécrétés et transmembranaires ainsi que les acides nucléiques codant pour ceux-ci
CA002591814A CA2591814A1 (fr) 2000-06-02 2001-06-01 Polypeptides secretes et transmembranaires et acides nucleiques codant lesdits polypeptides
CA002591590A CA2591590A1 (fr) 2000-06-02 2001-06-01 Polypeptides secretes et transmembranaires et acides nucleiques codant lesdits polypeptides
CA002591930A CA2591930A1 (fr) 2000-06-02 2001-06-01 Polypeptides secretes et transmembranaires et acides nucleiques codant lesdits polypeptides
CA002585822A CA2585822A1 (fr) 2000-06-02 2001-06-01 Marqueur polypeptidique pro19628 pour tumeur du sein, du rectum, du colon ou du poumon et acide nucleique encodant
EP05024033A EP1666493A1 (fr) 2000-06-02 2001-06-01 Polypeptides sécrétés et transmembranaires ainsi que les acides nucléiques codant pour ceux-ci
JP2002501551A JP2004510409A (ja) 2000-06-02 2001-06-01 分泌及び膜貫通ポリペプチドとそれをコードする核酸
EP05024035A EP1666594A3 (fr) 2000-06-02 2001-06-01 Polypeptide, acides nucléiques le codant, et leur utilisation pour le diagnostic du cancer
CA002594659A CA2594659A1 (fr) 2000-06-02 2001-06-01 Polypeptides secretes et transmembranaires et acides nucleiques codant lesdits polypeptides
EP04005726A EP1489095A1 (fr) 2000-06-02 2001-06-01 Polypeptide, acides nucléiques le codant, et leur utilisation pour le diagnostic du cancer
CA002591583A CA2591583A1 (fr) 2000-06-02 2001-06-01 Polypeptides secretes et transmembranaires et acides nucleiques codant lesdits polypeptides
EP05024037A EP1700867A3 (fr) 2000-06-02 2001-06-01 Polypeptide secrétée et transmembranaire, ainsi que les acides nucléiques qui les codent
EP05024038A EP1702928A3 (fr) 2000-06-02 2001-06-01 Polypeptides secrétées ou transmembranaire, ainsi que les acides nucléiques qui les codent
EP05024030A EP1666491A1 (fr) 2000-06-02 2001-06-01 Polypeptides sécrétés et transmembranaires ainsi que les acides nucléiques codant pour ceux-ci
CA002591630A CA2591630A1 (fr) 2000-06-02 2001-06-01 Polypeptides secretes et transmembranaires et acides nucleiques codant lesdits polypeptides
PCT/US2001/019692 WO2002000690A2 (fr) 2000-06-23 2001-06-20 Compositions et procedes de diagnostic et de traitement de troubles dont l'angiogenese
EP10182597A EP2275549A1 (fr) 2000-06-23 2001-06-20 Compositions et procédés pour le traitement et le diagnostic des troubles impliquant une angiogénèse
CA002648046A CA2648046A1 (fr) 2000-06-23 2001-06-20 Compositions et procedes de diagnostic et de traitement de troubles dont l'angiogenese
EP09004415A EP2168980A1 (fr) 2000-06-23 2001-06-20 Compositions et procédés pour le traitement et le diagnostic des troubles impliquant une angiogenèse
EP01957073A EP1309620A2 (fr) 2000-06-23 2001-06-20 Compositions et procedes de diagnose et traitement de maladies faisant intervenir l'angiogenese
EP14166919.2A EP2792747A1 (fr) 2000-06-23 2001-06-20 Compositions et procédés pour le traitement et le diagnostic des troubles impliquant une angiogenèse
EP08019420.2A EP2042597B1 (fr) 2000-06-23 2001-06-20 Compositions et procédés pour le traitement et le diagnostic des troubles impliquant une angiogénèse
CA002648051A CA2648051A1 (fr) 2000-06-23 2001-06-20 Compositions et procedes de diagnostic et de traitement de troubles dont l'angiogenese
CA2709771A CA2709771A1 (fr) 2000-06-23 2001-06-20 Compositions et methode de diagnostic et de traitement des troubles mettant en cause l'angiogenese
EP09004418A EP2075253A1 (fr) 2000-06-23 2001-06-20 Méthodes et composés pour la diagnose et le traitement de troubles associés à l'angiogenèse
DK08019420.2T DK2042597T3 (da) 2000-06-23 2001-06-20 Sammensætninger og fremgangsmåder til diagnose og behandling af sygdomme, der involverer angiogenese
EP09004417A EP2077276A1 (fr) 2000-06-23 2001-06-20 Compositions et procédés pour le traitement et le diagnostic des troubles impliquant une angiogenèse
AU2001278852A AU2001278852A1 (en) 2000-06-23 2001-06-20 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
CA002648048A CA2648048A1 (fr) 2000-06-23 2001-06-20 Compositions et procedes de diagnostic et de traitement de troubles dont l'angiogenese
CA002412211A CA2412211A1 (fr) 2000-06-23 2001-06-20 Compositions et procedes de diagnostic et de traitement de troubles dont l'angiogenese
JP2002505812A JP2004506413A (ja) 2000-06-23 2001-06-20 血管形成に関与する疾患の診断と治療のための組成物と方法
KR10-2003-7002685A KR20030029847A (ko) 2000-08-24 2001-06-22 종양의 진단 및 치료를 위한 조성물 및 방법
JP2002521524A JP2004520806A (ja) 2000-08-24 2001-06-22 腫瘍の診断と治療のための組成物と方法
EP04011258A EP1445318A2 (fr) 2000-08-24 2001-06-22 Composition et méthodes pour le diagnostic et pour le traitement d'une tumeur
AU2001270118A AU2001270118A1 (en) 2000-08-24 2001-06-22 Compositions and methods for the diagnosis and treatment of tumor
MXPA03001645A MXPA03001645A (es) 2000-08-24 2001-06-22 Composiciones y metodos para el diagnostico y tratamiento de tumores.
EP01948667A EP1311674A2 (fr) 2000-08-24 2001-06-22 Compositions et procedes de diagnostic et traitement de tumeurs
CA002420140A CA2420140A1 (fr) 2000-08-24 2001-06-22 Compositions et procedes de diagnostic et traitement de tumeurs
EP04011151A EP1445317A3 (fr) 2000-08-24 2001-06-22 Compositions et procédés de diagnostic et traitement de tumeurs
US09/888,257 US20030060612A1 (en) 1997-10-28 2001-06-22 Compositions and methods for the diagnosis and treatment of tumor
PCT/US2001/020118 WO2002016429A2 (fr) 2000-08-24 2001-06-22 Compositions et procedes de diagnostic et traitement de tumeurs
JP2002514192A JP2004514420A (ja) 2000-07-20 2001-06-29 分泌及び膜貫通ポリペプチドとそれをコードする核酸
AU2001273150A AU2001273150A1 (en) 2000-07-20 2001-06-29 Secreted and transmembrane polypeptides and nucleic acids encoding the same
CA002416456A CA2416456A1 (fr) 2000-07-20 2001-06-29 Polypeptides secretes et transmembranaires et acides nucleiques codant ces polypeptides
PCT/US2001/021066 WO2002008288A2 (fr) 2000-07-20 2001-06-29 Polypeptides secretes et transmembranaires et acides nucleiques codant ces polypeptides
AU7315001A AU7315001A (en) 2000-07-20 2001-07-02 Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP01951036A EP1309685A2 (fr) 2000-07-20 2001-07-09 COMPOSITIONs ET PROCEDEs DE DIAGNOSE ET TRAITEMENT DE MALADIES IMPLICANT ANGIOGENESIS
CA002416538A CA2416538A1 (fr) 2000-07-20 2001-07-09 Compositions et methodes diagnostiques et therapeutiques de troubles impliquant l'angiogenese
AU2001271973A AU2001271973A1 (en) 2000-07-20 2001-07-09 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
PCT/US2001/021735 WO2002008284A2 (fr) 2000-07-20 2001-07-09 Compositions et methodes diagnostiques et therapeutiques de troubles impliquant l'angiogenese
JP2002514188A JP2004516013A (ja) 2000-07-20 2001-07-09 血管形成に関連する障害を診断及び治療するための組成物と方法
US09/946,374 US20030073129A1 (en) 1998-09-01 2001-09-04 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US09/990,456 US20020137890A1 (en) 1997-03-31 2001-11-14 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/001,054 US20020192209A1 (en) 1997-09-17 2001-11-30 Methods and compositions for inhibiting neoplastic cell growth
US10/006,768 US6936697B2 (en) 1998-09-01 2001-12-06 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/006,063 US20030114652A1 (en) 1998-09-01 2001-12-06 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/006,485 US7026448B2 (en) 1998-09-01 2001-12-06 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/006,172 US7081514B2 (en) 1998-09-01 2001-12-06 PRO1347 polypeptides
US10/006,116 US20030082626A1 (en) 1998-09-01 2001-12-06 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/006,130 US7098312B2 (en) 1998-09-01 2001-12-06 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/006,867 US7160985B2 (en) 1997-10-29 2001-12-06 Pro180 polypeptide
US10/006,041 US6951921B2 (en) 1998-09-01 2001-12-06 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/007,236 US7034123B2 (en) 1998-09-01 2001-12-06 Anti-PRO1347 antibodies
US10/006,818 US20030054406A1 (en) 1998-09-01 2001-12-06 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/006,746 US7026449B2 (en) 1999-01-05 2001-12-06 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/006,856 US7538086B2 (en) 1998-09-01 2001-12-06 PRO1303 polypeptides
US10/007,194 US7041805B2 (en) 1998-09-01 2001-12-06 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/006,117 US7071304B2 (en) 1998-09-01 2001-12-06 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/012,754 US7375184B2 (en) 1998-09-01 2001-12-07 PRO1382 polypeptides
US10/012,121 US7022817B2 (en) 1998-09-01 2001-12-07 PRO1325 polypeptides
US10/012,137 US20030187189A1 (en) 1998-09-01 2001-12-07 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/012,754 US20030187191A1 (en) 1998-09-01 2001-12-07 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/011,833 US6951920B2 (en) 1998-09-01 2001-12-07 PRO1340 polypeptides
US10/012,755 US20030096955A1 (en) 1998-09-01 2001-12-07 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/011,795 US7012131B2 (en) 1998-09-01 2001-12-07 Pro1410 polypeptides
US10/012,752 US7026455B2 (en) 1998-09-01 2001-12-07 Anti-pro 1343 antibodies
US10/012,231 US6924355B2 (en) 1998-09-01 2001-12-07 PRO1343 polypeptides
US10/012,149 US7038019B2 (en) 1998-09-01 2001-12-07 Antibodies to PRO1410
US10/011,692 US20030109672A1 (en) 1998-09-01 2001-12-07 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/012,237 US20030191281A1 (en) 1998-09-01 2001-12-07 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/012,101 US20030187239A1 (en) 1998-09-01 2001-12-07 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/012,064 US6953841B2 (en) 1999-01-05 2001-12-07 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/012,753 US7488796B2 (en) 1998-09-01 2001-12-07 PRO1269 polypeptides
US10/011,671 US20030096954A1 (en) 1998-09-01 2001-12-07 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/013,430 US20030092883A1 (en) 1998-09-01 2001-12-10 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/013,909 US20030186318A1 (en) 1999-01-05 2001-12-10 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/013,906 US20030191282A1 (en) 1998-09-01 2001-12-10 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/013,907 US20030064925A1 (en) 1998-09-01 2001-12-10 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/015,822 US20030130491A1 (en) 1998-09-01 2001-12-10 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/013,911 US20030187193A1 (en) 1998-09-01 2001-12-10 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/013,913 US20030083462A1 (en) 1999-01-05 2001-12-10 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/013,910 US7057018B2 (en) 1999-01-05 2001-12-10 Pro 1474 polypeptides
US10/013,915 US20030204053A1 (en) 1998-09-01 2001-12-10 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/015,499 US20030065142A1 (en) 1998-09-01 2001-12-11 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/015,869 US7189530B2 (en) 1998-09-01 2001-12-11 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/015,389 US6936436B2 (en) 1998-09-01 2001-12-11 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/015,671 US6946263B2 (en) 1998-09-01 2001-12-11 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/015,653 US20030187195A1 (en) 1998-09-01 2001-12-11 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/015,480 US7074912B2 (en) 1998-09-01 2001-12-11 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/015,869 US20030073130A1 (en) 1998-09-01 2001-12-11 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/015,519 US7033785B2 (en) 1998-09-01 2001-12-11 PRO1347 nucleic acids
US10/015,393 US6951737B2 (en) 1998-09-01 2001-12-11 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/015,386 US7022498B2 (en) 1998-09-01 2001-12-12 Pro 1325 nucleic acids
US10/015,715 US7033786B2 (en) 1998-09-01 2001-12-12 Pro1340 nucleic acids
US10/015,385 US20030195347A1 (en) 1998-09-01 2001-12-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/015,388 US20030191299A1 (en) 1998-09-01 2001-12-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/015,391 US20030120053A1 (en) 1998-09-01 2001-12-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/015,390 US20030216562A1 (en) 1998-09-01 2001-12-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/015,387 US20030135034A1 (en) 1998-09-01 2001-12-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/017,867 US20030180792A1 (en) 1998-09-01 2001-12-13 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/017,527 US20030082628A1 (en) 1998-09-01 2001-12-13 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/017,306 US20030170718A1 (en) 1998-09-01 2001-12-13 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/017,610 US20030113795A1 (en) 1998-09-01 2001-12-13 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/020,063 US20030119097A1 (en) 1999-01-05 2001-12-13 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/017,407 US20030125535A1 (en) 1998-09-01 2001-12-13 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/081,056 US20040043927A1 (en) 1997-09-19 2002-02-20 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
US10/119,480 US20040087769A1 (en) 1998-09-10 2002-04-09 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,051 US20030092147A1 (en) 1997-03-31 2002-04-11 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,042 US20030096386A1 (en) 1997-03-31 2002-04-11 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,041 US20030077776A1 (en) 1997-03-31 2002-04-11 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,046 US20030194791A1 (en) 1997-03-31 2002-04-11 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,044 US20030190717A1 (en) 1997-03-31 2002-04-11 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,059 US20030190721A1 (en) 1997-03-31 2002-04-11 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,047 US20030077778A1 (en) 1997-03-31 2002-04-11 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,045 US20030073210A1 (en) 1997-03-31 2002-04-11 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,040 US20030082759A1 (en) 1997-03-31 2002-04-11 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,052 US20030199052A1 (en) 1997-03-31 2002-04-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,056 US20030082760A1 (en) 1997-03-31 2002-04-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,063 US20030199055A1 (en) 1997-03-31 2002-04-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,061 US20030082761A1 (en) 1997-03-31 2002-04-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,054 US20030199054A1 (en) 1997-03-31 2002-04-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,049 US20030022239A1 (en) 1997-06-18 2002-04-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,053 US20030199053A1 (en) 1997-03-31 2002-04-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,048 US20030199051A1 (en) 1997-03-31 2002-04-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,050 US20030054516A1 (en) 1997-03-31 2002-04-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,043 US7220831B2 (en) 1997-03-31 2002-04-12 PRO235 polypeptides
US10/121,058 US20030190720A1 (en) 1997-03-31 2002-04-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,057 US20030190719A1 (en) 1997-03-31 2002-04-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,062 US20030077779A1 (en) 1997-03-31 2002-04-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,055 US20030190718A1 (en) 1997-03-31 2002-04-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/121,060 US20030190722A1 (en) 1997-03-31 2002-04-12 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,213 US20030199057A1 (en) 1997-03-31 2002-04-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,108 US7635478B2 (en) 1997-03-31 2002-04-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,156 US20030194792A1 (en) 1997-03-31 2002-04-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,262 US20030049816A1 (en) 1997-03-31 2002-04-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,109 US20030190723A1 (en) 1997-03-31 2002-04-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,155 US20030068794A1 (en) 1997-03-31 2002-04-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,213 US7193048B2 (en) 1997-03-31 2002-04-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,214 US7343721B2 (en) 1997-03-31 2002-04-15 PRO4406 polypeptide
US10/123,261 US20030068796A1 (en) 1997-03-31 2002-04-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,154 US20030190724A1 (en) 1997-03-31 2002-04-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,212 US7276577B2 (en) 1997-03-31 2002-04-15 PRO1866 polypeptides
US10/123,292 US20030073211A1 (en) 1997-03-31 2002-04-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,215 US7291329B2 (en) 1997-03-31 2002-04-15 Antibodies against PRO4406
US10/123,322 US20030199059A1 (en) 1997-03-31 2002-04-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,235 US20030082762A1 (en) 1997-03-31 2002-04-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,291 US20030199058A1 (en) 1997-03-31 2002-04-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,157 US20030190725A1 (en) 1997-03-31 2002-04-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,771 US20030199060A1 (en) 1997-03-31 2002-04-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,236 US20030068795A1 (en) 1997-03-31 2002-04-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,908 US7335728B2 (en) 1997-03-31 2002-04-16 PRO1310 polypeptides
US10/123,911 US7408032B2 (en) 1997-03-31 2002-04-16 PRO1188 polypeptides
US10/123,905 US7285625B2 (en) 1997-06-18 2002-04-16 PRO536 polypeptides
US10/123,905 US20030087344A1 (en) 1997-06-18 2002-04-16 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,909 US7193049B2 (en) 1997-03-31 2002-04-16 PRO862 polypeptides
US10/123,912 US20030100087A1 (en) 1997-03-31 2002-04-16 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,907 US7084258B2 (en) 1997-03-31 2002-04-16 Antibodies against the PRO862 polypeptides
US10/123,903 US20030073212A1 (en) 1997-03-31 2002-04-16 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,906 US20030190726A1 (en) 1997-03-31 2002-04-16 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,904 US20030022328A1 (en) 1997-03-31 2002-04-16 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,910 US7329404B2 (en) 1997-03-31 2002-04-16 Antibodies against PRO1310
US10/123,913 US20030203462A1 (en) 1997-03-31 2002-04-16 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/123,902 US20030077781A1 (en) 1997-03-31 2002-04-16 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/124,820 US20030190729A1 (en) 1997-03-31 2002-04-17 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/124,823 US20030199062A1 (en) 1997-03-31 2002-04-17 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/124,821 US20030199023A1 (en) 1997-03-31 2002-04-17 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/124,813 US7312307B2 (en) 1997-03-31 2002-04-17 PRO1056 polypeptides
US10/124,818 US20030082763A1 (en) 1997-03-31 2002-04-17 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/125,805 US20030194794A1 (en) 1997-03-31 2002-04-17 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/124,822 US7109305B2 (en) 1997-03-31 2002-04-17 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/124,814 US7105335B2 (en) 1997-03-31 2002-04-17 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/124,824 US20030077659A1 (en) 1997-03-31 2002-04-17 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/125,704 US7357926B2 (en) 1997-03-31 2002-04-17 Antibodies against PRO1879 and the use thereof
US10/124,817 US20030077786A1 (en) 1997-03-31 2002-04-17 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/124,816 US20030190728A1 (en) 1997-03-31 2002-04-17 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/124,819 US7285626B2 (en) 1997-03-31 2002-04-17 PRO1076 polypeptides
US10/125,795 US7304131B2 (en) 1997-03-31 2002-04-17 PRO1483 polypeptides
US10/125,932 US7317079B2 (en) 1997-03-31 2002-04-19 PRO812 polypeptides
US10/125,922 US7309762B2 (en) 1997-03-31 2002-04-19 PRO1360 polypeptides
US10/125,931 US20030199063A1 (en) 1997-03-31 2002-04-19 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/125,924 US7342097B2 (en) 1997-03-31 2002-04-19 PRO1309 polypeptides
US10/125,927 US20030190731A1 (en) 1997-03-31 2002-04-19 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/127,831 US20030082689A1 (en) 1997-03-31 2002-04-22 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/128,689 US20030087365A1 (en) 1997-03-31 2002-04-23 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/131,825 US7282566B2 (en) 1997-03-31 2002-04-24 PRO1779 polypeptide
US10/131,817 US7291701B2 (en) 1997-03-31 2002-04-24 PRO1777 polypeptides
US10/131,823 US7304132B2 (en) 1997-03-31 2002-04-24 PRO1693 polypeptides
US10/137,865 US20030032155A1 (en) 1997-03-31 2002-05-03 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/137,868 US20030082764A1 (en) 1997-03-31 2002-05-03 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/137,867 US20030207349A1 (en) 1997-03-31 2002-05-03 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/139,963 US7288625B2 (en) 1997-03-31 2002-05-06 PRO4395 polypeptides
US10/140,023 US20030207416A1 (en) 1997-03-31 2002-05-06 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/140,474 US20030032156A1 (en) 1997-03-31 2002-05-06 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/140,470 US20030022331A1 (en) 1997-03-31 2002-05-06 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/140,020 US20030207415A1 (en) 1997-03-31 2002-05-06 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/139,980 US7247710B2 (en) 1997-03-31 2002-05-06 PRO4395 antibodies
US10/140,024 US20040058424A1 (en) 1997-03-31 2002-05-06 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/140,925 US20030073215A1 (en) 1997-03-31 2002-05-07 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/063,651 US7193057B2 (en) 1997-10-29 2002-05-07 Antibodies to a polypeptide encoded by a nucleic acid underexpressed in rectal tumor
US10/140,864 US20030207419A1 (en) 1997-03-31 2002-05-07 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/140,921 US7317080B2 (en) 1997-03-31 2002-05-07 PRO4303 polypeptides
US10/140,808 US7425621B2 (en) 1997-03-31 2002-05-07 Antibodies against the PRO4401 polypeptide
US10/140,805 US20030207417A1 (en) 1997-03-31 2002-05-07 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/140,860 US7307151B2 (en) 1997-03-31 2002-05-07 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/140,865 US20030207420A1 (en) 1997-03-31 2002-05-07 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/140,809 US20030207418A1 (en) 1997-03-31 2002-05-07 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/140,928 US20030068798A1 (en) 1997-03-31 2002-05-07 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/141,701 US20030207421A1 (en) 1997-03-31 2002-05-08 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/141,754 US7361732B2 (en) 1997-03-31 2002-05-08 PRO4400 polypeptides
US10/141,756 US7488586B2 (en) 1997-03-31 2002-05-08 PRO4409 polypeptides
US10/141,755 US7297764B2 (en) 1997-03-31 2002-05-08 PRO4318 polypeptides
US10/141,760 US7342104B2 (en) 1997-03-31 2002-05-08 Antibodies against the PRO4320 polypeptide
US10/143,113 US7329730B2 (en) 1997-03-31 2002-05-09 PRO4348 polypeptides
US10/142,430 US7309766B2 (en) 1997-03-31 2002-05-09 PRO5774 polypeptides
US10/142,425 US20030207424A1 (en) 1997-03-31 2002-05-09 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/143,114 US20030036180A1 (en) 1997-03-31 2002-05-09 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/142,417 US7304133B2 (en) 1997-03-31 2002-05-09 PRO4389 polypeptides
US10/142,423 US20030049817A1 (en) 1997-03-31 2002-05-10 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/142,419 US7153941B2 (en) 1997-03-31 2002-05-10 Antibodies that bind PRO4994 polypeptides
US10/142,431 US7285629B2 (en) 1997-03-31 2002-05-10 Pro5005 polypeptides
US10/143,032 US7408033B2 (en) 1997-03-31 2002-05-10 PRO5995 polypeptides
US10/146,792 US20030207428A1 (en) 1997-03-31 2002-05-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/146,730 US20030207427A1 (en) 1997-03-31 2002-05-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/147,528 US20030219885A1 (en) 1997-03-31 2002-05-16 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/147,536 US20040077064A1 (en) 1997-03-31 2002-05-17 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/147,519 US20030077791A1 (en) 1997-03-31 2002-05-17 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/147,492 US20030082765A1 (en) 1997-03-31 2002-05-17 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/152,395 US7189534B2 (en) 1997-03-31 2002-05-21 PRO4320 polynucleotide
US10/153,934 US20030129695A1 (en) 1997-03-31 2002-05-22 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/156,843 US20030207805A1 (en) 1997-06-18 2002-05-28 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/157,786 US20030208055A1 (en) 1997-03-31 2002-05-29 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/157,782 US20030077792A1 (en) 1997-03-31 2002-05-29 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/158,782 US20030082766A1 (en) 1997-03-31 2002-05-30 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/160,498 US20030073216A1 (en) 1997-03-31 2002-05-30 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/158,791 US20030207429A1 (en) 1997-03-31 2002-05-30 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/227,874 US20030100724A1 (en) 2001-03-01 2002-08-26 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/758,377 US20040126807A1 (en) 1999-06-02 2004-01-15 Compositions and methods for the diagnosis and treatment of tumor
US10/972,317 US7208321B2 (en) 1998-06-02 2004-10-22 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US11/025,607 US20050181478A1 (en) 1998-09-01 2004-12-28 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US11/341,175 US7468427B2 (en) 1997-03-31 2006-01-27 Antibodies to PRO1275 polypeptide
JP2006266069A JP2007049999A (ja) 2000-06-02 2006-09-28 分泌及び膜貫通ポリペプチドとそれをコードする核酸
US11/796,725 US20090197301A1 (en) 1998-09-01 2007-04-27 Secreted and transmembrane polypeptides and nucleic acids encoding the same
JP2008194721A JP2009039118A (ja) 2000-07-20 2008-07-29 血管形成に関連する障害を診断及び治療するための組成物と方法
JP2008194764A JP2009039119A (ja) 2000-07-20 2008-07-29 血管形成に関連する障害を診断及び治療するための組成物と方法
JP2008194678A JP2009039117A (ja) 2000-07-20 2008-07-29 血管形成に関連する障害を診断及び治療するための組成物と方法
JP2011173336A JP6033531B2 (ja) 2000-07-20 2011-08-08 血管形成に関連する障害を診断及び治療するための組成物と方法
JP2014187275A JP2015037408A (ja) 2000-07-20 2014-09-16 血管形成に関連する障害を診断及び治療するための組成物と方法

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US18720200P 2000-03-03 2000-03-03
US60/187,202 2000-03-03
US19101500P 2000-03-21 2000-03-21
US60/191,015 2000-03-21
PCT/US2000/014941 WO2000073348A2 (fr) 1999-06-02 2000-05-30 Procedes et compositions visant a inhiber la proliferation des cellules cancereuses
USPCT/US00/14941 2000-05-30
US20983200P 2000-06-05 2000-06-05
US60/209,832 2000-06-05
PCT/US2000/023328 WO2001016318A2 (fr) 1999-09-01 2000-08-24 Polypeptides secretes et transmembranaires et acides nucleiques codant pour ceux-ci
USPCT/US00/23328 2000-08-24
US60/000,000 2000-09-15
PCT/US2000/032678 WO2001040466A2 (fr) 1999-12-01 2000-12-01 Polypeptides secretes et transmembranaires et acides nucleiques codant ces polypeptides
USPCT/US00/32678 2000-12-01

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PCT/US2001/006520 Continuation WO2001068848A2 (fr) 1996-11-06 2001-02-28 Polypeptides secretes et transmembranaires et acides nucleiques codant pour ces polypeptides
PCT/US2001/006520 Continuation-In-Part WO2001068848A2 (fr) 1996-11-06 2001-02-28 Polypeptides secretes et transmembranaires et acides nucleiques codant pour ces polypeptides

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US09/816,744 Continuation US6579520B2 (en) 1997-03-31 2001-03-22 IL-17 related mammalian cytokine polypeptides (IL-17E)
US87203501A Continuation-In-Part 1996-11-06 2001-06-01
PCT/US2001/017800 Continuation-In-Part WO2001093983A1 (fr) 1996-11-06 2001-06-01 Polypeptides secretes et transmembranaires et acides nucleiques codant lesdits polypeptides
US09/888,257 Continuation US20030060612A1 (en) 1997-10-28 2001-06-22 Compositions and methods for the diagnosis and treatment of tumor
US10/081,056 Continuation US20040043927A1 (en) 1997-09-19 2002-02-20 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
US10/119,480 Continuation US20040087769A1 (en) 1998-09-10 2002-04-09 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/758,377 Continuation US20040126807A1 (en) 1999-06-02 2004-01-15 Compositions and methods for the diagnosis and treatment of tumor

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US7268223B2 (en) 2000-09-22 2007-09-11 Wyeth Isolated nucleic acid molecules which encode a soluble IL-TIF receptor or binding protein which binds to IL-TIF/IL-22, and uses thereof
US7094570B2 (en) 2003-03-11 2006-08-22 Ludwig Institute For Cancer Research Isolated nucleic acid molecules which encode a soluble IL-TIF/IL-22 receptor or binding protein which binds to IL-TIF/IL-22, and uses thereof
EP1191035A3 (fr) * 2000-09-25 2002-04-17 Schering Aktiengesellschaft Trois membres de la famille des recepteurs de la cytokine de classe II
CA2434652A1 (fr) 2001-01-12 2002-08-29 Genetics Institute, Llc. Recepteur de cytokine de type 2 et acides nucleiques codant ce recepteur

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