CA2416538A1 - Compositions et methodes diagnostiques et therapeutiques de troubles impliquant l'angiogenese - Google Patents
Compositions et methodes diagnostiques et therapeutiques de troubles impliquant l'angiogenese Download PDFInfo
- Publication number
- CA2416538A1 CA2416538A1 CA002416538A CA2416538A CA2416538A1 CA 2416538 A1 CA2416538 A1 CA 2416538A1 CA 002416538 A CA002416538 A CA 002416538A CA 2416538 A CA2416538 A CA 2416538A CA 2416538 A1 CA2416538 A1 CA 2416538A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- acid sequence
- amino acid
- sequence
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Abstract
La présente invention concerne des compositions et des méthodes permettant de stimuler ou d'inhiber l'angiogenèse et/ou la vascularisation cardiaque chez les mammifères, notamment les humains. Ces compositions pharmaceutiques renferment des polypeptides ou leurs antagonistes ayant été identifiés pour un ou plusieurs de ces usages. Parmi les troubles pouvant être diagnostiqués, prévenus, ou traités avec ces compositions, on note les traumas tels que les blessures, divers cancers, et les troubles vasculaires, notamment l'athérosclérose et l'hypertrophie cardiaque. Par ailleurs, l'invention concerne de nouveaux polypeptides et des molécules d'acides nucléiques codant ces polypeptides. Cette invention concerne également des vecteurs et des cellules hôtes contenant ces séquences d'acides nucléiques, des molécules de polypeptides chimères contenant les polypeptides de l'invention fusionnés aux séquences de polypeptides hétérologues, des anticorps qui se lient à ces polypeptides, ainsi que des méthodes de production desdits polypeptides.
Applications Claiming Priority (73)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21955600P | 2000-07-20 | 2000-07-20 | |
US60/219,556 | 2000-07-20 | ||
US22066400P | 2000-07-25 | 2000-07-25 | |
US22062400P | 2000-07-25 | 2000-07-25 | |
US60/220,624 | 2000-07-25 | ||
US60/220,664 | 2000-07-25 | ||
PCT/US2000/020710 WO2001009327A2 (fr) | 1999-07-28 | 2000-07-28 | Procede de prevention de la deterioration ou de la mort des cellules de la retine et de traitement des troubles oculaires |
USPCT/US00/20710 | 2000-07-28 | ||
US22269500P | 2000-08-02 | 2000-08-02 | |
US60/222,695 | 2000-08-02 | ||
US09/643,657 US6642024B1 (en) | 1998-01-29 | 2000-08-17 | Guanylate-binding protein |
US09/643,657 | 2000-08-17 | ||
USPCT/US00/23522 | 2000-08-23 | ||
PCT/US2000/023522 WO2001016319A2 (fr) | 1999-08-31 | 2000-08-23 | Compositions et procedes pour le traitement de maladies d'ordre immunologique |
USPCT/US00/23328 | 2000-08-24 | ||
PCT/US2000/023328 WO2001016318A2 (fr) | 1999-09-01 | 2000-08-24 | Polypeptides secretes et transmembranaires et acides nucleiques codant pour ceux-ci |
US23097800P | 2000-09-07 | 2000-09-07 | |
US60/230,978 | 2000-09-07 | ||
US60/000,000 | 2000-09-15 | ||
US66461000A | 2000-09-18 | 2000-09-18 | |
US66535000A | 2000-09-18 | 2000-09-18 | |
US09/665,350 | 2000-09-18 | ||
US09/664,610 | 2000-09-18 | ||
US24292200P | 2000-10-24 | 2000-10-24 | |
US60/242,922 | 2000-10-24 | ||
US70923800A | 2000-11-08 | 2000-11-08 | |
PCT/US2000/030952 WO2001049715A2 (fr) | 2000-01-06 | 2000-11-08 | Methodes et compositions permettant d'inhiber la croissance cellulaire neoplasique |
US09/709,238 | 2000-11-08 | ||
USPCT/US00/30952 | 2000-11-08 | ||
USPCT/US00/30873 | 2000-11-10 | ||
PCT/US2000/030873 WO2001040465A2 (fr) | 1999-11-30 | 2000-11-10 | Compositions et procedes de traitement de maladies d'ordre immunologique |
USPCT/US00/32678 | 2000-12-01 | ||
PCT/US2000/032678 WO2001040466A2 (fr) | 1999-12-01 | 2000-12-01 | Polypeptides secretes et transmembranaires et acides nucleiques codant ces polypeptides |
US09/747,259 | 2000-12-20 | ||
PCT/US2000/034956 WO2001046420A2 (fr) | 1999-12-23 | 2000-12-20 | Polypeptides homologues de l'il-17 et leurs utilisations therapeutiques |
US09/747,259 US6569645B2 (en) | 1999-05-14 | 2000-12-20 | IL-17 homologous polypeptides and therapeutic uses thereof |
USPCT/US00/34956 | 2000-12-20 | ||
US09/767,609 | 2001-01-22 | ||
US09/767,609 US20020042367A1 (en) | 1997-11-25 | 2001-01-22 | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders |
US79649801A | 2001-02-28 | 2001-02-28 | |
USPCT/US01/06520 | 2001-02-28 | ||
PCT/US2001/006520 WO2001068848A2 (fr) | 2000-03-01 | 2001-02-28 | Polypeptides secretes et transmembranaires et acides nucleiques codant pour ces polypeptides |
US09/796,498 | 2001-02-28 | ||
PCT/US2001/006666 WO2001066740A2 (fr) | 2000-03-03 | 2001-03-01 | Compositions et methodes de traitement de maladies d'origine immune |
USPCT/US01/06666 | 2001-03-01 | ||
US80270601A | 2001-03-09 | 2001-03-09 | |
US09/802,706 | 2001-03-09 | ||
US80868901A | 2001-03-14 | 2001-03-14 | |
US09/808,689 | 2001-03-14 | ||
US09/816,744 | 2001-03-22 | ||
US09/816,744 US6579520B2 (en) | 1998-05-15 | 2001-03-22 | IL-17 related mammalian cytokine polypeptides (IL-17E) |
US09/828,366 | 2001-04-05 | ||
US09/828,366 US20020010137A1 (en) | 1997-09-18 | 2001-04-05 | Methods and compositions for inhibiting neoplastic cell growth |
US09/854,280 | 2001-05-10 | ||
US09/854,280 US7115398B2 (en) | 1998-05-15 | 2001-05-10 | IL-17 homologous polypeptides and therapeutic uses thereof |
US09/854,208 US7217412B2 (en) | 1998-05-15 | 2001-05-10 | IL-17C related mammalian cytokine polypeptides |
US09/854,208 | 2001-05-10 | ||
US09/866,034 | 2001-05-25 | ||
USPCT/US01/17092 | 2001-05-25 | ||
US09/866,034 US20030170864A1 (en) | 2000-05-30 | 2001-05-25 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
PCT/US2001/017092 WO2001092331A2 (fr) | 2000-05-30 | 2001-05-25 | Compositions et methodes de traitement de maladies d'origine immune |
US09/866,028 | 2001-05-25 | ||
US09/866,028 US6642360B2 (en) | 1997-12-03 | 2001-05-25 | Secreted polypeptides that stimulate release of proteoglycans from cartilage |
USPCT/US01/17443 | 2001-05-30 | ||
US09/870,574 US6551799B2 (en) | 1999-12-07 | 2001-05-30 | Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders |
US09/870,574 | 2001-05-30 | ||
PCT/US2001/017443 WO2002016611A2 (fr) | 2000-08-24 | 2001-05-30 | Polypeptides d'interleukine-22, acides nucleiques codant pour lesdits polypeptides et methode permettant de traiter les affections pancreatiques |
USPCT/US01/17800 | 2001-06-01 | ||
PCT/US2001/017800 WO2001093983A1 (fr) | 2000-06-02 | 2001-06-01 | Polypeptides secretes et transmembranaires et acides nucleiques codant lesdits polypeptides |
USPCT/US01/19692 | 2001-06-20 | ||
PCT/US2001/019692 WO2002000690A2 (fr) | 2000-06-23 | 2001-06-20 | Compositions et procedes de diagnostic et de traitement de troubles dont l'angiogenese |
USPCT/US01/00000 | 2001-06-28 | ||
PCT/US2001/021735 WO2002008284A2 (fr) | 2000-07-20 | 2001-07-09 | Compositions et methodes diagnostiques et therapeutiques de troubles impliquant l'angiogenese |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2416538A1 true CA2416538A1 (fr) | 2002-01-31 |
Family
ID=56290165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002416538A Abandoned CA2416538A1 (fr) | 2000-07-20 | 2001-07-09 | Compositions et methodes diagnostiques et therapeutiques de troubles impliquant l'angiogenese |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1309685A2 (fr) |
JP (5) | JP2004516013A (fr) |
AU (1) | AU2001271973A1 (fr) |
CA (1) | CA2416538A1 (fr) |
WO (1) | WO2002008284A2 (fr) |
Families Citing this family (75)
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US7192589B2 (en) | 1998-09-16 | 2007-03-20 | Genentech, Inc. | Treatment of inflammatory disorders with STIgMA immunoadhesins |
US7419663B2 (en) | 1998-03-20 | 2008-09-02 | Genentech, Inc. | Treatment of complement-associated disorders |
US8007798B2 (en) | 1997-11-21 | 2011-08-30 | Genentech, Inc. | Treatment of complement-associated disorders |
DE69936382T3 (de) | 1998-05-15 | 2011-07-07 | Genentech, Inc., Calif. | Therapeutische verwendungen von il-17 homologe polypeptide |
US7771719B1 (en) | 2000-01-11 | 2010-08-10 | Genentech, Inc. | Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E |
US20030190669A1 (en) | 1998-12-30 | 2003-10-09 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US20030095967A1 (en) | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
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EP1623993A3 (fr) * | 1999-09-01 | 2006-06-07 | Genetech, Inc. | Protéines sécrétées et transmembranaire et acides nucléiques les codant |
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WO2000053751A1 (fr) * | 1999-03-08 | 2000-09-14 | Genentech, Inc. | Procedes et compositions pour l'inhibition de la croissance de cellules neoplasiques |
EP1017707A4 (fr) * | 1997-08-29 | 2004-04-28 | Human Genome Sciences Inc | 29 proteines humaines secretees |
WO1999043802A2 (fr) * | 1998-02-27 | 1999-09-02 | Sagami Chemical Research Center | Proteines humaines possedant des domaines transmembranaires et adn codant ces proteines |
DK1490386T3 (da) * | 1998-03-10 | 2008-12-15 | Genentech Inc | Nyt polypeptid og nukleinsyrer kodende for dette |
EP1068307A1 (fr) * | 1998-03-31 | 2001-01-17 | Genetics Institute, Inc. | Proteines secretees et polynucleotides les codant |
MXPA01002546A (es) * | 1998-09-14 | 2004-06-11 | Genentech Inc | Promocion o inibhicion de angiogenesis y cardiovascularizacion. |
KR20030002292A (ko) * | 1999-03-08 | 2003-01-08 | 제넨테크, 인크. | 분비 및 막횡단 폴리펩티드 및 이를 코딩하는 핵산 |
KR100543857B1 (ko) * | 1999-09-01 | 2006-01-23 | 제넨테크, 인크. | 혈관신생 및 심혈관형성의 촉진 또는 억제 |
JP2004506413A (ja) * | 2000-06-23 | 2004-03-04 | ジェネンテック・インコーポレーテッド | 血管形成に関与する疾患の診断と治療のための組成物と方法 |
-
2001
- 2001-07-09 CA CA002416538A patent/CA2416538A1/fr not_active Abandoned
- 2001-07-09 EP EP01951036A patent/EP1309685A2/fr not_active Withdrawn
- 2001-07-09 AU AU2001271973A patent/AU2001271973A1/en not_active Abandoned
- 2001-07-09 JP JP2002514188A patent/JP2004516013A/ja not_active Withdrawn
- 2001-07-09 WO PCT/US2001/021735 patent/WO2002008284A2/fr active Search and Examination
-
2008
- 2008-07-29 JP JP2008194721A patent/JP2009039118A/ja not_active Withdrawn
- 2008-07-29 JP JP2008194678A patent/JP2009039117A/ja not_active Withdrawn
- 2008-07-29 JP JP2008194764A patent/JP2009039119A/ja not_active Withdrawn
-
2011
- 2011-08-08 JP JP2011173336A patent/JP6033531B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2009039119A (ja) | 2009-02-26 |
WO2002008284A3 (fr) | 2003-03-13 |
JP2012005493A (ja) | 2012-01-12 |
WO2002008284A2 (fr) | 2002-01-31 |
JP2009039118A (ja) | 2009-02-26 |
JP2004516013A (ja) | 2004-06-03 |
JP2009039117A (ja) | 2009-02-26 |
AU2001271973A1 (en) | 2002-02-05 |
JP6033531B2 (ja) | 2016-11-30 |
EP1309685A2 (fr) | 2003-05-14 |
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EEER | Examination request | ||
FZDE | Discontinued |