WO2001065939A1 - Compositions bactericides comprenant un sel d'ammonium quaternaire - Google Patents

Compositions bactericides comprenant un sel d'ammonium quaternaire Download PDF

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Publication number
WO2001065939A1
WO2001065939A1 PCT/EP2001/001274 EP0101274W WO0165939A1 WO 2001065939 A1 WO2001065939 A1 WO 2001065939A1 EP 0101274 W EP0101274 W EP 0101274W WO 0165939 A1 WO0165939 A1 WO 0165939A1
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WO
WIPO (PCT)
Prior art keywords
compositions according
composition
bactericidal compositions
partial
hydrogen peroxide
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PCT/EP2001/001274
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English (en)
Inventor
Alexander Martin
Nicola Rogers
Gianluca Luccini
Marco Oliva
Original Assignee
Unilever N.V.
Unilever Plc
Hindustan Lever Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from GB0012831A external-priority patent/GB0012831D0/en
Application filed by Unilever N.V., Unilever Plc, Hindustan Lever Ltd filed Critical Unilever N.V.
Priority to AU2001246423A priority Critical patent/AU2001246423A1/en
Publication of WO2001065939A1 publication Critical patent/WO2001065939A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds

Definitions

  • the invention relates to bactericidal and cleaning compositions comprising a quaternary ammonium salt, a sequestering agent and hydrogen peroxide. Particularly the invention relates to bactericidal compositions comprising a benzalkonium salt as the quaternary ammonium compound.
  • compositions which act against micro-organisms o surfaces are those which contain active chlorine, the most common being sodium hypochlorite, which is widely used in cleaning compositions to assist m cleaning through reaction with soils and stains, and to kill microorganisms.
  • hypochlorite has an unpleasant odour and, when accidentally mixed with an acidic product can liberate toxic amounts of chlorine gas. Therefore there is a need for alternative bactericidal compositions.
  • Customary solutions containing 1% by weight or more of such quaternary ammonium salts have useful bactericidal properties when used as such e.g. for cleaning and disinfecting hard surfaces. More specifically US
  • 3,507,796 discloses antibacterial compositions comprising any one of a large number of chelating agents, any one of a large group of organic cation forming compounds, including quaternary ammonium salts, an alkaline buffer and a zwitterionic surfactant.
  • Phosphates are mentioned as being useful because they provide buffering and chelation at the same time.
  • a number of chelating agents were tested in the examples and EDTA and similar organic compounds rated the best, which is not surprising as they are known to have the highest Ca and Mg complexing power; several orders of magnitude higher than e.g. tripolyphosphate .
  • EP-A-0 175 338 discloses disinfecting compositions comprising dodecyl-dimethyl-benzyl-ammonium salt and preferably a chelating agent chosen from a wide variety of possibilities, including phosphates.
  • the pH is preferably 6.5-8.5.
  • Chelating agents such as EDTA and similar compounds are more specifically exemplified as particularly effective .
  • Hydrogen peroxide and persulphate salts are known to have bactericidal activity particularly against Gram-negative bacteria.
  • an acidic desinfection composition is diclosed comprising hydrogen peroxide, an acidic phosphate, and a complexing (chelating) agent such as EDTA and a surfactant.
  • the compositions may also contain a disinfecting quaternary ammonium salt.
  • Hydrogen peroxide is also often used for its bleaching and stain removal power and for that purpose is most effective at alkaline pH, particularly at pH 9 and above.
  • hydrogen peroxide is preferably used in combination with bleach activators.
  • Hard surface cleaning products are generally aqueous liquids. In such products chemical instability of hydrogen peroxide at alkaline pH is a problem which can limit long term storage stability, particularly at the alkaline pH at which it shows its greatest bleaching activity.
  • US-A-3, 760, 986 discloses a dispensing bottle for dispensing two separate fluids to a common point.
  • a bottle is formed with an opening at the top and a divider extending through the interior of the bottle to define two compartments which provide dual reservoirs for fluids.
  • the apparatus disclosed further comprises a pump means to simultaneously withdraw fluid from each compartment, via separate draw tubes, and discharge the fluid to a common point.
  • This device enables an alkaline and an acid material to be stored separately and sprayed from a single unit to a common point.
  • WO 95/16023 discloses a container comprising two chambers or reservoirs, one containing a liquid acid or neutral composition comprising a peroxide compound and the other containing a liquid alkaline composition.
  • the container is either provided with a spray system able to produce a single spray of a mixture of the two components or with a spray system providing simultaneous sprays of each component directed to the same point on a surface whereafter the components mix on the surface.
  • the resultant cleaning mixture is applied neat to the surface to be cleaned.
  • WO 97/31087 discloses a container comprising two chambers or reservoirs, one containing a liquid composition comprising a peroxygen bleach and the other containing a liquid composition comprising a builder or chelating agent and at least one of these liquids containing a pH adjusting agent which on mixing of the liquids brings the pH of the mixture to a value at which the peroxygen bleach is effectively cleaning as well as stable.
  • the peroxygen bleach is either a peracid or a persalt and the pH is between 9.0 and 11.5.
  • the two liquid compositions are mixed on delivery to the surface, preferably by a spray system. Again, the resultant cleaning mixture is applied neat to the surface to be cleaned.
  • Decomposition of hydrogen peroxide is often accompanied by evolution of oxygen gas and may therefore lead to foaming of a composition containing it, particularly if the composition also contains a surfactant.
  • Various antifoams are known in the art, however some of them are themselves susceptible to oxidation by hydrogen peroxide.
  • compositions which have bactericidal properties, also m high dilution and on soiled surfaces, against a broad range of bacteria, Gram-positive as well as Gram-negative bacteria, including relatively resistant species such as Pseudomonas aerugxnosa .
  • Such compositions should preferably contain a component which is able to prevent excessive foaming, also m the presence of easily foaming surfactants.
  • alkaline compositions comprising a benzalkonium salt, an inorganic phosphate sequestering agent and hydrogen peroxide have excellent bactericidal properties against a wide range of bacteria, also m high dilutions as are customary found m household cleaning situations.
  • the bactericidal properties of such compositions generally exceed those of comparable compositions containing EDTA instead of phosphate with one order of magnitude or more.
  • the compositions according tc the invention also have cleaning and stain removal properties.
  • the presence of the phosphate sequestering agent prevents the compositions from excessive foaming.
  • the invention provides alkaline bactericidal compositions comprising a benzalkonium salt, an inorganic phosphate sequestering agent and hydrogen peroxide.
  • the invention also provides a process for disinfecting a substrate comprising applying alkaline bactericidal compositions comprising a benzalkonium salt, an inorganic phosphate sequestering agent and hydrogen peroxide to such surfaces .
  • benzalkonium salts are defined as salts of inorganic or organic acids and a quaternary ammonium ion of the general structure:
  • Ri is a benzyl group of which the phenyl ring is optionally further substituted
  • R 2 is an alkyl group having 8-20 C-atoms and R 3 and R 4 independently represent a methyl or ethyl group.
  • Ri is a C1-C4 alkyl or unsubstituted benzyl group, more preferably unsubstituted.
  • R 2 has 8-18 carbon atoms, more preferably 10-16 carbon atoms.
  • R 3 and R 4 preferably are both methyl.
  • the corresponding anion may be derived from an organic or inorganic acid.
  • Very suitable anions are chloride, bromide, sulphate and tosylate.
  • Benzalkonium chloride is the best known example and abundantly available commercially.
  • compositions should contain at least 0.5% of the benzalkonium ion, preferably at least 1.0%, more preferably at least 2.0%, but preferably not more than 10%.
  • the inorganic phosphate sequestering agent may be any phosphate salt known to have sequestering properties, such as alkalimetal ortho-phosphate, pyrophosphate or polyphosphate . Alkalimetal (particularly sodium) tripolyphosphate is preferred.
  • the phosphate sequestering agent should be present m the compositions in a concentration of at least 0.5%, preferably at least 1.0%, more preferably at least 2.0%.
  • the preferred maximum amount of phosphate is 4%, more preferably 3%.
  • the ratio of benzalkonium ion to phosphate is preferable between 1 : 5 and 5 : 1
  • compositions according to the invention should have pH > 8, preferably pH > 8.5, more preferably pH > 9, most preferably ⁇ 9.5.
  • Suitable sources of alkalinity include alkalimetal hydroxides, carbonates, bicarbonates, ammonia, organic amines and the like.
  • the phosphate sequestering agent may itself provide sufficient alkalinity to obtain the desired pH.
  • compositions according to the invention also provide cleaning and stain removal action.
  • the invention also encompasses compositions which comprise a hydrogen peroxide precursor which provides hydrogen peroxide under the conditions of use.
  • the amount of hydrogen peroxide is preferably chosen such that the final composition will contain 0.05-5% active oxygen, more preferably 0.1-3%, most preferably at least 0.5%.
  • compositions according to the invention as defined above have good bactericidal properties even on soiled substrates and up to a dilution of 1:40 with ordinary tap water.
  • Such dilute solutions will often provide disinfection of the surface being effective even against Pseudomonas aeruginosa , i.e. provide log reduction m bacterial count of > 5.
  • Useful bactericidal properties may even be obtained on dilutuions of 1:100.
  • Such dilute solutions are also provided by the invention.
  • compositions may be used on a large variety of substrates, particularly household hard surfaces such as metal, ceramic, glass, plastic, stone, concrete, wooden and painted surfaces; laundry; curtains, carpets and other soft furnishings.
  • substrates particularly household hard surfaces such as metal, ceramic, glass, plastic, stone, concrete, wooden and painted surfaces; laundry; curtains, carpets and other soft furnishings.
  • a hydrogen peroxide solution is reasonably stable up to pH 10, although for longer term stability the pH should preferably not exceed 9.5, more preferably be at most 9.0, most preferably be at most 8.5 or even 8.0.
  • the compositions according to the invention may be provided as solids e.g. as a powder as granules or m tablet form. To the extend that a hydrogen peroxide precursor is available as a stable solid it can be incorporated in these solid compositions.
  • Stable solid hydrogen peroxide presursors such as perborate and percarbonate are well known in the art of laundry detergents. The solid compositions are dissolved in water to produce the bactericidal solution ready for final use.
  • compositions according to the invention may be provided as solutions m a suitable solvent, preferably water.
  • the pH ranges, specified above, at which hydrogen peroxide is stable m solution are at the lower end of, or even below, the pH range at which it is most active and at whicn the benzalkonium salt/phosphate combination is most bacte ⁇ cidally active.
  • a suitable arrangement to improve long term stability of the product it is therefore to provide separate peroxide solution and alkaline solution and mix them at the moment of actual use.
  • a suitable arrangement for this is to provide separate "partial" compositions which together contain all the required ingredients of the total composition and which are mixed ust before use.
  • the invention also provides liquid bactericidal compositions consisting of at least two liquid partial compositions which are held separate from each other in a single container comprising at least two chambers or reservoirs or compartments (hereinafter referred to as Chambers' ) wherein at least one partial composition comprises hydrogen peroxide, at least one partial composition comprises a benzalkonium salt, at least one partial composition comprises an inorganic phosphate sequestering agent and at least one partial composition other than that comprising the hydrogen peroxide comprises a alkaline pH adjusting compound which on mixing of the partial compositions is able to raise the pH of the final composition to a value at which both the benzalkonium chloride and the hydrogen peroxide are active.
  • Each partial composition has a pH such that the components of that partial composition are stable on storage.
  • the invention provides liquid bactericidal compositions obtained through mixing of the above mentioned liquid partial compositions. Also, the invention provides a container comprising two or more chambers holding the liquid partial compositions.
  • a ⁇ part ⁇ al composition' is defined as a solution of a component, or a mixture of more, but not all, components of the final composition, which solution is held m a separate chamber of the container containing the total composition. Two or more partial compositions together make up the final bactericidal composition according to this aspect of the invention.
  • a container suitable for holding the bactericidal compositions according to this aspect of the invention has at least as many separate chambers as the number of partial compositions making up the total composition.
  • Such container may have one outer wall embracing all chambers which are separated from each other by partion walls inside the container or, alternatively, it may be made up of a plurality of separate containers, equivalent to the chambers, which are held together by some external means, such as a connecting part of the walls or an adhesive sleeve surrounding them, m such a way that they can be held and handled as one container.
  • a dispensing system is provided such that each chamber is provided with an outlet opening through which the partial composition is dispensed.
  • outlet openings may all lead to a separate mixing chamber m which the dispensed amounts of the partial compositions mix just before being applied to the substrate or the cleaning solution through a dispensing opening m the mixing chamber.
  • the outlet openings may all lead to the outside of the container m such a way that the dispensed amounts of the partial compositions are all applied simultaneously to a disinfecting or cleaning solution or to the same area of the substrate so as to mix while being applied to the substrate or immediately after application onto the substrate.
  • the outlet openings will generally be positioned m close proximity to each other such that all partial compositions may be poured, squirted or sprayed onto the same area of the substrate m one action.
  • the outlet openings may be provided with a nozzle system designed to further improve the mixing of the partial components on leaving the container.
  • the container may be provided with a multiple spray system able to either produce a single spray of a mixture of all the partial compositions or simultaneous sprays of each partial composition directed to the same area of a substrate whereafter the partial compositions mix on the substrate.
  • the container preferably comprises no more than two chambers each holding a partial composition which compositions together make up the final bactericidal composition. This implies that for the same reasons the bactericidal compositions according to this aspect of the invention are preferably made up of two partial compositions. Additionally the container may comprise a mixing chamber as outlined above.
  • the amounts of the partial compositions making up the final composition need not necessarily all be equal as long as care is taken that the concentration of each component m each of the partial compositions is chosen such that on mixing of the envisaged amounts of the partial compositions the right concentration of each component is present m the final composition.
  • the volume of each chamber of the container is adapted to the amount of the partial composition contained m that chamber which is required to make up the total amount of the final composition.
  • the total liquid volume of the final composition to be obtained from the container m general will be determined by the total volume of the container, excluding the volume of the mixing chamber, if present.
  • the dispensing or outlet openings or other dispensing means of the various chambers m the container are dimensioned such that one single dispensing action dispenses the right amounts of all partial compositions necessary to properly make up the final m which each component is present m the required concentration.
  • the dispensing or spray system may be so dimensioned that the final composition is dispensed as a foam.
  • the containers will generally have a total volume of 0.1 - 2 liters, preferably at least 0.25 1, but preferably not more than 1.5 1. Also for practical purposes two-chamber containers preferably have chambers of about equal volume, holding about equal amounts of each of the two partial compositions.
  • the hydrogen peroxide is held in one partial composition at a pH at which it is stable while another partial composition contains a sufficient amount of an alkalising agent to make the total composition have the required pH.
  • the benzalkonium salt may be present in either or both of these partial compositions. Sometimes a small amount of nonionic surfactant can usefully be added to the partial composition contaning the benzalkonium salt to ensure complete solubilisation thereof.
  • the phosphate sequestering agent is preferably kept at alkaline pH.
  • compositions according to the invention may additionally contain detergent surfactants to provide them with even better cleaning properties and to improve their wetting properties on soiled surfaces.
  • surfactants are preferably present in a total amount of between 0.1 and 30%, more preferably between 0.5 and 20%, most preferably between 1 and 10%.
  • Surfactants may be chosen from a wide range of anionic, nonionic, cationic, amphote ⁇ c and zwitterionic surfactants well known in the art. However, m order to prevent adverse interaction between the benzalkonium ion and anionic surfactants, the latter should not be present in an amount exceeding 30% by weight of the cationic, preferably not exceeding 20%.
  • Suitable anionic surfactants are e.g. water-soluble salts, particularly alkali metal, alkaline earth metal and ammonium salts, of organic sulphate esters and sulphonic acids having in the molecular structure a C8-C22 alkyl radical or a C10-C22 alkaryl radical.
  • anionic surfactants are alkyl-benzene sulphonates such as those having a C9-C15 alkyl group attached to the benzene ring; secondary alkanesulphonates; sodium alkyl glyceryl ether sulphates, especially those ethers of the fatty alcohols derived from tallow and coconut oil; sodium fatty acid monoglyceride sulphates, especially those derived from coconut fatty acids; salts of 1-6 EO ethoxylated fatty alcohol sulphates; salts of 1-8 EO ethoxylated alkylphenol sulphates in which the alkyl radicals contain 4-14 C-atoms; the reaction product of fatty acids esterified with isethionic acid and neutralised with sodium hydroxide.
  • alkyl-benzene sulphonates such as those having a C9-C15 alkyl group attached to the benzene ring
  • secondary alkanesulphonates sodium alkyl glyceryl
  • the preferred water-soluble synthetic anionic surfactants are the alkyl benzene sulphonates, the olefin sulphonates, the alkyl sulphates, and the higher fatty acid monoglyceride sulphates.
  • fatty acids soaps are not very suitable for use in the cleaning compositions according to the invention.
  • hydrotropes which are known in the art specifically for their capacity to modify solution properties.
  • Well known examples of such compounds are the alkali metal salts of toluene-, xylene- and cumene-sulphonic acid and C6-C8 alkane sulphonic acids.
  • Suitable nonionic surfactants can be broadly described as compounds produced by the condensation of alkylene oxide groups, which are hydrophilic m nature, with an organic hydrophobic compound which may be aliphatic or alkylaromatic m nature.
  • the length of the hydrophilic or polyoxyalkylene radical which is attached to any particular hydrophobic group can be readily adjusted to yield a water-soluble or water dispersible compound having the desired balance between hydrophilic and hydrophobic elements.
  • Particular examples include the condensation products of straight chain or branched chain aliphatic alcohols having 8- 22 C-atoms with ethylene oxide, such as coconut oil fatty alcohol/ethylene oxide condensates having from 2 to 15 moles of ethylene oxide per mole of coconut alcohol; condensates of alkylphenols whose alkyl group contains 6-16 C-atoms with 2 to 25 moles of ethylene oxide per mole of alkylphenol; condensates of the reaction product of ethylenediamme and propylene oxide with ethylene oxide, the condensates containing from 40 to 80% of ethyleneoxy groups by weight and having a molecular weight of from 5,000 to 11,000.
  • tertiary amine oxides of general structure RRRN0 where one R is a C8-C22 alkyl group (preferably C8- C18) and the other Rs are each C1-C5 (preferably C1-C3) alkyl or hydroxyalkyl groups, for instance dimethyldodecylamme oxide
  • tertiary phosphme oxides of structure RRRP0 where one R is a C8-C22 alkyl group (preferably C8-C18) and the other Rs are each C1-C5 (preferably C1-C3) alkyl or hydroxyalkyl groups, for instance dimethyl-dodecylphosphme oxide
  • dialkyl sulphoxides of structure RRS0 where one R is a C10-C18 alkyl group and the other is methyl or ethyl, for instance methyltetradecyl sulphoxide
  • Suitable amphoteric surfactants are derivatives of aliphatic secondary and tertiary amines containing a C8-C18 alkyl group and an aliphatic group substituted by an anionic water- solubilismg group, for instance sodium 3-dodecyla ⁇ t ⁇ mo- propionate, sodium 3-dodecylammopropane sulphonate and sodium N-2-hydroxydodecyl-N-methyl taurate .
  • Suitable cationic surfactants are quaternary ammonium salts having at least one C8-C22 aliphatic or alkyl-aromatic group, e.g. dodecyl-trimethylammonium bromide or chloride, cetyltrimethyl-ammonium bromide or chloride, didecyl- dimethyl-ammonium bromide or chloride, octyl-benzyldimethyl- ammonium bromide or chloride. They may be used m addition to the benzalkonium salt, m an amount of up to 10%, preferably up to 8%, more preferably up to 6%
  • Suitable zwitterionic surfactants are derivatives of aliphatic quaternary ammonium, sulphomum and phosphonium compounds having a C8-C18 aliphatic group and an aliphatic group substituted by an anionic water-solubilismg group, for instance 3- (N, N-dimethyl-N-hexadecylammonium) propane-1- sulphonate betame, 3- (dodecyl-methyl-sulphonium) -propane-1- sulphonate betame and 3- (cetylmethyl-phosphonium) -ethane- sulphonate betame .
  • compositions according to the invention may also contain a thickening sytem which causes them to cling to non- horizontal hard surfaces when directly applied thereto. Thus they have an improved bactericidal action on such surfaces by increasing the contact time.
  • Suitable thickening systems may be formed by specific surfactants (or combinations of surfactants) , particularly nonionic surfactants, well known m the art.
  • certain thickening polymers may be used, such as certain natural gums, cellulose derivatives, polycarboxylates and other suitable polymers known the art.
  • the thickening system may comprise a polymeric thickening agent i.e. one of the many natural and synthetic polymers known the art for this purpose.
  • bactericidal compositions according to the invention may be present to further improve their cleaning or bactericidal properties, such as microbiocidally active compounds other than benzalkonium salt, or to improve their consumer appeal.
  • perfumes and dyes are included in the bactericidal compositions according to the invention.
  • perfumes and dyes are known m the art to have bactericidal properties as well.
  • perfumes and dyes are known m the art to have bactericidal properties as well.
  • Many other optional components customary the art of cleaning compositions may be present as well.
  • the bactericidal compositions, or the partial corpositions containing the hydrogen peroxide preferably also contains a small amount of a chelating agent particularly effective for binding transition metal ions, which could otherwise destabilise the hydrogen peroxide.
  • Preferred chelating agents are dipicolmic acid, hydroxyethylidene diphosphonic acid (Dequest 2010), ethylenediam e tetra (methylene-pnosphonic acid) (Dequest 2040), diethylene-triamme penta (methylene- phosphonic acid) (Dequest 2060) and similar organic phosphonates .
  • the activity of hydrogen peroxide could be further enhance ⁇ by the addition of activator compounds known tne art.
  • activator compounds known tne art it is well known to use acetylated amines and amides, of which TAED (tetracetyl-ethylenediamme) is prably the most well known example, m compositions containing sodium percarbonate or perborate.
  • Useful bleach activator compounds are the cationic nitriles, such as: the N-alkyl-ammonium acetonitriles, described in EP-A-0 303 520, EP-A-0 458 396, EP-A-0 464 880, WO 96/40661, WO 98/23533, DE 196 29 159 and EP-A-0 79C 244 and the cyanopy ⁇ dmium and pyridme-N-oxide compounds disclosed EP-A-0 806 473 and EP-A-0 819 673. Similarly useful cyano activator compounds are disclosed m EP-A-0 819 673 and DE 196 09 955.
  • Particularly useful bleach activator compounds are lmmes such as the sulfonim es described m US-A-5, 041, 232, US-A- and US-A-5, 047, 163, and quaternary lm e salts (inline quats) .
  • the lmme quats are generally described and many specific examples given m US-A-5, 360, 568 , US-A-5, 360, 569 and US-A-5, 478, 357. Further examples thereof are described in WO 96/34937, WO 97/10323, WO 98/16614 and US 5,710,116.
  • Preferred lmme quats are those having the 3,4-d ⁇ hydro- lsoquinoliniurri structure below:
  • RI and R2 may be hydrogen or a C1-C30 substituted or unsubstituted phenyl, aryl, heterocyclic ring, alkyl, cycloalkyl radical or a nitro, halo, cyano, alkoxy, carboxylic and carboalkoxy radical
  • R3 may be a C1-C30 unsubstituted or substituted phenyl, aryl, heterocyclic ring, alkyl and cycloalkyl radical.
  • RI may represent more than one substituent the aromatic ring. Representative examples of compounds according to the general structure (having one RI) are given the table below.
  • R3 is an alkyl group, such as methyl, or substituted alkyl group and/or wherein R2 is hydrogen or a C1-C5 alkyl or a phenyl group.
  • Examples of such lmine quats are N-methyl-3, - dihydroisoqu olmium salts and the corresponding quats which R2 are methyl or ethyl respectively. The latter are particularly advantageous when used m combination with hydrogen peroxide.
  • the counterion of the mine quat is preferably an ion which is stable the presence of hydrogen peroxide.
  • Examples 1 and 2 had pH 11.0 prior to dilution; examples 3-10 had pH 11.2 prior to dilution.
  • a result recorded as log 5 reduction represents the maximum log-reduction within the test limits.
  • Formulations were examined at 1 40 dilution. Contact times are 5 minutes. Test organisms were :
  • Gram -ve bacteria Esche ⁇ chia coli (Ec) Pseudomonas aerugmosa (Pa)
  • Gram +ve bacteria Staphylococcus aureus (Sa)
  • the reduction bacterial numbers is expressed on a log scale.
  • Peroxide is an anti-microbial agent especially against Gram -ve organisms. It is less effective against Gram +ve species, even the presence of anionic or nonionic surfactants.
  • CTAB Cetyl-trimethyl-ammonium bromide
  • PAS Primary alkyl sulphate Not determined

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Abstract

La présente invention concerne des compositions bactéricides alcalines qui comprennent un sel de benzalkonium, constitué d'un sel d'un acide inorganique ou organique et d'un ion d'ammonium quaternaire, de structure générale : R1R2R3R4N+, dans laquelle R¿1? représente un groupe phényle dont le cycle phénylique est éventuellement encore substitué, R2 représente un groupe alkyle ayant de 8 à 20 atomes de C et R3 et R4 représentent indépendamment un groupe méthyle ou éthyle, ainsi qu'un agent séquestrant à base de phosphate inorganique et du peroxyde d'hydrogène. Dans ledit sel de benzalkonium, R1 représente de préférence un benzyle non substitué, R3 et R4 représentent indépendamment de préférence un méthyle et le phosphate inorganique est de préférence un tripolyphosphate de sodium. Les compositions selon cette invention comprennent également de préférence un ou plusieurs agents tensio-actifs, tels que des agents tensio-actifs non ioniques.
PCT/EP2001/001274 2000-03-09 2001-02-06 Compositions bactericides comprenant un sel d'ammonium quaternaire WO2001065939A1 (fr)

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AU2001246423A AU2001246423A1 (en) 2000-03-09 2001-02-06 Bactericidal compositions comprising a quaternary ammonium salt

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP00301936.1 2000-03-09
EP00301936 2000-03-09
GB0012831A GB0012831D0 (en) 2000-05-25 2000-05-25 Cleaning compositions
GB0012831.4 2000-05-25

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008049616A1 (fr) * 2006-10-25 2008-05-02 Lonza Inc. Compositions de phosphonium et d'ammonium quaternaires aqueuses à mousse contrôlée
WO2009054540A1 (fr) 2007-10-26 2009-04-30 Kao Corporation Composition antifongique
US7658953B2 (en) 2006-01-13 2010-02-09 Aseptix Research B.V. Enhanced activity biocidal hydrogen peroxide composition
WO2010035008A2 (fr) * 2008-09-26 2010-04-01 Deonissi Limited Composition
WO2015104687A1 (fr) * 2014-01-13 2015-07-16 99 Holding S.A.R.L. Composition de biocide de peroxyde d'hydrogène activé
EP2785389A4 (fr) * 2011-11-28 2016-01-27 Hyprotek Inc Composition antimicrobienne comportant une pellicule ou une protection résiduelle
WO2016040230A1 (fr) * 2014-09-09 2016-03-17 Lonza, Inc. Composition désinfectante contenant des composés d'ammonium quaternaire
WO2016123716A1 (fr) * 2015-02-06 2016-08-11 Microbio Solutions Inc. Composition antimicrobienne
US10010072B2 (en) 2007-12-17 2018-07-03 Novapharm Research (Australia) Pty Ltd. Viricidal composition
CN114403144A (zh) * 2022-01-21 2022-04-29 广州蓝月亮实业有限公司 一种杀灭微生物的季铵盐组合物及其制备方法和应用

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WO2008049616A1 (fr) * 2006-10-25 2008-05-02 Lonza Inc. Compositions de phosphonium et d'ammonium quaternaires aqueuses à mousse contrôlée
WO2009054540A1 (fr) 2007-10-26 2009-04-30 Kao Corporation Composition antifongique
EP2206430A1 (fr) * 2007-10-26 2010-07-14 Kao Corporation Composition antifongique
EP2206430A4 (fr) * 2007-10-26 2012-08-22 Kao Corp Composition antifongique
US10010072B2 (en) 2007-12-17 2018-07-03 Novapharm Research (Australia) Pty Ltd. Viricidal composition
EP2227084B1 (fr) * 2007-12-17 2020-06-03 Novapharm Research (Australia) Pty. Limited Composition viricide
WO2010035008A2 (fr) * 2008-09-26 2010-04-01 Deonissi Limited Composition
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US10894153B2 (en) 2011-11-28 2021-01-19 Hyprotek, Inc. Port and surface cleaning devices and techniques
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EP2785389A4 (fr) * 2011-11-28 2016-01-27 Hyprotek Inc Composition antimicrobienne comportant une pellicule ou une protection résiduelle
US10238856B2 (en) 2011-11-28 2019-03-26 Hyprotek, Inc. Port and surface cleaning devices and techniques
US10207098B2 (en) 2011-11-28 2019-02-19 Hyprotek, Inc. Catheter devices and techniques
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WO2015104687A1 (fr) * 2014-01-13 2015-07-16 99 Holding S.A.R.L. Composition de biocide de peroxyde d'hydrogène activé
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JP7149072B6 (ja) 2014-09-09 2024-02-02 アークサーダ・リミテッド・ライアビリティ・カンパニー 四級アンモニウム化合物を含有する消毒組成物
US10136645B2 (en) 2015-02-06 2018-11-27 Microbio Solutions Inc. Antimicrobial composition
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CN114403144A (zh) * 2022-01-21 2022-04-29 广州蓝月亮实业有限公司 一种杀灭微生物的季铵盐组合物及其制备方法和应用
CN114403144B (zh) * 2022-01-21 2024-01-19 广州蓝月亮实业有限公司 一种杀灭微生物的季铵盐组合物及其制备方法和应用

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