WO2001062941A3 - Regulation of human gelatinase b-like enzyme 2 - Google Patents

Regulation of human gelatinase b-like enzyme 2 Download PDF

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Publication number
WO2001062941A3
WO2001062941A3 PCT/EP2001/001995 EP0101995W WO0162941A3 WO 2001062941 A3 WO2001062941 A3 WO 2001062941A3 EP 0101995 W EP0101995 W EP 0101995W WO 0162941 A3 WO0162941 A3 WO 0162941A3
Authority
WO
WIPO (PCT)
Prior art keywords
enzyme
regulation
human gelatinase
reagents
gelatinase
Prior art date
Application number
PCT/EP2001/001995
Other languages
French (fr)
Other versions
WO2001062941A2 (en
Inventor
Shyam Ramakrishnan
Original Assignee
Bayer Ag
Shyam Ramakrishnan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Shyam Ramakrishnan filed Critical Bayer Ag
Priority to AU2001240648A priority Critical patent/AU2001240648A1/en
Publication of WO2001062941A2 publication Critical patent/WO2001062941A2/en
Publication of WO2001062941A3 publication Critical patent/WO2001062941A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Reagents which regulate human gelatinase B-like enzyme 2 activity and reagents which bind to human gelatinase B-like enzyme 2 gene products can be used to regulate extracellular matrix degradation. Such regulation is particularly useful for treating metastasis of malignant cells, tumor angiogenesis, inflammation, atherosclerosis, neurodegenerative diseases, and pathogenic infections.
PCT/EP2001/001995 2000-02-24 2001-02-22 Regulation of human gelatinase b-like enzyme 2 WO2001062941A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001240648A AU2001240648A1 (en) 2000-02-24 2001-02-22 Regulation of human gelatinase b-like enzyme 2

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18466200P 2000-02-24 2000-02-24
US60/184,662 2000-02-24

Publications (2)

Publication Number Publication Date
WO2001062941A2 WO2001062941A2 (en) 2001-08-30
WO2001062941A3 true WO2001062941A3 (en) 2001-12-20

Family

ID=22677824

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/001995 WO2001062941A2 (en) 2000-02-24 2001-02-22 Regulation of human gelatinase b-like enzyme 2

Country Status (2)

Country Link
AU (1) AU2001240648A1 (en)
WO (1) WO2001062941A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0733369A1 (en) * 1995-03-23 1996-09-25 Stichting REGA V.Z.W. Protease inhibitors, a DNA construct for the expression of a protease and a process for measuring proteases and/or protease inhibitors
EP0736302A2 (en) * 1995-03-23 1996-10-09 Stichting REGA V.Z.W. Protease inhibitors, a DNA construct for the expression of a protease and a process for measuring proteases and/or protease inhibitors
WO2001062904A1 (en) * 2000-02-24 2001-08-30 Bayer Aktiengesellschaft Regulation of human gelatinase b-like enzyme 1

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0733369A1 (en) * 1995-03-23 1996-09-25 Stichting REGA V.Z.W. Protease inhibitors, a DNA construct for the expression of a protease and a process for measuring proteases and/or protease inhibitors
EP0736302A2 (en) * 1995-03-23 1996-10-09 Stichting REGA V.Z.W. Protease inhibitors, a DNA construct for the expression of a protease and a process for measuring proteases and/or protease inhibitors
WO2001062904A1 (en) * 2000-02-24 2001-08-30 Bayer Aktiengesellschaft Regulation of human gelatinase b-like enzyme 1

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EM_GSS [online] EMBL; 4 September 1998 (1998-09-04), SHAKER ET AL.: "HS_2171_B1_B11_MF CIT Approved Human Genomic Sperm Library D Homo sapiens genomic clone Plate=2171 Col=21 Row=D, genomic survey sequence", XP002177339, retrieved from EBI accession no. AQ125427 Database accession no. AQ125427 *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA, vol. 96, no. 17, 1999, pages 9739 - 9744 *
XIA YIYANG ET AL: "Cloning of rat 92-kDa type IV collagenase and expression of an active recombinant catalytic domain", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 382, no. 3, 1996, pages 285 - 288, XP002173233, ISSN: 0014-5793 *
YANG MAOZHOU ET AL: "A novel matrix metalloproteinase gene (XMMP) encoding vitronectin-like motifs is transiently expressed in Xenopus laevis early embryo development", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 21, 1997, pages 13527 - 13533, XP002173232, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
AU2001240648A1 (en) 2001-09-03
WO2001062941A2 (en) 2001-08-30

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