WO2002008392A3 - Regulation of human matriptase-like serine protease - Google Patents

Regulation of human matriptase-like serine protease Download PDF

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Publication number
WO2002008392A3
WO2002008392A3 PCT/EP2001/008182 EP0108182W WO0208392A3 WO 2002008392 A3 WO2002008392 A3 WO 2002008392A3 EP 0108182 W EP0108182 W EP 0108182W WO 0208392 A3 WO0208392 A3 WO 0208392A3
Authority
WO
WIPO (PCT)
Prior art keywords
serine protease
regulation
human matriptase
reagents
matriptase
Prior art date
Application number
PCT/EP2001/008182
Other languages
French (fr)
Other versions
WO2002008392A2 (en
Inventor
Yonghong Xiao
Original Assignee
Bayer Ag
Yonghong Xiao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Yonghong Xiao filed Critical Bayer Ag
Priority to AU2001278488A priority Critical patent/AU2001278488A1/en
Publication of WO2002008392A2 publication Critical patent/WO2002008392A2/en
Publication of WO2002008392A3 publication Critical patent/WO2002008392A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Reagents which regulate human matriptase-like serine protease activity and reagents which bind to human matriptase-like serine protease gene products can be used to regulate extracellular matrix degradation. Such regulation is particularly useful for treating cancer, including metastasis of malignant cells, chronic obstructive pulmonary disease, disorders of the peripheral or central nervous system, and cardiovascular disorders.
PCT/EP2001/008182 2000-07-25 2001-07-16 Regulation of human matriptase-like serine protease WO2002008392A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001278488A AU2001278488A1 (en) 2000-07-25 2001-07-16 Regulation of human matriptase-like serine protease

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22080700P 2000-07-25 2000-07-25
US60/220,807 2000-07-25
US28010901P 2001-04-02 2001-04-02
US60/280,109 2001-04-02

Publications (2)

Publication Number Publication Date
WO2002008392A2 WO2002008392A2 (en) 2002-01-31
WO2002008392A3 true WO2002008392A3 (en) 2002-11-21

Family

ID=26915210

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/008182 WO2002008392A2 (en) 2000-07-25 2001-07-16 Regulation of human matriptase-like serine protease

Country Status (2)

Country Link
AU (1) AU2001278488A1 (en)
WO (1) WO2002008392A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9290757B2 (en) 2006-07-05 2016-03-22 Catalyst Biosciences, Inc. Protease screening methods and proteases identified thereby
US9359598B2 (en) 2004-04-12 2016-06-07 Catalyst Biosciences, Inc. Mutant MT-SP1 proteases with altered substrate specificity or activity

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8573401A (en) * 2000-06-12 2001-12-24 Bayer Aktiengesellschaft Regulation of human epithin-like serine protease
US7157596B2 (en) 2000-09-08 2007-01-02 Dendreon Corporation Inhibitors of serine protease activity of matriptase or MTSP1
WO2003064641A1 (en) * 2002-01-30 2003-08-07 Geneprot, Inc. Gene encoding serine proteases
WO2003104394A2 (en) * 2002-05-21 2003-12-18 Dendreon San Diego Llc Nucleic acid molecules encoding a transmembrane serine protease 12, the encoded polypeptides and methods based thereon
EP1544304A4 (en) * 2002-07-31 2006-05-10 Astellas Pharma Inc Novel serine protease
US7939304B2 (en) 2002-10-02 2011-05-10 Catalyst Biosciences, Inc. Mutant MT-SP1 proteases with altered substrate specificity or activity
US7019019B2 (en) 2002-12-23 2006-03-28 Dendreon Corporation Matriptase inhibitors and methods of use
US7439226B2 (en) 2003-09-30 2008-10-21 The United States Of America As Represented By The Department Of Health And Human Services Serine protease inhibitors
CA2626356C (en) 2005-10-21 2017-08-22 Catalyst Biosciences, Inc. Modified proteases that inhibit complement activation
GB0916576D0 (en) * 2009-09-22 2009-10-28 Malmsten Nils M Polypeptides and uses thereof
DK3137595T3 (en) 2014-04-29 2019-06-17 Novartis Ag New vertebrate cells and methods for recombinant expression of a polypeptide of interest

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061748A1 (en) * 1999-04-09 2000-10-19 Human Genome Sciences, Inc. 48 human secreted proteins
WO2001057190A2 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2001075067A2 (en) * 2000-03-31 2001-10-11 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2001079466A2 (en) * 2000-04-18 2001-10-25 Bayer Aktiengesellschaft Regulation of human epithin-like serine protease
WO2001096378A2 (en) * 2000-06-12 2001-12-20 Bayer Aktiengesellschaft Human epithin-like serine protease
WO2002000860A2 (en) * 2000-06-26 2002-01-03 Sugen, Inc. Novel proteases

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061748A1 (en) * 1999-04-09 2000-10-19 Human Genome Sciences, Inc. 48 human secreted proteins
WO2001057190A2 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2001075067A2 (en) * 2000-03-31 2001-10-11 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2001079466A2 (en) * 2000-04-18 2001-10-25 Bayer Aktiengesellschaft Regulation of human epithin-like serine protease
WO2001096378A2 (en) * 2000-06-12 2001-12-20 Bayer Aktiengesellschaft Human epithin-like serine protease
WO2002000860A2 (en) * 2000-06-26 2002-01-03 Sugen, Inc. Novel proteases

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 13 February 2002 (2002-02-13), XP002212634, Database accession no. AAS85946 *
DATABASE EMBL [online] 13 February 2002 (2002-02-13), XP002212635, Database accession no. AAS85947 *
DATABASE EMBL [online] 18 February 2002 (2002-02-18), XP002212636, Database accession no. ABG21759 *
DATABASE EMBL [online] 8 October 1999 (1999-10-08), DOE JOINT GENOME INSTITUTE STANFORD HUMAN GENOME CENTER: "Home sapiens chromosome 19 clone LLNLF-208A9", XP002212633, Database accession no. AC011522 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9359598B2 (en) 2004-04-12 2016-06-07 Catalyst Biosciences, Inc. Mutant MT-SP1 proteases with altered substrate specificity or activity
US9290757B2 (en) 2006-07-05 2016-03-22 Catalyst Biosciences, Inc. Protease screening methods and proteases identified thereby

Also Published As

Publication number Publication date
WO2002008392A2 (en) 2002-01-31
AU2001278488A1 (en) 2002-02-05

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