WO2001062209A2 - Agent de nettoyage dentaire contenant du gaz propulseur - Google Patents

Agent de nettoyage dentaire contenant du gaz propulseur Download PDF

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Publication number
WO2001062209A2
WO2001062209A2 PCT/EP2001/001721 EP0101721W WO0162209A2 WO 2001062209 A2 WO2001062209 A2 WO 2001062209A2 EP 0101721 W EP0101721 W EP 0101721W WO 0162209 A2 WO0162209 A2 WO 0162209A2
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Prior art keywords
weight
agent according
cleaning agent
propellant gas
tooth cleaning
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PCT/EP2001/001721
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German (de)
English (en)
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WO2001062209A3 (fr
Inventor
Hans-Theo Leinen
Guido Poschen
Peter Wülknitz
Christian Bressler
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Henkel Kommanditgesellschaft Auf Aktien
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Priority to AU2001233770A priority Critical patent/AU2001233770A1/en
Publication of WO2001062209A2 publication Critical patent/WO2001062209A2/fr
Publication of WO2001062209A3 publication Critical patent/WO2001062209A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams

Definitions

  • the invention relates to a propellant-containing tooth cleaning and care agent in a dispenser system, which is released as a paste or gel strand when a valve is actuated and then swells slowly through the release of the propellant gas and develops a fine-bubble, stable foam.
  • Tooth cleaning agents are available in various forms and primarily serve to clean the tooth surface ; and prevention of tooth and gum disease. They usually contain a combination of polishing agents, humectants, surfactants, binders, flavorings and fluoride-containing and anti-microbial agents.
  • tooth cleaning agents are mainly offered in paste, cream and translucent or transparent gel form.
  • liquid or liquid toothpastes and mouthwashes have also become increasingly important.
  • a disadvantage of the products in paste, cream or gel form is their comparatively high viscosity and the resulting poor spreadability and slow release of the active ingredients and flavorings.
  • Foamed toothpastes which are usually dispensed from aerosol dispensers, improve the spreadability.
  • Such formulations are known from WO 99/22704, WO 82/03975, EP 0 208 009, AU 8542824, DE 2 217 953, DE 36 23 934, JP 5714520 A and JP 5714521 A.
  • CFCs, carbon dioxide, oxygen and low-boiling hydrocarbons are used as propellants.
  • fluorine-chlorine hydrocarbons CFCs
  • toothpaste foams are emulsions or dispersions that are released from the dispensers in an already foamed form.
  • the task was therefore to develop a dentifrice and care product with improved spreadability, which is initially dispensed from a dispenser as a non-foamed or only slightly foamed, and then gradually - especially when applied in the mouth - with a mousse-like, "tingling" foam
  • Another task was to optimize the composition in such a way that the propellant gas and toothpaste base form a stable dispersion that does not separate or blocks the line system of the dispenser.
  • a tooth cleaning agent containing a) at least one polishing agent b) at least one humectant c) at least one surfactant d) at least one oil / fat and / or wax component, characterized in that it is used together with a propellant gas or propellant gas mixture in a dispenser system is filled with a manually operated valve.
  • compositions according to the invention are stable against separation of the propellant gas / propellant gas mixture. Blockage of the donor's piping does not occur.
  • the composition according to the invention is dispensed from the dispenser in the form of a gel-like, not or only slightly foamed strand which forms an extremely stable, fine-bubble mousse through the gradual escape of the propellant gas / propellant gas mixture. This ensures a higher amount of active ingredient compared to preparations that are taken directly from the donors as voluminous foam.
  • the proportion of water in the composition according to the invention is 1-60% by weight, preferably 5-50% by weight and in particular 30-50% by weight.
  • the tooth cleaning agent usually has a pH of 5.5-9, preferably 6.5-8.0 and in particular 7.0-7.3.
  • compositions according to the invention are suitable for cleaning and caring for the teeth and for preventing gum and gum diseases.
  • the agent according to the invention without propellant gas at 25 ° C has a viscosity of at least 10,000 mPa-s (Brookfield rotational viscometer RVF, spindle 3 or 4 at 4rpm), which ensures the dimensional stability after removal of the agent from the dispenser, d. H. in particular prevents flow.
  • the agent can directly, e.g. B. be applied with a toothbrush, but is also particularly suitable as a mouthwash when diluted with water, since the fine foam is very easily dispersible in water.
  • compositions according to the invention can be filled together with the propellant gas using commercially available filling systems through the valve head opening of the dispenser, it is advantageous that the viscosity of the agent without propellant gas at 25 ° C is not higher than 100,000 mPa-s, with a range of 10,000 - 80,000 mPa-s and in particular between 10,000 and 50,000 mPa-s is preferred (Brookfield rotational viscometer RVF, spindle 3 - 5 at 4rpm).
  • Another object of the invention is a method for dental care and cleaning, characterized in that from a dispenser system, by manually actuating a valve, a toothpaste strand that is not or only slightly foamed is applied to an object suitable for mechanical cleaning of the teeth, the toothpaste strand at 20 ° C and normal pressure has an expansion rate of not more than 100% by volume in 5 seconds and then expands to not more than 6 times its volume in a period of 10-100 seconds, and the gas-containing tooth pasta mousse used to clean the tooth surfaces, interdental spaces and the oral cavity.
  • Water-insoluble inorganic substances are usually used as polishing agents, cleaning agents or abrasives, which mechanically remove the plaque without damaging the enamel or dentin.
  • polishing agents cleaning agents or abrasives, which mechanically remove the plaque without damaging the enamel or dentin.
  • the polishing agent is used in the compositions according to the invention in an amount of 5 to 50% by weight, preferably 8 to 30% by weight and in particular 10 to 20% by weight, based on the total composition. It is often particularly advantageous to use a combination of polishing agents.
  • water-insoluble metaphosphates such as z. B. sodium metaphosphate, calcium phosphates such. B. tricalcium phosphate, calcium hydrogen phosphate, calcium hydrogen phosphate dihydrate and calcium pyrophosphate, calcium carbonate (chalk), magnesium carbonate, magnesium dihydrogen phosphate, trimagnesium phosphate, aluminum oxide, calcined aluminum oxide, aluminum hydroxide and aluminum oxide hydrates, hydroxyapatite and various silicates.
  • Sodium bicarbonate can also be used as a polishing agent according to the invention, in particular in a mixture with other polishing agents.
  • the composition preferably contains at least one compound from the group of silicas or silicates as the polishing agent.
  • silicic acid polishing agents precipitated and gel silicic acids are preferred because their properties can be varied widely during manufacture and are particularly well tolerated with fluoride active substances. They are also particularly suitable for the production of gel or liquid toothpastes.
  • Gel silicas are produced by reacting sodium silicate solutions with strong aqueous mineral acids to form a hydrosol, aging to the hydrogel, washing and subsequent drying. If drying is carried out under gentle conditions to water contents of 15-35% by weight, so-called hydrogel silicas are obtained, as are known, for example, from US Pat. No. 4,153,680.
  • xerogel silicas are e.g. B. described in US 3,538,230.
  • Precipitated silicas are produced from aqueous alkali silicate solutions by precipitation with mineral acids and under conditions in which aggregation to form sol and gel cannot occur.
  • Suitable processes for the preparation of precipitated silicas are e.g. B. in DE-OS 25 22 486 and described in DE-OS 31 14 493.
  • suitable silica abrasives include, for example, under the name ® Sident 8, Zeodent ® 113 and 623, Sorbosil AC39 ®, Tixosü ® 123 and 73 commercially.
  • polishes among the silicates.
  • Sodium aluminum silicates can also be suitable as polishing agents, such as. B. synthetic zeolites, in particular zeolite A.
  • Particulate organic polymers e.g. B. polymethacrylate or polyethylene and polypropylene an average particle size of about 5 - 15 microns and an average molecular weight of 3000 g / mol can be used as a cleaning body.
  • Moisturizers are not only added to toothpastes to protect them from drying out, they also serve to provide consistency and low-temperature stability.
  • a moist holding agents can be used toxicologically harmless polyols, such as. B. sorbitol, xylitol, glycerin, mannitol, 1,2-propylene glycol or mixtures of these polyols.
  • Polyethylene glycols with molecular weights of 400-2000 can also be present in part as humectant components.
  • the agent according to the invention contains at least sorbitol, glycerol or xylitol or any mixture of these substances as a humectant.
  • the total composition contains the humectant or the mixture of humectants in an amount of 15-85% by weight, preferably 20-70% by weight and in particular 30-50% by weight.
  • the composition according to the invention preferably contains a mixture of humectants, in particular with a proportion of sorbitol / polyethylene glycol in a weight ratio of 10: (0.1-1).
  • a further improvement in the cleaning effect of the tooth cleaning agents according to the invention is achieved by adding a suitable surface-active surfactant or surfactant mixture.
  • a suitable surface-active surfactant or surfactant mixture A detailed list of suitable surfactants is given in U.S. 3,988,433 which are intended to be part of the disclosure of the present application.
  • the addition of surfactants also serves to generate a foam when brushing teeth and thus to better distribute active ingredients, to stabilize the polishing agent and propellant gas dispersion and to emulsify or solubilize the fats, oils, waxes and aroma oils.
  • the surfactant or surfactant mixture is used in the compositions according to the invention in an amount of 0.1-10% by weight, preferably 0.3-7% and in particular 1-5% by weight, based on the total composition.
  • the composition preferably contains a surfactant from the group of anionic surfactants, zwitterionic surfactants, amphoteric surfactants and nonionic surfactants or any mixture of these sur
  • Suitable surfactants with good foaming action are anionic surfactants, which also have a certain enzyme-inhibiting effect on the bacterial metabolism of the plaque. ben.
  • anionic surfactants include alkali or ammonium salts - in particular sodium salts of C 8 -C 8 -alkane carboxylic acids, of alkyl polyglycol ether sulfates with 12-16 C atoms in the linear alkyl group and 2-6 glycol ether groups in the molecule, of linear alkane (C ⁇ -C 18 ) sulfonates, sulfosuccinic acid monoalkyl (C 12 -C 18 ) esters, sulfated fatty acid monoglycerides, sulfated fatty acid alkanolamides, sulfoacetic acid alkyl (C 12 -C 16 ) esters, acyl sarcosines, acyl taurides and acyl isethionates each with 8
  • At least one anionic surfactant in particular a sodium alkyl sulfate with 12-18 C atoms in the alkyl group.
  • a surfactant is sodium lauryl sulfate which is, for example, under the name Texapon.RTM ® K1296 commercially.
  • Zwitterionic and ampholytic surfactants can also be used, preferably in combination with anionic surfactants.
  • the amphoteric surfactants which can be used according to the invention include, for. B. alkylaminopropane carboxylic acid.
  • the best known and most widespread group of zwitterionic surfactants is that of betaine surfactants, such as. B. alkyldimethylcarboxymethylbetaine and acylaminoalkyldimethylcarboxymethylbetaine. Cocosacylaminopropyldimethylammonium glycinates, known under the INCI name Cocamidopropylbetaine, are particularly suitable.
  • Such products are commercially available, for example, under the name Tego-Betain ® BL 215 and ZF 50 and Genagen ® CAB.
  • Non-ionic surfactants are particularly suitable for supporting the cleaning action, among which the addition products of ethylene oxide with fatty alcohols, with fatty acids, with fatty acid monoglycerides, with sorbitan fatty acid monoesters or with methyl glucoside fatty acid monoesters are preferred.
  • the amount of ethylene oxide added should be so high that the surfactants are water-soluble, ie at least 1 g of the product should be clearly soluble in 11 water at 20 ° C.
  • nonionic Surfactants are ethoxylated glyceryl monoalkyl esters with a degree of ethoxylation of 20-60 and a C 8 -C 18 alkyl chain, such as, for example, PEG-30 glyceryl stearate, which, for. B. is commercially available under the name Tagat ® S, and also acts as a solubilizer.
  • Suitable nonionic surfactants are also alkyl (oligo) glycosides with 8-16 carbon atoms in the alkyl group and a degree of oligomerization of the glycoside residue of 1-4 alkyl (oligo) glycosides.
  • Their preparation and use as surface-active substances are e.g. , B. from US-A-3,839,318, DE-A-20 36 472, EP-A-77 167 or WO-A-93/10132 known.
  • the degree of oligomerization is a statistical mean value which is based on a homolog distribution customary for such technical products.
  • an alkyl group suitable alkyl (oligo) glycoside is an alkyl (oligo) glucoside of the formula RO (C 6 H, 0 O) X -H, in which R 12 to 14 carbon atoms and x is a Has mean of 1 to 4.
  • Amine oxides can also be used as surfactants.
  • a mixture of anionic and nonionic surfactant or a mixture of anionic surfactant, nonionic surfactant and betaine is preferably used in the compositions according to the invention, for example sodium lauryl sulfate / PEG-30 glyceryl stearate / cocamidopropyl.
  • non-ionic solubilizers from the group of surface-active substances are used to improve the solubilization of the predominantly water-insoluble oil and wax components and the propellant gases.
  • these include in particular ethoxylated compounds with a degree of ethoxylation of 20-60.
  • Ethoxylated fatty acid glycerides, ethoxylated fatty acid sorbitan partial esters or fatty acid partial esters of glycerol or sorbitan ethoxylates are particularly suitable for this purpose.
  • Solubilizers from the group of ethoxylated fatty acid gly- cerides primarily include adducts of 20 to 60 moles of ethylene oxide with mono- and diglycerides of linear fatty acids with 12 to 18 carbon atoms or with triglycerides of hydroxy fatty acids such as oxystearic acid or ricinoleic acid.
  • Other suitable solubilizers are ethoxylated fatty acid sorbitan partial esters, e.g. B. Adducts of 20 to 60 moles of ethylene oxide with sorbitan monoesters and sorbitan diesters of fatty acids with 12 to 18 carbon atoms.
  • solubilizers are fatty acid partial esters of glycerol or sorbitan ethoxylates; the preferred are mono- and diesters of C I2 - C 18 fatty acids and addition products of 20 to 60 moles of ethylene oxide with 1 mole of glycerol or with 1 mol of sorbitol.
  • alkyl-trimethylammonium chloride alkyldimethylbenzylammonium chloride, alkylpyridinium chloride, alkyldimethylhyroxyethylammonium chloride, acylimidazolinium methosulfates and acyloxyethyltrimethylammonium chloride are suitable as surfactants in the agents according to the invention.
  • the oil fat and wax components are essential components of the composition according to the invention. In combination with the surfactants, they enable partial solubilization of the propellant gas or propellant gas mixture, stabilization of the foam and give the toothpaste base composition shine and smoothness.
  • natural, chemically modified and synthetic waxes, fats and oils can be used alone or in any combination.
  • the oil / fat and wax components are present in an amount of 0.1 to 10% by weight, based on the total composition, preferably 0.5 to 5% by weight and in particular 0.8 to 3% by weight. Oils / fats
  • the compositions of the invention comprise, as oil components triglycerides and / or a paraffin oil. These can be of vegetable, animal or synthetic origin.
  • Di- and triglycerides are the di- and triester of fatty acids with glycerin, ie acylglycerols, whereby the glycerin can be esterified with the same or with different fatty acids or fatty acid derivatives (eg lecithin).
  • the fatty acids are preferably C 6 -C 30 fatty acids, which can be saturated or unsaturated and branched or unbranched.
  • glycerol with naturally occurring fatty acids such as, for example, caproic acid, oenanthic acid, caprylic acid, pelargonic acid, capric acid, undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, margaric acid, stearic acid, nonadecanoic acid, arenic acid, arachinic acid , Lignoceric acid, cerotinic acid, melissic acid, 2-ethylhexanoic acid, isotridecanoic acid, isostearic acid, palmitoleic acid, oleic acid, elaidic acid, petroselinic acid, elaeostearic acid, erucic acid, linoleic acid, linolenic acid, arachidonic acid, clupanodonic acid and technical blends, docosaoleic acid and doco
  • natural fats and oils such as e.g. B. beef tallow, peanut oil, rape oil, cottonseed oil, soybean oil, sunflower oil, palm oil, palm kernel oil, linseed oil, almond oil, castor oil, corn oil, olive oil, rapeseed oil, sesame oil, cocoa butter and coconut oil and the like.
  • the hydrogenated or hardened oils e.g. B. hydrogenated soybean oil, castor oil and peanut oil can be used.
  • Thin to viscous silicone oils or natural and synthetic hydrocarbons such as thin to viscous paraffin can also be used according to the invention.
  • oils, isohexadecane, isoeicosane or polydecenes, e.g. B. are available under the name Emery ® 3004, 3006, 3010, Ethylflo ® or Nexbase ® 2004G.
  • inverse fats e.g. esters of vicinal tricarboxylic acids with C 6 -C 30 fatty alcohols
  • glyceryl trialkyethers is also conceivable here.
  • Waxes are understood to mean naturally or artificially obtained substances with the following properties: they have a firm to fragile hard consistency, coarse to fine crystalline, translucent to opaque, but not glassy, and melt without decomposition above 35 ° C. They are low viscosity and not stringy a little above the melting point and show a strongly temperature-dependent consistency and solubility. From a chemical point of view, the most common representatives from the wax group are esters from fatty acids and higher fatty alcohols, which are of animal and vegetable origin. Natural vegetable waxes, such as, for example, B.
  • the mineral waxes that can be used according to the invention also include the mineral waxes, such as. B.
  • waxes such as paraffin waxes (z. B. Vaseline) and micro waxes.
  • paraffin waxes z. B. Vaseline
  • micro waxes z. B. Vaseline
  • chemically modified waxes such as. B. Montanester waxes, Sasol waxes and hydrogenated jojoba waxes can be used.
  • the synthetic waxes which can be used according to the invention also include, for example, wax-like polyalkylene waxes and silicone waxes.
  • Synthetic waxes can also be used according to the invention, in particular the esters of C 6 -C 30 fatty acids with C 6 -C 30 fatty alcohols, which can be of natural or synthetic origin. Both the fatty acid component and the fatty alcohol component can be straight-chain or branched and saturated or mono- or polyunsaturated.
  • the wax component is preferably selected from the group of vegetable or animal and / or paraffin waxes or any mixture of these waxes.
  • the propellant gas or propellant gas mixture is preferably present in the compositions according to the invention in an amount of at least 1% by weight. A content of 1-10% by weight and in particular 3-4% by weight is particularly preferred.
  • the propellant gas or propellant mixture preferably contains at least one component which has a boiling point in the range from 0 to 40 ° C., preferably 15 to 35 ° C. and in particular 20 to 30 ° C. at normal pressure. In this way, a "post-foaming" effect can be produced in combination with the dispenser systems described below, hydrocarbon-containing propellants being particularly advantageous.
  • the propellant preferably contains a C 5 alkane.
  • Such formulations are still gel-like immediately after being dispensed from the dispenser and then swell gradually on the toothbrush to form a foam which is particularly at body temperature, that is, when the composition is applied inside the mouth, unfolds relatively quickly.
  • the tooth cleaning agents are filled in commercial filling systems together with the liquefied propellant gas or propellant gas mixture into dispenser systems which are sufficiently pressure-resistant that the propellant gas is liquefied in the composition.
  • a container for example, is suitable as a dispenser for the composition with valve made of a rigid material, which is equipped with a device which uses the contraction force of a stretched rubber hose and / or a stretched product container to eject the composition stored therein (i.e. dentifrice and propellant).
  • a dispenser is described for example in EP 69699.
  • the containers offered by 3D Dispenser-Distributions GmbH under the name FlexPack ® also use the restoring force of a stretched rubber to eject the composition.
  • containers which contain a folded, essentially gas-impermeable flexible inner bag made of a chemically inert plastic (for example PET) which is surrounded by an elastic, thick-walled rubber tube.
  • a chemically inert plastic for example PET
  • Such dispensers are described for example in US 5,927,551, US 4,964,540 and EP 69738 and are sold by the Exxel Container company under the name Atmos TM Dispensing System. In combination with such dispensers, pure butane as the propellant gas can already produce a "post-foaming" effect.
  • two-chamber aerosol cans with inner bags are preferably suitable as dispensers. These contain the contents (tooth cleaning agent with liquefied gas) in the inner bag and a further propellant gas in the outer chamber, which serves to expel the composition when the valve is actuated.
  • Such systems can either be filled through an opening in the bottom of the can or - as in the so-called "under cup system” - by lifting the valve.
  • the agent according to the invention additionally contains at least one binding or thickening agent.
  • Binding agents or thickeners have a consistency-regulating effect and help to prevent separation of the liquid and solid components. They are contained in the compositions according to the invention in a total amount of 0.1-5% by weight, preferably 0.1-3% by weight and in particular 0.5-2% by weight.
  • natural and / or synthetic water-soluble polymers such as alginates, carragenes, agar-agar, guar-gum, rubber are used arabicum, succinoglycan gum, guar flour, locust bean gum, tragacanth, karaya gum, xanthan, pectins, cellulose and their ionogenic and non-ionogenic derivatives such as B. carboxymethyl cellulose, hydroxyethyl cellulose or methyl hydroxypropyl cellulose, hydrophobically modified celluloses, starch and starch ethers.
  • natural and / or synthetic water-soluble polymers such as alginates, carragenes, agar-agar, guar-gum, rubber are used arabicum, succinoglycan gum, guar flour, locust bean gum, tragacanth, karaya gum, xanthan, pectins, cellulose and their ionogenic and non-ionogenic derivatives such as B. carboxymethyl
  • carboxyvinyl polymers for example Carbopol ® grades.
  • Polyvinyl alcohol, polyvinylpyrrolidone and high molecular weight polyethylene glycols are useful as binders and thickeners.
  • Layered silicates and finely divided silicas airgel silicas and pyrogenic silicas
  • Particularly suitable is powdered cellulose, which is offered for example, from J. Rettenmaier & Söhne under the name of Arbocel ® or Vitacel ®.
  • Arbocel ® CGP 5000 a highly viscous paste made of powder cellulose with thixotropic properties, is particularly preferably suitable according to the invention.
  • Arbocel ® celluloses are extremely effective thickeners, which increase the viscosity of the compositions considerably even at low use concentrations, are inert to ionic components and can be easily combined with other thickeners.
  • a further preferred embodiment of the tooth cleaning agent is characterized in that it contains anti-caries agents, antimicrobial agents, tartar inhibitors, remineralizing agents, flavoring agents or any combination of these substances as additional agents.
  • fluorine compounds are particularly suitable, preferably from the group of fluorides or monofluorophosphates in an amount of 0.1-0.5% by weight of fluorine.
  • Suitable fluorine compounds are e.g. As sodium fluoride, potassium fluoride, tin fluoride, disodium monofluorophosphate (Na 2 PO 3 F), dipotassium monofluorophosphate or the fluoride of an organic amino compound.
  • Antimicrobial agents are e.g. As sodium fluoride, potassium fluoride, tin fluoride, disodium monofluorophosphate (Na 2 PO 3 F), dipotassium monofluorophosphate or the fluoride of an organic amino compound.
  • antimicrobial component examples include, for. B. phenols, resorcinols, bisphenols, salicylanilides and amides and their halogenated derivatives, halogenated carbanilides and p-hydroxybenzoic acid esters.
  • antimicrobial components those which inhibit the growth of plaque bacteria are particularly suitable.
  • halogenated diphenyl ethers such as 2,4-dichloro-2'-hydroxydiphenyl ether, 4,4'-dichloro-2'-hydroxy diphenyl ether, 2,4,4 '-tribromo-2'-hydroxy diphenyl ether, 2,4,4 '-Trichlor-2' - hydroxydiphenyl ether (triclosan) suitable as antimicrobial agents.
  • bisbiguanides such as chlorhexidine and alexidine, phenylsalicylic acid esters and 5-amino-1,3-bis (2-ethylhexyl) hexahydro-5-methylpyrimidine (hexetidine)
  • zinc and copper ions also have an antimicrobial effect, with synergistic effects in particular in combination occur with hexetidine and triclosan.
  • Quaternary ammonium compounds such as. B. cetylpyridinium chloride, benzalkonium chloride, domiphen bromide and dequalinium chloride can be used.
  • Octapinol, octenidines and sanguinarine have also proven to be antimicrobial.
  • the antimicrobial active ingredients are preferably used in amounts of 0.01-1% by weight in the agents according to the invention and can also be used in the form of nanoparticles.
  • Irgacare ® MP is particularly preferred in an amount from 0.01 to 0.3 wt .-% is used.
  • Tartar is mineral deposits that are very similar to natural tooth enamel.
  • substances are added to the tooth cleaning agents according to the invention which specifically intervene in the crystal nucleation and prevent existing germs from continuing to grow.
  • These are, for example, condensed phosphates, which are preferably selected from the group of tripolyphosphates, pyrophophates, trimetaphosphates or mixtures thereof. They are used in the form of their alkali or ammonium salts, preferably in the form of their sodium or potassium salts.
  • Aqueous solutions of these phosphates typically have an alkaline reaction, so that the pH of the dentifrices according to the invention is adjusted to values of 7.5-9, if necessary by adding acid.
  • acids z. B.
  • citric acid, phosphoric acid or acid salts e.g. B. NaH 2 PO 4 can be used.
  • the desired pH of the dentifrice can also be achieved by adding acidic salts of the condensed phosphates, e.g. B. K 2 H 2 P 2 O 7 can be set.
  • Tartar inhibitors are usually used in amounts of 0.1-5% by weight, preferably 0.1-3% by weight and in particular 0.1-2% by weight in the agents according to the invention.
  • organophosphonates such as 1-azacycloheptane-2,2-diphosphonate (Na salt) or 1-hydroxyethane-1, 1-diphosphonate (Na salt) and zinc citrate.
  • the agents according to the invention preferably also contain substances which promote remineralization of the tooth enamel and are able to close dental lesions. These are usually contained in a total amount of 0.1-10% by weight, preferably 0.1-5% by weight and in particular 0.1-3% by weight. These include e.g. B. fluorides, phosphate salts of calcium such. As calcium glycerol phosphates, calcium hydrogen phosphate, hydroxyapatite, fluoroapatite, F-doped hydroxyapatite, dicalcium phosphate dihydrate and calcium fluoride. But also magnesium salts such as. B. magnesium sulfate, magnesium fluoride or magnesium monofluorophosphate have a remineralizing effect.
  • the agents according to the invention preferably contain flavorings, to which e.g. B. sweeteners and / or aromatic oils.
  • suitable sweeteners are saccharinates (in particular sodium saccharinate), cyclamates (in particular sodium cyclamate) and sucrose, lactose, maltose or fructose.
  • Aromatic oils that can be used are all natural and synthetic aromas that are common for oral and dental care products. Natural aromas can be used both in the form of the essential oils (mixture) isolated from the drugs and in the form of the individual components isolated from them.
  • At least one aromatic oil from the group peppermint oil, Spearmint oil, anise oil, star anise oil, caraway oil, eucalyptus oil, fennel oil, cinnamon oil, clove oil, geranium oil, sage oil, allspice oil, thyme oil, marjoram oil, basil oil, citrus oil, Gaultheria oil or one / more components of these oils isolated or synthetically produced.
  • aromatic oil from the group peppermint oil, Spearmint oil, anise oil, star anise oil, caraway oil, eucalyptus oil, fennel oil, cinnamon oil, clove oil, geranium oil, sage oil, allspice oil, thyme oil, marjoram oil, basil oil, citrus oil, Gaultheria oil or one / more components of these oils isolated or synthetically produced.
  • the most important components of the oils mentioned are e.g. B.
  • menthol carvone, anethole, cineol, eugenol, cinnamaldehyde, caryophyllene, geraniol, citronellol, linalool, salvos, thymol, terpinene, terpinol, methylchavicol and methyl salicylate.
  • suitable flavors are e.g. B. menthyl acetate, vanillin, jonone, linalyl acetate, rhodinol and piperiton.
  • a particularly preferred embodiment of the tooth cleaning agent contains a) 5-30% by weight of a polishing agent; b) 20-85% by weight of a humectant; c) 0.3-5% by weight of a surfactant or surfactant mixture; d) 0.1-40% by weight of an oil, fat and / or wax, e) 0.05-0.5% by weight of a fluoride; f) 5-50% by weight of water g) 1-10% by weight of a C 4 and / or C 5 -containing propellant gas or propellant gas mixture and in a dispenser system with a manually operable valve.
  • This combination enables a particularly good post-foaming effect and very easy distribution.
  • the agent according to the invention can preferably contain a number of further toothpaste ingredients. These include a .:
  • Vitamins e.g. B. retinol, biotin, tocopherol, ascorbic acid and their derivatives (e.g. esters, salts);
  • pigments e.g. B. titanium dioxide or zinc oxide
  • pH adjusting agents and buffer substances e.g. B. sodium citrate, sodium bicarbonate or potassium and sodium phosphates,
  • the dentifrice was prepared with degassing, i.e. H. in a moderate vacuum ( ⁇ 50 mbar), at room temperature.
  • the humectants, silicas and possibly other polishing agents were homogenized together with demineralized water in a vacuum with stirring.
  • the soluble salts and dyes were then added.
  • Cellulose - if used - was suspended in a little water and worked into the mass.
  • Organic binders e.g. xanthan gum etc.
  • the paste mass (90-99% by weight) was placed together with 1-10% by weight of the propellant gas / propellant gas mixture in the Atmos TM dispensing system (70 or 140 ml) from Exxel Container Inc. or in a two-chamber aerosol can bottled under the usual conditions for such systems (filling pressure: approx. 40 bar).
  • Example 1 composition without propellant
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • beeswax e.g. beeswax type 8100 DAB
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • carboxymethyl cellulose e.g. Cekol ® 2000 H
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. Brillant Blue FCF, 1% by weight in water
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropyl betaine e.g. Tego-Betain ® BL 215, 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • paraffin oil 1.0% by weight paraffin oil, low viscosity (e.g. Paraffinum perliquidum P 130)
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • xanthan gum e.g. Keltrol ® F
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. brilliant blue FCF, 1% by weight in water
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • beeswax e.g. beeswax type 8100 DAB
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • carboxymethyl cellulose e.g. Cekol ® 2000 H
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. Brillant Blue FCF, 1% by weight in water
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • paraffin oil e.g. Paraffinum perliquidum P 130
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • xanthan gum e.g. Keltrol ® F
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. Brillant Blue FCF, 1% by weight in water
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • xanthan gum e.g. Keltrol ® F
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. Brillant Blue FCF, 1% by weight in water
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • paraffin oil e.g. BP-Energol ® WM-6
  • viscous e.g. BP-Energol ® WM-6
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • carboxymethyl cellulose e.g. Cekol ® 2000H
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. brilliant blue FCF, 1% by weight in water
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • paraffin oil e.g. BP-Energol ® WM-6
  • viscous e.g. BP-Energol ® WM-6
  • glycerol monostearate e.g. Cutina ® GMS-V
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • xanthan gum e.g. Keltrol ® F
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. Brillant Blue FCF, 1% by weight in water
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • paraffin oil e.g. BP-Energol ® WM-6
  • viscous e.g. BP-Energol ® WM-6
  • glycerol monostearate e.g. Cutina ® GMS-V
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • xanthan gum e.g. Keltrol ® F
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. Brillant Blue FCF, 1% by weight in water
  • Süica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • cellulose e.g. Arbocel ® CGP 5000; 5% by weight in water
  • xanthan gum e.g. Keltrol ® F
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. combination of: Brillant Blue FCF, 1% by weight in
  • Example 10 composition without propellant
  • silica e.g. Sident ® 8
  • layered silicate e.g. Laponite ® DF
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • xanthan gum e.g. Keltrol ® F
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. combination of: Brillant Blue FCF, 1% by weight in
  • silica e.g. Sident ® 8
  • sorbitol e.g. Neosorb ® 70/70 B; 70% by weight in water
  • sodium lauryl sulfate e.g. Texapon ® K 1296
  • cocamidopropylbetaine e.g. Tego-Betain ® BL 215; 30% by weight in water
  • PEG-30 glyceryl stearate e.g. Tagat ® S
  • cellulose e.g. Arbocel ® CGP 5000; 5% by weight in water
  • xanthan gum e.g. Keltrol ® F
  • polyethylene glycol MG 1550 (e.g. Polywachs ® 1550)
  • triclosan e.g. Irgacare ® MP
  • dye solution e.g. combination of: Brillant Blue FCF, 1% by weight in

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Abstract

La présente invention concerne des agents de nettoyage dentaire comprenant des agents de polissage, des agents humidifiants et des agents tensioactifs en combinaison avec des huiles liquides ou des éléments cireux, et étant introduits dans un système de distribution à clapet en même temps que des gaz propulseurs.
PCT/EP2001/001721 2000-02-25 2001-02-16 Agent de nettoyage dentaire contenant du gaz propulseur WO2001062209A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001233770A AU2001233770A1 (en) 2000-02-25 2001-02-16 Dental cleaning agents containing propellant gas

Applications Claiming Priority (2)

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DE2000108837 DE10008837A1 (de) 2000-02-25 2000-02-25 Treibgashaltiges Zahnreinigungsmittel
DE10008837.6 2000-02-25

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EP1216688A2 (fr) * 2000-12-23 2002-06-26 Henkel Kommanditgesellschaft auf Aktien Crème dentifrice à demi-fluide
ITMI20081529A1 (it) * 2008-08-21 2010-02-22 Biotrading Di Mannone Maurizio Gius Eppe Metodo per la fluoroprofilassi dei denti mediante l'uso di una composizione spray a base di fluoro
EP2198836A1 (fr) * 2008-12-16 2010-06-23 Henkel AG & Co. KGaA Produit de soin et de nettoyage de la bouche et des dents reminéralisant comprenant une combinaison d'agents actifs spéciaux
US8337818B2 (en) 2004-11-03 2012-12-25 Colgate-Palmolive Company Post-foaming dental mousse and methods utilizing the same
WO2013139767A3 (fr) * 2012-03-19 2013-11-14 Arges Imaging, Inc. Application de motif de contraste pour imagerie tridimensionnelle
US8900553B2 (en) 2007-12-07 2014-12-02 Foamix Pharmaceuticals Ltd. Oil and liquid silicone foamable carriers and formulations
EP2732850A3 (fr) * 2012-11-19 2014-12-10 Henkel AG&Co. KGAA Crème dentaire finement moussante dotée d'une sensation en bouche améliorée
US9320705B2 (en) 2002-10-25 2016-04-26 Foamix Pharmaceuticals Ltd. Sensation modifying topical composition foam
US9622947B2 (en) 2002-10-25 2017-04-18 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US9636405B2 (en) 2003-08-04 2017-05-02 Foamix Pharmaceuticals Ltd. Foamable vehicle and pharmaceutical compositions thereof
US9662298B2 (en) 2007-08-07 2017-05-30 Foamix Pharmaceuticals Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US9668972B2 (en) * 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
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US9682021B2 (en) 2006-11-14 2017-06-20 Foamix Pharmaceuticals Ltd. Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US9713643B2 (en) 2002-10-25 2017-07-25 Foamix Pharmaceuticals Ltd. Foamable carriers
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
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US10092588B2 (en) 2009-07-29 2018-10-09 Foamix Pharmaceuticals Ltd. Foamable compositions, breakable foams and their uses
US10322085B2 (en) 2002-10-25 2019-06-18 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
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US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
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WO2009069006A2 (fr) 2007-11-30 2009-06-04 Foamix Ltd. Peroxyde de benzoyle contenant de la mousse
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EP1216688A2 (fr) * 2000-12-23 2002-06-26 Henkel Kommanditgesellschaft auf Aktien Crème dentifrice à demi-fluide
EP1216688A3 (fr) * 2000-12-23 2003-04-16 Henkel Kommanditgesellschaft auf Aktien Crème dentifrice à demi-fluide
US9713643B2 (en) 2002-10-25 2017-07-25 Foamix Pharmaceuticals Ltd. Foamable carriers
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US9622947B2 (en) 2002-10-25 2017-04-18 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US10322085B2 (en) 2002-10-25 2019-06-18 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US9668972B2 (en) * 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US9320705B2 (en) 2002-10-25 2016-04-26 Foamix Pharmaceuticals Ltd. Sensation modifying topical composition foam
US11033491B2 (en) 2002-10-25 2021-06-15 Vyne Therapeutics Inc. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
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US9636405B2 (en) 2003-08-04 2017-05-02 Foamix Pharmaceuticals Ltd. Foamable vehicle and pharmaceutical compositions thereof
US8337818B2 (en) 2004-11-03 2012-12-25 Colgate-Palmolive Company Post-foaming dental mousse and methods utilizing the same
US9682021B2 (en) 2006-11-14 2017-06-20 Foamix Pharmaceuticals Ltd. Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US10369102B2 (en) 2007-08-07 2019-08-06 Foamix Pharmaceuticals Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US9662298B2 (en) 2007-08-07 2017-05-30 Foamix Pharmaceuticals Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
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US11433025B2 (en) 2007-12-07 2022-09-06 Vyne Therapeutics Inc. Oil foamable carriers and formulations
ITMI20081529A1 (it) * 2008-08-21 2010-02-22 Biotrading Di Mannone Maurizio Gius Eppe Metodo per la fluoroprofilassi dei denti mediante l'uso di una composizione spray a base di fluoro
EP2198836A1 (fr) * 2008-12-16 2010-06-23 Henkel AG & Co. KGaA Produit de soin et de nettoyage de la bouche et des dents reminéralisant comprenant une combinaison d'agents actifs spéciaux
US10363216B2 (en) 2009-04-28 2019-07-30 Foamix Pharmaceuticals Ltd. Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
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