WO2001053834A3 - Detection of pathological defects in cells - Google Patents

Detection of pathological defects in cells Download PDF

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Publication number
WO2001053834A3
WO2001053834A3 PCT/NL2001/000036 NL0100036W WO0153834A3 WO 2001053834 A3 WO2001053834 A3 WO 2001053834A3 NL 0100036 W NL0100036 W NL 0100036W WO 0153834 A3 WO0153834 A3 WO 0153834A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibody
protein
cells
detection
pathological
Prior art date
Application number
PCT/NL2001/000036
Other languages
French (fr)
Other versions
WO2001053834A2 (en
Inventor
Arie Pieter Otte
Original Assignee
Univ Amsterdam
Arie Pieter Otte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Amsterdam, Arie Pieter Otte filed Critical Univ Amsterdam
Priority to AU2001234234A priority Critical patent/AU2001234234A1/en
Publication of WO2001053834A2 publication Critical patent/WO2001053834A2/en
Publication of WO2001053834A3 publication Critical patent/WO2001053834A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds

Abstract

The invention relates to a method for detecting a pathological defect in a cell by means of an antibody. According to the invention, an antibody is used which is specific for i) a protein of a Polycomb group complex; ii) a corepressor or a coactivator of a Polycomb group complex; or iii) a Boundary element-binding protein. Preferably the extent of binding of the antibody is compared with a reference value determined for a normal cell of that type. An abnormal concentration of a protein, and hence a different reference value, has been found to be a very good indicator for detecting a pathological defect, such as cancer.
PCT/NL2001/000036 2000-01-18 2001-01-18 Detection of pathological defects in cells WO2001053834A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001234234A AU2001234234A1 (en) 2000-01-18 2001-01-18 Detection of pathological defects in cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1014106 2000-01-18
NL1014106A NL1014106C2 (en) 2000-01-18 2000-01-18 Method for detecting a pathological abnormality in a cell, an antibody and an assay kit.

Publications (2)

Publication Number Publication Date
WO2001053834A2 WO2001053834A2 (en) 2001-07-26
WO2001053834A3 true WO2001053834A3 (en) 2002-08-08

Family

ID=19770617

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL2001/000036 WO2001053834A2 (en) 2000-01-18 2001-01-18 Detection of pathological defects in cells

Country Status (3)

Country Link
AU (1) AU2001234234A1 (en)
NL (1) NL1014106C2 (en)
WO (1) WO2001053834A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006110264A2 (en) 2005-03-16 2006-10-19 Sidney Kimmel Cancer Center Methods and compositions for predicting death from cancer and prostate cancer survival using gene expression signatures
US7890267B2 (en) * 2006-03-31 2011-02-15 Ordway Research Institute Prognostic and diagnostic method for cancer therapy
GB201115095D0 (en) 2011-09-01 2011-10-19 Singapore Volition Pte Ltd Method for detecting nucleosomes containing nucleotides
WO2013084002A2 (en) 2011-12-07 2013-06-13 Singapore Volition Pte Limited Method for detecting nucleosome adducts
SG11201703880VA (en) 2014-12-23 2017-07-28 Novartis Ag Triazolopyrimidine compounds and uses thereof
CN109790166A (en) 2016-06-20 2019-05-21 诺华股份有限公司 Imidazopyridine is used for treating cancer
CA3027246A1 (en) 2016-06-20 2017-12-28 Novartis Ag Crystalline forms of triazolopyrimidine compound
WO2017221092A1 (en) 2016-06-20 2017-12-28 Novartis Ag Triazolopyridine compounds and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007858A1 (en) * 1996-08-23 1998-02-26 Chiron Corporation HUMAN POLYHOMEOTIC 1(hphl) ACTS AS A TUMOR SUPPRESSOR
WO1998022585A1 (en) * 1996-11-19 1998-05-28 Chiron Corporation HUMAN POLYHOMEOTIC 2(hph2) ACTS AS AN ONCOGENE
WO1999033986A1 (en) * 1997-12-30 1999-07-08 Chiron Corporation MAMMALIAN ENHANCER OF POLYCOMB (epc) ACTS AS A TUMOR SUPPRESSOR

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007858A1 (en) * 1996-08-23 1998-02-26 Chiron Corporation HUMAN POLYHOMEOTIC 1(hphl) ACTS AS A TUMOR SUPPRESSOR
WO1998022585A1 (en) * 1996-11-19 1998-05-28 Chiron Corporation HUMAN POLYHOMEOTIC 2(hph2) ACTS AS AN ONCOGENE
WO1999033986A1 (en) * 1997-12-30 1999-07-08 Chiron Corporation MAMMALIAN ENHANCER OF POLYCOMB (epc) ACTS AS A TUMOR SUPPRESSOR

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
CALDAS, C. AND APARICIO, S.: "Cell memory and cancer - the story of the trithorax and Polycomb group genes", DEVELOPMENTAL BIOLOGY, vol. 18, no. 2, 1999, pages 313 - 329, XP000933822 *
JACOBS J J ET AL: "Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.", GENES AND DEVELOPMENT, (1999 OCT 15) 13 (20) 2678-90., XP000992903 *
JACOBS, JACQUELINE J. L. ET AL: "The oncogene and polycomb -group gene bmi - 1 regulates cell proliferation and senescence through the ink4a locus", NATURE (LONDON) (1999), 397(6715), 164-168, XP002144717 *
KANNO, MASAMOTO ET AL: "Polycomb group genes, Trithorax group genes and tumorigenesis", MOL. MED. (TOKYO) (1999), 36(11), 1324-1335, XP000997845 *
LESSARD J ET AL: "Functional antagonism of the Polycomb -Group genes eed and Bmi1 in hemopoietic cell proliferation.", GENES AND DEVELOPMENT, (1999 OCT 15) 13 (20) 2691-703., XP000992904 *
SATIJN, DAVID P. E. ET AL: "RING1 interacts with multiple polycomb -group proteins and displays tumorigenic activity", MOL. CELL. BIOL. (1999), 19(1), 57-68, XP000929524 *
SEWALT R G ET AL: "Characterization of interactions between the mammalian polycomb -group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb -group protein complexes.", MOLECULAR AND CELLULAR BIOLOGY, (1998 JUN) 18 (6) 3586-95., XP000929523 *
SEWALT, R.G.A.B. ET AL.: "Identification and functional analysis of human polycomb-group proteins", FASEB JOURNAL, vol. 13, 23 April 1999 (1999-04-23), pages a1466, XP000929503 *
SOULEZ M ET AL: "SSX and the synovial-sarcoma-specific chimaeric protein SYT-SSX co-localize with the human Polycomb group complex.", ONCOGENE, (1999 APR 29) 18 (17) 2739-46., XP000933465 *
VAN LOHUIZEN M: "The trithorax-group and polycomb -group chromatin modifiers: implications for disease.", CURRENT OPINION IN GENETICS AND DEVELOPMENT, (1999 JUN) 9 (3) 355-61. REF: 72, XP000997927 *
VONCKEN J W ET AL: "Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status.", JOURNAL OF CELL SCIENCE, (1999 DEC) 112 ( PT 24) 4627-39., XP000997938 *

Also Published As

Publication number Publication date
NL1014106C2 (en) 2001-07-20
AU2001234234A1 (en) 2001-07-31
WO2001053834A2 (en) 2001-07-26

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