WO2001053469A3 - Phosphatases - Google Patents

Phosphatases Download PDF

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Publication number
WO2001053469A3
WO2001053469A3 PCT/US2001/002088 US0102088W WO0153469A3 WO 2001053469 A3 WO2001053469 A3 WO 2001053469A3 US 0102088 W US0102088 W US 0102088W WO 0153469 A3 WO0153469 A3 WO 0153469A3
Authority
WO
WIPO (PCT)
Prior art keywords
provides
phosphatases
polynucleotides
agonists
diagnosing
Prior art date
Application number
PCT/US2001/002088
Other languages
French (fr)
Other versions
WO2001053469A2 (en
Inventor
Olga Bandman
Y Tom Tang
Yalda Azimzai
Henry Yue
Mariah R Baughn
Jennifer L Hillman
Preeti Lal
Eureka Wang
Ameena R Gandhi
Jennifer L Policky
Preete Mathur
Original Assignee
Incyte Genomics Inc
Olga Bandman
Y Tom Tang
Yalda Azimzai
Henry Yue
Mariah R Baughn
Jennifer L Hillman
Preeti Lal
Eureka Wang
Ameena R Gandhi
Jennifer L Policky
Preete Mathur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Olga Bandman, Y Tom Tang, Yalda Azimzai, Henry Yue, Mariah R Baughn, Jennifer L Hillman, Preeti Lal, Eureka Wang, Ameena R Gandhi, Jennifer L Policky, Preete Mathur filed Critical Incyte Genomics Inc
Priority to EP01942666A priority Critical patent/EP1254241A2/en
Priority to US10/181,590 priority patent/US20030152949A1/en
Priority to JP2001553930A priority patent/JP2003533180A/en
Priority to CA002396935A priority patent/CA2396935A1/en
Priority to AU2001229698A priority patent/AU2001229698A1/en
Publication of WO2001053469A2 publication Critical patent/WO2001053469A2/en
Publication of WO2001053469A3 publication Critical patent/WO2001053469A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The invention provides human phosphatases (PP) and polynucleotides which identify and encode PP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PP.
PCT/US2001/002088 2000-01-21 2001-01-18 Phosphatases WO2001053469A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01942666A EP1254241A2 (en) 2000-01-21 2001-01-18 Phosphatases
US10/181,590 US20030152949A1 (en) 2000-01-21 2001-01-18 Phosphatases
JP2001553930A JP2003533180A (en) 2000-01-21 2001-01-18 Phosphatase
CA002396935A CA2396935A1 (en) 2000-01-21 2001-01-18 Phosphatases
AU2001229698A AU2001229698A1 (en) 2000-01-21 2001-01-18 Phosphatases

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US17771900P 2000-01-21 2000-01-21
US60/177,719 2000-01-21
US17898800P 2000-01-28 2000-01-28
US60/178,988 2000-01-28
US18495900P 2000-02-25 2000-02-25
US60/184,959 2000-02-25
US19014200P 2000-03-17 2000-03-17
US60/190,142 2000-03-17

Publications (2)

Publication Number Publication Date
WO2001053469A2 WO2001053469A2 (en) 2001-07-26
WO2001053469A3 true WO2001053469A3 (en) 2002-02-07

Family

ID=27497245

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/002088 WO2001053469A2 (en) 2000-01-21 2001-01-18 Phosphatases

Country Status (5)

Country Link
EP (1) EP1254241A2 (en)
JP (1) JP2003533180A (en)
AU (1) AU2001229698A1 (en)
CA (1) CA2396935A1 (en)
WO (1) WO2001053469A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001057221A2 (en) * 2000-02-02 2001-08-09 Ceptyr, Inc. Dsp-12 and dsp-13 dual-specificity phosphatases
WO2002083904A1 (en) * 2001-03-27 2002-10-24 Bayer Aktiengesellschaft Regulation of human protein phosphatase 2c-like protein

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5460942A (en) * 1993-09-10 1995-10-24 The United States Of America As Represented By The Department Of Health And Human Services The catalytic moiety of the glucose-6-phosphatase system: the gene and protein and related mutations
WO1999006572A1 (en) * 1997-07-31 1999-02-11 Incyte Pharmaceuticals, Inc. Synaptojanin isoform

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5460942A (en) * 1993-09-10 1995-10-24 The United States Of America As Represented By The Department Of Health And Human Services The catalytic moiety of the glucose-6-phosphatase system: the gene and protein and related mutations
WO1999006572A1 (en) * 1997-07-31 1999-02-11 Incyte Pharmaceuticals, Inc. Synaptojanin isoform

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HEMMINGS ET AL.: "The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2Abeta catalytic subunit", NUCLEIC ACIDS RESEARCH, vol. 16, no. 23, 1988, pages 11366, XP002160654 *
NCI-CGAP: "EST", EMBL SEQUENCE DATABASE, 16 November 1998 (1998-11-16), HEIDELBERG DE, XP002170353 *
NCI-CGAP: "EST", EMBL SEQUENCE DATABASE, 17 May 1999 (1999-05-17), HEIDELBERG DE, XP002170354 *
PAN ET AL.: "Asparagine-linked oligosaccharides are localized to a luminal hydrophilic loop in human glucose-6-phosphatase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 34, 21 August 1998 (1998-08-21), pages 21658 - 21662, XP002170351 *
PAN ET AL.: "Glucose-6-phosphatase (EC 3.1.3.9) (G6Pase) (g-6-Pase)", SWISSPROT SEQUENCE DATA BASE, 1 June 1994 (1994-06-01), XP002170352 *

Also Published As

Publication number Publication date
EP1254241A2 (en) 2002-11-06
JP2003533180A (en) 2003-11-11
CA2396935A1 (en) 2001-07-26
WO2001053469A2 (en) 2001-07-26
AU2001229698A1 (en) 2001-07-31

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