WO2001044280A3 - Methods and compositions for the manufacture of replication incompetent adenovirus - Google Patents
Methods and compositions for the manufacture of replication incompetent adenovirus Download PDFInfo
- Publication number
- WO2001044280A3 WO2001044280A3 PCT/US2000/033123 US0033123W WO0144280A3 WO 2001044280 A3 WO2001044280 A3 WO 2001044280A3 US 0033123 W US0033123 W US 0033123W WO 0144280 A3 WO0144280 A3 WO 0144280A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- replication
- replication incompetent
- cell lines
- present
- particles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10351—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001544769A JP2003516743A (en) | 1999-12-14 | 2000-12-07 | Methods and compositions for the production of replication incompetent adenovirus |
EP00980987A EP1238091A2 (en) | 1999-12-14 | 2000-12-07 | Methods and compositions for the manufacture of replication incompetent adenovirus |
AU18174/01A AU1817401A (en) | 1999-12-14 | 2000-12-07 | Methods and compositions for the manufacture of replication incompetent adenovirus |
CA002393844A CA2393844A1 (en) | 1999-12-14 | 2000-12-07 | Methods and compositions for the manufacture of replication incompetent adenovirus |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17055099P | 1999-12-14 | 1999-12-14 | |
US60/170,550 | 1999-12-14 | ||
US19626600P | 2000-04-11 | 2000-04-11 | |
US60/196,266 | 2000-04-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001044280A2 WO2001044280A2 (en) | 2001-06-21 |
WO2001044280A3 true WO2001044280A3 (en) | 2001-11-29 |
Family
ID=26866208
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/033123 WO2001044280A2 (en) | 1999-12-14 | 2000-12-07 | Methods and compositions for the manufacture of replication incompetent adenovirus |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1238091A2 (en) |
JP (1) | JP2003516743A (en) |
AU (1) | AU1817401A (en) |
CA (1) | CA2393844A1 (en) |
WO (1) | WO2001044280A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6677156B2 (en) | 2001-07-23 | 2004-01-13 | Genvec, Inc. | Non-adenoviral gene product-based complementing cells for adenoviral vectors |
EP1327688A1 (en) * | 2002-01-14 | 2003-07-16 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Adenoviruses with enhanced lytic potency |
US20030158112A1 (en) | 2002-02-15 | 2003-08-21 | Johns Hopkins University School Of Medicine | Selective induction of apoptosis to treat ocular disease |
WO2004057035A2 (en) * | 2002-12-20 | 2004-07-08 | Qbiogene Inc. | Method and kit for detecting replication competent adenoviruses |
WO2009006300A2 (en) * | 2007-06-28 | 2009-01-08 | Advantagene, Inc. | Production cell lines for adenoviral manufacturing |
US8346485B2 (en) | 2008-11-25 | 2013-01-01 | Quest Diagnostics Investments Incorporated | Methods and apparatuses for estimating initial target nucleic acid concentration in a sample by modeling background signal and cycle-dependent amplification efficiency of a polymerase chain reaction |
US20230151438A1 (en) * | 2018-06-13 | 2023-05-18 | The Council Of The Queensland Institute Of Medical Research | Viral detection assay |
US20190292609A1 (en) * | 2019-05-30 | 2019-09-26 | Trizell Ltd. | Gene Therapy Vector Contamination Assay |
WO2023039243A2 (en) * | 2021-09-13 | 2023-03-16 | Achelois Biopharma, Inc. | Hepatitis b virus antivirus (hbv-antivirus) compositions and methods of use |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995013399A1 (en) * | 1993-11-12 | 1995-05-18 | The Public Health Research Institute Of The City Of New York, Inc. | Hybridization probes for nucleic acid detection, universal stems, methods and kits |
EP0745690A2 (en) * | 1995-05-12 | 1996-12-04 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide Probes, Assays and Kits |
WO1997015679A1 (en) * | 1995-10-27 | 1997-05-01 | The Trustees Of The University Of Pennsylvania | Recombinant viruses containing mobile genetic elements and methods of use in gene therapy |
WO1998013499A2 (en) * | 1996-09-25 | 1998-04-02 | Novartis Ag | Packaging cell lines for use in facilitating the development of high-capacity adenoviral vectors |
US5994128A (en) * | 1995-06-15 | 1999-11-30 | Introgene B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
US5994132A (en) * | 1996-10-23 | 1999-11-30 | University Of Michigan | Adenovirus vectors |
-
2000
- 2000-12-07 AU AU18174/01A patent/AU1817401A/en not_active Abandoned
- 2000-12-07 WO PCT/US2000/033123 patent/WO2001044280A2/en not_active Application Discontinuation
- 2000-12-07 CA CA002393844A patent/CA2393844A1/en not_active Abandoned
- 2000-12-07 EP EP00980987A patent/EP1238091A2/en not_active Withdrawn
- 2000-12-07 JP JP2001544769A patent/JP2003516743A/en not_active Withdrawn
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995013399A1 (en) * | 1993-11-12 | 1995-05-18 | The Public Health Research Institute Of The City Of New York, Inc. | Hybridization probes for nucleic acid detection, universal stems, methods and kits |
EP0745690A2 (en) * | 1995-05-12 | 1996-12-04 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide Probes, Assays and Kits |
US5994128A (en) * | 1995-06-15 | 1999-11-30 | Introgene B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
WO1997015679A1 (en) * | 1995-10-27 | 1997-05-01 | The Trustees Of The University Of Pennsylvania | Recombinant viruses containing mobile genetic elements and methods of use in gene therapy |
WO1998013499A2 (en) * | 1996-09-25 | 1998-04-02 | Novartis Ag | Packaging cell lines for use in facilitating the development of high-capacity adenoviral vectors |
US5994132A (en) * | 1996-10-23 | 1999-11-30 | University Of Michigan | Adenovirus vectors |
Non-Patent Citations (1)
Title |
---|
HERISSE J ET AL: "NUCLEOTIDE SEQUENCE OF ADENOVIRUS 2 DNA FRAGMENT ENCODING FOR THE CARBOXYLIC REGION OF THE FIBER PROTEIN AND THE ENTIRE E4 REGION", NUCLEIC ACIDS RESEARCH,GB,IRL PRESS LTD., OXFORD, vol. 9, no. 16, 25 August 1981 (1981-08-25), pages 4023 - 4042, XP002051626, ISSN: 0305-1048 * |
Also Published As
Publication number | Publication date |
---|---|
WO2001044280A2 (en) | 2001-06-21 |
JP2003516743A (en) | 2003-05-20 |
CA2393844A1 (en) | 2001-06-21 |
EP1238091A2 (en) | 2002-09-11 |
AU1817401A (en) | 2001-06-25 |
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