WO2001044266A3 - Nucleic acid compounds and screening assays using the same - Google Patents

Nucleic acid compounds and screening assays using the same Download PDF

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Publication number
WO2001044266A3
WO2001044266A3 PCT/GB2000/004862 GB0004862W WO0144266A3 WO 2001044266 A3 WO2001044266 A3 WO 2001044266A3 GB 0004862 W GB0004862 W GB 0004862W WO 0144266 A3 WO0144266 A3 WO 0144266A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
same
acid compounds
screening assays
nucleotides
Prior art date
Application number
PCT/GB2000/004862
Other languages
French (fr)
Other versions
WO2001044266A2 (en
Inventor
Jonathan Karn
Stephen Walker
Original Assignee
Ribotargets Ltd
Jonathan Karn
Stephen Walker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9929820.0A external-priority patent/GB9929820D0/en
Application filed by Ribotargets Ltd, Jonathan Karn, Stephen Walker filed Critical Ribotargets Ltd
Priority to EP00985610A priority Critical patent/EP1237899A2/en
Priority to AU22018/01A priority patent/AU2201801A/en
Priority to CA002391814A priority patent/CA2391814A1/en
Publication of WO2001044266A2 publication Critical patent/WO2001044266A2/en
Publication of WO2001044266A3 publication Critical patent/WO2001044266A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/18—Togaviridae; Flaviviridae

Abstract

The invention provides a compound comprising nucleotide sequences: -5'-P-N?1-N2-G-N3¿-C-I-3' and 3'-Q-N?4-N5-N6-N7-N8-N9¿-Y-J-5' wherein P and Q are any two nucleotides that can form a Watson-Crick base pair, I and J are any two nucleotides that can form a base pair, N?1 and N4¿ are not both C, when N2 is A, N7 is not G, N9 can only be U if N3 is A, when N3 is G, N9 is A, and wherein said sequences are capable of annealing, characterised in that said compound comprises 200 or fewer nucleotides.
PCT/GB2000/004862 1999-12-16 2000-12-18 Nucleic acid compounds and screening assays using the same WO2001044266A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00985610A EP1237899A2 (en) 1999-12-16 2000-12-18 Nucleic acid compounds and screening assays using the same
AU22018/01A AU2201801A (en) 1999-12-16 2000-12-18 Assays
CA002391814A CA2391814A1 (en) 1999-12-16 2000-12-18 Assays

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9929820.0A GB9929820D0 (en) 1999-12-16 1999-12-16 Assay
GB9929820.0 1999-12-16
US17180499P 1999-12-22 1999-12-22
US60/171,804 1999-12-22

Publications (2)

Publication Number Publication Date
WO2001044266A2 WO2001044266A2 (en) 2001-06-21
WO2001044266A3 true WO2001044266A3 (en) 2001-12-20

Family

ID=26316129

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/004862 WO2001044266A2 (en) 1999-12-16 2000-12-18 Nucleic acid compounds and screening assays using the same

Country Status (4)

Country Link
EP (1) EP1237899A2 (en)
AU (1) AU2201801A (en)
CA (1) CA2391814A1 (en)
WO (1) WO2001044266A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11851449B2 (en) 2013-07-03 2023-12-26 Takeda Pharmaceutical Company Limited Heterocyclic amide compounds having an RORvt inhibitory action

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10027383A1 (en) * 2000-06-02 2001-12-20 Rhein Biotech Proz & Prod Gmbh Nucleic acid molecule comprising a nucleic acid sequence coding for a chemokine, a neuropeptide precursor or at least one neuropeptide
WO2003018747A2 (en) * 2001-08-22 2003-03-06 Isis Pharmaceuticals, Inc. Molecular interaction sites of hepatitis c virus rna and methods of modulating the same
FR2848572B1 (en) * 2002-12-12 2005-12-09 Univ Joseph Fourier INHIBITOR MOLECULES OF PROTEIN SYNTHESIS OF HEPATITIS C VIRUS AND METHOD FOR SCREENING THESE INHIBITORY MOLECULES
WO2004078974A1 (en) * 2003-01-24 2004-09-16 Tokyo Metropolitan Organization For Medical Research Oligoribonucleotide or peptidic nucleic acid inhibiting function of hepatitis c virus
GB0302113D0 (en) * 2003-01-29 2003-03-05 Medical Res Council Ires
FR2974805B1 (en) 2011-05-02 2013-05-10 Isp Investments Inc NOVEL MODULATING PEPTIDES OF THE TRF-2 PROTEIN AND COMPOSITIONS COMPRISING THEM
EP2975031A4 (en) 2013-03-14 2017-04-19 Takeda Pharmaceutical Company Limited Heterocyclic compound
US10053468B2 (en) 2013-07-03 2018-08-21 Takeda Pharmaceutical Company Limited Heterocyclic compound

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009342A1 (en) * 1995-09-08 1997-03-13 Scriptgen Pharmaceuticals, Inc. Screen for compounds with affinity for rna
US5922857A (en) * 1992-09-28 1999-07-13 Chiron Corporation Methods and compositions for controlling translation of HCV proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922857A (en) * 1992-09-28 1999-07-13 Chiron Corporation Methods and compositions for controlling translation of HCV proteins
WO1997009342A1 (en) * 1995-09-08 1997-03-13 Scriptgen Pharmaceuticals, Inc. Screen for compounds with affinity for rna

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL EBI; 30 October 1998 (1998-10-30), MICHALEK ET AL.: "Hordeum vulgare genomic DNA fragment; clone MWG0065.rev", XP002178313 *
SIZOVA ET AL.: "Specific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis c virus and classical swine fever virus RNAs", JOURNAL OF VIROLOGY, vol. 72, no. 6, June 1998 (1998-06-01), pages 4775 - 4782, XP000993423 *
WALLIS ET AL.: "In vitro selection of a viomycin-binding RNA pseudoknot", CHEMISTRY AND BIOLOGY, vol. 4, no. 5, 1997, pages 357 - 366, XP001024489 *
WANG Y ET AL: "Specificity of aminoglycoside binding to RNA constructs derived from the 16S rRNA decoding region and the HIV-RRE activator region", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 36, 1997, pages 768 - 779, XP002120808, ISSN: 0006-2960 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11851449B2 (en) 2013-07-03 2023-12-26 Takeda Pharmaceutical Company Limited Heterocyclic amide compounds having an RORvt inhibitory action

Also Published As

Publication number Publication date
EP1237899A2 (en) 2002-09-11
WO2001044266A2 (en) 2001-06-21
AU2201801A (en) 2001-06-25
CA2391814A1 (en) 2001-06-21

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