WO2001040191A1 - Preparation of 3-substituted-4-arylquinolin-2-one derivatives - Google Patents
Preparation of 3-substituted-4-arylquinolin-2-one derivatives Download PDFInfo
- Publication number
- WO2001040191A1 WO2001040191A1 PCT/US2000/032382 US0032382W WO0140191A1 WO 2001040191 A1 WO2001040191 A1 WO 2001040191A1 US 0032382 W US0032382 W US 0032382W WO 0140191 A1 WO0140191 A1 WO 0140191A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- formula
- hydrogen
- chloro
- channels
- Prior art date
Links
- 0 *c(cc1C(O)=C2CCO)ccc1OC2=O Chemical compound *c(cc1C(O)=C2CCO)ccc1OC2=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001541876A JP2003515593A (en) | 1999-12-01 | 2000-11-28 | Production of 3-substituted-4-arylquinolin-2-one derivatives |
KR1020027007042A KR20020058066A (en) | 1999-12-01 | 2000-11-28 | Preparation of 3-substituted-4-arylquinolin-2-one derivatives |
IL14953400A IL149534A0 (en) | 1999-12-01 | 2000-11-28 | Preparation of 3-substituted-4-arylquinolin-2-one derivatives |
CA002393012A CA2393012A1 (en) | 1999-12-01 | 2000-11-28 | Preparation of 3-substituted-4-arylquinolin-2-one derivatives |
MXPA02005470A MXPA02005470A (en) | 1999-12-01 | 2000-11-28 | Preparation of 3 substituted 4 arylquinolin 2 one derivatives. |
EP00983775A EP1233947A4 (en) | 1999-12-01 | 2000-11-28 | Preparation of 3-substituted-4-arylquinolin-2-one derivatives |
HU0203364A HUP0203364A3 (en) | 1999-12-01 | 2000-11-28 | Method for preparation of 3-substituted-4-arylquinolin-2-one derivatives |
AU20487/01A AU769481B2 (en) | 1999-12-01 | 2000-11-28 | Preparation of 3-substituted-4-arylquinolin-2-one derivatives |
HK03100711.5A HK1048633A1 (en) | 1999-12-01 | 2003-01-28 | Preparation of 3-substituted-4-arylquinolin-2-one derivatives |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16834699P | 1999-12-01 | 1999-12-01 | |
US60/168,346 | 1999-12-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001040191A1 true WO2001040191A1 (en) | 2001-06-07 |
Family
ID=22611149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/032382 WO2001040191A1 (en) | 1999-12-01 | 2000-11-28 | Preparation of 3-substituted-4-arylquinolin-2-one derivatives |
Country Status (12)
Country | Link |
---|---|
US (1) | US6353119B1 (en) |
EP (1) | EP1233947A4 (en) |
JP (1) | JP2003515593A (en) |
KR (1) | KR20020058066A (en) |
AU (1) | AU769481B2 (en) |
CA (1) | CA2393012A1 (en) |
HK (1) | HK1048633A1 (en) |
HU (1) | HUP0203364A3 (en) |
IL (1) | IL149534A0 (en) |
MX (1) | MXPA02005470A (en) |
TW (1) | TW562799B (en) |
WO (1) | WO2001040191A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004099442A2 (en) * | 2003-05-06 | 2004-11-18 | University Hospital Of Basel | Kcnma1 as a therapeutic target in cancer treatment |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6939968B2 (en) | 2002-12-23 | 2005-09-06 | Bristol-Myers Squibb Company | Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives |
US7151180B2 (en) * | 2003-10-14 | 2006-12-19 | Bristol-Myers Squibb Company | Potassium channel modulators |
US7132542B2 (en) | 2003-10-14 | 2006-11-07 | Bristol-Myers Squibb Company | Compounds for the treatment of male erectile dysfunction |
US7049309B2 (en) * | 2003-10-14 | 2006-05-23 | Bristol-Myers Squibb Company | 3-Thia-4-arylquinolin-2-one potassium channel modulators |
US7145013B2 (en) * | 2003-10-14 | 2006-12-05 | Bristol-Myers Squibb Company | 3-thia-4-arylquinolin-2-one derivatives |
US7179920B2 (en) * | 2003-10-14 | 2007-02-20 | Bristol-Myers Squibb Company | 3-thia-4-arylquinolin-2-one derivatives |
US7002015B2 (en) * | 2003-10-14 | 2006-02-21 | Bristol-Myers Squibb Company | 3-Thia-4-arylquinolin-2-one derivatives as smooth muscle relaxants |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000034244A1 (en) * | 1998-12-04 | 2000-06-15 | Bristol-Myers Squibb Company | 3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5091428A (en) * | 1987-04-24 | 1992-02-25 | Syntex Pharmaceuticals, Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
US5200422A (en) | 1990-09-24 | 1993-04-06 | Neurosearch A/S | Benzimidazole derivatives, their preparation and use |
US5234947A (en) | 1991-11-07 | 1993-08-10 | New York University | Potassium channel activating compounds and methods of use thereof |
US5565472A (en) | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
TW504504B (en) | 1996-11-26 | 2002-10-01 | Bristol Myers Squibb Co | 4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modulators |
JP2003524574A (en) * | 1997-08-05 | 2003-08-19 | ノボ ノルディスク アクティーゼルスカブ | 2,5- and 3,5-disubstituted aniline derivatives, their preparation and use |
US5972961A (en) | 1997-08-28 | 1999-10-26 | Bristol-Myers Squibb Company | 4-aryl-3-aminoquinoline-2-one derivatives as potassium channel modulators |
-
2000
- 2000-11-24 TW TW089125068A patent/TW562799B/en not_active IP Right Cessation
- 2000-11-28 EP EP00983775A patent/EP1233947A4/en not_active Withdrawn
- 2000-11-28 IL IL14953400A patent/IL149534A0/en unknown
- 2000-11-28 CA CA002393012A patent/CA2393012A1/en not_active Abandoned
- 2000-11-28 AU AU20487/01A patent/AU769481B2/en not_active Ceased
- 2000-11-28 US US09/724,056 patent/US6353119B1/en not_active Expired - Lifetime
- 2000-11-28 KR KR1020027007042A patent/KR20020058066A/en not_active Application Discontinuation
- 2000-11-28 MX MXPA02005470A patent/MXPA02005470A/en active IP Right Grant
- 2000-11-28 JP JP2001541876A patent/JP2003515593A/en active Pending
- 2000-11-28 WO PCT/US2000/032382 patent/WO2001040191A1/en not_active Application Discontinuation
- 2000-11-28 HU HU0203364A patent/HUP0203364A3/en unknown
-
2003
- 2003-01-28 HK HK03100711.5A patent/HK1048633A1/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000034244A1 (en) * | 1998-12-04 | 2000-06-15 | Bristol-Myers Squibb Company | 3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators |
Non-Patent Citations (2)
Title |
---|
DATABASE CA [online] CHEMICAL ABSTRACTS (COLUMBUS, OHIO, USA); HEWAWASAM P.: "Preparation of 3-substituted-4-arylquinolin-2-one derivatives as calcium-activated potassium (BK) channel openers", XP002938724, accession no. STN Database accession no. 133:43452 * |
See also references of EP1233947A4 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004099442A2 (en) * | 2003-05-06 | 2004-11-18 | University Hospital Of Basel | Kcnma1 as a therapeutic target in cancer treatment |
WO2004099442A3 (en) * | 2003-05-06 | 2005-01-27 | Univ Hospital Of Basel | Kcnma1 as a therapeutic target in cancer treatment |
Also Published As
Publication number | Publication date |
---|---|
CA2393012A1 (en) | 2001-06-07 |
US6353119B1 (en) | 2002-03-05 |
KR20020058066A (en) | 2002-07-12 |
HK1048633A1 (en) | 2003-04-11 |
MXPA02005470A (en) | 2003-01-28 |
JP2003515593A (en) | 2003-05-07 |
EP1233947A1 (en) | 2002-08-28 |
AU769481B2 (en) | 2004-01-29 |
IL149534A0 (en) | 2002-11-10 |
HUP0203364A3 (en) | 2005-11-28 |
TW562799B (en) | 2003-11-21 |
EP1233947A4 (en) | 2003-01-02 |
HUP0203364A2 (en) | 2003-02-28 |
AU2048701A (en) | 2001-06-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6184231B1 (en) | 3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators | |
US5892045A (en) | 4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modulators | |
US5972961A (en) | 4-aryl-3-aminoquinoline-2-one derivatives as potassium channel modulators | |
US6353119B1 (en) | Preparation of 3-substituted-4-arylquinolin-2-one derivatives | |
JP2001526281A (en) | Novel sulfonamide-substituted chroman derivatives useful as beta-3 adrenergic receptor agonists | |
JPH10139775A (en) | 3-amidochromanylsulfonyl (thio)urea, its production, use thereof and pharmaceutical preparation comprising the same | |
JPH0587514B2 (en) | ||
EP0090360A2 (en) | New quinoline and related compounds useful as anti-allergy agents | |
EP0602458A1 (en) | 1,4-Benzoxazine derivatives | |
NO145274B (en) | PROCEDURE FOR THE PREPARATION OF A 1-BENZOYL-2- (2`, 6`-DICHLORPHENYLAMINO) -2-IMIDAZOLINE AND OF THEIR SALTS | |
JP3037979B2 (en) | Benzopyran derivative | |
NO153652B (en) | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITY 1,2,4-OXADIAZINE DERIVATIVES. | |
AU716832C (en) | 4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modulators | |
MXPA01005532A (en) | 3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators | |
JPS591705B2 (en) | Aminophenyl tetrazole derivatives and their salts | |
JPH0625233A (en) | Diazabicycloalkene derivative |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 149534 Country of ref document: IL |
|
WWE | Wipo information: entry into national phase |
Ref document number: IN/PCT/2002/00600/MU Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2393012 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 20487/01 Country of ref document: AU |
|
ENP | Entry into the national phase |
Ref document number: 2001 541876 Country of ref document: JP Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2002/005470 Country of ref document: MX Ref document number: 1020027007042 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2000983775 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1020027007042 Country of ref document: KR |
|
WWP | Wipo information: published in national office |
Ref document number: 2000983775 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWG | Wipo information: grant in national office |
Ref document number: 20487/01 Country of ref document: AU |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 2000983775 Country of ref document: EP |