WO2001034037A1 - Appareil et procede permettant d'inserer de multiples sutures durant une anastomose - Google Patents

Appareil et procede permettant d'inserer de multiples sutures durant une anastomose Download PDF

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Publication number
WO2001034037A1
WO2001034037A1 PCT/US2000/030418 US0030418W WO0134037A1 WO 2001034037 A1 WO2001034037 A1 WO 2001034037A1 US 0030418 W US0030418 W US 0030418W WO 0134037 A1 WO0134037 A1 WO 0134037A1
Authority
WO
WIPO (PCT)
Prior art keywords
vessel
physiological
crown
strand
strands
Prior art date
Application number
PCT/US2000/030418
Other languages
English (en)
Inventor
Gregory E. Sancoff
John T. Rice
Frederic P. Field
Original Assignee
Onux Medical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Onux Medical, Inc. filed Critical Onux Medical, Inc.
Priority to EP00976930A priority Critical patent/EP1233704A1/fr
Priority to CA002393799A priority patent/CA2393799A1/fr
Priority to JP2001536050A priority patent/JP2003513696A/ja
Priority to MXPA02004493A priority patent/MXPA02004493A/es
Priority to IL14947400A priority patent/IL149474A0/xx
Priority to AU14637/01A priority patent/AU1463701A/en
Publication of WO2001034037A1 publication Critical patent/WO2001034037A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A61B17/115—Staplers for performing anastomosis in a single operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064—Surgical staples, i.e. penetrating the tissue
    • A61B17/0644—Surgical staples, i.e. penetrating the tissue penetrating the tissue, deformable to closed position
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064—Surgical staples, i.e. penetrating the tissue
    • A61B17/0643—Surgical staples, i.e. penetrating the tissue with separate closing member, e.g. for interlocking with staple
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/128—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for applying or removing clamps or clips
    • A61B17/1285—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for applying or removing clamps or clips for minimally invasive surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064—Surgical staples, i.e. penetrating the tissue
    • A61B2017/0641—Surgical staples, i.e. penetrating the tissue having at least three legs as part of one single body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A61B2017/1107—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis for blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A61B2017/1135—End-to-side connections, e.g. T- or Y-connections

Definitions

  • the invention generally relates to apparatus and methods for surgery. More specifically, the invention relates to apparatus and methods for the surgical formation of anastomosis of physiological vessels.
  • connections include: end-to-end, end-to-side, and side-to-side connections. As these structures often carry fluid, the connections formed must be at least substantially complete around the entire surface. Traditional means for connecting together these structures include the use of sutures or staples.
  • blood vessels such as the coronary arteries, or those vessels used to form bypasses, are small in diameter and have very thin walls. The thin walls cause these vessels to adopt a collapsed configuration during handling which causes difficulty in handling and positioning the vessels.
  • An object of the invention is to provide an apparatus for placing multiple sutures during anastomosis of physiological vessels. Another object of the invention is to provide a method for placing multiple sutures during anastomosis of physiological vessels.
  • An apparatus for placing multiple sutures during anastomosis of physiological vessels includes a crown portion having a plurality of strands connected together by one or more circular bands.
  • the strands each form a point at one end with a curved hook at the same end.
  • the curved hook acts as a suture to retain one or more of the vessels.
  • An alternative embodiment includes a plurality of strands, or wires, that are inserted through one or more vessels to simultaneously place multiple sutures.
  • the present invention also comprises a method for placing a plurality of sutures simultaneously with an apparatus .
  • Figs. 1A-1E illustrate an embodiment of a crown for placing multiple sutures.
  • Figs. 2A-2D illustrate a crown including a retaining ring.
  • Fig. 3 illustrates a crown including a handle.
  • Figs. 4A-4N illustrate various embodiments of an apparatus for surgical anastomosis using an eversion technique.
  • Figs. 5A-5C illustrate an internal version of a crown.
  • Figs. 6A-6B, 7A-7B and 8A-8B illustrate various embodiments of strands having structures for additional flexibility.
  • Figs. 9-11 illustrate various eversion techniques using a crown.
  • Figs. 12A-12D illustrate a crown formed of a planar material.
  • Figs. 13A-13B illustrate a crown having a unitary ring structure.
  • Figs. 14A-14B illustrate an embodiment of the invention with hooks at both ends of a crown.
  • Figs. 15A-15B illustrate an embodiment of the invention with a self-locking hook.
  • Figs. 16-19 illustrate various pointed ends of a strand.
  • Fig. 20 illustrates an external version of a crown.
  • Figs. 21A-21F illustrate a device that places and secures sutures for making anastomotic connections.
  • Figs. 22A-22D illustrate various wire end configurations .
  • Figs. 23A-23F illustrate various die surface embodiments of a device that places and secures sutures for making anastomotic connections.
  • Figs. 24A-24B illustrate embodiments of a hinged device that places and secures sutures for making anastomotic connections.
  • Figs. 25A-25B illustrate an inflatable mandrel at the end of a catheter for a device that places and secures sutures for making anastomotic connections.
  • apparatus 10 for surgical formation of an anastomosis.
  • apparatus 10 includes a crown 15 with a plurality of strands 20 joined together by at least two rings 25.
  • Each strand 20 is joined to rings 25 adjacent a first end 30 and has a pointed barb 35 at a second end 40.
  • Strand 20 includes a curved portion 45 adjacent barb 35 and second end 40. Curved portion 45 may be in the form of a hook.
  • crown 15 is shown with a retaining ring 50 for restraining hooks 45 of each strand 20.
  • Retaining ring 50 allows positioning of second end 40 of crown 15 adjacent tissue of physiological vessels. Removal of retaining ring 50 causes deployment of hooks 45 which secure to one, or more, physiological vessels.
  • Figs. 3 and 4A-4N illustrate a method for surgical formation of an anastomosis of vessels, referred to as an eversion technique.
  • apparatus 10 is positioned over one end of a physiological vessel 55 and a scope 60 positioned therethrough is shown.
  • a handle 56 attached to crown 15 is provided to manipulate apparatus 10.
  • Handle 56 contains a separation means 57 which includes, but is not limited to, a prefabricated breaking point.
  • Fig. 4A the progression of crown 15 up the length of vessel 55 is shown.
  • the end of vessel 55 is folded back and impaled upon hooks 45 as shown in Fig. 4B.
  • crown 15 surrounding vessel 55 is positioned within physiological vessel 65 as shown in Fig. 4D and as shown in a cross-sectional view in Fig. 4E.
  • Retaining ring 50 is shown in the cross- sectional view of Fig. 4E and is accessible to the outside of the apparatus 10. Retaining ring 50 is removed by cutting therethrough. Alternatively, retaining ring 50 may be removed from hooks 45 by other methods such as repositioning to an area adjacent rings 25.
  • FIGs. 4F and 4G apparatus 10 is shown after retaining ring 50 is removed and hooks 45 are driven through vessel 65. As shown in Fig. 4G, a gap 75 may be created between vessel 55 and vessel 65 during the eversion technique.
  • a sealing ring 70 is also used in conjunction with crown 15 to form apparatus 10, as illustrated in Figs. 4H-4K.
  • Sealing ring 70 is formed of a puncturable, implantable material such as an elastic material including, but not limited to, plastic or elastomer.
  • sealing ring 70 is placed onto crown 15 as shown in Figs. 4H and 41.
  • Fig. 4J it can be seen that the outer surface of sealing ring 70 contacts vessel 55 and vessel 65 as sealing ring 70 is impaled onto pointed barbs 35. This simultaneous contact eliminates any passageway created by gap 75.
  • sealing ring 70 having an appropriately sized cross-sectional radius can also contact crown 15 above hooks 45 in addition to vessel 55 and vessel 65 to provide a more secure seal of gap 75.
  • an alternative embodiment includes a plurality of sutures 80, placed around apparatus 10 to close gap 75 between vessel 55 and vessel 65.
  • Sealing ring 70 may also be used as described above for protection of pointed barbs 35 in addition to the placement of sutures 80 for closure of gap 75.
  • FIGs. 4L-4N another preferred embodiment including a clover leaf bender 82 to drive the ends of hooks 45 containing pointed barb 35 toward vessel 65 is shown.
  • Clover leaf bender 82 is formed with a series of protrusions 83 and recesses 84.
  • clover leaf bender 82 is placed around crown 15 after vessel 55 and vessel 65 are attached to one another.
  • recesses 84 contain the outwardly extending ends of hooks 45 with protrusions 83 therebetween.
  • clover leaf bender 82 is rotated, as shown in Fig. 4N, to drive the ends of hooks 45 radially and downwardly toward vessel 65.
  • clover leaf bender 82 is turned to drive the ends of hooks 45 substantially parallel to vessel 65 and is then removed from crown 15. In another embodiment, clover leaf bender 82 is turned only enough to deflect the outwardly extending ends of hooks 45 and is left in contact with hooks 45. Clover leaf bender 82 acts in a similar manner as sealing ring 70 when left in attachment to crown 15.
  • Figs. 5A-5C illustrate an alternative arrangement in which crown 15 is placed within physiological vessel 55.
  • lock ring 85 is provided to secure crown 15 within vessel 55 and hooks 45 are restrained by retaining ring 50 prior to insertion into vessel 65.
  • first end 30 (shown in Fig. 5A) of crown 15 is shown inserted into vessel 55 with lock ring 85 securely fastened over vessel 55 between crown rings 25.
  • Hooks 45 are still restrained by retaining ring 50 for insertion of second end 40 (shown in Fig. 5A) of crown 15 into vessel 65.
  • second end 40 of crown 15 is shown during insertion into vessel 65.
  • Retaining ring 50 is removed, preferably by cutting, and hooks 45 deploy to secure crown 15 to vessel 65 as described above.
  • other embodiments described herein, such as sealing ring 70 and/or sutures 80, may be implemented to further seal together vessel 55 and vessel 65.
  • FIGs. 6A-6B, 7A-7B and 8A-8B alternative embodiments are shown which provide greater flexibility in strands 20 attaching hooks 45 to crown rings 25.
  • each of the strands 20 contains a bend 90 to provide additional flexibility.
  • each of strands 20 contains a spring 95 to provide additional flexibility.
  • Figs. 8A and 8B an embodiment is shown in which each of strands 20 uses a spring structure 100 for attachment to one of crown rings 25.
  • Strand bend 90, strand spring 95 and spring structure 100 are advantageous in that less force is required to position hooks 45 with retaining ring 50 or with any other instrument.
  • Strand bend 90, strand spring 95 and spring structure 100 also permit greater deflection without material failure of strand 20 and to increase the force of hooks 45 to penetrate vessel 65.
  • vessel 55 and vessel 65 are shown attached together using the eversion technique at an angle relative to one another.
  • vessel 55 and vessel 65 are shown being attached together using the eversion technique in series with each other.
  • a view is shown looking from the inside of vessel 65 attached to vessel 55 with hooks 45 about the perimeter of the attachment.
  • FIGs. 12A-12D an alternative embodiment of an apparatus and method where crown 15 is stamped or etched from a sheet of material 105 is shown.
  • sheet 105 is shown intact before stamping or etching to create crown 15.
  • Phantom lines 110 on sheet 105 depict the configuration of the stamping or etching.
  • crown 15 is stamped or etched from sheet 105 to form a planar crown 115 as shown in Fig. 12B.
  • Planar crown has a first end 120 and a second end 125 on opposing ends of crown rings 25 to connect together strands 20.
  • Planar crown 115 is rolled to connect first end 120 to second end 125 to form crown 15, as shown in Fig. 12C.
  • Crown 15 formed by planar crown 115 has substantially straight strands 20.
  • hooks 45 are formed as shown in Fig. 12D. In this configuration, crown 15 is utilized as otherwise described herein.
  • crown rings 25 of crown 15 are a unitary structure 130.
  • Crown 15 having unitary structure 130 is formed either by one of the techniques described above, by molding a single element or by using other known processes. Then hooks 45 are formed as shown in Fig. 13B. Crown 15 is attached to at least one vessel structure using the techniques described herein.
  • FIGs. 14A and 14B an alternative embodiment of crown 15 having hooks 45 at both first end 30 and at second end 40 is shown.
  • vessel 55 is attached to hooks 45 at first end 30 and then vessel 65 is attached to hooks 45 at second end 40 to complete the surgical anastomosis of the vessels.
  • other embodiments and methods described herein may be incorporated into this embodiment .
  • Figs. 15A and 15B an alternative embodiment to restrain hooks 45 containing pointed barbs 35 is shown.
  • Strands 20 each contain an articulating portion 132 which allows the positioning of hook 45 around and the positioning of barb 35 behind strand 20 toward first end 30 of crown 15.
  • second end 40 of crown 15 is positioned within a vessel.
  • hook 45 springs outward, penetrating vessel 65, and then it is snapped back around strand 20, as shown in Fig. 15B, thus capturing vessels 55 and 65.
  • Pointed barbs 35 include a range of structures including, but not limited to, several embodiments shown in Figs. 16-19.
  • pointed bairb 20 is conically shaped at the end of a cylindrical shaped strand 20.
  • pointed barb 20 is formed from a cut at an acute angle from a cylindrical shaped strand 20.
  • pointed barb 20 is formed from a pair of cuts at acute angles at the end of a rectangular shaped strand 20.
  • pointed barb 20 is formed in a pyramidal shape at the end of a rectangular shaped strand 20.
  • the preferred embodiment of the invention also includes sealants to facilitate closure of gap 75, or any other opening.
  • Sealants are contained on crown 15 adjacent hooks 45. Sealants include, but are not limited to, various glues and clotting agents. After placement of crown 15 and effecting the surgical anastomosis, these sealants further aid in closure of any gaps and openings .
  • An alternative embodiment of the invention includes an apparatus and method to place vessel 55 inside crown 15 and to secure crown 15 with an internal lock ring 135 placed in vessel 55 at a position between two crown rings 25. Lock ring 135 exerts an outward force to hold vessel 55 to crown 15.
  • Figs. 21A-21F show another embodiment of an apparatus and method to use metal suture wires to form an anastomotic connection between vessel 55 and vessel 65.
  • a flexible mandrel 140 with a flanged end 145 is inserted into vessel 55 such that the end of vessel 55 is flared against flanged end 145 of mandrel 140.
  • a main body section 150 is placed over vessel 55.
  • Section 150 consists of a tubular section 155 with a flanged end 160 that mates with that of flexible mandrel 140.
  • wire tubes 165 that contain short pieces of metallic wire 170.
  • Above tubes 165 is a sleeve 175 that slides along the outside of main body 150.
  • receiving holes 180 for wire tubes 165, and plungers 185 extending from the receiving holes 180.
  • Receiving holes 180, in combination with wire tubes 165 form a telescoping tube pair 190 that supports wire 170 as the end of the sleeve side is advanced forward.
  • Figs. 22A-22D show four possible end configurations for the tip of wire 170 to maintain the approximation of the tissue. If wire 170 is made of a very elastic material such as Nitinol, wire 170 can be preformed into these shapes and resume these shapes once it has been pushed out of wire tubes 165. Wire 170, as shown in Figs. 22A, 22C, and 22D, holds the tissue in place because the tissue would otherwise have to bend wire 170 to provide an exit path. The distal end of wire 170, as shown in Fig. 22B, forms a loop about a section of the proximal strand, or vice versa, thereby creating an even more secure hold on the tissue.
  • wire 170 is made of a very elastic material such as Nitinol
  • Wire 170 holds the tissue in place because the tissue would otherwise have to bend wire 170 to provide an exit path.
  • the distal end of wire 170 forms a loop about a section of the proximal strand, or vice versa
  • the section of suture wires 170 that have passed through die surface 195 can be formed into various shapes depending on the geometry of die surface 195.
  • main body 150 and sleeve 175 are circumscribing vessel 55 after it has been sutured, a method to remove main body 150 and sleeve 170 after the sutures have been placed is provided.
  • Embodiments of main body 150 and sleeve 175 that have been split lengthwise and hinged at one edge are shown in Fig. 24A. After wire sutures 170 have been placed, sleeve 175 is opened up and pulled away, followed by main body 150 in the same fashion.
  • FIGs. 25A and 25B show flexible mandrel 140 that has an inflatable flanged end 200 with die surfaces 195 that expand with the inflation.
  • the fluid pressure to expand mandrel 140 comes from a catheter 210 that is also used to deliver fluid from a point somewhere in the body or outside the body. Because die surfaces 195 need to be rigid, die surfaces 195 are placed on a separate surface 220 from flange 200 that can expand but also remain rigid to deflect wire 170.
  • the present devices provide a means of placing and securing wire sutures around the circumference of vessels during an anastomosis.

Abstract

L'invention concerne un appareil (10) permettant d'insérer de multiples sutures durant l'anastomose de vaisseaux physiologiques. Ledit appareil comprend une couronne (15) pourvue de plusieurs filaments (20) connectés ensemble par un ou plusieurs anneaux (25). Chaque filament forme un point à une extrémité avec un crochet recourbé (45) à la même extrémité. Le crochet recourbé (45) sert de suture pour retenir un ou plusieurs vaisseaux. Dans un autre mode de réalisation, l'appareil comprend plusieurs filaments, ou fils (170), insérés dans un ou plusieurs vaisseaux afin d'y insérer simultanément de multiples sutures. La présente invention concerne également une méthode permettant d'insérer simultanément plusieurs sutures à l'aide d'un appareil.
PCT/US2000/030418 1999-11-05 2000-11-03 Appareil et procede permettant d'inserer de multiples sutures durant une anastomose WO2001034037A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP00976930A EP1233704A1 (fr) 1999-11-05 2000-11-03 Appareil et procede permettant d'inserer de multiples sutures durant une anastomose
CA002393799A CA2393799A1 (fr) 1999-11-05 2000-11-03 Appareil et procede permettant d'inserer de multiples sutures durant une anastomose
JP2001536050A JP2003513696A (ja) 1999-11-05 2000-11-03 吻合中に複数の縫合を配置する装置および方法
MXPA02004493A MXPA02004493A (es) 1999-11-05 2000-11-03 Aparato y metodo para colocar multiples suturas durante la anastomosis.
IL14947400A IL149474A0 (en) 1999-11-05 2000-11-03 Apparatus and method for placing multiple sutures during anastomosis
AU14637/01A AU1463701A (en) 1999-11-05 2000-11-03 Apparatus and method for placing multiple sutures during anastomosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16368099P 1999-11-05 1999-11-05
US60/163,680 1999-11-05

Publications (1)

Publication Number Publication Date
WO2001034037A1 true WO2001034037A1 (fr) 2001-05-17

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PCT/US2000/030418 WO2001034037A1 (fr) 1999-11-05 2000-11-03 Appareil et procede permettant d'inserer de multiples sutures durant une anastomose

Country Status (7)

Country Link
EP (1) EP1233704A1 (fr)
JP (1) JP2003513696A (fr)
AU (1) AU1463701A (fr)
CA (1) CA2393799A1 (fr)
IL (1) IL149474A0 (fr)
MX (1) MXPA02004493A (fr)
WO (1) WO2001034037A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004010898A1 (fr) * 2002-07-29 2004-02-05 Sumit Roy Polymorphes de l'ezetimibe
WO2004086985A1 (fr) * 2003-03-28 2004-10-14 St Jude Medical Atg, Inc. Dispositif de realisation de raccordement anastomotique plus large que le conduit de greffe
WO2005060836A2 (fr) * 2003-12-23 2005-07-07 Umc Utrecht Holding B.V. Element d'operation, ensemble d'operation et procede d'utilisation associe

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004026858D1 (de) * 2003-05-20 2010-06-10 Cleveland Clinic Foundation Vorrichtung zur reparatur von herzklappen
US20050080482A1 (en) * 2003-10-14 2005-04-14 Craig Bonsignore Graft coupling apparatus and methods of using same

Citations (5)

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Publication number Priority date Publication date Assignee Title
US4553543A (en) * 1984-03-05 1985-11-19 Amarasinghe Disamodha C Suturing assembly and method
US5122156A (en) * 1990-12-14 1992-06-16 United States Surgical Corporation Apparatus for securement and attachment of body organs
US5234447A (en) * 1990-08-28 1993-08-10 Robert L. Kaster Side-to-end vascular anastomotic staple apparatus
US6113612A (en) * 1998-11-06 2000-09-05 St. Jude Medical Cardiovascular Group, Inc. Medical anastomosis apparatus
US6152937A (en) * 1998-11-06 2000-11-28 St. Jude Medical Cardiovascular Group, Inc. Medical graft connector and methods of making and installing same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4553543A (en) * 1984-03-05 1985-11-19 Amarasinghe Disamodha C Suturing assembly and method
US5234447A (en) * 1990-08-28 1993-08-10 Robert L. Kaster Side-to-end vascular anastomotic staple apparatus
US5122156A (en) * 1990-12-14 1992-06-16 United States Surgical Corporation Apparatus for securement and attachment of body organs
US6113612A (en) * 1998-11-06 2000-09-05 St. Jude Medical Cardiovascular Group, Inc. Medical anastomosis apparatus
US6152937A (en) * 1998-11-06 2000-11-28 St. Jude Medical Cardiovascular Group, Inc. Medical graft connector and methods of making and installing same

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004010898A1 (fr) * 2002-07-29 2004-02-05 Sumit Roy Polymorphes de l'ezetimibe
US8545524B2 (en) 2002-07-29 2013-10-01 Anastomosis As Method and device for interconnection of two tubular organs
WO2004086985A1 (fr) * 2003-03-28 2004-10-14 St Jude Medical Atg, Inc. Dispositif de realisation de raccordement anastomotique plus large que le conduit de greffe
US8790358B2 (en) 2003-03-28 2014-07-29 St. Jude Medical, Cardiology Division, Inc. Methods and apparatus for making anastomotic connections larger than the graft conduit
WO2005060836A2 (fr) * 2003-12-23 2005-07-07 Umc Utrecht Holding B.V. Element d'operation, ensemble d'operation et procede d'utilisation associe
WO2005060836A3 (fr) * 2003-12-23 2005-11-03 Umc Utrecht Holding Bv Element d'operation, ensemble d'operation et procede d'utilisation associe

Also Published As

Publication number Publication date
EP1233704A1 (fr) 2002-08-28
CA2393799A1 (fr) 2001-05-17
JP2003513696A (ja) 2003-04-15
AU1463701A (en) 2001-06-06
IL149474A0 (en) 2002-11-10
MXPA02004493A (es) 2002-09-02

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