WO2001032934A2 - Station d"hybridation - Google Patents

Station d"hybridation Download PDF

Info

Publication number
WO2001032934A2
WO2001032934A2 PCT/US2000/041899 US0041899W WO0132934A2 WO 2001032934 A2 WO2001032934 A2 WO 2001032934A2 US 0041899 W US0041899 W US 0041899W WO 0132934 A2 WO0132934 A2 WO 0132934A2
Authority
WO
WIPO (PCT)
Prior art keywords
carrier
chamber
station
raised portion
fluid
Prior art date
Application number
PCT/US2000/041899
Other languages
English (en)
Other versions
WO2001032934A3 (fr
Inventor
Thomas M. Baer
Bruce J. Richardson
Chris T. Kitazawa
Darren Berns
Keith E. Moravick
Bruce A. Johnson
Alan L. Schenck
Craig S. Barker
Original Assignee
Arcturus Engineering, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arcturus Engineering, Inc. filed Critical Arcturus Engineering, Inc.
Priority to AU37927/01A priority Critical patent/AU3792701A/en
Publication of WO2001032934A2 publication Critical patent/WO2001032934A2/fr
Publication of WO2001032934A3 publication Critical patent/WO2001032934A3/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004—Cleaning sample transfer devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

La présente invention concerne une station permettant de préparer rapidement des lames disposées en jeux ordonnés en vue de leur hybridation. A cet effet, on insère au moins une lame de micro-arrangements dans un support. Un élément de chambre en contact avec la lame forme une chambre d"hybridation. Le support peut être inséré dans la station de manière amovible en vue de la réalisation de plusieurs étapes associées aux processus de pré-hybridation et de post-hybridation. La station comprend généralement au moins un ensemble station de lavage, un système d"apport de fluide, un système d"apport des échantillons ainsi qu"un système de régulation de la température.
PCT/US2000/041899 1999-11-04 2000-11-03 Station d"hybridation WO2001032934A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU37927/01A AU3792701A (en) 1999-11-04 2000-11-03 Hybridization station

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16363499P 1999-11-04 1999-11-04
US60/163,634 1999-11-04

Publications (2)

Publication Number Publication Date
WO2001032934A2 true WO2001032934A2 (fr) 2001-05-10
WO2001032934A3 WO2001032934A3 (fr) 2002-09-12

Family

ID=22590883

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/041899 WO2001032934A2 (fr) 1999-11-04 2000-11-03 Station d"hybridation

Country Status (2)

Country Link
AU (1) AU3792701A (fr)
WO (1) WO2001032934A2 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100408167B1 (ko) * 2001-05-21 2003-12-03 (주)지노믹트리 디엔에이 마이크로 어레이 시스템용 하이브리다이제이션챔버
KR100419003B1 (ko) * 2001-05-11 2004-02-14 (주)로봇앤드디자인 디엔에이/프로테인 어레이어의 가습조절 장치
US6913931B2 (en) 2002-10-03 2005-07-05 3M Innovative Properties Company Devices, methods and systems for low volume microarray processing
DE102004046724B3 (de) * 2004-09-27 2006-02-02 Zell-Kontakt Gmbh Reaktionsgefäß und Verfahren zur Behandlung biologischen Materials
EP1724564A1 (fr) * 2005-05-18 2006-11-22 Miltenyi Biotec GmbH Chambre améliorée d'échantillonnage pour un dispositif d'analyse.
US7517498B2 (en) 2003-08-19 2009-04-14 Agilent Technologies, Inc. Apparatus for substrate handling
EP2169383A1 (fr) 2001-06-15 2010-03-31 Bayer Technology Services GmbH Organe pour l'écoulement à travers des cuvettes et son utilisation
CN105044371A (zh) * 2015-04-14 2015-11-11 广州安必平医药科技股份有限公司 样品反应仓

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993019207A1 (fr) * 1992-03-23 1993-09-30 Gene Tec Corporation Appareil permettant de confiner des specimens biologiques devant subir un traitement thermique
EP0611598A2 (fr) * 1993-02-16 1994-08-24 The Perkin-Elmer Corporation Procédé d'amplification PCR in situ

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993019207A1 (fr) * 1992-03-23 1993-09-30 Gene Tec Corporation Appareil permettant de confiner des specimens biologiques devant subir un traitement thermique
EP0611598A2 (fr) * 1993-02-16 1994-08-24 The Perkin-Elmer Corporation Procédé d'amplification PCR in situ

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100419003B1 (ko) * 2001-05-11 2004-02-14 (주)로봇앤드디자인 디엔에이/프로테인 어레이어의 가습조절 장치
KR100408167B1 (ko) * 2001-05-21 2003-12-03 (주)지노믹트리 디엔에이 마이크로 어레이 시스템용 하이브리다이제이션챔버
EP2169383A1 (fr) 2001-06-15 2010-03-31 Bayer Technology Services GmbH Organe pour l'écoulement à travers des cuvettes et son utilisation
US6913931B2 (en) 2002-10-03 2005-07-05 3M Innovative Properties Company Devices, methods and systems for low volume microarray processing
US7517498B2 (en) 2003-08-19 2009-04-14 Agilent Technologies, Inc. Apparatus for substrate handling
DE102004046724B3 (de) * 2004-09-27 2006-02-02 Zell-Kontakt Gmbh Reaktionsgefäß und Verfahren zur Behandlung biologischen Materials
EP1724564A1 (fr) * 2005-05-18 2006-11-22 Miltenyi Biotec GmbH Chambre améliorée d'échantillonnage pour un dispositif d'analyse.
WO2006122968A1 (fr) * 2005-05-18 2006-11-23 Miltenyi Biotec Gmbh Enceinte d'echantillonnage amelioree pour un dispositif d'analyse
CN105044371A (zh) * 2015-04-14 2015-11-11 广州安必平医药科技股份有限公司 样品反应仓

Also Published As

Publication number Publication date
AU3792701A (en) 2001-05-14
WO2001032934A3 (fr) 2002-09-12

Similar Documents

Publication Publication Date Title
CA2364381C (fr) Cartouche de puce a ecoulement continu, porte-puce, systeme et son procede
US9677133B2 (en) Biological chip hybridization system
US6773676B2 (en) Devices for performing array hybridization assays and methods of using the same
US5333675A (en) Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US7772010B2 (en) Mixing and dispensing homogeneous compounds of a reactant on a surface
KR100298487B1 (ko) 증폭반응용의폐기가능한이중챔버반응용기,이에대한반응공정스테이션,및이것의사용방법
CN1892220B (zh) 生化反应盒
US20050277125A1 (en) High-density reaction chambers and methods of use
JP4721425B2 (ja) 流体移動方法および流体移動装置
US20080153714A1 (en) Nucleic acid detection cassette and nucleic acid detection system
US20030091477A1 (en) Flow-thru chip cartridge, chip holder, system & method thereof
EP2402427A2 (fr) Appareil à bloc d'échantillons et procédé de maintien d'une microcarte sur un bloc d'échantillons
US20080268458A1 (en) Method of Preparing Nucleic Acids for Detection
KR102206856B1 (ko) 중합효소 연쇄반응 시스템
CN107002005B (zh) 核酸检测盒
WO2001032934A2 (fr) Station d"hybridation
JP2005504974A (ja) 物質ライブラリー基板保持装置
EP1214149A2 (fr) Dispositif de traitement rapide d'echantillons d'adn a manipulation des liquides, thermocyclage, et purification integres
US20100276309A1 (en) Fluid containing cartridge and utilization of the same
US20020106787A1 (en) Device for repid DNA sample processing with integrated liquid handling, thermocycling, and purification
US7695952B2 (en) Disposable sample processing module for detecting nucleic acids
WO2003004162A1 (fr) Cartouche de puce d'analyse biomoleculaire ftc, support systeme et procede correspondants
KR200323025Y1 (ko) 하이브리다이제이션 장치

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase