WO2001032628A1 - Composes cyano utiles en tant qu"inhibiteurs du facteur xa - Google Patents
Composes cyano utiles en tant qu"inhibiteurs du facteur xa Download PDFInfo
- Publication number
- WO2001032628A1 WO2001032628A1 PCT/US2000/030209 US0030209W WO0132628A1 WO 2001032628 A1 WO2001032628 A1 WO 2001032628A1 US 0030209 W US0030209 W US 0030209W WO 0132628 A1 WO0132628 A1 WO 0132628A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- phenyl
- substituted
- occurrence
- alkyl
- aminomethyl
- Prior art date
Links
- 0 ON*1C(NNC2C#CC2)=CC([Zn])=*1 Chemical compound ON*1C(NNC2C#CC2)=CC([Zn])=*1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00976822A EP1226123A1 (fr) | 1999-11-03 | 2000-11-02 | Composes cyano utiles en tant qu'inhibiteurs du facteur xa |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16326899P | 1999-11-03 | 1999-11-03 | |
US60/163,268 | 1999-11-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001032628A1 true WO2001032628A1 (fr) | 2001-05-10 |
Family
ID=22589221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/030209 WO2001032628A1 (fr) | 1999-11-03 | 2000-11-02 | Composes cyano utiles en tant qu"inhibiteurs du facteur xa |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP1226123A1 (fr) |
WO (1) | WO2001032628A1 (fr) |
Cited By (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6747047B2 (en) | 2000-03-22 | 2004-06-08 | E.I. Du Pont De Nemours And Company | Insecticidal anthranilamides |
WO2004050636A2 (fr) * | 2002-12-04 | 2004-06-17 | Aventis Pharma Deutschland Gmbh | Derives de l'imidazole utilises comme inhibiteurs du facteur xa |
EP1433788A1 (fr) * | 2002-12-23 | 2004-06-30 | Aventis Pharma Deutschland GmbH | Dérivés de pyrazole en tant qu'inhibiteurs du facteur Xa |
WO2004056815A1 (fr) * | 2002-12-23 | 2004-07-08 | Aventis Pharma Deutschland Gmbh | Derives de pyrazole utilises en tant qu'inhibiteurs du facteur xa |
EP1479674A1 (fr) * | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Dérivés d'imidazole en tant qu'inhibiteurs du facteur xa |
EP1479679A1 (fr) * | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Dérivés de triazoles en tant qu'inhibiteurs du facteur Xa |
EP1479678A1 (fr) * | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Derivés du pyrazole en tant qu'inhibiteurs du facteur Xa |
EP1568698A1 (fr) * | 2004-02-27 | 2005-08-31 | Aventis Pharma Deutschland GmbH | Dérivés de pyrrole en tant qu'inhibiteurs du facteur xa |
US6949550B2 (en) | 2001-12-04 | 2005-09-27 | Bristol-Myers Squibb Company | Substituted amino methyl factor Xa inhibitors |
US6967208B2 (en) | 2001-09-21 | 2005-11-22 | Bristol-Myers Squibb Pharma Company | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors |
US7115627B2 (en) | 2001-12-04 | 2006-10-03 | Bristol-Myers Squibb Company | Glycinamides as factor Xa inhibitors |
US7122557B2 (en) | 2003-03-18 | 2006-10-17 | Bristol-Myers Squibb Company | Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors |
US7148217B2 (en) | 2001-10-15 | 2006-12-12 | E. I. Du Pont De Nemours And Company | Iminobenzoxazines, iminobenzthiazines and iminoquinazolines for controlling invertebrate pests |
WO2005123050A3 (fr) * | 2004-06-15 | 2007-01-04 | Bristol Myers Squibb Co | Heterocycles a cinq chainons utilises comme inhibiteurs de la serine protease |
US7179824B2 (en) | 2001-09-21 | 2007-02-20 | E. I. Du Pont De Nemours And Company | Arthropodicidal anthranilamides |
US7199138B2 (en) | 2001-08-16 | 2007-04-03 | E. I. Du Pont De Nemours And Company | Substituted anthranilamides for controlling invertebrate pests |
US7223780B2 (en) | 2003-05-19 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Triazole-derivatives as blood clotting enzyme factor Xa inhibitors |
US7232836B2 (en) | 2001-08-13 | 2007-06-19 | E. I. Du Pont De Nemours And Company | Arthropodicidal anthranilamides |
US7288554B2 (en) | 2001-08-15 | 2007-10-30 | E.I. Du Pont De Nemours And Company | Ortho-substituted aryl amides for controlling invertebrate pests |
US7312214B2 (en) | 2002-05-10 | 2007-12-25 | Bristol-Myers Squibb Company | 1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors |
US7338963B2 (en) | 2001-09-21 | 2008-03-04 | Bristol-Myers Squibb Company | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors |
US7358268B2 (en) | 2002-12-04 | 2008-04-15 | Sanofi-Aventis Deutschland Gmbh | Imidazole derivatives as factor Xa inhibitors |
US7375232B2 (en) | 2001-08-15 | 2008-05-20 | E.I. Du Pont De Nemours And Company | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests |
US7429581B2 (en) | 2002-12-23 | 2008-09-30 | Sanofi-Aventis Deutschland Gmbh | Pyrazole-derivatives as factor Xa inhibitors |
US7696232B2 (en) | 2001-09-21 | 2010-04-13 | E. I. Du Pont De Nemours And Company | Anthranilamide arthropodicide treatment |
US7696233B2 (en) | 2001-08-13 | 2010-04-13 | E. I. Du Pont De Nemours And Company | Method for controlling particular insect pests by applying anthranilamide compounds |
US7767677B2 (en) | 2004-09-20 | 2010-08-03 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
US7777036B2 (en) | 2004-09-20 | 2010-08-17 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
JP2010215655A (ja) * | 2002-12-23 | 2010-09-30 | 4Sc Ag | 抗炎症剤、免疫調節剤及び増殖抑制剤としての芳香族化合物 |
US7829712B2 (en) | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
US7919496B2 (en) | 2004-09-20 | 2011-04-05 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes |
US7951805B2 (en) | 2004-09-20 | 2011-05-31 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
US8026360B2 (en) | 2004-09-20 | 2011-09-27 | Xenon Pharmaceuticals Inc. | Substituted pyridazines as stearoyl-CoA desaturase inhibitors |
US8071603B2 (en) | 2004-09-20 | 2011-12-06 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
US8202999B2 (en) | 2005-01-07 | 2012-06-19 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
US8541457B2 (en) | 2005-06-03 | 2013-09-24 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors |
US20130302839A1 (en) * | 2010-11-22 | 2013-11-14 | Universitat Heidelberg | ANALYSIS OF DIRECT FACTOR Xa INHIBITORS |
US10391094B2 (en) | 2010-11-07 | 2019-08-27 | Impact Biomedicines, Inc. | Compositions and methods for treating myelofibrosis |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998028269A1 (fr) * | 1996-12-23 | 1998-07-02 | Du Pont Pharmaceuticals Company | COMPOSES HETEROAROMATIQUES CONTENANT DE L'AZOTE, UTILISES EN TANT QU'INHIBITEURS DU FACTEUR Xa |
WO1998057937A2 (fr) * | 1997-06-19 | 1998-12-23 | The Du Pont Merck Pharmaceutical Company | INHIBITEURS DU FACTEUR Xa COMPRENANT UN GROUPE A SPECIFICITE P1 NEUTRE |
WO1999032454A1 (fr) * | 1997-12-22 | 1999-07-01 | Du Pont Pharmaceuticals Company | Heteroaromatiques contenant de l'azote, presentant des groupes p1 a substitution ortho, et utilises en tant qu'inhibiteurs du facteur xa |
-
2000
- 2000-11-02 WO PCT/US2000/030209 patent/WO2001032628A1/fr not_active Application Discontinuation
- 2000-11-02 EP EP00976822A patent/EP1226123A1/fr not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998028269A1 (fr) * | 1996-12-23 | 1998-07-02 | Du Pont Pharmaceuticals Company | COMPOSES HETEROAROMATIQUES CONTENANT DE L'AZOTE, UTILISES EN TANT QU'INHIBITEURS DU FACTEUR Xa |
WO1998057937A2 (fr) * | 1997-06-19 | 1998-12-23 | The Du Pont Merck Pharmaceutical Company | INHIBITEURS DU FACTEUR Xa COMPRENANT UN GROUPE A SPECIFICITE P1 NEUTRE |
WO1999032454A1 (fr) * | 1997-12-22 | 1999-07-01 | Du Pont Pharmaceuticals Company | Heteroaromatiques contenant de l'azote, presentant des groupes p1 a substitution ortho, et utilises en tant qu'inhibiteurs du facteur xa |
Cited By (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6747047B2 (en) | 2000-03-22 | 2004-06-08 | E.I. Du Pont De Nemours And Company | Insecticidal anthranilamides |
US7338978B2 (en) | 2000-03-22 | 2008-03-04 | E.I. Du Pont De Nemours And Company | Insecticidal anthranilamides |
US6995178B2 (en) | 2000-03-22 | 2006-02-07 | E. I. Du Pont De Nemours And Company | Insecticidal anthranilamides |
US9113630B2 (en) | 2001-08-13 | 2015-08-25 | E I Du Pont De Nemours And Company | Method of controlling particular insect pests by applying anthranilamide compounds |
US8697734B2 (en) | 2001-08-13 | 2014-04-15 | E I Du Pont De Nemours And Company | Method for controlling particular insect pests by applying anthranilamide compounds |
US7696233B2 (en) | 2001-08-13 | 2010-04-13 | E. I. Du Pont De Nemours And Company | Method for controlling particular insect pests by applying anthranilamide compounds |
US9445593B1 (en) | 2001-08-13 | 2016-09-20 | E I Du Pont De Nemours And Company | Arthropodicidal anthranilamides |
US9078437B2 (en) | 2001-08-13 | 2015-07-14 | E I Du Pont De Nemours And Company | Arthropodicidal anthranilamides |
US7232836B2 (en) | 2001-08-13 | 2007-06-19 | E. I. Du Pont De Nemours And Company | Arthropodicidal anthranilamides |
US9084422B2 (en) | 2001-08-13 | 2015-07-21 | E I Du Pont De Nemours And Company | Anthranilamides compositions |
US8921400B2 (en) | 2001-08-13 | 2014-12-30 | E I Du Pont De Nemours And Company | Arthropodicidal anthranilamides |
US9029365B2 (en) | 2001-08-13 | 2015-05-12 | E I Du Pont De Nemours And Company | Arthropodicidal anthranilamides |
US8148521B2 (en) | 2001-08-13 | 2012-04-03 | E.I. Du Pont De Nemours And Company | Arthropodicidal anthranilamides |
US7902231B2 (en) | 2001-08-13 | 2011-03-08 | E.I. Du Pont De Nemours And Company | Anthropodicidal anthranilamides |
US9049861B2 (en) | 2001-08-13 | 2015-06-09 | E I Du Pont De Nemours And Company | Arthropodicidal anthranilamides |
US9049862B2 (en) | 2001-08-13 | 2015-06-09 | E I Du Pont De Nemours And Company | Arthropodicidal anthranilamides |
US8158802B2 (en) | 2001-08-13 | 2012-04-17 | E.I. Du Pont De Nemours And Company | Arthropodicidal anthranilamides |
US7375232B2 (en) | 2001-08-15 | 2008-05-20 | E.I. Du Pont De Nemours And Company | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests |
US7288554B2 (en) | 2001-08-15 | 2007-10-30 | E.I. Du Pont De Nemours And Company | Ortho-substituted aryl amides for controlling invertebrate pests |
US7629463B2 (en) | 2001-08-15 | 2009-12-08 | E. I. Du Pont De Nemours And Company | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests |
US7199138B2 (en) | 2001-08-16 | 2007-04-03 | E. I. Du Pont De Nemours And Company | Substituted anthranilamides for controlling invertebrate pests |
US7541377B2 (en) | 2001-08-16 | 2009-06-02 | E.I. Du Pont De Nemours And Company | Substituted anthranilamides for controlling invertebrate pests |
US6989391B2 (en) | 2001-09-21 | 2006-01-24 | Bristol-Myers-Squibb Pharma Company | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors |
US7179824B2 (en) | 2001-09-21 | 2007-02-20 | E. I. Du Pont De Nemours And Company | Arthropodicidal anthranilamides |
US7696232B2 (en) | 2001-09-21 | 2010-04-13 | E. I. Du Pont De Nemours And Company | Anthranilamide arthropodicide treatment |
US7960411B2 (en) | 2001-09-21 | 2011-06-14 | Bristol-Myers Squibb Company | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors |
US7691846B2 (en) | 2001-09-21 | 2010-04-06 | Bristol-Myers Squibb Company | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors |
US9173400B2 (en) | 2001-09-21 | 2015-11-03 | E I Du Pont De Nemours And Company | Anthranilamide arthropodicide treatment |
US9975891B2 (en) | 2001-09-21 | 2018-05-22 | Bristol-Myers Squibb Company | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors |
US7338963B2 (en) | 2001-09-21 | 2008-03-04 | Bristol-Myers Squibb Company | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors |
US8188120B2 (en) | 2001-09-21 | 2012-05-29 | Bristol-Myers Squibb Company | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors |
EP2105436A1 (fr) | 2001-09-21 | 2009-09-30 | Bristol-Myers Squibb Company | Composés comprenant un lactame et leurs dérivés en tant qu'inhibiteurs du facteur Xa |
US7371761B2 (en) | 2001-09-21 | 2008-05-13 | Bristol-Myers Squibb Company | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors |
US7005435B2 (en) | 2001-09-21 | 2006-02-28 | Bristol-Myers Squibb Pharma Company | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors |
US8470854B2 (en) | 2001-09-21 | 2013-06-25 | Bristol-Meyers Squibb Company | Lactam-containing compounds and derivatives thereof as factor XA inhibitors |
US6995172B2 (en) | 2001-09-21 | 2006-02-07 | Bristol-Myers Squibb Pharma Company | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors |
US6967208B2 (en) | 2001-09-21 | 2005-11-22 | Bristol-Myers Squibb Pharma Company | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors |
US7531535B2 (en) | 2001-09-21 | 2009-05-12 | Bristol-Meyers Squibb Company | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors |
US8637552B2 (en) | 2001-09-21 | 2014-01-28 | E I Du Pont De Nemours And Company | Anthranilamide arthropodicide treatment |
US7326704B2 (en) | 2001-10-15 | 2008-02-05 | E.I. Dupont De Nemours And Company | Iminobenzoxazines, iminobenzthiazines and iminoquinazolines for controlling invertebrate pests |
US7148217B2 (en) | 2001-10-15 | 2006-12-12 | E. I. Du Pont De Nemours And Company | Iminobenzoxazines, iminobenzthiazines and iminoquinazolines for controlling invertebrate pests |
US6949550B2 (en) | 2001-12-04 | 2005-09-27 | Bristol-Myers Squibb Company | Substituted amino methyl factor Xa inhibitors |
US7115627B2 (en) | 2001-12-04 | 2006-10-03 | Bristol-Myers Squibb Company | Glycinamides as factor Xa inhibitors |
US7312214B2 (en) | 2002-05-10 | 2007-12-25 | Bristol-Myers Squibb Company | 1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors |
US7358268B2 (en) | 2002-12-04 | 2008-04-15 | Sanofi-Aventis Deutschland Gmbh | Imidazole derivatives as factor Xa inhibitors |
WO2004050636A3 (fr) * | 2002-12-04 | 2004-10-14 | Aventis Pharma Gmbh | Derives de l'imidazole utilises comme inhibiteurs du facteur xa |
AU2003285336B2 (en) * | 2002-12-04 | 2009-11-26 | Sanofi-Aventis Deutschland Gmbh | Imidazole-derivatives as factor Xa inhibitors |
JP2006514093A (ja) * | 2002-12-04 | 2006-04-27 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Xa因子阻害剤としてのイミダゾール誘導体 |
WO2004050636A2 (fr) * | 2002-12-04 | 2004-06-17 | Aventis Pharma Deutschland Gmbh | Derives de l'imidazole utilises comme inhibiteurs du facteur xa |
WO2004056815A1 (fr) * | 2002-12-23 | 2004-07-08 | Aventis Pharma Deutschland Gmbh | Derives de pyrazole utilises en tant qu'inhibiteurs du facteur xa |
JP2010215655A (ja) * | 2002-12-23 | 2010-09-30 | 4Sc Ag | 抗炎症剤、免疫調節剤及び増殖抑制剤としての芳香族化合物 |
EP1433788A1 (fr) * | 2002-12-23 | 2004-06-30 | Aventis Pharma Deutschland GmbH | Dérivés de pyrazole en tant qu'inhibiteurs du facteur Xa |
US7910606B2 (en) | 2002-12-23 | 2011-03-22 | Sanofi-Aventis Deutschland Gmbh | Pyrazole-derivatives as factor Xa inhibitors |
US7429581B2 (en) | 2002-12-23 | 2008-09-30 | Sanofi-Aventis Deutschland Gmbh | Pyrazole-derivatives as factor Xa inhibitors |
US7122557B2 (en) | 2003-03-18 | 2006-10-17 | Bristol-Myers Squibb Company | Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors |
JP2006528941A (ja) * | 2003-05-19 | 2006-12-28 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 第Xa因子阻害剤としてのトリアゾール誘導体 |
EP1479674A1 (fr) * | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Dérivés d'imidazole en tant qu'inhibiteurs du facteur xa |
EP1479679A1 (fr) * | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Dérivés de triazoles en tant qu'inhibiteurs du facteur Xa |
EP1479678A1 (fr) * | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Derivés du pyrazole en tant qu'inhibiteurs du facteur Xa |
WO2004101555A1 (fr) * | 2003-05-19 | 2004-11-25 | Sanofi-Aventis Deutschland Gmbh | Derives de triazole utilises comme inhibiteurs du factor xa |
US7223780B2 (en) | 2003-05-19 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Triazole-derivatives as blood clotting enzyme factor Xa inhibitors |
US7465806B2 (en) | 2004-02-27 | 2008-12-16 | Sanofi-Aventis Deutschland Gmbh | Pyrrole-derivatives as factor Xa inhibitors |
EP1568698A1 (fr) * | 2004-02-27 | 2005-08-31 | Aventis Pharma Deutschland GmbH | Dérivés de pyrrole en tant qu'inhibiteurs du facteur xa |
US7453002B2 (en) | 2004-06-15 | 2008-11-18 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
US8101778B2 (en) | 2004-06-15 | 2012-01-24 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
US10112936B2 (en) | 2004-06-15 | 2018-10-30 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
US9617224B2 (en) | 2004-06-15 | 2017-04-11 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
US8716492B2 (en) | 2004-06-15 | 2014-05-06 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
US9079860B2 (en) | 2004-06-15 | 2015-07-14 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
WO2005123050A3 (fr) * | 2004-06-15 | 2007-01-04 | Bristol Myers Squibb Co | Heterocycles a cinq chainons utilises comme inhibiteurs de la serine protease |
US7919496B2 (en) | 2004-09-20 | 2011-04-05 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes |
US7951805B2 (en) | 2004-09-20 | 2011-05-31 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
US7829712B2 (en) | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
US7767677B2 (en) | 2004-09-20 | 2010-08-03 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
US8071603B2 (en) | 2004-09-20 | 2011-12-06 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
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