WO2001032143A1 - Composition pharmaceutique pour administer des substances actives sur le plan pharmaceutique insolubles dans l'eau et procede de preparation afferent - Google Patents

Composition pharmaceutique pour administer des substances actives sur le plan pharmaceutique insolubles dans l'eau et procede de preparation afferent Download PDF

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Publication number
WO2001032143A1
WO2001032143A1 PCT/IN1999/000062 IN9900062W WO0132143A1 WO 2001032143 A1 WO2001032143 A1 WO 2001032143A1 IN 9900062 W IN9900062 W IN 9900062W WO 0132143 A1 WO0132143 A1 WO 0132143A1
Authority
WO
WIPO (PCT)
Prior art keywords
component
composition
water
cyclosporin
fatty acids
Prior art date
Application number
PCT/IN1999/000062
Other languages
English (en)
Inventor
Amar Lulla
Geena Malhotra
Original Assignee
Cipla Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd. filed Critical Cipla Ltd.
Priority to AU21274/00A priority Critical patent/AU2127400A/en
Priority to PCT/IN1999/000062 priority patent/WO2001032143A1/fr
Priority to ARP990106120A priority patent/AR026101A1/es
Priority to EP00971598A priority patent/EP1227793A1/fr
Priority to PCT/GB2000/004143 priority patent/WO2001032142A1/fr
Priority to AU10432/01A priority patent/AU1043201A/en
Publication of WO2001032143A1 publication Critical patent/WO2001032143A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Definitions

  • microemulsions for solid microfme cyclosporin to be formed during their
  • EP-A-327280 describes dissolving cyclosporin in a mono-or di- glyceride of C6-C10 fatty acid. The solution may then be emulsified in an aqueous medium.
  • these emulsions are not microemulsions and do not contain the mixture of lecithin and another surfactant which is especially used, together with the particular triglycerides component (b) all of which are necessary to obtain the significant advantages of the invention.

Abstract

L'invention concerne une composition pharmaceutique sous forme de microémulsion stable huile-dans-l'eau préparée conformément au procédé selon l'invention. Cette composition est essentiellement composée d'une substance active sur le plan pharmaceutique insoluble dans l'eau, d'esters d'acides gras de propylène glycol en C8-C20 d'huiles végétales et d'esters de glyceryl d'acides gras ou de glycerides d'huile végétale d'acides gras, de tensio-actif et d'une phase hydrophile.
PCT/IN1999/000062 1999-11-02 1999-11-02 Composition pharmaceutique pour administer des substances actives sur le plan pharmaceutique insolubles dans l'eau et procede de preparation afferent WO2001032143A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU21274/00A AU2127400A (en) 1999-11-02 1999-11-02 A pharmaceutical composition for the administration of water-insoluble pharmaceutically active substances and process for preparation thereof
PCT/IN1999/000062 WO2001032143A1 (fr) 1999-11-02 1999-11-02 Composition pharmaceutique pour administer des substances actives sur le plan pharmaceutique insolubles dans l'eau et procede de preparation afferent
ARP990106120A AR026101A1 (es) 1999-11-02 1999-12-01 Un proceso para la preparacion de una composicion farmaceutica para la administracion de sustancias farmaceuticamente activas insolubles en agua
EP00971598A EP1227793A1 (fr) 1999-11-02 2000-10-27 Formulation de cyclosporine
PCT/GB2000/004143 WO2001032142A1 (fr) 1999-11-02 2000-10-27 Formulation de cyclosporine
AU10432/01A AU1043201A (en) 1999-11-02 2000-10-27 Cyclosporin formulation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN1999/000062 WO2001032143A1 (fr) 1999-11-02 1999-11-02 Composition pharmaceutique pour administer des substances actives sur le plan pharmaceutique insolubles dans l'eau et procede de preparation afferent

Publications (1)

Publication Number Publication Date
WO2001032143A1 true WO2001032143A1 (fr) 2001-05-10

Family

ID=11076677

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN1999/000062 WO2001032143A1 (fr) 1999-11-02 1999-11-02 Composition pharmaceutique pour administer des substances actives sur le plan pharmaceutique insolubles dans l'eau et procede de preparation afferent

Country Status (3)

Country Link
AR (1) AR026101A1 (fr)
AU (1) AU2127400A (fr)
WO (1) WO2001032143A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003017986A1 (fr) * 2001-08-27 2003-03-06 Won Jin Biopharma Co., Ltd. Compositions contenant de l'itraconazole et leurs procedes de preparation
WO2005102277A1 (fr) * 2004-04-19 2005-11-03 Hewlett-Packard Development Company, L.P. Composition de micro-emulsion giclable, procede permettant de preparer celle-ci ainsi que systeme d'administration
US20140011753A1 (en) * 2005-07-13 2014-01-09 Allergan, Inc. Cyclosporin compositions
US20140057855A1 (en) * 2005-07-13 2014-02-27 Allergan, Inc. Cyclosporin compositions

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0327280A1 (fr) * 1988-01-29 1989-08-09 Sankyo Company Limited Compositions contenant de la cyclosporine
GB2228198A (en) * 1989-02-20 1990-08-22 Sandoz Ltd Orally administrable cyclosporin solutions
EP0539319A2 (fr) * 1991-06-27 1993-04-28 Sandoz Ltd. Composition pharmaceutique de cyclosphorine
EP0760237A1 (fr) * 1995-08-30 1997-03-05 Cipla Limited Microémulsions huile-dans-l'eau
WO1998040051A1 (fr) * 1997-03-12 1998-09-17 Abbott Laboratories Systemes lipophiles binaires permettant l'administration de composes lipophiles
WO1999044584A1 (fr) * 1998-03-06 1999-09-10 Novartis Ag Preconcentres d'emulsion a base de cyclosporine ou d'un macrolide

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0327280A1 (fr) * 1988-01-29 1989-08-09 Sankyo Company Limited Compositions contenant de la cyclosporine
GB2228198A (en) * 1989-02-20 1990-08-22 Sandoz Ltd Orally administrable cyclosporin solutions
EP0539319A2 (fr) * 1991-06-27 1993-04-28 Sandoz Ltd. Composition pharmaceutique de cyclosphorine
EP0760237A1 (fr) * 1995-08-30 1997-03-05 Cipla Limited Microémulsions huile-dans-l'eau
WO1998040051A1 (fr) * 1997-03-12 1998-09-17 Abbott Laboratories Systemes lipophiles binaires permettant l'administration de composes lipophiles
WO1999044584A1 (fr) * 1998-03-06 1999-09-10 Novartis Ag Preconcentres d'emulsion a base de cyclosporine ou d'un macrolide

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003017986A1 (fr) * 2001-08-27 2003-03-06 Won Jin Biopharma Co., Ltd. Compositions contenant de l'itraconazole et leurs procedes de preparation
WO2005102277A1 (fr) * 2004-04-19 2005-11-03 Hewlett-Packard Development Company, L.P. Composition de micro-emulsion giclable, procede permettant de preparer celle-ci ainsi que systeme d'administration
US20140011753A1 (en) * 2005-07-13 2014-01-09 Allergan, Inc. Cyclosporin compositions
US20140057855A1 (en) * 2005-07-13 2014-02-27 Allergan, Inc. Cyclosporin compositions
US8969306B2 (en) * 2005-07-13 2015-03-03 Allergan, Inc. Cyclosporin compositions
US8969307B2 (en) * 2005-07-13 2015-03-03 Allergan, Inc. Cyclosporin compositions
US10456474B2 (en) 2005-07-13 2019-10-29 Saint Regis Mohawk Tribe Cyclosporin compositions

Also Published As

Publication number Publication date
AR026101A1 (es) 2003-01-29
AU2127400A (en) 2001-05-14

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