WO2001029221A3 - Proteins and polynucleotides encoding them - Google Patents

Proteins and polynucleotides encoding them Download PDF

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Publication number
WO2001029221A3
WO2001029221A3 PCT/US2000/029052 US0029052W WO0129221A3 WO 2001029221 A3 WO2001029221 A3 WO 2001029221A3 US 0029052 W US0029052 W US 0029052W WO 0129221 A3 WO0129221 A3 WO 0129221A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
polynucleotides
polypeptides
polynucleotides encoding
antagonists
Prior art date
Application number
PCT/US2000/029052
Other languages
French (fr)
Other versions
WO2001029221A2 (en
Inventor
Darrell C Conklin
David P Yee
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to AU12200/01A priority Critical patent/AU1220001A/en
Publication of WO2001029221A2 publication Critical patent/WO2001029221A2/en
Publication of WO2001029221A3 publication Critical patent/WO2001029221A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides polynucleotides and secreted proteins encoded by the polynucleotides. The proteins include a variety of fusion proteins, including fusions comprising a signal peptide selected from the group consisting of signal peptides shown in SEQ ID NO:M, wherein M is an even integer from 2 to 422, operably linked to a second polypeptide. The invention further provides therapeutic and diagnostic methods utilizing the polynucleotides, polypeptides, and antagonists of the polypeptides.
PCT/US2000/029052 1999-10-20 2000-10-20 Proteins and polynucleotides encoding them WO2001029221A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU12200/01A AU1220001A (en) 1999-10-20 2000-10-20 Novel proteins and polynucleotides encoding them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16071299P 1999-10-20 1999-10-20
US60/160,712 1999-10-20

Publications (2)

Publication Number Publication Date
WO2001029221A2 WO2001029221A2 (en) 2001-04-26
WO2001029221A3 true WO2001029221A3 (en) 2002-01-24

Family

ID=22578103

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/029052 WO2001029221A2 (en) 1999-10-20 2000-10-20 Proteins and polynucleotides encoding them

Country Status (2)

Country Link
AU (1) AU1220001A (en)
WO (1) WO2001029221A2 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030170864A1 (en) 2000-05-30 2003-09-11 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7091315B1 (en) 1998-07-15 2006-08-15 Human Genome Sciences, Inc. Protein HDPBQ71
US20030009013A1 (en) 1998-12-30 2003-01-09 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
ATE332308T1 (en) * 1999-01-12 2006-07-15 Genentech Inc SECRETED AND TRANSMEMBRANE POLYPEPTIDE AND NUCLEIC ACID CODING THEREOF
US20030224379A1 (en) * 2000-01-21 2003-12-04 Tang Y. Tom Novel nucleic acids and polypeptides
WO2002000841A2 (en) * 2000-06-23 2002-01-03 Millennium Pharmaceuticals, Inc. 58199, a membrane-associated protein and uses therefor
CA2420320A1 (en) * 2000-08-28 2002-03-07 Human Genome Sciences, Inc. 7 human secreted proteins
AU2001297794A1 (en) 2000-10-19 2002-12-03 Millenium Pharmaceuticals, Inc. Methods and compositions of human proteins and uses thereof.
US20020127556A1 (en) * 2001-03-06 2002-09-12 Yan Luo DNA encoding human Cid2
CA2442134A1 (en) 2001-03-29 2002-10-10 Celltech R & D, Inc. Compositions and methods for diagnosing or treating psoriasis
JP4219808B2 (en) * 2001-08-23 2009-02-04 塩野義製薬株式会社 A novel gene with a guanine nucleotide exchange factor-like sequence
CA2399569A1 (en) * 2001-09-25 2003-03-25 Yusuke Nakamura Diagnostic markers and drug targets for treatment of cancer
AU2002329061A1 (en) 2001-09-25 2003-04-07 Japan As Represented By The President Of The University Of Tokyo Gene and protein relating to hepatocellular carcinoma
AU2002359252A1 (en) 2001-10-05 2003-04-22 Keck Graduate Institute Of Applied Life Sciences Human tyrosine-dna phosphodiesterase variant polypeptides and methods of use therefor
WO2003033703A2 (en) * 2001-10-15 2003-04-24 Amersham Plc Human gtp-activator protein for rab-like gtpase
GB0127217D0 (en) * 2001-11-12 2002-01-02 Univ Bristol MET a novel suppresser of estrogen induced transcription
US7202335B2 (en) 2001-12-06 2007-04-10 Genentech, Inc. PRO300 polypeptides
EP1536010A4 (en) * 2002-08-21 2006-04-12 Takeda Pharmaceutical Preventives/remedies for cancer
WO2004024068A2 (en) 2002-09-11 2004-03-25 Genentech, Inc. Novel composition and methods for the treatment of immune related diseases
FR2844713A1 (en) * 2002-09-25 2004-03-26 Exonhit Therapeutics Sa Use of inhibitor of FLJ protein, for treatment and prevention of e.g. cancer, diabetic retinopathy or arthritis, also new protein, nucleic acid and their inhibitors
WO2005025624A2 (en) 2003-09-15 2005-03-24 Cenix Bioscience Gmbh The use of eukaryotic genes affecting cell cycle control or cell cycle progression for diagnosis and treatment of proliferattive diseases
WO2005030805A1 (en) * 2003-09-25 2005-04-07 Takeda Pharmaceutical Company Limited Novel protein complex and use thereof
GB0414325D0 (en) * 2004-06-25 2004-07-28 Celltech R&D Ltd A protein involved in cancer
TWI596109B (en) * 2007-02-21 2017-08-21 腫瘤療法 科學股份有限公司 Peptide vaccines for cancers expressing tumor-associated antigens
EP2125775A4 (en) 2007-03-01 2011-07-13 Cedars Sinai Medical Center Antioxidant polymers containing [1,2]-dithiolane moieties and uses thereof
US9028874B2 (en) 2008-01-03 2015-05-12 Cedars-Sinai Medical Center Antioxidant nanosphere comprising [1,2]-dithiolane moieties
JP5770624B2 (en) 2008-04-09 2015-08-26 ジェネンテック， インコーポレイテッド Novel compositions and methods for the treatment of immune related diseases
EP2300451A1 (en) 2008-06-02 2011-03-30 Cedars-Sinai Medical Center Nanometer-sized prodrugs of nsaids
TW201008574A (en) 2008-08-19 2010-03-01 Oncotherapy Science Inc INHBB epitope peptides and vaccines containing the same
EP2370435B1 (en) 2008-11-24 2015-01-07 Cedars-Sinai Medical Center Antioxidant camptothecin derivatives and antioxidant antineoplastic nanospheres thereof
FR2955013A1 (en) * 2010-01-12 2011-07-15 Centre Nat Rech Scient METHOD FOR INCREASING THE SIZE OF A PLANT OR PLANT PART
WO2012173781A2 (en) * 2011-06-13 2012-12-20 Ngm Biopharmaceuticals, Inc. Methods of treating glucose metabolism disorders
LT3021869T (en) 2013-07-16 2020-10-12 F. Hoffmann-La Roche Ag Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors
CN113956358A (en) 2015-09-25 2022-01-21 豪夫迈·罗氏有限公司 anti-TIGIT antibodies and methods of use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
WO1997029765A1 (en) * 1996-02-16 1997-08-21 The Regents Of The University Of California Antimicrobial peptides and methods of use
WO1999031117A1 (en) * 1997-12-18 1999-06-24 Human Genome Sciences, Inc. 110 human secreted proteins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
WO1997029765A1 (en) * 1996-02-16 1997-08-21 The Regents Of The University Of California Antimicrobial peptides and methods of use
WO1999031117A1 (en) * 1997-12-18 1999-06-24 Human Genome Sciences, Inc. 110 human secreted proteins

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 21 July 2000 (2000-07-21), Y. LI ET AL: "a novel gene expresed in human liver non-tumor-tissue", XP002165460 *
DATABASE EMBL 22 February 2000 (2000-02-22), S. SUGANO ET AL: "Homo sapiens cDNA FLJ20826 fis, clone ADSE00129. NEDO human cDNA sequencing project", XP002165461 *
DATABASE EMBL 30 August 1999 (1999-08-30), A. DUESTERHOEFT ET AL: "Homo sapiens mRNA; cDNA DKFZp586G1624", XP002165459 *
UNPUBLISHED *

Also Published As

Publication number Publication date
WO2001029221A2 (en) 2001-04-26
AU1220001A (en) 2001-04-30

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