WO2001028670A1 - Melangeur fluidique - Google Patents

Melangeur fluidique Download PDF

Info

Publication number
WO2001028670A1
WO2001028670A1 PCT/GB2000/003989 GB0003989W WO0128670A1 WO 2001028670 A1 WO2001028670 A1 WO 2001028670A1 GB 0003989 W GB0003989 W GB 0003989W WO 0128670 A1 WO0128670 A1 WO 0128670A1
Authority
WO
WIPO (PCT)
Prior art keywords
mixer
nozzle
fluid
nozzles
exit
Prior art date
Application number
PCT/GB2000/003989
Other languages
English (en)
Inventor
Ray Allen
John Tippetts
Vaclav Tesar
Original Assignee
The University Of Sheffield
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9924776A external-priority patent/GB2355543A/en
Priority claimed from GB0019756A external-priority patent/GB0019756D0/en
Application filed by The University Of Sheffield filed Critical The University Of Sheffield
Priority to AU78088/00A priority Critical patent/AU7808800A/en
Publication of WO2001028670A1 publication Critical patent/WO2001028670A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B01F25/23—Mixing by intersecting jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C1/00—Circuit elements having no moving parts
    • F15C1/14—Stream-interaction devices; Momentum-exchange devices, e.g. operating by exchange between two orthogonal fluid jets ; Proportional amplifiers
    • F15C1/146—Stream-interaction devices; Momentum-exchange devices, e.g. operating by exchange between two orthogonal fluid jets ; Proportional amplifiers multiple arrangements thereof, forming counting circuits, sliding registers, integration circuits or the like
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C1/00—Circuit elements having no moving parts
    • F15C1/22—Oscillators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/2204—Mixing chemical components in generals in order to improve chemical treatment or reactions, independently from the specific application
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00858—Aspects relating to the size of the reactor
    • B01J2219/0086—Dimensions of the flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00993—Design aspects
    • B01J2219/00995—Mathematical modeling

Definitions

  • the present invention relates to devices for mixing fluids and, in particular, to microfluidic mixers.
  • a well known problem in microchemistry is the efficient mixing of reactants. Such efficient mixing is crucial for almost all synthesis reactions. It is also essential in analytical chemistry where the results often strongly depend on the concentration of the reagents.
  • classical mechanical stirrers do not provide a practical solution to the requirement for efficient and thorough mixing when the scale of the device of the mixing devices and the microreactors involved are of the order of several microns in size.
  • a proposed solution which overcomes the difficulties associated with mechanical stirrers (which have a limited operating life and suffer from mechanical fatigue) are so called "static mixers". These static mixers generate small-sized volumes of fluid and bring them into mutual contact. A mixed formation is achieved by relying upon diffusive transport between the volumes. The fluids to be mixed are brought into contact in a longitudinal flow within a channel having a length determined by the rate of diffusion of the fluids to be mixed. To use effectively available space, channel lengths should be small which requires small sizes of volumes generated in the mixer.
  • a first aspect of the present invention provides a fluidic mixer comprising a first nozzle and a second nozzle to feed a cavity having at least two exit channels; the first and second nozzles being arranged to produce mutually opposing first and second fluid flows that form in at least one exit channel interleaved layers of the first fluid and the second fluid.
  • embodiments of the present invention allow static fluidic mixers to be realised.
  • embodiments can be realised to mix fluid flows at relatively low Reynolds numbers .
  • a second aspect of the present invention provides a mixer comprising a first nozzle and a second nozzle that feed a cavity having at least two exit channels; the first and second nozzles being arranged to produce mutually opposing flows of a first fluid and a second fluid that are arranged to oscillate to feed in an alternating manner the two exit channels .
  • figure 1 illustrates a perspective view of the structure of a static mixer according to an embodiment
  • figure 2a shows the perspective view of the static mixer illustrated in figure 1 together with an indication of the preferred relative dimensions of the features of that static mixer
  • figure 2b shows in greater detail the structure of a nozzle of the embodiment of figure 2b
  • figure 3 illustrates schematically the operation of a fluidic mixer
  • figure 4 illustrates schematically a fluid feedback loop which was observed during the operation of a practical embodiment of the present invention
  • figure 5 shows an approximate mathematical model for embodiments of a fluidic mixer
  • figure 6 shows an embodiment of a two stage mixer in which two primary mixers feed a secondary mixer
  • figures 7a and 7b show two extreme positions of oscillating fluid flows.
  • a microfluidic mixer 100 comprising a first inlet 102 for a first fluid and a second inlet 104 for a second fluid.
  • the first inlet 102 has a first nozzle 106.
  • the second inlet 104 has a corresponding second nozzle 108. Both the first nozzle 106 and the second nozzle 108 are directed towards an interaction cavity 110, that is, the nozzles are arranged to produce mutually opposing fluid flows, or at least fluid flows having mutually opposing components.
  • the mixer 100 also comprises first 112 and second 114 exit channels.
  • the axes of the first 112 and the second 114 exit channels are perpendicular to the axes of the first 106 and second 108 nozzles.
  • the microfluidic mixer has been etched from a body 116.
  • the inlet was 2.94 times the nozzle width, b.
  • the behaviour of the nozzles is relatively insensitive to changes in inlet width providing there is a contraction of the cross-sectional area of the inlet as compared to the cross-sectional area of the nozzle which is of the order of a factor of two.
  • FIG 2a there is shown the embodiment of a microfluidic mixer 100 as shown in figure 1 together with relative dimensions of the features of the microfluidic mixer.
  • the inlets 102 and 104 have parallel walls 202 to 208 which are connected at the ends most remote from the respective nozzles 106 and 108 by semicircular surfaces 210 and 212.
  • the parallel walls 202 to 208 are coupled with respective constriction portions 214 to 220 which narrow the inlets 102 and 104 to form respective nozzle channels 222 and 224 of the first 106 and second 108 nozzles.
  • the constriction portions are formed as inflexions between first 226 and second 228 radii.
  • the inflexion portions reduce the width of the inlets to the width of the channel of the nozzles.
  • the constriction portions comprise, in an embodiment, respective linear portions between two different radii.
  • the inflexions that form the constriction portions are defined by a convex
  • each nozzle has a nozzle exit formed by respective nozzle lips 230 and 232.
  • the nozzle exits (and nozzle lips 230 and 232) are separated by a pre-determined distance, s. It can be appreciated that the nozzle lips protrude into the volume defined by the side walls 234 to 240 of the exit channels 112 and 114.
  • the nozzle lips comprise respective linear portions between two radii of pre-determinable values .
  • the nozzles have respective axes (only the axis 242 of the first nozzle 106 is shown in figure 2) .
  • the axes of the first 106 and second 104 nozzles are colinear.
  • the linear portions of the constriction and the nozzle lips are substantially parallel and are inclined at a pre-determined angle relative to a respective nozzle axis.
  • a preferred embodiment preferably has angles of inclination of 45°.
  • other angles may be used which provide a sufficient contraction down to a preferred nozzle width.
  • the angles may take a value in the range of 20° to 60°.
  • the nozzle width is b.
  • the dimensions of the remaining features of the microfluidic mixer are defined relative to the nozzle width b.
  • b has submillimetre dimensions.
  • the value of b will in practice be determined by the operating conditions for the mixer. Embodiments can - be realised in which the value of b has a lower limit of 0.005 mm. Embodiment can be realised in which the value of b has an upper limit of 10 mm.
  • a practical, but relatively large scale, embodiment of the present invention was realised.
  • the embodiment was operated using water.
  • the fluid flow from the first nozzle comprised clear water.
  • the fluid flow from the second nozzle comprised coloured water.
  • Table 2 shows various operating parameters associated with the practical embodiment. Indeed, table 2 illustrates two sets of operating conditions. The operating conditions are labelled G and H .
  • w is the fluid nozzle exit velocity
  • f is the frequency of oscillation.
  • FIG 3 there is shown a schematic illustration of a static mixer 300 which comprises first 302 and second 304 inlets that carry respective fluids 306 and 308.
  • the fluids leave the inlets via nozzle exits 310 and 312.
  • the first fluid 306 produces a flow which oscillates between two positions 314 and 316.
  • the second fluid also produces a flow which oscillates between two positions. However, only one position 318 of the second flow is shown.
  • a first exit channel carries the mixed first 306 and second 308 fluids.
  • the nozzle exit velocities are both assumed to be w. It can be seen that the first 306 and second 308 fluids are initially carried in interleaved layers of thickness ⁇ and at a velocity of w p .
  • the interleaved layers 322 result from the oscillation of the first 306 and second 308 fluids emanating from their respective nozzles. It will be appreciated that figure 3 is highly schematic. In practice the interleaved fluid layers are not linear, they assume a complex curved shape.
  • FIG 4 there is shown a still photograph 400 taken from a video recording of the above practical realisation of a static mixer.
  • the still clearly shows first 102 and second 104 inlets which feed the first 106 and second 108 nozzles.
  • the fluid flow 402 emanating from the first nozzle 106 can be seen to form a feedback loop which influences the flow of the first nozzle. It has been observed that the fluid flow 402 is deflected to reach a substantially fully deflected position as shown in figure 4. It is thought that the fluid flow 402 when it finally arrives at the fully deflected position as shown in figure 4, cannot remain deflected and switches to the other exit channel.
  • the fluid flow 402 is forced to straighten and after doing so performs a further traversal motion which results in the fluid flow being deflected into the other exit channel. It is thought that the overswing to the other exit channel is caused by fluid inertia. It is also thought that the feedback action of the leading front of the feedback loop may cause the fluid flow 402 to be deflected when that front acts on the fluid flow 402 as it emanates from the nozzle 106.
  • An embodiment provides for the feedback loop of given nozzle to influence the flow of fluid from that nozzle substantially at the exit of that nozzle.
  • the feedback loops alternate, that is, oscillate about the respective axes of the nozzles.
  • FIG 5 there is shown, without wishing to be bound by any theory, a current mathematical model of the oscillation of embodiments of the fluidic mixers.
  • the simplified expression for the feedback loop path length does not consider transverse motion or transverse components of the feedback loop path. It can also be appreciated that the assumption is made that the fluid flow 402 reaches the opposing wall of the exit channel which, as can be observed from figure 4, it does not. Therefore, the simplified mathematical model shown in figure 5 has been adjusted to incorporate a dimensionless parameter, ⁇ , which can be varied to allow the predicted oscillation frequency to match the experimentally determined oscillation frequency. Therefore, the corrected fluid flow path length is m( ⁇ + ⁇ ) where ⁇ is of the order of 1 and involves corrections for effects including the fluid velocity not being constant for the whole of the feedback loop path and the period not being equal to twice the fluid flow traversal time.
  • Table 3 below shows the experimental data derived from the above practical embodiment for the operating conditions shown in column G of table 2 above.
  • the frequency of oscillation varies according to required mixer operational parameters.
  • the predetermined frequency of oscillation has a value in the range of 0.2 Hz to 100 kHz.
  • the process of producing interleaved layers of fluid 322 as shown in figure 3 can, without wishing to be bound by any particular theory, be modelled as follows.
  • the time taken to form one layer is approximately equal to one half of the oscillation period ⁇ t p .
  • the flow in the exit channels travels a distance given by
  • FIG. 6 shows a two stage mixer 600 which mixers first 602 and second 604 fluids.
  • the two stage mixer 600 comprises two primary mixers 606 that are arranged to feed a secondary mixer 608. At least one or both of the primary and secondary mixers may be realised using any or a combination of the above embodiments.
  • the exit channels 610, 612 and 614 of the primary mixers 606 are arranged to feed or coincide with the inlets for the nozzles 616 and 618 of the secondary mixer 608.
  • the mixed fluid contained in the exit channels 620 and 622 of the secondary mixer 608 can then be output for further processing.
  • the two stage mixer 600 comprises a number of separate channels 624. The separate channels 624 are fed from the exit channels 602 and 622 of the secondary mixer 608.
  • the above embodiments are operated at Reynolds numbers which are of the order of less than 450, and preferably of the order of 10 to 100.
  • the plurality of channels 624 are arranged to feed respective microreactors for high throughout catalyst testing.
  • a cover or top plates containing through holes is arranged to cover the etched features.
  • the through holes are arranged to coincide with the inlet and outlets of the mixer.
  • FIG. 7a A number of stills take from a video recording of the operation of the practical embodiment of the mixer are shown in figures 7a to 7b.
  • a first fluid 700 has been deflected to one side of the nozzle axes while the second fluid 702 has been deflected to the other side of the nozzle axes.
  • the first fluid feeds the flow 704 of the upper outlet channel and the second fluid feeds the flow 706 of the lower outlet channel.
  • the first fluid 700 has been deflected downwards to feed the flow 706 carried by the lower outlet channel.
  • the second fluid 702 has been deflected upwards to feed the flow 704 carried by the upper outlet channel.
  • each nozzle would be arranged to accommodate a respective fluid.
  • the embodiments described above are substantially symmetrical. However, embodiments can be realised that are asymmetrical, which may result from mixing different fluids. In such asymmetrical embodiments the nozzle widths would be calculated for a respective fluid. If the fluids were different, the respective nozzle widths would be different .
  • the aspect ratio of the nozzle influences the degree and/or frequency of oscillation.
  • the above embodiments are provided in which the aspect ratio is greater than one.
  • the above embodiments in some applications, may find an aspect ratio of one or less to be acceptable.

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Mechanical Engineering (AREA)
  • Organic Chemistry (AREA)

Abstract

La présente invention concerne un mélangeur fluidique mélangeant deux fluides sans agitateurs mécaniques. Ces deux fluides sont introduits dans une cavité interactive dans des conditions prédéterminables assurant que le flux des fluides oscille et alimente, de manière alternée, deux canaux de sortie. Les fluides se trouvant à l'intérieur des canaux de sortie forment des couches entrelacées présentant des largeurs relatives à la fréquence d'oscillation. Les fluides présentent des nombres de Reynolds relativement faibles et, de préférence, des nombres de Reynolds inférieurs à 100.
PCT/GB2000/003989 1999-10-20 2000-10-18 Melangeur fluidique WO2001028670A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU78088/00A AU7808800A (en) 1999-10-20 2000-10-18 Fluidic mixer

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB9924776.9 1999-10-20
GB9924776A GB2355543A (en) 1999-10-20 1999-10-20 Fluidic flow control and fluidic device
GB0019770.7 2000-08-11
GB0019756.6 2000-08-11
GB0019770A GB2355414A (en) 1999-10-20 2000-08-11 Static micro-mixer for fluids comprising opposed fluid flows
GB0019756A GB0019756D0 (en) 2000-08-11 2000-08-11 Fluidic mixer

Publications (1)

Publication Number Publication Date
WO2001028670A1 true WO2001028670A1 (fr) 2001-04-26

Family

ID=27255840

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/003989 WO2001028670A1 (fr) 1999-10-20 2000-10-18 Melangeur fluidique

Country Status (2)

Country Link
AU (1) AU7808800A (fr)
WO (1) WO2001028670A1 (fr)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003037493A1 (fr) * 2001-10-29 2003-05-08 Tetra Laval Holdings & Finance Sa Procede et dispositif de melange continu de deux courants
EP1339496A2 (fr) * 2000-11-06 2003-09-03 The Government of the United States of America, as represented by the Secretary of Health and Human Services Systeme d'apport d'echantillon comportant un melange laminaire pour la biodetection de microvolumes
WO2004098758A1 (fr) * 2003-05-05 2004-11-18 Haagen & Rinau Mischtechnik Gmbh Disperseur
WO2004103565A2 (fr) * 2003-05-19 2004-12-02 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Dispositif et procede de structuration de liquides et de dosage de liquides de reaction vers des compartiments a liquides noyes dans un fluide de separation
US6877892B2 (en) 2002-01-11 2005-04-12 Nanostream, Inc. Multi-stream microfluidic aperture mixers
US6890093B2 (en) 2000-08-07 2005-05-10 Nanostream, Inc. Multi-stream microfludic mixers
WO2005058477A1 (fr) * 2003-12-16 2005-06-30 Unilever Plc Dispositif microfluidique
US6919046B2 (en) 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
US6935772B2 (en) 2000-08-07 2005-08-30 Nanostream, Inc. Fluidic mixer in microfluidic system
DE10296876B4 (de) * 2001-05-28 2005-12-29 Yamatake Corp. Mikro-Mischer
WO2006039895A1 (fr) * 2004-10-11 2006-04-20 Technische Universität Darmstadt Reacteur microcapillaire et procede de melange controle de fluides miscibles de maniere non homogene a l'aide de ce reacteur microcapillaire
DE102007013932A1 (de) * 2007-03-23 2008-09-25 Forschungszentrum Karlsruhe Gmbh Vorrichtung und Verfahren zum Mischen von mindestens zwei Flüssigkeiten und Verwendung der Vorrichtung
JP2008238168A (ja) * 2008-04-14 2008-10-09 Konica Minolta Holdings Inc 液体混合機構
CN1767890B (zh) * 2003-04-08 2011-08-03 利乐拉瓦尔集团及财务有限公司 一种连续混合两种流体的方法和装置
WO2017103498A1 (fr) * 2015-12-17 2017-06-22 Universite De Nantes Dispositif et procédé pour réaliser une émulsion en continu de deux liquides immiscibles
CN114471217A (zh) * 2022-04-02 2022-05-13 深圳市瑞吉生物科技有限公司 一种用于脂质体合成的对冲流混合装置及方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3446228A (en) * 1966-10-19 1969-05-27 Martin Marietta Corp Opposed jet pure fluid amplifier
US3601137A (en) * 1968-07-10 1971-08-24 Bowles Corp App. and method for providing variable function generation in fluidic systems
NL7012762A (fr) * 1970-08-28 1972-03-01
DE19536856A1 (de) * 1995-10-03 1997-04-10 Danfoss As Mikromischer und Mischverfahren
DE19919638A1 (de) * 1999-04-30 1999-09-16 Meonic Sys Eng Gmbh Vorrichtung zum Anzeigen von Preisen und Artikelbezeichnungen an Warenträgern

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3446228A (en) * 1966-10-19 1969-05-27 Martin Marietta Corp Opposed jet pure fluid amplifier
US3601137A (en) * 1968-07-10 1971-08-24 Bowles Corp App. and method for providing variable function generation in fluidic systems
NL7012762A (fr) * 1970-08-28 1972-03-01
DE19536856A1 (de) * 1995-10-03 1997-04-10 Danfoss As Mikromischer und Mischverfahren
DE19919638A1 (de) * 1999-04-30 1999-09-16 Meonic Sys Eng Gmbh Vorrichtung zum Anzeigen von Preisen und Artikelbezeichnungen an Warenträgern

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BRANEBJERG J ET AL: "FAST MICING BY LAMINATION", PROCEEDINGS OF THE ANNUAL INTERNATIONAL WORKSHOP ON MICRO ELECTRO MECHANICAL SYSTEMS,US,NEW YORK, IEEE, vol. WORKSHOP 9, 11 February 1996 (1996-02-11), pages 441 - 446, XP000689310, ISBN: 0-7803-2986-4 *

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6890093B2 (en) 2000-08-07 2005-05-10 Nanostream, Inc. Multi-stream microfludic mixers
US6935772B2 (en) 2000-08-07 2005-08-30 Nanostream, Inc. Fluidic mixer in microfluidic system
EP1339496A2 (fr) * 2000-11-06 2003-09-03 The Government of the United States of America, as represented by the Secretary of Health and Human Services Systeme d'apport d'echantillon comportant un melange laminaire pour la biodetection de microvolumes
EP1339496A4 (fr) * 2000-11-06 2004-10-27 Us Gov Health & Human Serv Systeme d'apport d'echantillon comportant un melange laminaire pour la biodetection de microvolumes
DE10296876B4 (de) * 2001-05-28 2005-12-29 Yamatake Corp. Mikro-Mischer
US6919046B2 (en) 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
WO2003037493A1 (fr) * 2001-10-29 2003-05-08 Tetra Laval Holdings & Finance Sa Procede et dispositif de melange continu de deux courants
US6877892B2 (en) 2002-01-11 2005-04-12 Nanostream, Inc. Multi-stream microfluidic aperture mixers
CN1767890B (zh) * 2003-04-08 2011-08-03 利乐拉瓦尔集团及财务有限公司 一种连续混合两种流体的方法和装置
WO2004098758A1 (fr) * 2003-05-05 2004-11-18 Haagen & Rinau Mischtechnik Gmbh Disperseur
US7563019B2 (en) 2003-05-05 2009-07-21 Ekato Process Technologies Gmbh Dispersing device
WO2004103565A2 (fr) * 2003-05-19 2004-12-02 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Dispositif et procede de structuration de liquides et de dosage de liquides de reaction vers des compartiments a liquides noyes dans un fluide de separation
WO2004103565A3 (fr) * 2003-05-19 2005-04-21 Knoell Hans Forschung Ev Dispositif et procede de structuration de liquides et de dosage de liquides de reaction vers des compartiments a liquides noyes dans un fluide de separation
WO2005058477A1 (fr) * 2003-12-16 2005-06-30 Unilever Plc Dispositif microfluidique
WO2006039895A1 (fr) * 2004-10-11 2006-04-20 Technische Universität Darmstadt Reacteur microcapillaire et procede de melange controle de fluides miscibles de maniere non homogene a l'aide de ce reacteur microcapillaire
DE102007013932A1 (de) * 2007-03-23 2008-09-25 Forschungszentrum Karlsruhe Gmbh Vorrichtung und Verfahren zum Mischen von mindestens zwei Flüssigkeiten und Verwendung der Vorrichtung
JP4683066B2 (ja) * 2008-04-14 2011-05-11 コニカミノルタホールディングス株式会社 液体混合機構
JP2008238168A (ja) * 2008-04-14 2008-10-09 Konica Minolta Holdings Inc 液体混合機構
WO2017103498A1 (fr) * 2015-12-17 2017-06-22 Universite De Nantes Dispositif et procédé pour réaliser une émulsion en continu de deux liquides immiscibles
FR3045404A1 (fr) * 2015-12-17 2017-06-23 Univ Nantes Dispositif et procede pour realiser une emulsion en continu de deux liquides immiscibles
CN108472604A (zh) * 2015-12-17 2018-08-31 南特大学 用于实施两种不混溶液体的连续乳化液的装置和方法
CN114471217A (zh) * 2022-04-02 2022-05-13 深圳市瑞吉生物科技有限公司 一种用于脂质体合成的对冲流混合装置及方法
WO2023186122A1 (fr) * 2022-04-02 2023-10-05 深圳瑞吉生物科技有限公司 Dispositif de mélange d'écoulement à contre-courant et procédé de synthèse de liposomes

Also Published As

Publication number Publication date
AU7808800A (en) 2001-04-30

Similar Documents

Publication Publication Date Title
WO2001028670A1 (fr) Melangeur fluidique
US7032607B2 (en) Capillary reactor distribution device and method
KR101211752B1 (ko) 혼합 및 압력 강하를 최적화하는 미세구조 설계
US20080106968A1 (en) Components for Static Micromixers, Micromixers Constructed from such Components and Use of such Micromixers for Mixing or Dispersing or for Carrying Out Chemical Reactions
Doku et al. On-microchip multiphase chemistry—a review of microreactor design principles and reagent contacting modes
JP2020114585A (ja) プロセス強化マイクロ流体装置
KR100845200B1 (ko) 2개 이상의 유체를 혼합 및 반응시키는 장치
EP1908514B1 (fr) Microréacteur
US20090092526A1 (en) Micro-channels, micro-mixers, and micro-reactors
EP1997553A2 (fr) Mélangeur de fuide et procédé de formation d'un fluide mélangé
EP0701474B1 (fr) Reacteur passif etage interphase
US9023296B2 (en) Method of manufacturing a reactor and set of reactors
GB2355414A (en) Static micro-mixer for fluids comprising opposed fluid flows
KR20030019393A (ko) 액상용 에멀션화 및 분리 장치
TWI672174B (zh) 微型流道裝置
JP2005118634A (ja) マイクロミキシングデバイス
JP2003164745A (ja) マイクロ反応器
CN106999875B (zh) 流体混合结构、连续反应单元、连续反应反应器及使用其的方法
WO2004101124A1 (fr) Micro-melangeur a inertie
JP2005169218A (ja) マイクロミキサ
US7727475B2 (en) Micro chemical apparatus
EP2949389A1 (fr) Utilisation de micro-mélangeurs pour générer de la mousse
AU697093B2 (en) Multiphase staged passive reactor
CA2490084C (fr) Reacteur passif etage a plusieurs phases
WO2024069350A1 (fr) Procédé et appareil de mélange passif d'écoulement polyphasique

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP