WO2001023589A3 - 23431, a novel human ubiquitin protease - Google Patents

23431, a novel human ubiquitin protease Download PDF

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Publication number
WO2001023589A3
WO2001023589A3 PCT/US2000/026962 US0026962W WO0123589A3 WO 2001023589 A3 WO2001023589 A3 WO 2001023589A3 US 0026962 W US0026962 W US 0026962W WO 0123589 A3 WO0123589 A3 WO 0123589A3
Authority
WO
WIPO (PCT)
Prior art keywords
ubiquitin protease
polynucleotides
invention further
ubiquitin
relates
Prior art date
Application number
PCT/US2000/026962
Other languages
French (fr)
Other versions
WO2001023589A9 (en
WO2001023589A2 (en
Inventor
Rosana Kapeller-Libermann
Original Assignee
Millennium Pharm Inc
Kapeller Libermann Rosana
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc, Kapeller Libermann Rosana filed Critical Millennium Pharm Inc
Priority to AU10719/01A priority Critical patent/AU1071901A/en
Publication of WO2001023589A2 publication Critical patent/WO2001023589A2/en
Publication of WO2001023589A3 publication Critical patent/WO2001023589A3/en
Publication of WO2001023589A9 publication Critical patent/WO2001023589A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a newly identified human ubiquitin protease belonging to the family of mammalian deubiquitinating enzymes. The invention also relates to polynucleotides encoding he ubiquitin protease. The invention further relates to methods using the ubiquitin protease polypeptides and polynucleotides as a target for diagnosis and treatment in ubiquitin-mediated or -related disorders. The invention further relates to drug-screening methods using the ubiquitin protease polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the ubiquitin protease polypeptides and polynucleotides. The invention further relates to procedures for producing the ubiquitin protease polypeptides and polynucleotides.
PCT/US2000/026962 1999-09-29 2000-09-29 23431, a novel human ubiquitin protease WO2001023589A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU10719/01A AU1071901A (en) 1999-09-29 2000-09-29 23431, a novel human ubiquitin protease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40735699A 1999-09-29 1999-09-29
US09/407,356 1999-09-29

Publications (3)

Publication Number Publication Date
WO2001023589A2 WO2001023589A2 (en) 2001-04-05
WO2001023589A3 true WO2001023589A3 (en) 2002-01-17
WO2001023589A9 WO2001023589A9 (en) 2002-12-05

Family

ID=23611699

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/026962 WO2001023589A2 (en) 1999-09-29 2000-09-29 23431, a novel human ubiquitin protease

Country Status (2)

Country Link
AU (1) AU1071901A (en)
WO (1) WO2001023589A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030014771A1 (en) * 2001-03-29 2003-01-16 Leviten Michael W. Transgenic mice containing USP3-like deubiquitinating enzyme gene disruptions
GB0218518D0 (en) 2002-03-22 2002-09-18 Aventis Pharma Inc Human deubiquitinating protease gene on chromosome 7 and its murine ortholog
BR0307759A (en) * 2002-03-22 2004-12-21 Aventis Pharma Inc Human desubiquitinating protease gene on chromosome 7 and mouse ortholog
US20040053324A1 (en) * 2002-08-30 2004-03-18 Brian Wong Assays and compositions for identifying agents that modulate the activity of deubiquitinating agents
US7947279B2 (en) 2005-06-30 2011-05-24 The Trustees Of Columbia University In The City Of New York Peptide having hydrolase activity
EP3533455A1 (en) * 2018-03-01 2019-09-04 International Institute of Molecular and Cell Biology in Warsaw Inhibition of proteolytic activity in the treatment of mitochondriopathies
KR102162847B1 (en) * 2019-01-23 2020-10-07 차의과학대학교 산학협력단 Analytical method for diagnosing urolithiasis and kit therefor
KR102260585B1 (en) * 2019-01-23 2021-06-03 차의과학대학교 산학협력단 Analytical method for diagnosing urolithiasis and kit therefor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997006247A2 (en) * 1995-08-09 1997-02-20 Dana Farber Cancer Institute Deubiquitinating enzymes that regulate cell growth
WO2001010903A2 (en) * 1999-08-09 2001-02-15 Incyte Genomics, Inc. Proteases and protease inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997006247A2 (en) * 1995-08-09 1997-02-20 Dana Farber Cancer Institute Deubiquitinating enzymes that regulate cell growth
WO2001010903A2 (en) * 1999-08-09 2001-02-15 Incyte Genomics, Inc. Proteases and protease inhibitors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 15 June 1998 (1998-06-15), XP002169003 *
DATABASE EMBL 23 June 1999 (1999-06-23), "National Cancer Institute, Cancer Genome Anatomy Project (CGAP), .......", XP002169002 *
THE SANGER CENTRE (UK) AND THE WASHINGTON UNIVERSITY GENOME SEQUENCING CENTER (USA): "Toward a complete human genome sequence.", GENOME RESEARCH, vol. 8, no. 11, November 1998 (1998-11-01), pages 1097 - 1108, XP002169000, ISSN: 1088-9051 *
ZHU YUAN ET AL: "DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 1, 1997, pages 51 - 57, XP002169001, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2001023589A9 (en) 2002-12-05
AU1071901A (en) 2001-04-30
WO2001023589A2 (en) 2001-04-05

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