WO2001032885A3 - Human lipase - Google Patents

Human lipase Download PDF

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Publication number
WO2001032885A3
WO2001032885A3 PCT/US2000/030514 US0030514W WO0132885A3 WO 2001032885 A3 WO2001032885 A3 WO 2001032885A3 US 0030514 W US0030514 W US 0030514W WO 0132885 A3 WO0132885 A3 WO 0132885A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipase
polynucleotides
invention further
polypeptides
relates
Prior art date
Application number
PCT/US2000/030514
Other languages
French (fr)
Other versions
WO2001032885A9 (en
WO2001032885A2 (en
Inventor
Rosana Kapeller-Libermann
Laura A Rudolph-Owen
Original Assignee
Millennium Pharm Inc
Kapeller Libermann Rosana
Rudolph Owen Laura A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc, Kapeller Libermann Rosana, Rudolph Owen Laura A filed Critical Millennium Pharm Inc
Priority to AU13616/01A priority Critical patent/AU1361601A/en
Publication of WO2001032885A2 publication Critical patent/WO2001032885A2/en
Publication of WO2001032885A3 publication Critical patent/WO2001032885A3/en
Publication of WO2001032885A9 publication Critical patent/WO2001032885A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to a newly identified human lipase belonging to the family of mammalian lipases. The invention also relates to polynucleotides encoding the lipase. The invention further relates to methods using the lipase polypeptides and polynucleotides as a target for diagnosis and treatment in lipase-mediated or -related disorders. The invention further relates to drug-screening methods using the lipase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the lipase polypeptides and polynucleotides. The invention further relates to procedures for producing the lipase polypeptides and polynucleotides.
PCT/US2000/030514 1999-11-05 2000-11-03 Human lipase WO2001032885A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU13616/01A AU1361601A (en) 1999-11-05 2000-11-03 18892, a novel human lipase

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US43531199A 1999-11-05 1999-11-05
US09/435,311 1999-11-05
US70491800A 2000-11-02 2000-11-02
US09/704,918 2000-11-02

Publications (3)

Publication Number Publication Date
WO2001032885A2 WO2001032885A2 (en) 2001-05-10
WO2001032885A3 true WO2001032885A3 (en) 2002-03-28
WO2001032885A9 WO2001032885A9 (en) 2002-05-16

Family

ID=27030514

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/030514 WO2001032885A2 (en) 1999-11-05 2000-11-03 Human lipase

Country Status (2)

Country Link
AU (1) AU1361601A (en)
WO (1) WO2001032885A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001278773A1 (en) * 2000-10-11 2002-04-22 Mochida Pharmaceutical Co., Ltd. Novel pla1
WO2003072767A2 (en) * 2002-02-27 2003-09-04 Bayer Healthcare Ag Regulation of human lipase

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024888A2 (en) * 1996-12-06 1998-06-11 Rhone-Poulenc Rorer Pharmaceuticals Inc. Polypeptides encoded by a human lipase-like gene, compositions and methods

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024888A2 (en) * 1996-12-06 1998-06-11 Rhone-Poulenc Rorer Pharmaceuticals Inc. Polypeptides encoded by a human lipase-like gene, compositions and methods

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 15 December 1996 (1996-12-15), HILLIER L ET AL: "zo01c06.r1 Stratagene colon (#937204) Homo sapiens cDNA clone IMAGE:566410 5', mRNA sequence.", XP002172171 *
DATABASE EMBL 30 October 1996 (1996-10-30), HILLIER L ET AL: "zl90f03.r1 Stratagene colon (#937204) Homo sapiens cDNA clone IMAGE:511901 5' similar to TR:G56600 G56600 TRIACYLGLYCEROL LIPASE PRECURSOR ;, mRNA sequence.", XP002172170 *
DATABASE EMBL 8 April 2001 (2001-04-08), REMINGTON S G ET AL: "Oryctolagus cuniculus lacrimal lipase mRNA, complete cds.", XP002172173 *
DATABASE SWISSPROT 1 May 1999 (1999-05-01), VAN GRONINGEN J J M ET AL: "NMD PROTEIN", XP002172172 *

Also Published As

Publication number Publication date
WO2001032885A9 (en) 2002-05-16
WO2001032885A2 (en) 2001-05-10
AU1361601A (en) 2001-05-14

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