WO2001023428A3 - Interleukin-2 receptor associated polypeptides - Google Patents

Interleukin-2 receptor associated polypeptides Download PDF

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Publication number
WO2001023428A3
WO2001023428A3 PCT/US2000/025963 US0025963W WO0123428A3 WO 2001023428 A3 WO2001023428 A3 WO 2001023428A3 US 0025963 W US0025963 W US 0025963W WO 0123428 A3 WO0123428 A3 WO 0123428A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
interleukin
receptor associated
daltons
associated polypeptides
Prior art date
Application number
PCT/US2000/025963
Other languages
French (fr)
Other versions
WO2001023428A2 (en
Inventor
Carolyn K Goldman
Neil D Goldman
Thomas A Waldmann
Original Assignee
Us Health
Carolyn K Goldman
Neil D Goldman
Thomas A Waldmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health, Carolyn K Goldman, Neil D Goldman, Thomas A Waldmann filed Critical Us Health
Priority to AU11887/01A priority Critical patent/AU1188701A/en
Publication of WO2001023428A2 publication Critical patent/WO2001023428A2/en
Publication of WO2001023428A3 publication Critical patent/WO2001023428A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/246—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to the identification of two polypeptides which associate with the IL-2 receptor, and are immunologically recognized by the monoclonal antibody produced from the hybridoma designated by the ATCC deposit number PTA-82. These polypeptides, designated interleukin-2 receptor associated proteins or ILRAPs, have molecular weights of about 32,000 to 34,000 daltons and 26,000 to 28,000 daltons, respectively. The invention further relates to the use of the antibody of the invention for the detection of these polypeptides and for their isolation and purification from biological samples.
PCT/US2000/025963 1999-09-24 2000-09-21 Interleukin-2 receptor associated polypeptides WO2001023428A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU11887/01A AU1188701A (en) 1999-09-24 2000-09-21 Interleukin-2 receptor associated polypeptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15596899P 1999-09-24 1999-09-24
US60/155,968 1999-09-24

Publications (2)

Publication Number Publication Date
WO2001023428A2 WO2001023428A2 (en) 2001-04-05
WO2001023428A3 true WO2001023428A3 (en) 2002-05-16

Family

ID=22557510

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/025963 WO2001023428A2 (en) 1999-09-24 2000-09-21 Interleukin-2 receptor associated polypeptides

Country Status (2)

Country Link
AU (1) AU1188701A (en)
WO (1) WO2001023428A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0162699A2 (en) * 1984-05-21 1985-11-27 Immunex Corporation Interleukin-2 receptor and DNA encoded therefor and their preparation
WO1996021732A1 (en) * 1995-01-09 1996-07-18 Boehringer Ingelheim International Gmbh Il-2r-associated polypeptide and dna molecules coding therefor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0162699A2 (en) * 1984-05-21 1985-11-27 Immunex Corporation Interleukin-2 receptor and DNA encoded therefor and their preparation
WO1996021732A1 (en) * 1995-01-09 1996-07-18 Boehringer Ingelheim International Gmbh Il-2r-associated polypeptide and dna molecules coding therefor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
TOSHIKAZU TAKESHITA ET AL: "An associated molecule, p64, with iL-2 receptor beta chain. Its possible involvement in the formation of the functional intermediate-Affinity iL-2 Receptor complex", JOURNAL OF IMMUNOLOGY., vol. 148, no. 7, 1 April 1992 (1992-04-01), THE WILLIAMS AND WILKINS CO. BALTIMORE., US, pages 2154 - 2158, XP002169168, ISSN: 0022-1767 *
WALDMANN T A: "MULTICHAIN INTERLEUKIN-2 RECEPTOR: A TARGET FOR IMMUNOTHERAPY IN LYMPHOMA", JOURNAL OF THE NATIONAL CANCER INSTITUTE,US,US DEPT. OF HEALTH, EDICATIONAND WELFARE, PUBLIC HEALTH, vol. 81, no. 12, 1989, pages 914 - 923, XP000915779, ISSN: 0027-8874 *

Also Published As

Publication number Publication date
AU1188701A (en) 2001-04-30
WO2001023428A2 (en) 2001-04-05

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