WO2001014539A3 - Methods and compositions for the construction and use of fusion libraries - Google Patents
Methods and compositions for the construction and use of fusion libraries Download PDFInfo
- Publication number
- WO2001014539A3 WO2001014539A3 PCT/US2000/022906 US0022906W WO0114539A3 WO 2001014539 A3 WO2001014539 A3 WO 2001014539A3 US 0022906 W US0022906 W US 0022906W WO 0114539 A3 WO0114539 A3 WO 0114539A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleic acid
- enzyme
- nam
- fusion
- encoding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00955779A EP1212411A2 (en) | 1999-08-20 | 2000-08-18 | Methods and compositions for the construction and use of fusion libraries |
KR1020027002204A KR20020059370A (en) | 1999-08-20 | 2000-08-18 | Methods and compositions for the construction and use of fusion libraries |
AU67925/00A AU781478B2 (en) | 1999-08-20 | 2000-08-18 | Methods and compositions for the construction and use of fusion libraries |
JP2001518853A JP2003507063A (en) | 1999-08-20 | 2000-08-18 | Methods and compositions for constructing and using fusion libraries |
CA002382483A CA2382483A1 (en) | 1999-08-20 | 2000-08-18 | Methods and compositions for the construction and use of fusion libraries |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15000499P | 1999-08-20 | 1999-08-20 | |
US60/150,004 | 1999-08-20 | ||
US20913000P | 2000-06-02 | 2000-06-02 | |
US60/209,130 | 2000-06-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001014539A2 WO2001014539A2 (en) | 2001-03-01 |
WO2001014539A3 true WO2001014539A3 (en) | 2001-09-27 |
Family
ID=26847232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/022906 WO2001014539A2 (en) | 1999-08-20 | 2000-08-18 | Methods and compositions for the construction and use of fusion libraries |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1212411A2 (en) |
JP (1) | JP2003507063A (en) |
KR (1) | KR20020059370A (en) |
CN (1) | CN1378593A (en) |
AU (1) | AU781478B2 (en) |
CA (1) | CA2382483A1 (en) |
WO (1) | WO2001014539A2 (en) |
Cited By (3)
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US8852586B2 (en) | 2004-11-12 | 2014-10-07 | Xencor, Inc. | Fc variants with altered binding to FcRn |
US8937158B2 (en) | 2003-03-03 | 2015-01-20 | Xencor, Inc. | Fc variants with increased affinity for FcγRIIc |
US9200079B2 (en) | 2004-11-12 | 2015-12-01 | Xencor, Inc. | Fc variants with altered binding to FcRn |
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AU775997B2 (en) | 1998-12-02 | 2004-08-19 | Bristol-Myers Squibb Company | DNA-protein fusions and uses thereof |
US20030036643A1 (en) * | 2000-09-14 | 2003-02-20 | Jin Cheng He | Methods and compositions for the construction and use of fusion libraries |
WO2002022826A2 (en) * | 2000-09-14 | 2002-03-21 | Xencor, Inc. | Methods and compositions for the construction and use of fusion libraries |
US20030124537A1 (en) * | 2000-12-14 | 2003-07-03 | Yuan-Chin Liu | Procaryotic libraries and uses |
US20020168640A1 (en) * | 2001-02-22 | 2002-11-14 | Min Li | Biochips comprising nucleic acid/protein conjugates |
US20030049647A1 (en) * | 2001-02-22 | 2003-03-13 | Bassil Dahiyat | Use of nucleic acid libraries to create toxicological profiles |
WO2002068453A2 (en) * | 2001-02-22 | 2002-09-06 | Xencor | Methods and compositions for the construction and use of fusion libraries using computational protein design methods |
NZ532635A (en) * | 2001-11-13 | 2007-05-31 | Univ Pennsylvania | A method of identifying unknown adeno-associated virus (AAV) sequences and a kit for the method |
WO2003100100A1 (en) * | 2002-05-24 | 2003-12-04 | Somagenics, Inc. | Methods and compositions for production of directed sequence libraries |
US8399618B2 (en) | 2004-10-21 | 2013-03-19 | Xencor, Inc. | Immunoglobulin insertions, deletions, and substitutions |
US8883147B2 (en) | 2004-10-21 | 2014-11-11 | Xencor, Inc. | Immunoglobulins insertions, deletions, and substitutions |
US9714282B2 (en) | 2003-09-26 | 2017-07-25 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
CN1997749A (en) | 2003-11-21 | 2007-07-11 | 约翰·霍普金斯大学 | Biomolecule partition motifs and uses thereof |
WO2005086679A2 (en) | 2004-03-05 | 2005-09-22 | Medical College Of Ohio | Methods and compositions for assessing nucleic acids and alleles |
EP1745157A4 (en) | 2004-04-12 | 2008-06-11 | Ohio Med College | Methods and compositions for assaying analytes |
EP1931709B1 (en) | 2005-10-03 | 2016-12-07 | Xencor, Inc. | Fc variants with optimized fc receptor binding properties |
JP5634262B2 (en) * | 2007-07-26 | 2014-12-03 | ユニキュアー アイピー ビー.ブイ. | Baculovirus vector containing repetitive coding sequences with differential codon bias |
PL2235059T3 (en) | 2007-12-26 | 2015-08-31 | Xencor Inc | Fc variants with altered binding to fcrn |
US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
GB2505237A (en) * | 2012-08-24 | 2014-02-26 | Stefan Grimm | Method of screening for therapeutic agents using cell lines including a reference cell line |
WO2015191508A1 (en) | 2014-06-09 | 2015-12-17 | Voyager Therapeutics, Inc. | Chimeric capsids |
CN107106689A (en) | 2014-11-05 | 2017-08-29 | 沃雅戈治疗公司 | AADC polynucleotides for treating Parkinson's |
MX2017006216A (en) | 2014-11-14 | 2018-08-29 | Voyager Therapeutics Inc | Compositions and methods of treating amyotrophic lateral sclerosis (als). |
SG11201703419UA (en) | 2014-11-14 | 2017-05-30 | Voyager Therapeutics Inc | Modulatory polynucleotides |
EP3230441A4 (en) | 2014-12-12 | 2018-10-03 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scaav |
KR102333255B1 (en) * | 2015-05-11 | 2021-12-01 | 일루미나, 인코포레이티드 | Platform for discovery and analysis of therapeutic agents |
EP3384035A4 (en) | 2015-12-02 | 2019-08-07 | Voyager Therapeutics, Inc. | Assays for the detection of aav neutralizing antibodies |
US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
US11299751B2 (en) | 2016-04-29 | 2022-04-12 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
SG11201809643UA (en) | 2016-05-18 | 2018-12-28 | Voyager Therapeutics Inc | Compositions and methods of treating huntington's disease |
KR102392236B1 (en) | 2016-05-18 | 2022-05-03 | 보이저 테라퓨틱스, 인크. | Regulatory Polynucleotides |
EP3831281A1 (en) | 2016-08-30 | 2021-06-09 | The Regents of The University of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
GB201702938D0 (en) * | 2017-02-23 | 2017-04-12 | Univ Southampton | Methods of generating and screening compartmentalised peptides libraries |
EP3619308A4 (en) | 2017-05-05 | 2021-01-27 | Voyager Therapeutics, Inc. | Compositions and methods of treating huntington's disease |
CA3061652A1 (en) | 2017-05-05 | 2018-11-08 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
JOP20190269A1 (en) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | Aadc polynucleotides for the treatment of parkinson's disease |
JP7229989B2 (en) | 2017-07-17 | 2023-02-28 | ボイジャー セラピューティクス インコーポレイテッド | Trajectory array guide system |
KR20200044793A (en) | 2017-08-03 | 2020-04-29 | 보이저 테라퓨틱스, 인크. | Compositions and methods for delivery of AAV |
WO2019079242A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
JP7502991B2 (en) | 2017-10-16 | 2024-06-19 | ボイジャー セラピューティクス インコーポレイテッド | Treatment of amyotrophic lateral sclerosis (ALS) |
WO2020212439A1 (en) * | 2019-04-16 | 2020-10-22 | F. Hoffmann-La Roche Ag | Small molecule screening cellular assay using modified beads |
CN110452303B (en) * | 2019-08-08 | 2022-03-04 | 中国科学院武汉病毒研究所 | Method for covalently linking nucleic acid and peptide or protein and application thereof |
US20230000063A1 (en) * | 2019-12-13 | 2023-01-05 | Chugai Seiyaku Kabushiki Kaisha | System for detecting extracellular purinergic receptor ligand, and non-human animal having the system introduced thereinto |
CN111704655A (en) * | 2020-04-24 | 2020-09-25 | 吉林农业大学 | Goose parvovirus protein capable of inducing goose embryo fibroblast apoptosis and preparation method thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5270170A (en) * | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
WO1998023781A1 (en) * | 1996-11-26 | 1998-06-04 | Johns Hopkins University | Ligand detection system and methods of use thereof |
US5856090A (en) * | 1994-09-09 | 1999-01-05 | The Scripps Research Institute | DNA-methylase linking reaction |
-
2000
- 2000-08-18 CA CA002382483A patent/CA2382483A1/en not_active Abandoned
- 2000-08-18 WO PCT/US2000/022906 patent/WO2001014539A2/en active IP Right Grant
- 2000-08-18 KR KR1020027002204A patent/KR20020059370A/en active IP Right Grant
- 2000-08-18 AU AU67925/00A patent/AU781478B2/en not_active Ceased
- 2000-08-18 JP JP2001518853A patent/JP2003507063A/en active Pending
- 2000-08-18 CN CN00814124A patent/CN1378593A/en active Pending
- 2000-08-18 EP EP00955779A patent/EP1212411A2/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5270170A (en) * | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
US5856090A (en) * | 1994-09-09 | 1999-01-05 | The Scripps Research Institute | DNA-methylase linking reaction |
WO1998023781A1 (en) * | 1996-11-26 | 1998-06-04 | Johns Hopkins University | Ligand detection system and methods of use thereof |
Non-Patent Citations (8)
Title |
---|
CODY C W ET AL: "CHEMICAL STRUCTURE OF THE HEXAPEPTIDE CHROMOPHORE OF THE AEQUOREA GREEN-FLUORESCENT PROTEIN", BIOCHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. EASTON, PA, vol. 32, no. 5, 2 February 1993 (1993-02-02), pages 1212 - 1218, XP002030240, ISSN: 0006-2960 * |
CULL M G ET AL: "Screening for receptor ligands using large libraries of peptides linked to the C terminus of the lac repressor.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1992 MAR 1) 89 (5) 1865-9., XP002043736 * |
INOUYE S ET AL: "AEQUOREA GREEN FLUORESCENT PROTEIN EXPRESSION OF THE GENE AND FLUORESCENCE CHARACTERISTICS OF THE RECOMBINANT PROTEIN", FEBS LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 341, no. 2/03, 21 March 1994 (1994-03-21), pages 277 - 280, XP002030244, ISSN: 0014-5793 * |
MARTIN ET AL: "THE AFFINITY-SELECTION OF A MINIBODY POLYPEPTIDE INHIBITOR OF HUMAN INTERLEUKIN 6", EMBO JOURNAL,GB,OXFORD UNIVERSITY PRESS, SURREY, no. 13, 1994, pages 5303 - 5309, XP002076260, ISSN: 0261-4189 * |
MCCONNELL S J ET AL: "Tendamistat as a scaffold for conformationally constrained phage peptide libraries.", JOURNAL OF MOLECULAR BIOLOGY, (1995 JUL 21) 250 (4) 460-70., XP000985692 * |
MICELI R ET AL: "The coiled coil stem loop miniprotein as a presentation scaffold.", DRUG DESIGN AND DISCOVERY, (1996 APR) 13 (3-4) 95-105., XP000985689 * |
SILHAVY T J ET AL: "USES OF LAC FUSIONS FOR THE STUDY OF BIOLOGICAL PROBLEMS", MICROBIOLOGICAL REVIEWS,AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC,US, vol. 49, no. 4, 1 December 1985 (1985-12-01), pages 398 - 418, XP000570644, ISSN: 0146-0749 * |
SPENCER D M ET AL: "CONTROLLING SIGNAL TRANSDUCTION WITH SYNTHETIC LIGANDS", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 262, 12 November 1993 (1993-11-12), pages 1019 - 1024, XP000568878, ISSN: 0036-8075 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8937158B2 (en) | 2003-03-03 | 2015-01-20 | Xencor, Inc. | Fc variants with increased affinity for FcγRIIc |
US8852586B2 (en) | 2004-11-12 | 2014-10-07 | Xencor, Inc. | Fc variants with altered binding to FcRn |
US8883973B2 (en) | 2004-11-12 | 2014-11-11 | Xencor, Inc. | Fc variants with altered binding to FcRn |
US9200079B2 (en) | 2004-11-12 | 2015-12-01 | Xencor, Inc. | Fc variants with altered binding to FcRn |
Also Published As
Publication number | Publication date |
---|---|
AU6792500A (en) | 2001-03-19 |
CA2382483A1 (en) | 2001-03-01 |
KR20020059370A (en) | 2002-07-12 |
WO2001014539A2 (en) | 2001-03-01 |
CN1378593A (en) | 2002-11-06 |
AU781478B2 (en) | 2005-05-26 |
EP1212411A2 (en) | 2002-06-12 |
JP2003507063A (en) | 2003-02-25 |
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