WO2001000875A3 - Novel methods and products for arrayed microsphere analysis - Google Patents

Novel methods and products for arrayed microsphere analysis Download PDF

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Publication number
WO2001000875A3
WO2001000875A3 PCT/US2000/017421 US0017421W WO0100875A3 WO 2001000875 A3 WO2001000875 A3 WO 2001000875A3 US 0017421 W US0017421 W US 0017421W WO 0100875 A3 WO0100875 A3 WO 0100875A3
Authority
WO
WIPO (PCT)
Prior art keywords
arrayed
products
novel methods
microsphere analysis
microsphere
Prior art date
Application number
PCT/US2000/017421
Other languages
French (fr)
Other versions
WO2001000875A2 (en
Inventor
Walter Klimecki
George Maracas
Original Assignee
Motorola Inc
Walter Klimecki
George Maracas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Motorola Inc, Walter Klimecki, George Maracas filed Critical Motorola Inc
Priority to AU57645/00A priority Critical patent/AU5764500A/en
Publication of WO2001000875A2 publication Critical patent/WO2001000875A2/en
Publication of WO2001000875A3 publication Critical patent/WO2001000875A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

Among other things, the invention provides components, devices, and methods for arrayed microsphere analysis (AMA), and more particularly, for fluorescent arrayed microsphere analysis (FAMA).
PCT/US2000/017421 1999-06-25 2000-06-23 Novel methods and products for arrayed microsphere analysis WO2001000875A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU57645/00A AU5764500A (en) 1999-06-25 2000-06-23 Novel methods and products for arrayed microsphere analysis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33989299A 1999-06-25 1999-06-25
US09/339,892 1999-06-25

Publications (2)

Publication Number Publication Date
WO2001000875A2 WO2001000875A2 (en) 2001-01-04
WO2001000875A3 true WO2001000875A3 (en) 2001-09-13

Family

ID=23331067

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/017421 WO2001000875A2 (en) 1999-06-25 2000-06-23 Novel methods and products for arrayed microsphere analysis

Country Status (2)

Country Link
AU (1) AU5764500A (en)
WO (1) WO2001000875A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10065632A1 (en) 2000-05-12 2001-11-15 Smtech Biovision Holding Ag Ec Detecting polynucleotides by hybridizing an array of sequences on a carrier with detection probes, but not immobilized
WO2001085991A2 (en) * 2000-05-12 2001-11-15 Gnothis Holding Sa Method for detecting polynucleotides using fluorescence correlation spectroscopy
DE10065148B4 (en) * 2000-12-22 2004-01-22 Institut für Physikalische Hochtechnologie e.V. Magnetic gripping-holding arrangement
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
CN1424405A (en) * 2001-12-14 2003-06-18 宋克 Gene chip molecular probe and related technology
FR2858689B1 (en) * 2003-08-04 2007-01-05 Phylogene Sa METHOD AND DEVICE FOR DETECTION AND / OR DETERMINATION OF MOLECULES
FR2858688A1 (en) * 2003-08-04 2005-02-11 Gilbert Skorski Measuring biochemical parameters in a sample, for in vitro diagnosis, comprises that magnetic micro-balls colored by their parameters are carried through the sample and reagent(s) by magnets to a scanning station with a camera
ES2374788T3 (en) 2005-12-23 2012-02-22 Nanostring Technologies, Inc. NANOINFORMERS AND METHODS FOR PRODUCTION AND USE.
EP3162900B1 (en) 2008-08-14 2018-07-18 Nanostring Technologies, Inc Stable nanoreporters
EP3236264A3 (en) 2009-10-13 2017-11-08 Nanostring Technologies, Inc Protein detection via nanoreporters
AU2011215753B2 (en) 2010-02-11 2015-09-03 Bruker Spatial Biology, Inc. Compositions and methods for the detection of small RNAs
US9758834B2 (en) 2011-03-28 2017-09-12 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
US10501777B2 (en) 2015-07-17 2019-12-10 Nanostring Technologies, Inc. Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue
CN114350752A (en) 2015-07-17 2022-04-15 纳米线科技公司 Simultaneous quantification of gene expression in user-defined regions of cross-sectional tissue
US10415080B2 (en) 2016-11-21 2019-09-17 Nanostring Technologies, Inc. Chemical compositions and methods of using same
EP3752635A1 (en) 2018-02-12 2020-12-23 Nanostring Technologies, Inc. Biomolecular probes and methods of detecting gene and protein expression
SG11202011274YA (en) 2018-05-14 2020-12-30 Nanostring Technologies Inc Chemical compositions and methods of using same
CN110967336A (en) * 2018-09-28 2020-04-07 陈洁 Periodontal disease detection kit and use method thereof
WO2023081905A2 (en) * 2021-11-08 2023-05-11 Georgia Tech Research Corporation Detection platform for unlabeled oligonucleotides

Citations (6)

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US4292920A (en) * 1976-04-26 1981-10-06 Smith Kendall O Magnetic attraction transfer devices for use in solid phase radioimmunoassays and in other assay methods
WO1986006493A1 (en) * 1985-04-29 1986-11-06 Labsystems Oy Method and device for carrying out immunological assays
WO1992005443A1 (en) * 1990-09-15 1992-04-02 Medical Research Council Reagent separation
WO1997014028A2 (en) * 1995-10-11 1997-04-17 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
WO1999009217A1 (en) * 1997-08-15 1999-02-25 Hyseq, Inc. Methods and compositions for detection or quantification of nucleic acid species
WO1999064867A1 (en) * 1997-12-04 1999-12-16 Amersham Pharmacia Biotech Uk Limited Multiple assay method

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292920A (en) * 1976-04-26 1981-10-06 Smith Kendall O Magnetic attraction transfer devices for use in solid phase radioimmunoassays and in other assay methods
WO1986006493A1 (en) * 1985-04-29 1986-11-06 Labsystems Oy Method and device for carrying out immunological assays
WO1992005443A1 (en) * 1990-09-15 1992-04-02 Medical Research Council Reagent separation
WO1997014028A2 (en) * 1995-10-11 1997-04-17 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
WO1999009217A1 (en) * 1997-08-15 1999-02-25 Hyseq, Inc. Methods and compositions for detection or quantification of nucleic acid species
WO1999064867A1 (en) * 1997-12-04 1999-12-16 Amersham Pharmacia Biotech Uk Limited Multiple assay method

Non-Patent Citations (3)

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Title
LACKNER K J ET AL: "MULTIPLEX DNA-UND RNA-ANALYSE AN FLUORESZENTEN MICROBEADS ALS ALTERNATIVE ZUM DNA-ARRAY", MEDIZINISCHE GENETIK,BERUFSVERBAND MEDIZINISCHE GENETIK, MUNCHEN,,DE, vol. 11, no. 1, 1999, pages 16 - 17, XP000930079, ISSN: 0936-5931 *
R J FULTON ET AL: "Advanced multiplexd analysis with the FlowMetrix(TM) system", CLINICAL CHEMISTRY,US,AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY. WINSTON, vol. 43, no. 9, September 1997 (1997-09-01), pages 1749 - 1756, XP002142645, ISSN: 0009-9147 *
VLIEGER A M ET AL: "QUANTITATION OF POLYMERASE CHAIN REACTION PRODUCTS BY HYBRIDIZATION-BASED ASSAYS WITH FLUORESCENT, COLORIMETRIC, OR CHEMILUMINESCENT DETECTION1", ANALYTICAL BIOCHEMISTRY,US,ACADEMIC PRESS, SAN DIEGO, CA, vol. 205, no. 1, 15 August 1992 (1992-08-15), pages 1 - 7, XP000294452, ISSN: 0003-2697 *

Also Published As

Publication number Publication date
AU5764500A (en) 2001-01-31
WO2001000875A2 (en) 2001-01-04

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