WO2001000804A3 - Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins - Google Patents

Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins Download PDF

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Publication number
WO2001000804A3
WO2001000804A3 PCT/IB2000/000922 IB0000922W WO0100804A3 WO 2001000804 A3 WO2001000804 A3 WO 2001000804A3 IB 0000922 W IB0000922 W IB 0000922W WO 0100804 A3 WO0100804 A3 WO 0100804A3
Authority
WO
WIPO (PCT)
Prior art keywords
srt
proteins
nucleic acid
acid molecules
corynebacterium glutamicum
Prior art date
Application number
PCT/IB2000/000922
Other languages
French (fr)
Other versions
WO2001000804A2 (en
Inventor
Markus Pompejus
Burkhard Kroeger
Hartwig Schroeder
Oskar Zelder
Gregor Haberhauer
Heung-Shick Lee
Hyung-Joon Kim
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to HU0203340A priority Critical patent/HUP0203340A2/en
Priority to JP2001506798A priority patent/JP2003525593A/en
Priority to EP00944135A priority patent/EP1290178A2/en
Priority to ES00944135T priority patent/ES2184658T1/en
Priority to AU58369/00A priority patent/AU783703B2/en
Priority to KR1020017016588A priority patent/KR100834986B1/en
Application filed by Basf Ag filed Critical Basf Ag
Priority to SK1888-2001A priority patent/SK18882001A3/en
Priority to CA002380870A priority patent/CA2380870A1/en
Priority to MXPA01012844A priority patent/MXPA01012844A/en
Publication of WO2001000804A2 publication Critical patent/WO2001000804A2/en
Publication of WO2001000804A3 publication Critical patent/WO2001000804A3/en
Priority to AU2006200801A priority patent/AU2006200801A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Isolated nucleic acid molecules, designated SRT nucleic acid molecules, which encode novel SRT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SRT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SRT proteins, mutated SRT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SRT genes in this organism.
PCT/IB2000/000922 1999-06-25 2000-06-23 Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins WO2001000804A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP2001506798A JP2003525593A (en) 1999-06-25 2000-06-23 Stress, tolerance and tolerability proteins encoding Corynebacterium glutamicum gene
EP00944135A EP1290178A2 (en) 1999-06-25 2000-06-23 Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins
ES00944135T ES2184658T1 (en) 1999-06-25 2000-06-23 CORYNEBACTERIUM GLUTAMICUM GENES THAT CODIFY EFFORT, RESISTANCE AND TOLERANCE PROTEINS.
AU58369/00A AU783703B2 (en) 1999-06-25 2000-06-23 Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins
KR1020017016588A KR100834986B1 (en) 1999-06-25 2000-06-23 Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins
HU0203340A HUP0203340A2 (en) 1999-06-25 2000-06-23 Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins
SK1888-2001A SK18882001A3 (en) 1999-06-25 2000-06-23 Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins
CA002380870A CA2380870A1 (en) 1999-06-25 2000-06-23 Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins
MXPA01012844A MXPA01012844A (en) 1999-06-25 2000-06-23 Corynebacterium glutamicum.
AU2006200801A AU2006200801A1 (en) 1999-06-25 2006-02-24 Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins

Applications Claiming Priority (24)

Application Number Priority Date Filing Date Title
US14103199P 1999-06-25 1999-06-25
US60/141,031 1999-06-25
US14269299P 1999-07-01 1999-07-01
DE19930429 1999-07-01
DE19930429.7 1999-07-01
US60/142,692 1999-07-01
DE19931541.8 1999-07-08
DE19931541 1999-07-08
DE19931413 1999-07-08
DE19931413.6 1999-07-08
DE19931457.8 1999-07-08
DE19931457 1999-07-08
DE19932209 1999-07-09
DE19932230.9 1999-07-09
DE19932209.0 1999-07-09
DE19932230 1999-07-09
DE19932914.1 1999-07-14
DE19932914 1999-07-14
US15121499P 1999-08-27 1999-08-27
DE19940764 1999-08-27
US60/151,214 1999-08-27
DE19940764.9 1999-08-27
DE19941382 1999-08-31
DE19941382.7 1999-08-31

Publications (2)

Publication Number Publication Date
WO2001000804A2 WO2001000804A2 (en) 2001-01-04
WO2001000804A3 true WO2001000804A3 (en) 2001-08-02

Family

ID=27582954

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2000/000922 WO2001000804A2 (en) 1999-06-25 2000-06-23 Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins

Country Status (12)

Country Link
EP (1) EP1290178A2 (en)
JP (3) JP2003525593A (en)
KR (4) KR20070087095A (en)
AU (1) AU783703B2 (en)
CA (1) CA2380870A1 (en)
ES (1) ES2184658T1 (en)
HU (1) HUP0203340A2 (en)
MX (1) MXPA01012844A (en)
PL (1) PL359863A1 (en)
SK (1) SK18882001A3 (en)
TR (1) TR200103709T2 (en)
WO (1) WO2001000804A2 (en)

Families Citing this family (29)

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Publication number Priority date Publication date Assignee Title
BR0012020A (en) 1999-07-02 2002-07-02 Ajinomoto Kk Protein, and DNA
US6569650B1 (en) 1999-08-13 2003-05-27 Degussa Ag Process for the fermentative preparation of metabolic products and for the nucleotide sequences encoding for the sod gene
EP1156115A1 (en) 2000-05-12 2001-11-21 Degussa AG Corynebacterium glutamicum strain with enhanced secretion activity
DE10032350A1 (en) 2000-07-04 2002-01-24 Degussa New coryneform bacterium in which the mdhA gene is attenuated, preferably eliminated, useful for fermentative production of L-amino acids such as L-lysine
ATE274061T1 (en) * 2000-08-10 2004-09-15 Degussa NUCLEOTIDE SEQUENCES CODING FOR THE LYSR2 GENE
DE10042051A1 (en) 2000-08-26 2002-03-07 Degussa New nucleotide sequences coding for the cstA gene
EP1320543A2 (en) 2000-09-02 2003-06-25 Degussa AG Nucleotide sequence coding for the sigc gene of corynebacterium glutamicum
WO2002020792A1 (en) 2000-09-09 2002-03-14 Degussa Ag Efflux protein dep33 of corynebacterium glutamicum
AU2002219032A1 (en) 2000-09-09 2002-03-26 Degussa A.G. Nucleotide sequences which code for the dep34 gene
US6759224B2 (en) 2000-09-09 2004-07-06 Degussa Ag Nucleotide sequences which code for the sahH gene
DE10154181A1 (en) * 2001-11-05 2003-05-15 Basf Ag Genes that code for stress resistance and tolerance proteins
DE10154180A1 (en) 2001-11-05 2003-05-15 Basf Ag genes which code for genetic stability, gene expression and folding proteins
US8008545B2 (en) 2003-04-15 2011-08-30 Basf Plant Science Gmbh Process for the production of fine chemicals
US7468262B2 (en) 2003-05-16 2008-12-23 Ajinomoto Co., Inc. Polynucleotides encoding useful polypeptides in corynebacterium glutamicum ssp. lactofermentum
EP1654368A2 (en) * 2003-08-01 2006-05-10 BASF Plant Science GmbH Process for the production of fine chemicals
US8728795B2 (en) 2003-12-18 2014-05-20 Basf Se Pgro expression units
DE10359594A1 (en) 2003-12-18 2005-07-28 Basf Ag PEF TU-expression units
DE10359660A1 (en) 2003-12-18 2005-07-28 Basf Ag Psod expression units
DE102004035065A1 (en) 2004-07-20 2006-02-16 Basf Ag P-ET-TS expression units
JP5537818B2 (en) * 2008-03-04 2014-07-02 国立大学法人信州大学 Method for producing useful substances
EP2400024A4 (en) * 2009-02-18 2012-10-31 Univ Shinshu Process for producing useful substance
KR101694850B1 (en) * 2014-10-08 2017-01-10 씨제이제일제당 주식회사 Microorganism producing L-glutamine and process for preparing L-glutamine using the same
KR101941745B1 (en) * 2016-07-20 2019-01-24 씨제이제일제당 (주) Microorganisms having an acyltransferase activity and the use thereof
EP3456833A1 (en) 2017-09-18 2019-03-20 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
EP3467099A1 (en) 2017-10-05 2019-04-10 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
RU2019128538A (en) 2018-09-26 2021-03-11 Эвоник Оперейшенс ГмбХ METHOD FOR ENZYMATIC PRODUCTION OF L-LYSINE
CN111088202B (en) * 2019-12-25 2022-01-04 南京工业大学 Recombinant corynebacterium glutamicum for producing lysine through biological film-forming continuous fermentation and construction method thereof
CN111909912B (en) * 2020-09-11 2022-03-08 四川农业大学 MAP3K-19 gene for improving high-temperature tolerance of rice in heading stage, protein obtained by encoding same and application thereof
WO2023165952A1 (en) * 2022-03-01 2023-09-07 Evonik Operations Gmbh Biotechnological production of collagen proteins and bacterial collagen-like proteins by recombinant microorganisms

Citations (5)

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Publication number Priority date Publication date Assignee Title
EP0252558A2 (en) * 1986-07-04 1988-01-13 SCLAVO S.p.A. Element of dna of corynebacterium diphteriae with typical properties of an is insertion element
FR2607827A2 (en) * 1985-09-27 1988-06-10 Pasteur Institut DNA fragment comprising at least a portion of a gene for resistance to lincosamides and biochemical and biological applications.
WO1988009819A2 (en) * 1987-06-12 1988-12-15 Massachusetts Institute Of Technology C. glutamicum threonine biosynthetic pathway
EP0752472A1 (en) * 1994-02-24 1997-01-08 Ajinomoto Co., Inc. Novel gene originating in corynebacterium and use thereof
WO1999002692A1 (en) * 1997-07-09 1999-01-21 Ajinomoto Co., Inc. TEMPERATURE SENSITIVE dtsR GENES

Patent Citations (6)

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FR2607827A2 (en) * 1985-09-27 1988-06-10 Pasteur Institut DNA fragment comprising at least a portion of a gene for resistance to lincosamides and biochemical and biological applications.
EP0252558A2 (en) * 1986-07-04 1988-01-13 SCLAVO S.p.A. Element of dna of corynebacterium diphteriae with typical properties of an is insertion element
WO1988009819A2 (en) * 1987-06-12 1988-12-15 Massachusetts Institute Of Technology C. glutamicum threonine biosynthetic pathway
EP0752472A1 (en) * 1994-02-24 1997-01-08 Ajinomoto Co., Inc. Novel gene originating in corynebacterium and use thereof
WO1999002692A1 (en) * 1997-07-09 1999-01-21 Ajinomoto Co., Inc. TEMPERATURE SENSITIVE dtsR GENES
EP1002866A1 (en) * 1997-07-09 2000-05-24 Ajinomoto Co., Inc. TEMPERATURE SENSITIVE dtsR GENES

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CHAN MING-SHUN ET AL: "Cloning of m-fluorophenylalanine-resistant gene and mutational analysis of feedback-resistant prephenate dehydratase from Corynebacterium glutamicum.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 219, no. 2, 1996, pages 537 - 542, XP002152526, ISSN: 0006-291X *
DATABASE EBI 14 March 2000 (2000-03-14), KIM H. AND LEE H.: "Nucleotide sequence of the lmrB gene in Corynebacterium glutamicum", XP002152528 *
DATABASE EBI 19 March 1999 (1999-03-19), BARASH S. ET AL.: "Enterococcus faecalis genome contig", XP002152527 *
JAEGER WOLFGANG ET AL: "A Corynebacterium glutamicum gene conferring multidrug resistance in the heterologous host Escherichia coli.", JOURNAL OF BACTERIOLOGY, vol. 179, no. 7, 1997, pages 2449 - 2451, XP002152524, ISSN: 0021-9193 *
PETER H ET AL: "CORYNEBACTERIUM GLUTAMICUM IS EQUIPPED WITH FOUR SECONDARY CARRIERSFOR COMPATIBLE SOLUTES: IDENTIFICATION, SEQUENCING, AND CHARACTERIZATION OF THE PROLINE/ECTOINE UPTAKE SYSTEM, PROP, AND THE ECTOINE/PROLINE/GLYCINE BETAINE CARRIER, ECTP", JOURNAL OF BACTERIOLOGY,WASHINGTON, DC,US, vol. 180, no. 22, 1998, pages 6005 - 6012, XP000917352, ISSN: 0021-9193 *
WEHRMANN AXEL ET AL: "Different modes of diaminopimelate synthesis and their role in cell wall integrity: A study with Corynebacterium glutamicum.", JOURNAL OF BACTERIOLOGY, vol. 180, no. 12, June 1998 (1998-06-01), pages 3159 - 3165, XP002152525, ISSN: 0021-9193 *

Also Published As

Publication number Publication date
KR20060118631A (en) 2006-11-23
HUP0203340A2 (en) 2003-01-28
KR20070087094A (en) 2007-08-27
JP2007244391A (en) 2007-09-27
WO2001000804A2 (en) 2001-01-04
JP2007244392A (en) 2007-09-27
KR20070087095A (en) 2007-08-27
KR20030000013A (en) 2003-01-03
EP1290178A2 (en) 2003-03-12
JP2003525593A (en) 2003-09-02
AU5836900A (en) 2001-01-31
AU783703B2 (en) 2005-11-24
MXPA01012844A (en) 2002-07-09
TR200103709T2 (en) 2002-08-21
CA2380870A1 (en) 2001-01-04
PL359863A1 (en) 2004-09-06
KR100834986B1 (en) 2008-06-03
SK18882001A3 (en) 2002-09-10
ES2184658T1 (en) 2003-04-16
KR100878335B1 (en) 2009-01-14

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