WO2001000661A3 - Carnitine carrier related protein-1 - Google Patents

Carnitine carrier related protein-1 Download PDF

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Publication number
WO2001000661A3
WO2001000661A3 PCT/IB2000/001010 IB0001010W WO0100661A3 WO 2001000661 A3 WO2001000661 A3 WO 2001000661A3 IB 0001010 W IB0001010 W IB 0001010W WO 0100661 A3 WO0100661 A3 WO 0100661A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
related protein
ccrp
polypeptides
individual
Prior art date
Application number
PCT/IB2000/001010
Other languages
French (fr)
Other versions
WO2001000661A2 (en
Inventor
Barbara Bour
Stephane Bejanin
Bernard Bihain
Catherine Clusel
Original Assignee
Genset Sa
Barbara Bour
Stephane Bejanin
Bernard Bihain
Catherine Clusel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genset Sa, Barbara Bour, Stephane Bejanin, Bernard Bihain, Catherine Clusel filed Critical Genset Sa
Priority to AU58382/00A priority Critical patent/AU5838200A/en
Publication of WO2001000661A2 publication Critical patent/WO2001000661A2/en
Publication of WO2001000661A3 publication Critical patent/WO2001000661A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention concerns CCRP-1 polynucleotides and polypeptides. The invention further relates to methods of directing polynucleotides, polypeptides, and small molecules to mitochondria. The invention further relates to methods of reducing blood levels of fatty acids in an individual. The invention also concerns methods of identifying individuals who are at increased risk or who have a predisposition for developing, or present state of having, a disease or disorder, such as obesity or heart disease, by determining the level of a CCRP-1 gene product in an individual.
PCT/IB2000/001010 1999-06-25 2000-06-21 Carnitine carrier related protein-1 WO2001000661A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU58382/00A AU5838200A (en) 1999-06-25 2000-06-21 Carnitine carrier related protein-1

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14103299P 1999-06-25 1999-06-25
US60/141,032 1999-06-25
US46909999A 1999-12-21 1999-12-21
US09/469,099 1999-12-21

Publications (2)

Publication Number Publication Date
WO2001000661A2 WO2001000661A2 (en) 2001-01-04
WO2001000661A3 true WO2001000661A3 (en) 2002-01-10

Family

ID=26838728

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/IB2000/001011 WO2001000803A2 (en) 1998-12-22 2000-06-21 Apolipoprotein a-iv-related protein: polypeptide, polynucleotide sequences and biallelic markers thereof
PCT/IB2000/000951 WO2001000806A2 (en) 1997-11-13 2000-06-21 Dna's encoding proteins with signal peptides
PCT/IB2000/001010 WO2001000661A2 (en) 1999-06-25 2000-06-21 Carnitine carrier related protein-1

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/IB2000/001011 WO2001000803A2 (en) 1998-12-22 2000-06-21 Apolipoprotein a-iv-related protein: polypeptide, polynucleotide sequences and biallelic markers thereof
PCT/IB2000/000951 WO2001000806A2 (en) 1997-11-13 2000-06-21 Dna's encoding proteins with signal peptides

Country Status (4)

Country Link
EP (1) EP1200576A2 (en)
AU (2) AU5559400A (en)
CA (1) CA2368098A1 (en)
WO (3) WO2001000803A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001049715A2 (en) * 2000-01-06 2001-07-12 Genentech, Inc. Methods and compositions for inhibiting neoplastic cell growth
US7125550B2 (en) 2000-01-19 2006-10-24 University Of Virginia Patent Foundation Human sperm specific lysozyme-like proteins
EP1250429A2 (en) * 2000-01-19 2002-10-23 The University of Virginia Patent Foundation Human sperm specific lysozyme-like proteins
US7135559B2 (en) * 2000-02-21 2006-11-14 Kureha Chemical Industry Co., Ltd. Proteins and novel genes encoding the same
US7094566B2 (en) 2000-03-16 2006-08-22 Amgen Inc., IL-17 receptor like molecules and uses thereof
WO2003002737A1 (en) * 2001-06-27 2003-01-09 Riken Novel human topoisomerase 2α inhibitory protein and utilization thereof
EP1428882A4 (en) * 2001-08-24 2005-05-25 Hisamitsu Pharmaceutical Co Nucleic acids showing difference in expression between hepatoblastoma anc normal liver
US7238475B2 (en) 2001-08-27 2007-07-03 The Regents Of The University Of California Apolipoprotein gene involved in lipid metabolism
FR2843395A1 (en) * 2002-08-12 2004-02-13 Genfit S A New synthetic peptide from apolipoprotein AIV related protein, useful for raising antibodies, used for diagnosis and treatment of disorders of lipid metabolism
FR2829581A1 (en) * 2001-09-07 2003-03-14 Genfit S A New synthetic peptide from apolipoprotein AIV related protein, useful for raising antibodies, used for diagnosis and treatment of disorders of lipid metabolism
WO2003023408A1 (en) * 2001-09-07 2003-03-20 Genfit Compositions and methods for aa4rp assay
US20060089297A1 (en) * 2003-01-16 2006-04-27 Herr John C Sperm specific lysozyme-like proteins
AU2011213901B2 (en) * 2003-09-26 2012-07-05 BioNTech SE Identification of tumour-associated cell surface antigens for diagnosis and therapy
DE10344799A1 (en) 2003-09-26 2005-04-14 Ganymed Pharmaceuticals Ag Identification of surface-associated antigens for tumor diagnosis and therapy
EP2275556B1 (en) 2004-01-17 2013-04-24 Korea Research Institute of Bioscience and Biotechnology Rapid screening method of translational fusion partners for producing recombinant proteins and translational fusion partners screened therefrom
US7892733B1 (en) 2004-04-22 2011-02-22 Amgen Inc. Response element regions
KR20070009269A (en) 2005-07-15 2007-01-18 한국생명공학연구원 Library of translational fusion partners for producing recombinant proteins and translational fusion partners screened therefrom
CN102239183B (en) 2008-12-04 2017-06-30 韩国生命工学研究院 The screening of the albumen of a large amount of secretions is applied as fusion partner with them in recombinant protein preparation
WO2012060666A2 (en) 2010-11-04 2012-05-10 한국생명공학연구원 Method for producing human epidermal growth factor in large volume from yeast
US8854361B1 (en) 2013-03-13 2014-10-07 Cambridgesoft Corporation Visually augmenting a graphical rendering of a chemical structure representation or biological sequence representation with multi-dimensional information

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000037491A2 (en) * 1998-12-22 2000-06-29 Genset Dnas encoding proteins with signal sequences

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686605B1 (en) * 1992-01-27 1994-03-11 Rhone Poulenc Rorer Sa NOVEL POLYPEPTIDES, THEIR PREPARATION AND THEIR USE.
US6046031A (en) * 1997-01-21 2000-04-04 Human Genome Sciences, Inc. Metalloproteinases
EP0973899A2 (en) * 1997-04-10 2000-01-26 Genetics Institute, Inc. SECRETED EXPRESSED SEQUENCE TAGS (sESTs)
DE19816395A1 (en) * 1998-04-03 1999-10-07 Metagen Gesellschaft Fuer Genomforschung Mbh Human nucleic acid sequences from ovarian normal tissue

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000037491A2 (en) * 1998-12-22 2000-06-29 Genset Dnas encoding proteins with signal sequences

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GUSTAFSON B ET AL: "REGULATION OF CARNITINE BINDING TO PLASMA MEMBRANES BY AN ATP- DEPENDENT MECHANISM", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,US,ACADEMIC PRESS INC. ORLANDO, FL, vol. 231, no. 2, 1997, pages 249 - 253, XP000867851, ISSN: 0006-291X *
INDIVERI CESARE ET AL: "The mitochondrial carnitine carrier protein: cDNA cloning, primary structure and comparison with other mitochondrial transport proteins.", BIOCHEMICAL JOURNAL, vol. 321, no. 3, 1997, pages 713 - 719, XP002159737, ISSN: 0264-6021 *

Also Published As

Publication number Publication date
WO2001000806A2 (en) 2001-01-04
WO2001000806A3 (en) 2002-01-10
EP1200576A2 (en) 2002-05-02
WO2001000803A3 (en) 2001-12-27
WO2001000661A2 (en) 2001-01-04
AU5559400A (en) 2001-01-31
CA2368098A1 (en) 2001-01-04
AU5838200A (en) 2001-01-31
WO2001000803A2 (en) 2001-01-04

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