WO2000078800A3 - Combined decorin binding protein and outer surface protein compositions and methods of use - Google Patents

Combined decorin binding protein and outer surface protein compositions and methods of use Download PDF

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Publication number
WO2000078800A3
WO2000078800A3 PCT/US2000/016763 US0016763W WO0078800A3 WO 2000078800 A3 WO2000078800 A3 WO 2000078800A3 US 0016763 W US0016763 W US 0016763W WO 0078800 A3 WO0078800 A3 WO 0078800A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
combined
compositions
binding protein
decorin binding
Prior art date
Application number
PCT/US2000/016763
Other languages
French (fr)
Other versions
WO2000078800A2 (en
Inventor
Mark S Hanson
Nita K Patel
David R Cassatt
Original Assignee
Medimmune Inc
Mark S Hanson
Nita K Patel
David R Cassatt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Inc, Mark S Hanson, Nita K Patel, David R Cassatt filed Critical Medimmune Inc
Priority to AU56228/00A priority Critical patent/AU5622800A/en
Publication of WO2000078800A2 publication Critical patent/WO2000078800A2/en
Publication of WO2000078800A3 publication Critical patent/WO2000078800A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed are surprisingly effective compositions, therapeutic kits and vaccines comprising one or more Borrelia decorin binding protein components and one or more Borrelia outer surface protein components. Methods and medical uses are also disclosed in which the compositions, kits and vaccines are administered to prevent and/or treat Borrelial infections, notably the Borrelial infections that cause Lyme disease.
PCT/US2000/016763 1999-06-18 2000-06-16 Combined decorin binding protein and outer surface protein compositions and methods of use WO2000078800A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU56228/00A AU5622800A (en) 1999-06-18 2000-06-16 Combined decorin binding protein and outer surface protein compositions and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14025899P 1999-06-18 1999-06-18
US60/140,258 1999-06-18

Publications (2)

Publication Number Publication Date
WO2000078800A2 WO2000078800A2 (en) 2000-12-28
WO2000078800A3 true WO2000078800A3 (en) 2001-07-19

Family

ID=22490442

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/016763 WO2000078800A2 (en) 1999-06-18 2000-06-16 Combined decorin binding protein and outer surface protein compositions and methods of use

Country Status (2)

Country Link
AU (1) AU5622800A (en)
WO (1) WO2000078800A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2949473B1 (en) 2009-08-28 2013-08-09 Biomerieux Sa PROTEINS USED FOR THE DIAGNOSIS OF A LYME BORRELIOSE
FR2949472B1 (en) 2009-08-28 2013-08-09 Biomerieux Sa PROTEINS USED FOR THE DIAGNOSIS OF A LYME BORRELIOSE
CN103229055A (en) * 2010-09-27 2013-07-31 康奈尔大学 Methods for diagnosing lyme disease
US10006912B2 (en) * 2013-12-06 2018-06-26 Biopeptides Llc Peptides for diagnosing lyme disease
EP3359558B1 (en) * 2015-10-06 2023-12-13 Bio-Rad Laboratories, Inc. Borrelia immunoassays and materials therefor
WO2020086758A1 (en) 2018-10-23 2020-04-30 Dragonfly Therapeutics, Inc. Heterodimeric fc-fused proteins
JP2023522972A (en) 2020-04-22 2023-06-01 ドラゴンフライ セラピューティクス， インコーポレイテッド Formulations, Dosing Regimens, and Manufacturing Processes for Heterodimeric Fc Fusion Proteins

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998039028A1 (en) * 1997-03-05 1998-09-11 Merial Limited Lyme combination compositions and uses
US5853987A (en) * 1995-04-24 1998-12-29 The Texas A & M University System Decorin binding protein compositions and methods of use
WO1999012960A2 (en) * 1997-09-10 1999-03-18 Symbicom Ab P13 ANTIGENS FROM $i(BORRELIA)

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5853987A (en) * 1995-04-24 1998-12-29 The Texas A & M University System Decorin binding protein compositions and methods of use
WO1998039028A1 (en) * 1997-03-05 1998-09-11 Merial Limited Lyme combination compositions and uses
WO1999012960A2 (en) * 1997-09-10 1999-03-18 Symbicom Ab P13 ANTIGENS FROM $i(BORRELIA)

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CASSATT D R ET AL: "PROTECTION OF BORRELIA BURGDORFERI INFECTION BY ANTIBODIES TO DECORIN-BINDING PROTEIN", VACCINES,XX,XX, 1997, pages 191 - 195, XP000881024 *
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; CHONG-CERRILLO C. ET AL: "Immune serum from rabbits infected with Borrelia burgdorferi B31 confers complete passive protection against homologous challenge.", XP002155953, retrieved from STN Database accession no. 2000301873 *
FENG S ET AL: "HUMORAL IMMUNITY TO BORRELIA BURGDORFERI N40 DECORIN BINDING PROTEINS DURING INFECTION OF LABORATORY MICE", INFECTION AND IMMUNITY,US,AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, vol. 66, June 1998 (1998-06-01), pages 2827 - 2835, XP000872691, ISSN: 0019-9567 *
HANSON MARK S ET AL: "EVIDENCE FOR VACCINE SYNERGY BETWEEN BORRELIA BURGDORFERI DECORIN BINDING PROTEIN A AND OUTER SURFACE PROTEIN A IN THE MOUSE MODEL OF LYME BORRELIOSIS.", INFECTION AND IMMUNITY, vol. 68, no. 11, November 2000 (2000-11-01), pages 6457 - 6460, XP002155952, ISSN: 0019-9567 *
JOURNAL OF SPIROCHETAL AND TICK-BORNE DISEASES, (2000) 7/SPRING/SUMMER (3-9). *
M HANSON ET AL: "ACTIVE AND PASSIVE IMMUNITY AGAINST BORRELIA BERDORFII DBPA PROTECTS AGAINS INFECTION", INFECTION AND IMMUNITY,AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON,US, vol. 66, 1998, pages 2143 - 2153, XP002154988, ISSN: 0019-9567 *

Also Published As

Publication number Publication date
AU5622800A (en) 2001-01-09
WO2000078800A2 (en) 2000-12-28

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