WO2000064458A3 - Verfahren zur erzeugung einer spender-toleranz im menschlichen körper - Google Patents

Verfahren zur erzeugung einer spender-toleranz im menschlichen körper Download PDF

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Publication number
WO2000064458A3
WO2000064458A3 PCT/EP2000/003623 EP0003623W WO0064458A3 WO 2000064458 A3 WO2000064458 A3 WO 2000064458A3 EP 0003623 W EP0003623 W EP 0003623W WO 0064458 A3 WO0064458 A3 WO 0064458A3
Authority
WO
WIPO (PCT)
Prior art keywords
tolerance
inducing
human body
animal
stem cells
Prior art date
Application number
PCT/EP2000/003623
Other languages
English (en)
French (fr)
Other versions
WO2000064458A2 (de
Inventor
Georg S Wengler
Original Assignee
Georg S Wengler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georg S Wengler filed Critical Georg S Wengler
Priority to EP00927014A priority Critical patent/EP1107769A2/de
Publication of WO2000064458A2 publication Critical patent/WO2000064458A2/de
Publication of WO2000064458A3 publication Critical patent/WO2000064458A3/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Die Erfindung betrifft ein Verfahren zur Erzeugung einer tierischen Toleranz im menschlichen Körper, bei der nach der Entnahme von fötalem oder embryonalem tierischen Gewebe aus einem Spendertier Stammzellen aus dem Gewebe gewonnen werden. Die Stammzellen werden vorzugsweise zur Eliminierung von Infektionen vorbehandelt. Daraufhin wird eine Toleranzsubstanz unter Verwendung der gewonnenen Stammzellen präpariert und diese Toleranzsubstanz in einen menschlichen Fötus oder Embryo zur Erzeugung einer tierischen Toleranz injiziert.
PCT/EP2000/003623 1999-04-22 2000-04-20 Verfahren zur erzeugung einer spender-toleranz im menschlichen körper WO2000064458A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP00927014A EP1107769A2 (de) 1999-04-22 2000-04-20 Verfahren zur erzeugung einer spender-toleranz im menschlichen körper

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19918327A DE19918327A1 (de) 1999-04-22 1999-04-22 Verfahren zur Erzeugung einer Spender-Toleranz im menschlichen Körper
DE19918327.9 1999-04-22

Publications (2)

Publication Number Publication Date
WO2000064458A2 WO2000064458A2 (de) 2000-11-02
WO2000064458A3 true WO2000064458A3 (de) 2001-04-12

Family

ID=7905527

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/003623 WO2000064458A2 (de) 1999-04-22 2000-04-20 Verfahren zur erzeugung einer spender-toleranz im menschlichen körper

Country Status (3)

Country Link
EP (1) EP1107769A2 (de)
DE (1) DE19918327A1 (de)
WO (1) WO2000064458A2 (de)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995012317A1 (en) * 1993-11-05 1995-05-11 The Regents Of The University Of California Improved postanatal and in utero fetal hematopoietic stem cell transplantation methods

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19726597C1 (de) * 1997-06-23 1998-11-19 Wengler Georg S Verfahren zur Herstellung von monoklonalen Antikörper

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995012317A1 (en) * 1993-11-05 1995-05-11 The Regents Of The University Of California Improved postanatal and in utero fetal hematopoietic stem cell transplantation methods

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
COWAN AND GOLBUS: "in utero hemapoietic stem cell transplants for inherited diseases", THE AMERICAN JOURNAL OF PEDIATRIC HEMATOLOGY/ONCOLOGY, vol. 16, no. 1, February 1994 (1994-02-01), pages 35 - 42, XP000960710 *
FLAKE ALAN W ET AL: "Cellular therapy.", OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA, vol. 24, no. 1, 1997, pages 159 - 177, XP000960716, ISSN: 0889-8545 *
KIM HEUNG BAE ET AL: "In utero bone marrow transplantation induces donor specific tolerance by a combination of clonal deletion and anergy.", PEDIATRICS, vol. 102, no. 3 PART 2, 1998, Annual Meeting of the American Academy of Pediatrics;San Francisco, California, USA; October 16-21, 1998, pages 792, XP000960730, ISSN: 0031-4005 *
KIM HEUNG BAE ET AL: "Microchimerism and tolerance after in utero bone marrow transplantation in mice.", JOURNAL OF SURGICAL RESEARCH, vol. 77, no. 1, June 1998 (1998-06-01), pages 1 - 5, XP000960729, ISSN: 0022-4804 *
MYCHALISKA GEORGE B ET AL: "In utero hematopoietic stem cell transplants induce tolerance for postnatal kidney transplantation in monkeys.", SURGICAL FORUM, vol. 47, 1996, pages 443 - 445, XP000960726, ISSN: 0071-8041 *
TOURAINE J -L ET AL: "Immunological tolerance following stem cell transplantation in human fetuses in utero.", TRANSPLANTATION PROCEEDINGS, vol. 29, no. 5, 1997, Second Congress on Pregnancy after Transplantation;Ajaccio, Corsica, France; May 31-June 1, 1996, pages 2477, XP000960728, ISSN: 0041-1345 *

Also Published As

Publication number Publication date
EP1107769A2 (de) 2001-06-20
WO2000064458A2 (de) 2000-11-02
DE19918327A1 (de) 2000-10-26

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