WO2000063435A3 - Method of identifying toxic agents using differential gene expression - Google Patents

Method of identifying toxic agents using differential gene expression Download PDF

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Publication number
WO2000063435A3
WO2000063435A3 PCT/US2000/010076 US0010076W WO0063435A3 WO 2000063435 A3 WO2000063435 A3 WO 2000063435A3 US 0010076 W US0010076 W US 0010076W WO 0063435 A3 WO0063435 A3 WO 0063435A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene expression
differential gene
toxic agents
identifying toxic
identifying
Prior art date
Application number
PCT/US2000/010076
Other languages
French (fr)
Other versions
WO2000063435A8 (en
WO2000063435A2 (en
Inventor
Bonnie E Gould-Rothberg
Vincent A Dipippo
Original Assignee
Curagen Corp
Bonnie E Gould-Rothberg
Vincent A Dipippo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curagen Corp, Bonnie E Gould-Rothberg, Vincent A Dipippo filed Critical Curagen Corp
Priority to AU43502/00A priority Critical patent/AU4350200A/en
Priority to JP2000612512A priority patent/JP2003513613A/en
Priority to CA002369969A priority patent/CA2369969A1/en
Priority to EP00923362A priority patent/EP1169481A1/en
Publication of WO2000063435A2 publication Critical patent/WO2000063435A2/en
Publication of WO2000063435A8 publication Critical patent/WO2000063435A8/en
Publication of WO2000063435A3 publication Critical patent/WO2000063435A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Disclosed are methods of identifying toxic agents, e.g., hepatotoxic agents, using differential gene expression. Also disclosed are novel nucleic acid sequences whose expression is differentially regulated by troglitazone.
PCT/US2000/010076 1999-04-15 2000-04-14 Method of identifying toxic agents using differential gene expression WO2000063435A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU43502/00A AU4350200A (en) 1999-04-15 2000-04-14 Method of identifying toxic agents using differential gene expression
JP2000612512A JP2003513613A (en) 1999-04-15 2000-04-14 Methods for identifying virulence factors using differential gene expression
CA002369969A CA2369969A1 (en) 1999-04-15 2000-04-14 Method of identifying toxic agents using differential gene expression
EP00923362A EP1169481A1 (en) 1999-04-15 2000-04-14 Method of identifying toxic agents using differential gene expression

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US12976399P 1999-04-15 1999-04-15
US60/129,763 1999-04-15
US15692499P 1999-09-28 1999-09-28
US60/156,924 1999-09-28
US54858900A 2000-04-13 2000-04-13
US09/548,589 2000-04-13

Publications (3)

Publication Number Publication Date
WO2000063435A2 WO2000063435A2 (en) 2000-10-26
WO2000063435A8 WO2000063435A8 (en) 2001-05-10
WO2000063435A3 true WO2000063435A3 (en) 2002-09-12

Family

ID=27383925

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/010076 WO2000063435A2 (en) 1999-04-15 2000-04-14 Method of identifying toxic agents using differential gene expression

Country Status (4)

Country Link
EP (1) EP1169481A1 (en)
JP (1) JP2003513613A (en)
CA (1) CA2369969A1 (en)
WO (1) WO2000063435A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000065091A2 (en) * 1999-04-23 2000-11-02 Curagen Corporation Method of identifying ligands for the peroxisome proliferator activated receptor gamma using differential gene expression
US6852845B1 (en) 1999-11-22 2005-02-08 Curagen Corporation Method of identifying toxic agents using NSAID-induced differential gene expression in liver
WO2002095000A2 (en) 2001-05-22 2002-11-28 Gene Logic, Inc. Molecular toxicology modeling
US7447594B2 (en) 2001-07-10 2008-11-04 Ocimum Biosolutions, Inc. Molecular cardiotoxicology modeling
US7469185B2 (en) 2002-02-04 2008-12-23 Ocimum Biosolutions, Inc. Primary rat hepatocyte toxicity modeling
US7778782B1 (en) 2002-12-17 2010-08-17 Entelos, Inc. Peroxisome proliferation activated receptor alpha (PPARα) signatures
US7396645B1 (en) 2002-12-17 2008-07-08 Entelos, Inc. Cholestasis signature
US7422854B1 (en) 2002-12-20 2008-09-09 Entelos, Inc. Cholesterol reduction signature
US7519519B1 (en) 2002-12-20 2009-04-14 Entelos, Inc. Signature projection score
CA2533922A1 (en) * 2003-08-07 2005-02-17 Gene Logic, Inc. Primary rat hepatocyte toxicity modeling
US7348144B2 (en) * 2003-08-13 2008-03-25 Agilent Technologies, Inc. Methods and system for multi-drug treatment discovery
US7795390B2 (en) 2005-06-24 2010-09-14 Teijin Pharma Limited Biological substance nesfatin and its related substances and uses thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997013877A1 (en) * 1995-10-12 1997-04-17 Lynx Therapeutics, Inc. Measurement of gene expression profiles in toxicity determination
WO1998013353A1 (en) * 1996-09-26 1998-04-02 Aurora Biosciences Corporation Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and use for cellular assays in drug discovery
WO2001002609A2 (en) * 1999-07-02 2001-01-11 Curagen Corporation Method of identifying toxic agents using differential gene expression
WO2001032928A2 (en) * 1999-11-05 2001-05-10 Phase-1 Molecular Toxicology Methods of determining individual hypersensitivity to an agent
WO2001051638A2 (en) * 2000-01-14 2001-07-19 Incyte Genomics, Inc. Drug metabolizing enzymes
WO2001053514A1 (en) * 2000-01-21 2001-07-26 Glaxo Group Limited Toxicant-induced differential gene expression

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997013877A1 (en) * 1995-10-12 1997-04-17 Lynx Therapeutics, Inc. Measurement of gene expression profiles in toxicity determination
WO1998013353A1 (en) * 1996-09-26 1998-04-02 Aurora Biosciences Corporation Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and use for cellular assays in drug discovery
WO2001002609A2 (en) * 1999-07-02 2001-01-11 Curagen Corporation Method of identifying toxic agents using differential gene expression
WO2001032928A2 (en) * 1999-11-05 2001-05-10 Phase-1 Molecular Toxicology Methods of determining individual hypersensitivity to an agent
WO2001051638A2 (en) * 2000-01-14 2001-07-19 Incyte Genomics, Inc. Drug metabolizing enzymes
WO2001053514A1 (en) * 2000-01-21 2001-07-26 Glaxo Group Limited Toxicant-induced differential gene expression

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANNALS OF INTERNAL MEDICINE, vol. 129, no. 1, 1 July 1998 (1998-07-01), pages 38 - 41, ISSN: 0003-4819 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1 July 1998 (1998-07-01), NEUSCHWANDER-TETRI BRENT A ET AL: "Troglitazone-induced hepatic failure leading to liver transplantation. A case report.", XP002179971, Database accession no. PREV199800354952 *

Also Published As

Publication number Publication date
CA2369969A1 (en) 2000-10-26
WO2000063435A8 (en) 2001-05-10
WO2000063435A2 (en) 2000-10-26
EP1169481A1 (en) 2002-01-09
JP2003513613A (en) 2003-04-15

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