WO2001002609A3 - Method of identifying toxic agents using differential gene expression - Google Patents

Method of identifying toxic agents using differential gene expression Download PDF

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Publication number
WO2001002609A3
WO2001002609A3 PCT/US2000/040292 US0040292W WO0102609A3 WO 2001002609 A3 WO2001002609 A3 WO 2001002609A3 US 0040292 W US0040292 W US 0040292W WO 0102609 A3 WO0102609 A3 WO 0102609A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene expression
differential gene
toxic agents
identifying toxic
identifying
Prior art date
Application number
PCT/US2000/040292
Other languages
French (fr)
Other versions
WO2001002609A2 (en
Inventor
Bonnie E Gould-Rothberg
Vincent A Dipippo
Laura Milroy
Kellye K Daniels
Original Assignee
Curagen Corp
Bonnie E Gould-Rothberg
Vincent A Dipippo
Laura Milroy
Kellye K Daniels
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curagen Corp, Bonnie E Gould-Rothberg, Vincent A Dipippo, Laura Milroy, Kellye K Daniels filed Critical Curagen Corp
Priority to JP2001508380A priority Critical patent/JP2003518365A/en
Priority to EP00960121A priority patent/EP1255857A2/en
Priority to CA002377768A priority patent/CA2377768A1/en
Priority to AU71330/00A priority patent/AU7133000A/en
Publication of WO2001002609A2 publication Critical patent/WO2001002609A2/en
Publication of WO2001002609A3 publication Critical patent/WO2001002609A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed are methods of identifying toxic agents, e.g., hepatotoxic agents, using differential gene expression. Also disclosed are novel nucleic acid sequences whose expression is differentially regulated by acetaminophen.
PCT/US2000/040292 1999-07-02 2000-06-30 Method of identifying toxic agents using differential gene expression WO2001002609A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001508380A JP2003518365A (en) 1999-07-02 2000-06-30 Methods for identifying virulence factors using differential gene expression
EP00960121A EP1255857A2 (en) 1999-07-02 2000-06-30 Method of identifying toxic agents using differential gene expression
CA002377768A CA2377768A1 (en) 1999-07-02 2000-06-30 Method of identifying toxic agents using differential gene expression
AU71330/00A AU7133000A (en) 1999-07-02 2000-06-30 Method of identifying toxic agents using differential gene expression

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14233599P 1999-07-02 1999-07-02
US60/142,335 1999-07-02
US60753900A 2000-06-29 2000-06-29
US09/607,539 2000-06-29

Publications (2)

Publication Number Publication Date
WO2001002609A2 WO2001002609A2 (en) 2001-01-11
WO2001002609A3 true WO2001002609A3 (en) 2002-09-12

Family

ID=26840003

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/040292 WO2001002609A2 (en) 1999-07-02 2000-06-30 Method of identifying toxic agents using differential gene expression

Country Status (5)

Country Link
EP (1) EP1255857A2 (en)
JP (1) JP2003518365A (en)
AU (1) AU7133000A (en)
CA (1) CA2377768A1 (en)
WO (1) WO2001002609A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9555148B2 (en) 2011-11-17 2017-01-31 Evonik Degussa Gmbh Superabsorbing polymers with rapid absorption properties and method for producing the same

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2369969A1 (en) * 1999-04-15 2000-10-26 Curagen Corporation Method of identifying toxic agents using differential gene expression
EP1255857A2 (en) * 1999-07-02 2002-11-13 Curagen Corporation Method of identifying toxic agents using differential gene expression
US7415358B2 (en) 2001-05-22 2008-08-19 Ocimum Biosolutions, Inc. Molecular toxicology modeling
US7469185B2 (en) 2002-02-04 2008-12-23 Ocimum Biosolutions, Inc. Primary rat hepatocyte toxicity modeling
EP1344834A3 (en) * 2002-03-14 2004-06-02 F. Hoffmann-La Roche Ag Methods for the toxicity prediction of a compound
WO2005014793A2 (en) * 2003-08-07 2005-02-17 Gene Logic, Inc. Primary rat hepatocyte toxicity modeling
US9302248B2 (en) 2013-04-10 2016-04-05 Evonik Corporation Particulate superabsorbent polymer composition having improved stability

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997013877A1 (en) * 1995-10-12 1997-04-17 Lynx Therapeutics, Inc. Measurement of gene expression profiles in toxicity determination
WO1998013353A1 (en) * 1996-09-26 1998-04-02 Aurora Biosciences Corporation Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and use for cellular assays in drug discovery
WO2001002609A2 (en) * 1999-07-02 2001-01-11 Curagen Corporation Method of identifying toxic agents using differential gene expression
WO2001032928A2 (en) * 1999-11-05 2001-05-10 Phase-1 Molecular Toxicology Methods of determining individual hypersensitivity to an agent
WO2001051638A2 (en) * 2000-01-14 2001-07-19 Incyte Genomics, Inc. Drug metabolizing enzymes
WO2001053514A1 (en) * 2000-01-21 2001-07-26 Glaxo Group Limited Toxicant-induced differential gene expression

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997013877A1 (en) * 1995-10-12 1997-04-17 Lynx Therapeutics, Inc. Measurement of gene expression profiles in toxicity determination
WO1998013353A1 (en) * 1996-09-26 1998-04-02 Aurora Biosciences Corporation Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and use for cellular assays in drug discovery
WO2001002609A2 (en) * 1999-07-02 2001-01-11 Curagen Corporation Method of identifying toxic agents using differential gene expression
WO2001032928A2 (en) * 1999-11-05 2001-05-10 Phase-1 Molecular Toxicology Methods of determining individual hypersensitivity to an agent
WO2001051638A2 (en) * 2000-01-14 2001-07-19 Incyte Genomics, Inc. Drug metabolizing enzymes
WO2001053514A1 (en) * 2000-01-21 2001-07-26 Glaxo Group Limited Toxicant-induced differential gene expression

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1988, MEYERS L L ET AL: "ACETAMINOPHEN-INDUCED INHIBITION OF HEPATIC MITOCHONDRIAL RESPIRATION IN MICE", XP002179998, Database accession no. PREV198886033625 *
TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 93, no. 3, 1988, pages 378 - 387, ISSN: 0041-008X *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9555148B2 (en) 2011-11-17 2017-01-31 Evonik Degussa Gmbh Superabsorbing polymers with rapid absorption properties and method for producing the same

Also Published As

Publication number Publication date
WO2001002609A2 (en) 2001-01-11
CA2377768A1 (en) 2001-01-11
EP1255857A2 (en) 2002-11-13
AU7133000A (en) 2001-01-22
JP2003518365A (en) 2003-06-10

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