WO2000063370A3 - Nucleic acids coding for novel truncated cart proteins, corresponding truncated cart polypeptides and their use for therapeutic and diagnostic purposes - Google Patents

Nucleic acids coding for novel truncated cart proteins, corresponding truncated cart polypeptides and their use for therapeutic and diagnostic purposes Download PDF

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Publication number
WO2000063370A3
WO2000063370A3 PCT/GB2000/001445 GB0001445W WO0063370A3 WO 2000063370 A3 WO2000063370 A3 WO 2000063370A3 GB 0001445 W GB0001445 W GB 0001445W WO 0063370 A3 WO0063370 A3 WO 0063370A3
Authority
WO
WIPO (PCT)
Prior art keywords
cart
truncated
truncated cart
proteins
nucleic acids
Prior art date
Application number
PCT/GB2000/001445
Other languages
French (fr)
Other versions
WO2000063370A2 (en
Inventor
Alistair Dixon
James Hamer Murray
Original Assignee
Warner Lambert Co
Alistair Dixon
James Hamer Murray
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co, Alistair Dixon, James Hamer Murray filed Critical Warner Lambert Co
Priority to CA002373359A priority Critical patent/CA2373359A1/en
Priority to EP00927399A priority patent/EP1169451A2/en
Priority to BR0010594-5A priority patent/BR0010594A/en
Priority to JP2000612449A priority patent/JP2002541842A/en
Priority to AU45806/00A priority patent/AU4580600A/en
Priority to MXPA01010483A priority patent/MXPA01010483A/en
Publication of WO2000063370A2 publication Critical patent/WO2000063370A2/en
Publication of WO2000063370A3 publication Critical patent/WO2000063370A3/en
Priority to HK02105104.0A priority patent/HK1044796A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention is directed to nucleic acids encoding novel truncated CART polypeptides, particularly CART proteins having 88 amino acids in length, as well as nucleic acid fragments thereof, the related recombinant vectors and recombinant host cells containing such recombinant vectors. The invention also deals with a truncated CART protein particularly a truncated CART protein having 88 amino acids in length, uses thereof in the identification of ligands, as well as antibodies specially directed against this protein, these antibodies being useful as diagnostic reagents. The invention also relates to the use of the nucleic acids encoding the truncated CART proteins of the invention or the truncated CART proteins themselves for therapeutic purposes and particularly to decrease or prevent neuronal degeneration and to promote neuronal regeneration and restoration of function, to treat addiction by aiding clearance of the polypeptide or its truncated forms in vitro and in vivo and also in order to regulate food intake.
PCT/GB2000/001445 1999-04-15 2000-04-14 Nucleic acids coding for novel truncated cart proteins, corresponding truncated cart polypeptides and their use for therapeutic and diagnostic purposes WO2000063370A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002373359A CA2373359A1 (en) 1999-04-15 2000-04-14 Nucleic acids coding for novel truncated cart proteins, corresponding truncated cart polypeptides and their use for therapeutic and diagnostic purposes
EP00927399A EP1169451A2 (en) 1999-04-15 2000-04-14 Nucleic acids coding for novel truncated cart proteins, corresponding truncated cart polypeptides and their use for therapeutic and diagnostic purposes
BR0010594-5A BR0010594A (en) 1999-04-15 2000-04-14 nucleic acids encoding new truncated carton proteins, corresponding to truncated carton polypeptides or their use for therapeutic and diagnostic purposes
JP2000612449A JP2002541842A (en) 1999-04-15 2000-04-14 Nucleic acids encoding novel truncated CART proteins corresponding to truncated CART polypeptides and their use for therapeutic and diagnostic purposes
AU45806/00A AU4580600A (en) 1999-04-15 2000-04-14 Nucleic acids coding for novel truncated cart proteins, corresponding truncated cart polypeptides and their use for therapeutic and diagnostic purposes
MXPA01010483A MXPA01010483A (en) 1999-04-15 2000-04-14 Nucleic acids coding for novel truncated cart proteins, corresponding truncated cart polypeptides and their use for therapeutic and diagnostic purposes.
HK02105104.0A HK1044796A1 (en) 1999-04-15 2002-07-09 Nucleic acids coding for novel truncated cart proteins, corresponding truncated cart polypeptides and their use for therapeutic and diagnostic purposes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12947999P 1999-04-15 1999-04-15
US60/129,479 1999-04-15

Publications (2)

Publication Number Publication Date
WO2000063370A2 WO2000063370A2 (en) 2000-10-26
WO2000063370A3 true WO2000063370A3 (en) 2001-09-13

Family

ID=22440165

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/001445 WO2000063370A2 (en) 1999-04-15 2000-04-14 Nucleic acids coding for novel truncated cart proteins, corresponding truncated cart polypeptides and their use for therapeutic and diagnostic purposes

Country Status (7)

Country Link
EP (1) EP1169451A2 (en)
JP (1) JP2002541842A (en)
AU (1) AU4580600A (en)
BR (1) BR0010594A (en)
CA (1) CA2373359A1 (en)
MX (1) MXPA01010483A (en)
WO (1) WO2000063370A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034619A1 (en) * 1995-05-04 1996-11-07 Amgen Inc. Methods of preventing neuron degeneration and promoting neuron regeneration
US5798258A (en) * 1995-05-04 1998-08-25 Oregon Health Sciences University Cart protein and DNA encoding therefor
WO1998048824A1 (en) * 1997-05-01 1998-11-05 Emory University Bioactive peptides derived from cocaine and amphetamine regulated transcript protein

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034619A1 (en) * 1995-05-04 1996-11-07 Amgen Inc. Methods of preventing neuron degeneration and promoting neuron regeneration
US5798258A (en) * 1995-05-04 1998-08-25 Oregon Health Sciences University Cart protein and DNA encoding therefor
WO1998048824A1 (en) * 1997-05-01 1998-11-05 Emory University Bioactive peptides derived from cocaine and amphetamine regulated transcript protein

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL SEQUENCES 15 July 1998 (1998-07-15), MARRA M.: "Mus musculus CART", XP002164047 *
DOUGLASS J ET AL: "Characterization of the human cDNA and genomic DNA encoding CART: a cocaine- and amphetamine-regulated transcript", GENE,NL,ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, vol. 169, no. 2, 9 March 1996 (1996-03-09), pages 241 - 245, XP004042910, ISSN: 0378-1119 *
DOUGLASS J ET AL: "PCR DIFFERENTIAL DISPLAY IDENTIFIES A RAT BRAIN MRNA THAT IS TRANSCRIPTIONALLY REGULATED BY COCAINE AND AMPHETAMINE", JOURNAL OF NEUROSCIENCE,US,NEW YORK, NY, vol. 15, no. 3, PART 02, 1 March 1995 (1995-03-01), pages 2471 - 2481, XP000601505, ISSN: 0270-6474 *
See also references of EP1169451A2 *

Also Published As

Publication number Publication date
MXPA01010483A (en) 2002-09-18
EP1169451A2 (en) 2002-01-09
BR0010594A (en) 2002-02-19
AU4580600A (en) 2000-11-02
CA2373359A1 (en) 2000-10-26
JP2002541842A (en) 2002-12-10
WO2000063370A2 (en) 2000-10-26

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